Aop:1 Event:142 increased MESH D006965 hyperplasia Aop:1 Event:334 increased MESH D006528 hepatocellular carcinoma Aop:1 Event:57 increased GO GO:0008283 cell proliferation Aop:3 Event:887 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0008137 NADH dehydrogenase (ubiquinone) activity Aop:3 Event:888 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0006120 mitochondrial electron transport, NADH to ubiquinone Aop:3 Event:177 functional change GO GO:0005739 mitochondrion Aop:3 Event:889 abnormal CHEBI CHEBI:36080 protein MESH D057165 Proteostasis deficiencies Aop:3 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:3 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:3 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:3 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:4 Event:103 increased GO GO:0008230 ecdysone receptor holocomplex GO GO:0035076 ecdysone receptor-mediated signaling pathway Aop:4 Event:988 decreased GO GO:0008255 ecdysis-triggering hormone activity Aop:4 Event:1264 increased MESH C061375 Eip75B protein, Drosophila GO GO:0010467 gene expression Aop:4 Event:1265 increased PR PR:P33244 nuclear hormone receptor FTZ-F1 (fruit fly) GO GO:0010467 gene expression Aop:4 Event:1266 decreased PR PR:Q9VCW0 cardioactive peptide (fruit fly) GO GO:0002790 peptide secretion Aop:4 Event:1267 decreased CL CL:0000100 motor neuron GO GO:0019226 transmission of nerve impulse Aop:4 Event:993 increased GO GO:0006936 muscle contraction Aop:4 Event:990 increased CHEBI CHEBI:17029 chitin GO GO:0006031 chitin biosynthetic process Aop:4 Event:350 increased MESH D009026 mortality Aop:6 Event:858 decreased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035624 receptor transactivation Aop:6 Event:861 decreased MESH D007662 ketosis Aop:6 Event:862 abnormal MP MP:0002118 abnormal lipid homeostasis Aop:6 Event:862 abnormal CHEBI CHEBI:73693 ketone body Aop:6 Event:864 decreased MP MP:0001262 decreased body weight Aop:6 Event:863 increased MESH D009124 muscle protein GO GO:0030163 protein catabolic process Aop:6 Event:998 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0048019 receptor antagonist activity Aop:6 Event:1000 increased PR PR:000011048 nuclear receptor corepressor 2 GO GO:0003714 transcription corepressor activity Aop:6 Event:1000 increased PR PR:000011047 nuclear receptor corepressor 1 GO GO:0003714 transcription corepressor activity Aop:6 Event:1528 decreased GO GO:0006635 fatty acid beta-oxidation Aop:7 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:7 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:7 Event:406 decreased MESH D005298 fertility Aop:7 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:7 Event:405 disrupted UBERON UBERON:0001305 ovarian follicle GO GO:0042698 ovulation cycle Aop:7 Event:408 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:7 Event:408 decreased PR PR:000006100 aromatase GO GO:0009299 mRNA transcription Aop:8 Event:239 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:8 Event:319 increased MP MP:0000032 cochlear degeneration Aop:8 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:8 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:8 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0015020 glucuronosyltransferase activity Aop:8 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0003824 catalytic activity Aop:8 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:8 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:8 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:8 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:10 Event:64 decreased CHEBI CHEBI:17996 chloride GO GO:0022851 GABA-gated chloride ion channel activity Aop:10 Event:616 occurrence GO GO:0051899 membrane depolarization Aop:10 Event:613 occurrence NBO NBO:0000025 seizures Aop:10 Event:667 increased PR PR:000007766 gamma-aminobutyric acid receptor subunit alpha-1 GO GO:0050811 GABA receptor binding Aop:10 Event:667 increased PR PR:000007770 gamma-aminobutyric acid receptor subunit alpha-5 GO GO:0050811 GABA receptor binding Aop:10 Event:667 increased PR PR:000007771 gamma-aminobutyric acid receptor subunit alpha-6 GO GO:0050811 GABA receptor binding Aop:10 Event:669 decreased GO GO:0007268 chemical synaptic transmission Aop:10 Event:682 occurrence GO GO:0060079 excitatory postsynaptic potential Aop:11 Event:245 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:12 Event:195 decreased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:12 Event:352 increased MP MP:0002229 neurodegeneration Aop:12 Event:52 decreased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:12 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0010467 gene expression Aop:12 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0046903 secretion Aop:12 Event:55 increased GO GO:0008219 cell death Aop:12 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:12 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:12 Event:341 decreased GO GO:0007612 learning Aop:12 Event:341 decreased GO GO:0007613 memory Aop:13 Event:52 decreased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:13 Event:195 decreased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:13 Event:341 decreased GO GO:0007612 learning Aop:13 Event:341 decreased GO GO:0007613 memory Aop:13 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0010467 gene expression Aop:13 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0046903 secretion Aop:13 Event:382 abnormal GO GO:0030425 dendrite GO GO:0048813 dendrite morphogenesis Aop:13 Event:385 decreased GO GO:0045202 synapse GO GO:0007416 synapse assembly Aop:13 Event:386 decreased GO GO:0099536 synaptic signaling Aop:13 Event:383 decreased CHEBI CHEBI:14321 glutamate(1-) GO GO:0014047 glutamate secretion Aop:13 Event:55 increased GO GO:0008219 cell death Aop:14 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:14 Event:202 decreased PR PR:000001753 transcription factor NF-kappa-B subunit GO GO:0007249 I-kappaB kinase/NF-kappaB signaling Aop:14 Event:152 decreased GO GO:0002534 cytokine production involved in inflammatory response Aop:14 Event:168 decreased CL CL:0000542 lymphocyte Aop:14 Event:145 increased PR PR:000003292 NF-kappa-B inhibitor GO GO:0007252 I-kappaB phosphorylation Aop:14 Event:323 increased MESH D004198 Disease Susceptibility Aop:14 Event:403 increased UBERON UBERON:0002405 immune system GO GO:0044414 suppression of host defenses Aop:15 Event:336 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:15 Event:97 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006305 DNA alkylation Aop:15 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:15 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:16 Event:351 increased MESH D009026 mortality Aop:16 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:16 Event:10 increased CHEBI CHEBI:15355 acetylcholine Aop:16 Event:445 increased MP MP:0001954 respiratory distress Aop:16 Event:39 increased MP MP:0001393 ataxia Aop:16 Event:39 increased MP MP:0001399 hyperactivity Aop:16 Event:39 increased MP MP:0000753 paralysis Aop:16 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:17 Event:1392 increased MP MP:0003674 oxidative stress Aop:17 Event:55 increased GO GO:0008219 cell death Aop:17 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:17 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:17 Event:386 decreased GO GO:0099536 synaptic signaling Aop:17 Event:341 decreased GO GO:0007612 learning Aop:17 Event:341 decreased GO GO:0007613 memory Aop:17 Event:1492 increased GO GO:0002263 cell activation involved in immune response Aop:17 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:18 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:18 Event:406 decreased MESH D005298 fertility Aop:18 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:18 Event:266 decreased PR PR:000015715 