{"id":26,"title":"My DART AOPs","purpose":"A collection of AOPs considered related to Developmental and Reproductive Toxicity","creation_strategy":"A list of candidate DART-related AOPs, identified with the help of AI, as presented in the 24 September 2026 ISTNET-DART meeting in Basel, Switzerland","creation_strategy_notes":"","collection_type":"aop","status":"submitted","creator_id":72,"submitted_at":"2026-10-13T05:30:54.000-04:00","approved_at":null,"rejected_at":null,"contributors":[{"id":72,"name":"Clemens Wittwehr"},{"id":19508,"name":"Lidwina Gerner"}],"item_count":11,"items":[{"id":12,"title":"Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging"},{"id":13,"title":"Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities"},{"id":15,"title":"Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations"},{"id":17,"title":"Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory"},{"id":23,"title":"Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)"},{"id":25,"title":"Aromatase inhibition leading to reproductive dysfunction"},{"id":42,"title":"Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals"},{"id":43,"title":"Disruption of VEGFR Signaling Leading to Developmental Defects"},{"id":212,"title":"Histone deacetylase inhibition leading to testicular atrophy"},{"id":346,"title":"Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation"},{"id":442,"title":"Binding to voltage gate sodium channels during development leads to cognitive impairment"}]}