{"id":19,"title":"Adverse Outcome Pathways with Reactive Oxygen Species as a MIE","purpose":"AOPs in which increased reactive oxygen species (ROS) serves as a molecular initiating event (MIE), leading to diverse adverse outcomes following exposure to different chemical, physical, or biological stressors.","creation_strategy":"Manual inspection of AOPs containing increased reactive oxygen species (ROS) as at least one MIE. Search term in the MIE column: *reactive oxygen species\r\n","creation_strategy_notes":"AOP 647 (ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response)  could not be added to the collection.","collection_type":"aop","status":"draft","creator_id":21063,"submitted_at":null,"approved_at":null,"rejected_at":null,"contributors":[],"item_count":31,"items":[{"id":282,"title":"Adverse outcome pathway on photochemical toxicity initiated by light exposure"},{"id":298,"title":"Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer"},{"id":324,"title":"Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption"},{"id":325,"title":"Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death"},{"id":326,"title":"Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation"},{"id":327,"title":"Excessive reactive oxygen species production leading to mortality (1)"},{"id":328,"title":"Excessive reactive oxygen species production leading to mortality (2)"},{"id":329,"title":"Excessive reactive oxygen species production leading to mortality (3)"},{"id":330,"title":"Excessive reactive oxygen species production leading to mortality (4)"},{"id":331,"title":"Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death"},{"id":332,"title":"Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation"},{"id":333,"title":"Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death"},{"id":423,"title":" Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway "},{"id":462,"title":"Activation of reactive oxygen species leading the atherosclerosis"},{"id":476,"title":"Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity"},{"id":481,"title":"AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases."},{"id":488,"title":"Increased reactive oxygen species production leading to decreased cognitive function"},{"id":505,"title":"Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway"},{"id":511,"title":"The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects "},{"id":513,"title":"Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway"},{"id":540,"title":"Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production"},{"id":595,"title":"Emerging OPFRS reproductive outcome pathway"},{"id":596,"title":"Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death"},{"id":598,"title":"Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation"},{"id":599,"title":"Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death"},{"id":600,"title":"Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth"},{"id":601,"title":"Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation"},{"id":602,"title":"Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage"},{"id":603,"title":"Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption"},{"id":636,"title":"Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)"},{"id":638,"title":"Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis"}]}