STAR GO GO:0010467 gene expression Aop:18 Event:447 decreased CHEBI CHEBI:16113 cholesterol GO GO:0006839 mitochondrial transport Aop:18 Event:413 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:18 Event:289 decreased PR PR:000016757 translocator protein GO GO:0010467 gene expression Aop:18 Event:348 morphological change UBERON UBERON:0003135 male reproductive organ Aop:18 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:18 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:19 Event:310 abnormal GO GO:1990909 Wnt signalosome GO GO:0016055 Wnt signaling pathway Aop:19 Event:240 arrested UBERON UBERON:0003135 male reproductive organ GO GO:0032502 developmental process Aop:19 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:19 Event:337 decreased MESH D005298 fertility Aop:19 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:21 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:21 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:21 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:21 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:21 Event:317 morphological change MP MP:0001544 abnormal cardiovascular system physiology Aop:21 Event:317 abnormal UBERON UBERON:0004535 cardiovascular system GO GO:0072358 cardiovascular system development Aop:21 Event:1269 increased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0010467 gene expression Aop:21 Event:947 increased MP MP:0008762 embryonic lethality Aop:21 Event:947 increased MESH D009026 mortality Aop:23 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:23 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:23 Event:274 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:23 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:23 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:23 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:23 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:23 Event:78 decreased VT VT:1000294 egg quantity Aop:23 Event:221 decreased MESH D014819 vitellogenins Aop:23 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:23 Event:309 decreased GO GO:0001555 oocyte growth Aop:23 Event:309 decreased GO GO:0048599 oocyte development Aop:23 Event:129 decreased CHEBI CHEBI:81568 Luteinizing hormone Aop:23 Event:129 decreased CHEBI CHEBI:81569 Follicle stimulating hormone Aop:25 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:25 Event:36 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:25 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:25 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:25 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:25 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:25 Event:309 decreased GO GO:0001555 oocyte growth Aop:25 Event:309 decreased GO GO:0048599 oocyte development Aop:25 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:25 Event:78 decreased VT VT:1000294 egg quantity Aop:25 Event:221 decreased MESH D014819 vitellogenins Aop:26 Event:51 decreased GO GO:0090534 calcium ion-transporting ATPase complex GO GO:0005388 calcium-transporting ATPase activity Aop:26 Event:50 increased CHEBI CHEBI:39124 calcium ion Aop:26 Event:178 disrupted GO GO:0005746 mitochondrial respiratory chain Aop:26 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:26 Event:193 decreased CHEBI CHEBI:16480 nitric oxide Aop:26 Event:166 decreased GO GO:0060291 long-term synaptic potentiation Aop:26 Event:1392 increased MP MP:0003674 oxidative stress Aop:26 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:27 Event:41 decreased PR PR:000003549 bile salt export pump GO GO:0006810 transport Aop:27 Event:288 increased PR PR:000011396 bile acid receptor GO GO:0010467 gene expression Aop:27 Event:214 increased UBERON UBERON:0001970 bile Aop:27 Event:87 increased FMA FMA:84050 Cytokine GO GO:0050663 cytokine secretion Aop:27 Event:149 increased GO GO:0006954 inflammatory response Aop:27 Event:209 increased MP MP:0003674 oxidative stress Aop:27 Event:357 occurrence MESH D002779 cholestasis Aop:27 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:28 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:28 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:28 Event:243 decreased CHEBI CHEBI:15551 prostaglandin E2 Aop:28 Event:49 decreased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:28 Event:49 decreased CHEBI CHEBI:17544 hydrogencarbonate GO GO:0015701 bicarbonate transport Aop:28 Event:106 decreased UBERON UBERON:0005079 eggshell Aop:28 Event:119 functional change UBERON UBERON:0005079 eggshell Aop:28 Event:253 abnormal GO GO:0044703 multi-organism reproductive process Aop:29 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:29 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:29 Event:78 decreased VT VT:1000294 egg quantity Aop:29 Event:220 increased MESH D014819 vitellogenins Aop:29 Event:307 increased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:29 Event:252 increased MESH D007674 Kidney Diseases Aop:29 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:29 Event:363 abnormal GO GO:0019098 reproductive behavior Aop:29 Event:339 abnormal GO GO:0002164 larval development Aop:29 Event:364 abnormal UBERON UBERON:0003133 reproductive organ GO GO:0032502 developmental process Aop:30 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:30 Event:112 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:30 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:30 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:30 Event:221 decreased MESH D014819 vitellogenins Aop:30 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:30 Event:309 decreased GO GO:0001555 oocyte growth Aop:30 Event:309 decreased GO GO:0048599 oocyte development Aop:30 Event:78 decreased VT VT:1000294 egg quantity Aop:31 Event:213 increased GO GO:0006788 heme oxidation Aop:31 Event:21 abnormal PR PR:P69905 hemoglobin subunit alpha (human) GO GO:0010467 gene expression Aop:31 Event:250 increased MESH D006461 hemolysis Aop:31 Event:118 increased CHEBI CHEBI:35703 xenobiotic GO GO:0042541 hemoglobin biosynthetic process Aop:31 Event:118 increased GO GO:0030492 hemoglobin binding Aop:31 Event:131 decreased PR PR:000007749 glucose-6-phosphate 1-dehydrogenase GO GO:0010467 gene expression Aop:31 Event:246 increased CL CL:0000232 erythrocyte Aop:31 Event:246 increased MP MP:0010019 liver vascular congestion Aop:31 Event:161 increased MESH D006486 hemosiderosis Aop:31 Event:173 increased MESH D008708 Methemoglobinemia Aop:31 Event:173 decreased CHEBI CHEBI:35143 hemoglobin Aop:31 Event:173 increased CL CL:0000232 erythrocyte Aop:31 Event:321 occurrence MESH D003490 Cyanosis Aop:31 Event:1392 increased MP MP:0003674 oxidative stress Aop:32 Event:77 increased CHEBI CHEBI:39185 thiamethoxam GO GO:0008152 metabolic process Aop:32 Event:77 increased CHEBI CHEBI:25212 metabolite GO GO:0008152 metabolic process Aop:32 Event:164 decreased HP HP:0001410 Decreased liver function Aop:32 Event:147 decreased PR PR:000011326 nitric oxide synthase, brain GO GO:0004517 nitric-oxide synthase activity Aop:32 Event:270 increased MI MI:2141 hepatotoxicity Aop:32 Event:269 increased GO GO:0072574 hepatocyte proliferation Aop:32 Event:347 increased MESH D006528 hepatocellular carcinoma Aop:33 Event:9 increased PR PR:000001168 5-hydroxytryptamine receptor 2C GO GO:0023052 signaling Aop:33 Event:759 increased MP MP:0003606 kidney failure Aop:34 Event:167 increased PR PR:000011394 oxysterols receptor LXR-beta GO GO:0023052 signaling Aop:34 Event:167 increased PR PR:000011395 oxysterols receptor LXR-alpha GO GO:0023052 signaling Aop:34 Event:54 increased PR PR:000001905 platelet glycoprotein 4 GO GO:0010467 gene expression Aop:34 Event:115 increased CHEBI CHEBI:35366 fatty acid GO GO:2000193 positive regulation of fatty acid transport Aop:34 Event:66 increased PR PR:000010460 carbohydrate-responsive element-binding protein GO GO:0023052 signaling Aop:34 Event:264 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0032933 SREBP signaling pathway Aop:34 Event:116 increased PR PR:000007348 fatty acid synthase GO GO:0004312 fatty acid synthase activity Aop:34 Event:258 increased PR PR:000014497 acyl-CoA desaturase GO GO:0010467 gene expression Aop:34 Event:89 increased CHEBI CHEBI:35366 fatty acid GO GO:0006633 fatty acid biosynthetic process Aop:34 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:34 Event:345 occurrence MESH D005234 fatty liver Aop:34 Event:228 increased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:34 Event:177 functional change GO GO:0005739 mitochondrion Aop:35 Event:46 increased GO GO:0016020 membrane Aop:35 Event:169 abnormal GO GO:0005886 plasma membrane Aop:36 Event:231 decreased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:36 Event:232 decreased PR PR:000013057 peroxisome proliferator-activated receptor delta GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:36 Event:233 decreased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:36 Event:327 increased CHEBI CHEBI:35366 fatty acid Aop:36 Event:140 decreased PR PR:000008774 3-hydroxyacyl-CoA dehydrogenase type-2 GO GO:0010467 gene expression Aop:36 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:36 Event:8 decreased PR PR:000008774 3-hydroxyacyl-CoA dehydrogenase type-2 GO GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Aop:36 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:37 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:37 Event:716 increased CL CL:0000422 mitogenic signaling cell GO GO:0008283 cell proliferation Aop:37 Event:716 increased CL CL:0000182 hepatocyte GO GO:0072574 hepatocyte proliferation Aop:37 Event:719 increased MESH D000236 Adenoma Aop:37 Event:719 increased MESH D002277 Carcinoma Aop:37 Event:719 increased MESH D000236 Adenoma MESH D006528 hepatocellular carcinoma Aop:38 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:38 Event:244 increased GO GO:0008213 protein alkylation Aop:38 Event:55 increased GO GO:0008219 cell death Aop:38 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:38 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:38 Event:1492 increased GO GO:0002263 cell activation involved in immune response Aop:38 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:39 Event:313 increased MESH D012130 Respiratory Hypersensitivity Aop:39 Event:398 increased GO GO:0001775 cell activation Aop:39 Event:398 increased GO GO:0002396 MHC protein complex assembly Aop:39 Event:272 increased CL CL:0000084 T cell GO GO:0042110 T cell activation Aop:39 Event:272 increased CL CL:0000813 memory T cell GO GO:0008283 cell proliferation Aop:39 Event:396 increased CHEBI CHEBI:59739 electrophilic reagant GO GO:0005515 protein binding Aop:39 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:39 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:39 Event:1496 increased GO GO:0006956 complement activation Aop:39 Event:1496 increased FMA FMA:86578 Interleukin Aop:40 Event:396 increased CHEBI CHEBI:59739 electrophilic reagant GO GO:0005515 protein binding Aop:40 Event:826 increased GO GO:0032980 keratinocyte activation Aop:40 Event:826 increased GO GO:0002534 cytokine production involved in inflammatory response Aop:40 Event:398 increased GO GO:0001775 cell activation Aop:40 Event:398 increased GO GO:0002396 MHC protein complex assembly Aop:40 Event:272 increased CL CL:0000084 T cell GO GO:0042110 T cell activation Aop:40 Event:272 increased CL CL:0000813 memory T cell GO GO:0008283 cell proliferation Aop:41 Event:139 occurrence MESH D008107 Liver Diseases Aop:41 Event:165 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0023052 signaling Aop:41 Event:853 abnormal GO GO:0019725 cellular homeostasis Aop:41 Event:853 decreased GO GO:0006915 apoptotic process Aop:41 Event:854 abnormal FMA FMA:63179 Liver cell GO GO:0008283 cell proliferation Aop:41 Event:854 increased CL CL:0002196 hepatic oval stem cell MESH D006965 hyperplasia Aop:41 Event:854 increased CL CL:0002538 intrahepatic bile duct epithelial cell MESH D006965 hyperplasia Aop:41 Event:856 increased MESH D006528 hepatocellular carcinoma Aop:41 Event:856 increased MESH D001650 Bile Duct Neoplasms Aop:42 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:42 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:42 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:42 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:42 Event:402 decreased GO GO:0007611 learning or memory Aop:42 Event:402 decreased GO GO:0050890 cognition Aop:42 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:42 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:42 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:43 Event:305 decreased PR PR:000002112 vascular endothelial growth factor receptor 2 GO GO:0043184 vascular endothelial growth factor receptor 2 binding Aop:43 Event:305 decreased PR PR:000007563 vascular endothelial growth factor receptor 1 GO GO:0043184 vascular endothelial growth factor receptor 2 binding Aop:43 Event:28 decreased GO GO:0001525 angiogenesis Aop:43 Event:110 abnormal GO GO:0003158 endothelium development Aop:43 Event:298 decreased UBERON UBERON:0000178 blood GO GO:0008015 blood circulation Aop:43 Event:298 abnormal UBERON UBERON:0035753 capillary plexus Aop:43 Event:1001 morphological change GO GO:0009653 anatomical structure morphogenesis Aop:46 Event:373 abnormal FMA FMA:67194 Nuclear deoxyribonucleic acid GO GO:0006305 DNA alkylation Aop:46 Event:378 increased MESH D006528 hepatocellular carcinoma Aop:46 Event:376 increased PR PR:000003035 cellular tumor antigen p53 MESH D009154 mutation Aop:46 Event:409 increased GO GO:0008152 metabolic process Aop:46 Event:491 increased CL CL:0000182 hepatocyte GO GO:0072574 hepatocyte proliferation Aop:46 Event:493 functional change FMA FMA:67194 Nuclear deoxyribonucleic acid GO GO:0006281 DNA repair Aop:48 Event:177 functional change GO GO:0005739 mitochondrion Aop:48 Event:341 decreased GO GO:0007612 learning Aop:48 Event:341 decreased GO GO:0007613 memory Aop:48 Event:55 increased GO GO:0008219 cell death Aop:48 Event:352 increased MP MP:0002229 neurodegeneration Aop:48 Event:388 increased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:48 Event:388 morphological change GO GO:0032591 dendritic spine membrane MP MP:0011267 abnormal excitatory postsynaptic current amplitude Aop:48 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:48 Event:618 decreased GO GO:0099536 synaptic signaling Aop:48 Event:875 increased GO GO:0008328 ionotropic glutamate receptor complex GO GO:0004970 ionotropic glutamate receptor activity Aop:48 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:48 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:51 Event:406 decreased MESH D005298 fertility Aop:51 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:51 Event:414 increased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0042446 hormone biosynthetic process Aop:51 Event:415 increased MESH D006965 hyperplasia Aop:51 Event:416 increased GO GO:0008283 cell proliferation Aop:51 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:51 Event:413 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:51 Event:447 decreased CHEBI CHEBI:16113 cholesterol GO GO:0006839 mitochondrial transport Aop:51 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:51 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:52 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:52 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:52 Event:417 abnormal MESH D012744 sex ratio Aop:53 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:53 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:53 Event:418 increased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:53 Event:220 increased MESH D014819 vitellogenins Aop:53 Event:419 increased MESH D014819 vitellogenins Aop:53 Event:421 functional change UBERON UBERON:0005777 glomerular basement membrane Aop:53 Event:421 increased MP MP:0001914 hemorrhage Aop:53 Event:422 increased HP HP:0000112 Nephropathy Aop:54 Event:425 decreased CHEBI CHEBI:16382 iodide GO GO:0015705 iodide transport Aop:54 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:54 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0010467 gene expression Aop:54 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0046903 secretion Aop:54 Event:385 decreased GO GO:0045202 synapse GO GO:0007416 synapse assembly Aop:54 Event:341 decreased GO GO:0007612 learning Aop:54 Event:341 decreased GO GO:0007613 memory Aop:54 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:54 Event:851 abnormal MP MP:0002882 abnormal neuron morphology Aop:54 Event:424 decreased PR PR:000015171 sodium/iodide cotransporter GO GO:0008507 sodium:iodide symporter activity Aop:54 Event:386 decreased GO GO:0099536 synaptic signaling Aop:54 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:57 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:57 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:57 Event:450 decreased CHEBI CHEBI:39027 very-low-density lipoprotein GO GO:0046903 secretion Aop:57 Event:451 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:57 Event:327 increased CHEBI CHEBI:35366 fatty acid Aop:57 Event:216 decreased PR PR:000012416 phosphoenolpyruvate carboxykinase, cytosolic [GTP] GO GO:0010467 gene expression Aop:57 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:57 Event:54 increased PR PR:000001905 platelet glycoprotein 4 GO GO:0010467 gene expression Aop:57 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:57 Event:466 increased PR PR:000009744 low-density lipoprotein receptor GO GO:0010467 gene expression Aop:57 Event:467 increased CHEBI CHEBI:39026 low-density lipoprotein GO GO:0006898 receptor-mediated endocytosis Aop:57 Event:80 increased PR PR:000006101 cytochrome P450 1A1 GO GO:0010467 gene expression Aop:57 Event:462 increased PR PR:000014497 acyl-CoA desaturase GO GO:0010467 gene expression Aop:57 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:58 Event:456 decreased PR PR:000011398 nuclear receptor subfamily 1 group I member 3 GO GO:0023052 signaling Aop:58 Event:457 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0023052 signaling Aop:58 Event:457 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0032933 SREBP signaling pathway Aop:58 Event:66 increased PR PR:000010460 carbohydrate-responsive element-binding protein GO GO:0023052 signaling Aop:58 Event:458 increased CHEBI CHEBI:35366 fatty acid GO GO:0006633 fatty acid biosynthetic process Aop:58 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:58 Event:454 increased CHEBI CHEBI:17855 triglyceride GO GO:0019432 triglyceride biosynthetic process Aop:58 Event:454 increased CHEBI CHEBI:17855 triglyceride GO GO:0009058 biosynthetic process Aop:58 Event:54 increased PR PR:000001905 platelet glycoprotein 4 GO GO:0010467 gene expression Aop:58 Event:462 increased PR PR:000014497 acyl-CoA desaturase GO GO:0010467 gene expression Aop:58 Event:463 increased PR PR:000007348 fatty acid synthase GO GO:0010467 gene expression Aop:58 Event:468 decreased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:58 Event:167 increased PR PR:000011394 oxysterols receptor LXR-beta GO GO:0023052 signaling Aop:58 Event:167 increased PR PR:000011395 oxysterols receptor LXR-alpha GO GO:0023052 signaling Aop:58 Event:228 increased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:58 Event:451 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:58 Event:327 increased CHEBI CHEBI:35366 fatty acid Aop:58 Event:470 increased PR PR:000003596 acetyl-CoA carboxylase 1 GO GO:0003989 acetyl-CoA carboxylase activity Aop:58 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:59 Event:461 decreased PR PR:000008654 hepatocyte nuclear factor 4-alpha GO GO:0023052 signaling Aop:60 Event:245 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:60 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:60 Event:471 decreased PR PR:000007603 hepatocyte nuclear factor 3-beta GO GO:0023052 signaling Aop:60 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:60 Event:472 decreased PR PR:000005835 carnitine O-palmitoyltransferase 1, liver isoform GO GO:0010467 gene expression Aop:60 Event:474 decreased PR PR:000008638 hydroxymethylglutaryl-CoA synthase, mitochondrial GO GO:0010467 gene expression Aop:60 Event:462 increased PR PR:000014497 acyl-CoA desaturase GO GO:0010467 gene expression Aop:60 Event:54 increased PR PR:000001905 platelet glycoprotein 4 GO GO:0010467 gene expression Aop:60 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:60 Event:477 decreased MESH D007662 ketosis Aop:60 Event:454 increased CHEBI CHEBI:17855 triglyceride GO GO:0019432 triglyceride biosynthetic process Aop:60 Event:454 increased CHEBI CHEBI:17855 triglyceride GO GO:0009058 biosynthetic process Aop:60 Event:327 increased CHEBI CHEBI:35366 fatty acid Aop:61 Event:478 increased PR PR:000011170 nuclear factor erythroid 2-related factor 2 GO GO:0023052 signaling Aop:61 Event:479 increased PR PR:000011396 bile acid receptor GO GO:0023052 signaling Aop:61 Event:480 increased PR PR:000011391 nuclear receptor subfamily 0 group B member 2 GO GO:0023052 signaling Aop:61 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:61 Event:482 decreased PR PR:000008778 17-beta-hydroxysteroid dehydrogenase 14 GO GO:0003824 catalytic activity Aop:61 Event:451 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:61 Event:483 increased PR PR:000011395 oxysterols receptor LXR-alpha GO GO:0023052 signaling Aop:61 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:61 Event:878 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0032933 SREBP signaling pathway Aop:61 Event:879 increased PR PR:000003392 microsomal triglyceride transfer protein large subunit MTTP GO GO:0023052 signaling Aop:61 Event:880 increased PR PR:000004145 apolipoprotein B-100 GO GO:0010467 gene expression Aop:61 Event:881 increased CHEBI CHEBI:17855 triglyceride GO GO:0009058 biosynthetic process Aop:61 Event:458 increased CHEBI CHEBI:35366 fatty acid GO GO:0006633 fatty acid biosynthetic process Aop:62 Event:484 increased PR PR:000003912 RAC-beta serine/threonine-protein kinase GO GO:0023052 signaling Aop:62 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:62 Event:486 occurrence GO GO:0006954 inflammatory response Aop:62 Event:457 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0023052 signaling Aop:62 Event:457 increased PR PR:000015611 sterol regulatory element-binding protein 1 GO GO:0032933 SREBP signaling pathway Aop:63 Event:675 decreased GO GO:0022414 reproductive process Aop:63 Event:675 decreased GO GO:0000003 reproduction Aop:63 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:63 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:63 Event:488 decreased GO GO:0030728 ovulation Aop:63 Event:685 decreased CHEBI CHEBI:26333 prostaglandin Aop:63 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:64 Event:494 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:64 Event:495 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:64 Event:496 increased GO GO:0006915 apoptotic process Aop:64 Event:413 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:64 Event:520 decreased VT VT:0002673 sperm quantity Aop:64 Event:520 morphological change CL CL:0000019 sperm Aop:64 Event:520 decreased MESH D005298 fertility Aop:64 Event:520 decreased CL CL:0000019 sperm Aop:64 Event:406 decreased MESH D005298 fertility Aop:64 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:64 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:64 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:65 Event:424 decreased PR PR:000015171 sodium/iodide cotransporter GO GO:0008507 sodium:iodide symporter activity Aop:65 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:65 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:65 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:65 Event:186 abnormal UBERON UBERON:0001016 nervous system GO GO:0048856 anatomical structure development Aop:65 Event:192 abnormal MP MP:0003633 abnormal nervous system physiology Aop:65 Event:402 decreased GO GO:0007611 learning or memory Aop:65 Event:402 decreased GO GO:0050890 cognition Aop:66 Event:505 decreased MESH D005298 fertility Aop:66 Event:505 decreased CL CL:0000019 sperm Aop:66 Event:653 increased CHEBI CHEBI:16827 corticosterone Aop:66 Event:654 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:66 Event:655 increased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:66 Event:656 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:66 Event:657 increased MP MP:0013603 abnormal fetal Leydig cell differentiation Aop:66 Event:657 increased HP HP:0008715 Testicular dysgenesis Aop:67 Event:505 decreased MESH D005298 fertility Aop:67 Event:505 decreased CL CL:0000019 sperm Aop:67 Event:658 increased PR PR:000007204 estrogen receptor Aop:67 Event:659 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:67 Event:655 increased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:67 Event:660 increased MP MP:0013603 abnormal fetal Leydig cell differentiation Aop:67 Event:660 increased HP HP:0008715 Testicular dysgenesis Aop:67 Event:656 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:68 Event:505 decreased MESH D005298 fertility Aop:68 Event:505 decreased CL CL:0000019 sperm Aop:68 Event:661 abnormal MESH D005326 fetal proteins Aop:68 Event:655 increased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:68 Event:657 increased MP MP:0013603 abnormal fetal Leydig cell differentiation Aop:68 Event:657 increased HP HP:0008715 Testicular dysgenesis Aop:68 Event:656 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:69 Event:642 decreased CHEBI CHEBI:16113 cholesterol GO GO:0006695 cholesterol biosynthetic process Aop:69 Event:643 decreased CHEBI CHEBI:6495 lipoprotein GO GO:0042953 lipoprotein transport Aop:69 Event:644 decreased CHEBI CHEBI:16113 cholesterol GO GO:0032367 intracellular cholesterol transport Aop:69 Event:645 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:69 Event:646 decreased CL CL:0000019 sperm Aop:70 Event:520 decreased VT VT:0002673 sperm quantity Aop:70 Event:520 morphological change CL CL:0000019 sperm Aop:70 Event:520 decreased MESH D005298 fertility Aop:70 Event:520 decreased CL CL:0000019 sperm Aop:70 Event:640 decreased GO GO:0006694 steroid biosynthetic process Aop:70 Event:647 decreased GO GO:0050810 regulation of steroid biosynthetic process Aop:70 Event:648 increased CL CL:0000178 Leydig cell GO GO:0006915 apoptotic process Aop:70 Event:649 abnormal CL CL:0000178 Leydig cell GO GO:0007010 cytoskeleton organization Aop:71 Event:525 decreased CHEBI CHEBI:17347 testosterone Aop:71 Event:525 increased GO GO:0006915 apoptotic process Aop:71 Event:520 decreased VT VT:0002673 sperm quantity Aop:71 Event:520 morphological change CL CL:0000019 sperm Aop:71 Event:520 decreased MESH D005298 fertility Aop:71 Event:520 decreased CL CL:0000019 sperm Aop:71 Event:650 increased CHEBI CHEBI:24261 glucocorticoid GO GO:0006704 glucocorticoid biosynthetic process Aop:71 Event:650 increased GO GO:0001775 cell activation Aop:71 Event:651 abnormal PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:71 Event:652 abnormal GO GO:0050810 regulation of steroid biosynthetic process Aop:72 Event:228 increased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:72 Event:1028 decreased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:73 Event:526 decreased PR PR:000006294 dopamine beta-hydroxylase GO GO:0004500 dopamine beta-monooxygenase activity Aop:73 Event:527 decreased MESH D005298 fertility Aop:73 Event:527 decreased MESH D005298 fertility MP MP:0001921 reduced fertility Aop:73 Event:528 decreased CHEBI CHEBI:18357 (R)-noradrenaline GO GO:0042421 norepinephrine biosynthetic process Aop:73 Event:529 decreased PR PR:P01101 proto-oncogene c-Fos (mouse) GO GO:0023052 signaling Aop:73 Event:530 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:73 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0033684 regulation of luteinizing hormone secretion Aop:73 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:73 Event:532 delayed MP MP:0001928 abnormal ovulation Aop:73 Event:533 decreased GO GO:0060473 cortical granule GO GO:0046903 secretion Aop:73 Event:534 abnormal GO GO:0060387 fertilization envelope Aop:73 Event:535 abnormal GO GO:0035037 sperm entry Aop:73 Event:536 increased MP MP:0004023 abnormal chromosome number Aop:74 Event:543 decreased MESH D005298 fertility Aop:74 Event:543 decreased CL CL:0000019 sperm Aop:74 Event:662 increased GO GO:0044026 DNA hypermethylation Aop:74 Event:655 increased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:74 Event:540 increased MP MP:0013603 abnormal fetal Leydig cell differentiation Aop:74 Event:540 increased HP HP:0008715 Testicular dysgenesis Aop:74 Event:541 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:74 Event:541 increased MP MP:0013604 abnormal adult Leydig cell differentiation Aop:77 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:77 Event:177 functional change GO GO:0005739 mitochondrion Aop:77 Event:341 decreased GO GO:0007612 learning Aop:77 Event:341 decreased GO GO:0007613 memory Aop:77 Event:560 abnormal GO GO:0060756 foraging behavior Aop:77 Event:563 increased MESH D056631 colony collapse Aop:77 Event:1107 increased MESH D056631 colony collapse Aop:77 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005488 binding Aop:77 Event:1243 abnormal PR PR:000004978 calmodulin GO GO:0023052 signaling Aop:77 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005516 calmodulin binding Aop:78 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:78 Event:177 functional change GO GO:0005739 mitochondrion Aop:78 Event:386 decreased GO GO:0099536 synaptic signaling Aop:78 Event:341 decreased GO GO:0007612 learning Aop:78 Event:341 decreased GO GO:0007613 memory Aop:78 Event:565 decreased GO GO:0019098 reproductive behavior Aop:78 Event:565 decreased MP MP:0001386 abnormal maternal nurturing Aop:78 Event:566 abnormal GO GO:0002164 larval development Aop:78 Event:563 increased MESH D056631 colony collapse Aop:79 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:79 Event:177 functional change GO GO:0005739 mitochondrion Aop:79 Event:563 increased MESH D056631 colony collapse Aop:79 Event:568 abnormal NBO NBO:0000051 thermoregulation behavior Aop:79 Event:1107 increased MESH D056631 colony collapse Aop:80 Event:177 functional change GO GO:0005739 mitochondrion Aop:80 Event:570 functional change FMA FMA:67199 Mitochondrial deoxyribonucleic acid GO GO:0009611 response to wounding Aop:80 Event:571 premature GO GO:0007568 aging Aop:80 Event:572 decreased PCO PCO:0000001 population of organisms Aop:80 Event:568 abnormal NBO NBO:0000051 thermoregulation behavior Aop:80 Event:563 increased MESH D056631 colony collapse Aop:80 Event:664 abnormal FMA FMA:67199 Mitochondrial deoxyribonucleic acid GO GO:0006281 DNA repair Aop:80 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:81 Event:573 increased MP MP:0004889 increased energy expenditure Aop:81 Event:573 increased MESH D013312 Stress, Physiological Aop:81 Event:574 increased MESH D001066 Appetite Aop:81 Event:560 abnormal GO GO:0060756 foraging behavior Aop:81 Event:572 decreased PCO PCO:0000001 population of organisms Aop:81 Event:563 increased MESH D056631 colony collapse Aop:82 Event:565 decreased GO GO:0019098 reproductive behavior Aop:82 Event:565 decreased MP MP:0001386 abnormal maternal nurturing Aop:82 Event:566 abnormal GO GO:0002164 larval development Aop:82 Event:563 increased MESH D056631 colony collapse Aop:84 Event:403 increased UBERON UBERON:0002405 immune system GO GO:0044414 suppression of host defenses Aop:84 Event:576 increased MP MP:0002418 increased susceptibility to viral infection Aop:84 Event:577 abnormal GO GO:0032502 developmental process Aop:84 Event:572 decreased PCO PCO:0000001 population of organisms Aop:84 Event:568 abnormal NBO NBO:0000051 thermoregulation behavior Aop:84 Event:563 increased MESH D056631 colony collapse Aop:85 Event:403 increased UBERON UBERON:0002405 immune system GO GO:0044414 suppression of host defenses Aop:85 Event:576 increased MP MP:0002418 increased susceptibility to viral infection Aop:85 Event:560 abnormal GO GO:0060756 foraging behavior Aop:85 Event:572 decreased PCO PCO:0000001 population of organisms Aop:85 Event:563 increased MESH D056631 colony collapse Aop:86 Event:578 decreased CHEBI CHEBI:16217 D-glucono-1,5-lactone GO GO:0046562 glucose oxidase activity Aop:86 Event:579 decreased CHEBI CHEBI:16240 hydrogen peroxide GO GO:0050665 hydrogen peroxide biosynthetic process Aop:86 Event:561 decreased NBO NBO:0000079 feeding behavior Aop:86 Event:566 abnormal GO GO:0002164 larval development Aop:86 Event:563 increased MESH D056631 colony collapse Aop:87 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:87 Event:177 functional change GO GO:0005739 mitochondrion Aop:87 Event:341 decreased GO GO:0007612 learning Aop:87 Event:341 decreased GO GO:0007613 memory Aop:87 Event:560 abnormal GO GO:0060756 foraging behavior Aop:87 Event:563 increased MESH D056631 colony collapse Aop:87 Event:1107 increased MESH D056631 colony collapse Aop:87 Event:1108 abnormal MESH D012380 role Aop:87 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005488 binding Aop:87 Event:1243 abnormal PR PR:000004978 calmodulin GO GO:0023052 signaling Aop:87 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005516 calmodulin binding Aop:88 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:88 Event:341 decreased GO GO:0007612 learning Aop:88 Event:341 decreased GO GO:0007613 memory Aop:88 Event:563 increased MESH D056631 colony collapse Aop:88 Event:560 abnormal GO GO:0060756 foraging behavior Aop:88 Event:663 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0030549 acetylcholine receptor activator activity Aop:88 Event:663 decreased GO GO:0030545 receptor regulator activity Aop:88 Event:1107 increased MESH D056631 colony collapse Aop:88 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005488 binding Aop:88 Event:1243 abnormal PR PR:000004978 calmodulin GO GO:0023052 signaling Aop:88 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005516 calmodulin binding Aop:89 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:89 Event:341 decreased GO GO:0007612 learning Aop:89 Event:341 decreased GO GO:0007613 memory Aop:89 Event:563 increased MESH D056631 colony collapse Aop:89 Event:560 abnormal GO GO:0060756 foraging behavior Aop:89 Event:663 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0030549 acetylcholine receptor activator activity Aop:89 Event:663 decreased GO GO:0030545 receptor regulator activity Aop:89 Event:1107 increased MESH D056631 colony collapse Aop:89 Event:1108 abnormal MESH D012380 role Aop:89 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005488 binding Aop:89 Event:1243 abnormal PR PR:000004978 calmodulin GO GO:0023052 signaling Aop:89 Event:1243 abnormal CHEBI CHEBI:39124 calcium ion GO GO:0005516 calmodulin binding Aop:90 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:90 Event:341 decreased GO GO:0007612 learning Aop:90 Event:341 decreased GO GO:0007613 memory Aop:90 Event:565 decreased GO GO:0019098 reproductive behavior Aop:90 Event:565 decreased MP MP:0001386 abnormal maternal nurturing Aop:90 Event:566 abnormal GO GO:0002164 larval development Aop:90 Event:563 increased MESH D056631 colony collapse Aop:90 Event:663 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0030549 acetylcholine receptor activator activity Aop:90 Event:663 decreased GO GO:0030545 receptor regulator activity Aop:90 Event:386 decreased GO GO:0099536 synaptic signaling Aop:91 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:91 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0023052 signaling Aop:91 Event:585 decreased GO GO:0001508 action potential Aop:91 Event:586 decreased NBO NBO:0000371 aquatic locomotion Aop:91 Event:587 decreased NBO NBO:0000079 feeding behavior Aop:91 Event:588 increased GO GO:0002120 predatory behavior Aop:91 Event:592 decreased VT VT:0005372 life span trait Aop:93 Event:585 decreased GO GO:0001508 action potential Aop:93 Event:586 decreased NBO NBO:0000371 aquatic locomotion Aop:93 Event:588 increased GO GO:0002120 predatory behavior Aop:93 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:93 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0023052 signaling Aop:94 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:94 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0023052 signaling Aop:94 Event:444 increased MESH D054537 atrioventricular block Aop:94 Event:444 increased MESH D001919 decreased heart rate Aop:94 Event:445 increased MP MP:0001954 respiratory distress Aop:94 Event:590 decreased MP MP:0005039 hypoxia Aop:94 Event:591 increased MESH C565682 Amputation, Congenital Aop:94 Event:585 decreased GO GO:0001508 action potential Aop:95 Event:585 decreased GO GO:0001508 action potential Aop:95 Event:586 decreased NBO NBO:0000371 aquatic locomotion Aop:95 Event:587 decreased NBO NBO:0000079 feeding behavior Aop:95 Event:588 increased GO GO:0002120 predatory behavior Aop:95 Event:592 decreased VT VT:0005372 life span trait Aop:95 Event:593 decreased PR PR:Q12809 potassium voltage-gated channel subfamily H member 2 (human) GO GO:0019870 potassium channel inhibitor activity Aop:96 Event:598 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:96 Event:599 increased GO GO:0051899 membrane depolarization Aop:96 Event:600 increased GO GO:0007269 neurotransmitter secretion Aop:96 Event:601 increased GO GO:0006936 muscle contraction Aop:96 Event:602 increased MP MP:0001393 ataxia Aop:96 Event:602 increased MP MP:0001399 hyperactivity Aop:96 Event:602 increased MP MP:0000753 paralysis Aop:96 Event:351 increased MESH D009026 mortality Aop:97 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:97 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:97 Event:623 increased GO GO:0002120 predatory behavior Aop:97 Event:1142 increased UBERON UBERON:0003978 valve GO GO:0050881 musculoskeletal movement Aop:97 Event:624 increased NBO NBO:0000071 fossorial locomotion behavior Aop:97 Event:622 increased GO GO:0040011 locomotion Aop:97 Event:626 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0001820 serotonin secretion Aop:97 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:98 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:98 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:98 Event:626 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0001820 serotonin secretion Aop:98 Event:627 decreased NBO NBO:0000018 fear/anxiety related behavior Aop:98 Event:629 decreased MP MP:0014039 abnormal sheltering behavior Aop:98 Event:588 increased GO GO:0002120 predatory behavior Aop:99 Event:633 decreased CL CL:0011110 histaminergic neuron GO GO:0043179 rhythmic excitation Aop:99 Event:634 increased MESH D000758 anesthesia Aop:99 Event:635 decreased GO GO:0040011 locomotion Aop:99 Event:636 decreased VT VT:0005372 life span trait Aop:99 Event:588 increased GO GO:0002120 predatory behavior Aop:99 Event:638 decreased PR PR:000001423 histamine H2 receptor GO GO:0004969 histamine receptor activity Aop:99 Event:341 decreased GO GO:0007612 learning Aop:99 Event:341 decreased GO GO:0007613 memory Aop:100 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:100 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:100 Event:671 decreased CHEBI CHEBI:15553 prostaglandin F2alpha Aop:100 Event:672 decreased CHEBI CHEBI:15553 prostaglandin F2alpha GO GO:0001516 prostaglandin biosynthetic process Aop:100 Event:673 abnormal MESH D005298 fertility Aop:100 Event:674 decreased NBO NBO:0000280 attraction-related behavior Aop:100 Event:675 decreased GO GO:0022414 reproductive process Aop:100 Event:675 decreased GO GO:0000003 reproduction Aop:100 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:101 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:101 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:101 Event:674 decreased NBO NBO:0000280 attraction-related behavior Aop:101 Event:675 decreased GO GO:0022414 reproductive process Aop:101 Event:675 decreased GO GO:0000003 reproduction Aop:101 Event:678 decreased CHEBI CHEBI:26013 pheromone GO GO:0071834 mating pheromone secretion Aop:101 Event:681 decreased CHEBI CHEBI:15553 prostaglandin F2alpha GO GO:0001516 prostaglandin biosynthetic process Aop:101 Event:671 decreased CHEBI CHEBI:15553 prostaglandin F2alpha Aop:101 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:102 Event:687 decreased CHEBI CHEBI:15551 prostaglandin E2 Aop:102 Event:689 decreased MESH D007987 Gonadotropin Releasing Hormone Aop:102 Event:690 decreased CHEBI CHEBI:81568 Luteinizing hormone Aop:102 Event:691 decreased CHEBI CHEBI:26764 steroid hormone Aop:102 Event:692 decreased CHEBI CHEBI:26764 steroid hormone GO GO:0003707 steroid hormone receptor activity Aop:102 Event:692 decreased CHEBI CHEBI:26764 steroid hormone GO GO:0023052 signaling Aop:102 Event:694 decreased GO GO:0008315 G2/MI transition of meiotic cell cycle Aop:102 Event:693 increased CHEBI CHEBI:58165 3',5'-cyclic AMP(1-) Aop:102 Event:675 decreased GO GO:0022414 reproductive process Aop:102 Event:675 decreased GO GO:0000003 reproduction Aop:102 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:102 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:102 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:103 Event:79 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:103 Event:79 decreased PR PR:000013428 prostaglandin G/H synthase 2 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:103 Event:687 decreased CHEBI CHEBI:15551 prostaglandin E2 Aop:103 Event:689 decreased MESH D007987 Gonadotropin Releasing Hormone Aop:103 Event:690 decreased CHEBI CHEBI:81568 Luteinizing hormone Aop:103 Event:691 decreased CHEBI CHEBI:26764 steroid hormone Aop:103 Event:692 decreased CHEBI CHEBI:26764 steroid hormone GO GO:0003707 steroid hormone receptor activity Aop:103 Event:692 decreased CHEBI CHEBI:26764 steroid hormone GO GO:0023052 signaling Aop:103 Event:695 increased PR PR:Q9VNE1 MAD2 like protein (fruit fly) GO GO:1902426 deactivation of mitotic spindle assembly checkpoint Aop:103 Event:696 abnormal GO GO:0007059 chromosome segregation Aop:103 Event:675 decreased GO GO:0022414 reproductive process Aop:103 Event:675 decreased GO GO:0000003 reproduction Aop:103 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:104 Event:697 decreased PR PR:Q12809 potassium voltage-gated channel subfamily H member 2 (human) GO GO:0005216 ion channel activity Aop:104 Event:697 decreased PR PR:000001978 ATP-sensitive inward rectifier potassium channel 1 GO GO:0005216 ion channel activity Aop:104 Event:351 increased MESH D009026 mortality Aop:104 Event:698 abnormal GO GO:0001508 action potential Aop:104 Event:699 increased MESH D001145 Arrhythmias, Cardiac Aop:105 Event:708 increased PR PR:P02761 major urinary protein (rat) Aop:105 Event:709 increased CL CL:1000507 kidney tubule cell GO GO:0008219 cell death Aop:105 Event:710 increased CL CL:1000507 kidney tubule cell GO GO:0050673 epithelial cell proliferation Aop:105 Event:713 increased MESH D000236 Adenoma Aop:105 Event:713 increased MESH D002277 Carcinoma Aop:105 Event:713 increased MESH D000236 Adenoma MESH D002292 Carcinoma, Renal Cell Aop:105 Event:767 increased CL CL:1000507 kidney tubule cell MESH D006965 hyperplasia Aop:105 Event:714 increased PR PR:P02761 major urinary protein (rat) GO GO:0005488 binding Aop:106 Event:718 increased PR PR:000028799 tubulin GO GO:0015631 tubulin binding Aop:106 Event:718 disrupted GO GO:0045298 tubulin complex Aop:106 Event:720 increased GO GO:0005874 microtubule GO GO:0007019 microtubule depolymerization Aop:106 Event:721 decreased GO GO:0005819 spindle GO GO:0007051 spindle organization Aop:106 Event:728 increased MP MP:0004023 abnormal chromosome number Aop:106 Event:752 abnormal GO GO:0005694 chromosome GO GO:0051305 chromosome movement towards spindle pole Aop:106 Event:723 increased MP MP:0004023 abnormal chromosome number Aop:107 Event:715 increased PR PR:000011398 nuclear receptor subfamily 1 group I member 3 GO GO:0023052 signaling Aop:107 Event:716 increased CL CL:0000422 mitogenic signaling cell GO GO:0008283 cell proliferation Aop:107 Event:716 increased CL CL:0000182 hepatocyte GO GO:0072574 hepatocyte proliferation Aop:107 Event:719 increased MESH D000236 Adenoma Aop:107 Event:719 increased MESH D002277 Carcinoma Aop:107 Event:719 increased MESH D000236 Adenoma MESH D006528 hepatocellular carcinoma Aop:107 Event:774 increased MP MP:0003902 abnormal cell mass MP MP:0002009 preneoplasia Aop:107 Event:1214 abnormal GO GO:0010468 regulation of gene expression Aop:108 Event:719 increased MESH D000236 Adenoma Aop:108 Event:719 increased MESH D002277 Carcinoma Aop:108 Event:719 increased MESH D000236 Adenoma MESH D006528 hepatocellular carcinoma Aop:108 Event:768 increased GO GO:0008219 cell death Aop:108 Event:768 increased GO GO:0001909 leukocyte mediated cytotoxicity Aop:108 Event:209 increased MP MP:0003674 oxidative stress Aop:108 Event:726 increased PR PR:000023575 pyruvate dehydrogenase [ubiquinone] GO GO:0004738 pyruvate dehydrogenase activity Aop:108 Event:724 decreased PR PR:Q63065 Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) GO GO:0004738 pyruvate dehydrogenase activity Aop:108 Event:769 increased GO GO:0045333 cellular respiration Aop:109 Event:733 increased CL CL:0002328 bronchial epithelial cell GO GO:0008219 cell death Aop:109 Event:734 increased CL CL:0002328 bronchial epithelial cell GO GO:0050673 epithelial cell proliferation Aop:109 Event:735 increased CL CL:0002328 bronchial epithelial cell MESH D006965 hyperplasia Aop:109 Event:736 increased MESH D000236 Adenoma Aop:109 Event:736 increased MESH D002277 Carcinoma Aop:109 Event:770 increased CL CL:0000158 Clara cell GO GO:0008219 cell death Aop:110 Event:739 increased CL CL:0002258 thyroid follicular cell GO GO:0008283 cell proliferation Aop:110 Event:739 increased CL CL:0002258 thyroid follicular cell MESH D006984 hypertrophy Aop:110 Event:740 increased CL CL:0002258 thyroid follicular cell MESH D006965 hyperplasia Aop:110 Event:741 increased MESH D000236 Adenoma Aop:110 Event:741 increased MESH D002277 Carcinoma Aop:110 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:110 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:110 Event:1023 increased CHEBI CHEBI:81567 Thyroid stimulating hormone Aop:110 Event:424 decreased PR PR:000015171 sodium/iodide cotransporter GO GO:0008507 sodium:iodide symporter activity Aop:111 Event:743 decreased CHEBI CHEBI:17347 testosterone GO GO:0005102 receptor binding Aop:111 Event:744 increased CL CL:0000178 Leydig cell MP MP:0001152 Leydig cell hyperplasia Aop:111 Event:745 increased MP MP:0002006 neoplasm Aop:111 Event:754 increased CHEBI CHEBI:81568 Luteinizing hormone Aop:111 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:112 Event:746 increased GO GO:0001963 synaptic transmission, dopaminergic Aop:112 Event:747 decreased CHEBI CHEBI:81580 Prolactin Aop:112 Event:749 decreased CHEBI CHEBI:17026 progesterone GO GO:0042701 progesterone secretion Aop:112 Event:772 increased CL CL:0002656 glandular cell of endometrium MP MP:0009092 endometrium hyperplasia Aop:112 Event:772 increased CL CL:0000150 glandular epithelial cell MESH D006965 hyperplasia Aop:112 Event:773 increased MESH D000236 Adenoma Aop:112 Event:773 increased MESH D002277 Carcinoma Aop:112 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:112 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:113 Event:760 increased PR PR:Q94900 glutamate-gated chloride channel (fruit fly) GO GO:0005254 chloride channel activity Aop:113 Event:761 increased CHEBI CHEBI:17996 chloride GO GO:1902476 chloride transmembrane transport Aop:113 Event:763 increased GO GO:0060081 membrane hyperpolarization Aop:113 Event:764 increased MP MP:0001393 ataxia Aop:113 Event:764 increased MP MP:0001399 hyperactivity Aop:113 Event:764 increased MP MP:0000753 paralysis Aop:113 Event:351 increased MESH D009026 mortality Aop:113 Event:765 decreased PCO PCO:0000003 population quality Aop:114 Event:766 decreased PR PR:P32755 4-hydroxyphenylpyruvate dioxygenase (rat) GO GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity Aop:114 Event:775 increased CHEBI CHEBI:18186 tyrosine Aop:114 Event:776 increased CL CL:0000575 corneal epithelial cell GO GO:0008219 cell death Aop:114 Event:777 increased CL CL:0000575 corneal epithelial cell GO GO:0006954 inflammatory response Aop:114 Event:778 increased CL CL:0000575 corneal epithelial cell GO GO:0008283 cell proliferation Aop:114 Event:779 increased MESH D010212 papilloma Aop:114 Event:779 increased MESH D002277 Carcinoma Aop:115 Event:780 increased CL CL:0000066 epithelial cell GO GO:0008219 cell death Aop:115 Event:149 increased GO GO:0006954 inflammatory response Aop:115 Event:781 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:115 Event:782 increased CL CL:0000066 epithelial cell MP MP:0005493 stomach epithelial hyperplasia Aop:115 Event:779 increased MESH D010212 papilloma Aop:115 Event:779 increased MESH D002277 Carcinoma Aop:116 Event:783 increased CL CL:1000494 nephron tubule epithelial cell GO GO:0008219 cell death Aop:116 Event:710 increased CL CL:1000507 kidney tubule cell GO GO:0050673 epithelial cell proliferation Aop:116 Event:784 increased CL CL:1000494 nephron tubule epithelial cell MP MP:0004968 kidney epithelium hyperplasia Aop:116 Event:713 increased MESH D000236 Adenoma Aop:116 Event:713 increased MESH D002277 Carcinoma Aop:116 Event:713 increased MESH D000236 Adenoma MESH D002292 Carcinoma, Renal Cell Aop:117 Event:716 increased CL CL:0000422 mitogenic signaling cell GO GO:0008283 cell proliferation Aop:117 Event:716 increased CL CL:0000182 hepatocyte GO GO:0072574 hepatocyte proliferation Aop:117 Event:774 increased MP MP:0003902 abnormal cell mass MP MP:0002009 preneoplasia Aop:117 Event:719 increased MESH D000236 Adenoma Aop:117 Event:719 increased MESH D002277 Carcinoma Aop:117 Event:719 increased MESH D000236 Adenoma MESH D006528 hepatocellular carcinoma Aop:117 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:118 Event:786 increased CL CL:0000182 hepatocyte GO GO:0008219 cell death Aop:118 Event:787 increased CL CL:0000182 hepatocyte GO GO:0008283 cell proliferation Aop:118 Event:774 increased MP MP:0003902 abnormal cell mass MP MP:0002009 preneoplasia Aop:118 Event:719 increased MESH D000236 Adenoma Aop:118 Event:719 increased MESH D002277 Carcinoma Aop:118 Event:719 increased MESH D000236 Adenoma MESH D006528 hepatocellular carcinoma Aop:119 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:119 Event:739 increased CL CL:0002258 thyroid follicular cell GO GO:0008283 cell proliferation Aop:119 Event:739 increased CL CL:0002258 thyroid follicular cell MESH D006984 hypertrophy Aop:119 Event:740 increased CL CL:0002258 thyroid follicular cell MESH D006965 hyperplasia Aop:119 Event:741 increased MESH D000236 Adenoma Aop:119 Event:741 increased MESH D002277 Carcinoma Aop:119 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:119 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:119 Event:1023 increased CHEBI CHEBI:81567 Thyroid stimulating hormone Aop:120 Event:791 increased CHEBI CHEBI:81568 Luteinizing hormone Aop:120 Event:744 increased CL CL:0000178 Leydig cell MP MP:0001152 Leydig cell hyperplasia Aop:120 Event:745 increased MP MP:0002006 neoplasm Aop:120 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:120 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:121 Event:793 increased MESH D002137 Calculi MP MP:0011625 cystolithiasis Aop:121 Event:794 increased CL CL:0000731 urothelial cell GO GO:0008219 cell death Aop:121 Event:795 increased CL CL:0000731 urothelial cell GO GO:0008283 cell proliferation Aop:121 Event:796 increased CL CL:0000731 urothelial cell MESH D006965 hyperplasia Aop:121 Event:797 increased MESH D000236 Adenoma Aop:121 Event:797 increased MESH D002277 Carcinoma Aop:122 Event:798 decreased MESH D064828 Prolyl hydroxylases GO GO:0003824 catalytic activity Aop:122 Event:799 increased PR PR:G5EGD2 hypoxia-inducible factor 1 (Caenorhabditis elegans) GO GO:0010467 gene expression Aop:122 Event:799 increased PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0010467 gene expression Aop:122 Event:800 decreased PR PR:000038849 aromatase isoform 1 GO GO:0070330 aromatase activity Aop:122 Event:800 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:122 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:122 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:122 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:122 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:122 Event:221 decreased MESH D014819 vitellogenins Aop:122 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:122 Event:309 decreased GO GO:0001555 oocyte growth Aop:122 Event:309 decreased GO GO:0048599 oocyte development Aop:122 Event:78 decreased VT VT:1000294 egg quantity Aop:122 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:123 Event:801 abnormal PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0023052 signaling Aop:123 Event:799 increased PR PR:G5EGD2 hypoxia-inducible factor 1 (Caenorhabditis elegans) GO GO:0010467 gene expression Aop:123 Event:799 increased PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0010467 gene expression Aop:123 Event:802 increased PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0010467 gene expression Aop:123 Event:800 decreased PR PR:000038849 aromatase isoform 1 GO GO:0070330 aromatase activity Aop:123 Event:800 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:123 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:123 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:123 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:123 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:123 Event:221 decreased MESH D014819 vitellogenins Aop:123 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:123 Event:309 decreased GO GO:0001555 oocyte growth Aop:123 Event:309 decreased GO GO:0048599 oocyte development Aop:123 Event:78 decreased VT VT:1000294 egg quantity Aop:123 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:124 Event:804 decreased PR PR:000008636 3-hydroxy-3-methylglutaryl-coenzyme A reductase GO GO:0042282 hydroxymethylglutaryl-CoA reductase activity Aop:124 Event:805 decreased CHEBI CHEBI:25350 mevalonate Aop:124 Event:807 decreased CHEBI CHEBI:16113 cholesterol GO GO:0006695 cholesterol biosynthetic process Aop:124 Event:807 decreased CHEBI CHEBI:16113 cholesterol GO GO:0030301 cholesterol transport Aop:124 Event:807 decreased CHEBI CHEBI:17002 cholesteryl ester GO GO:0030301 cholesterol transport Aop:124 Event:809 morphological change UBERON UBERON:0000079 male reproductive system Aop:124 Event:330 decreased MESH D005298 fertility Aop:124 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:124 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:126 Event:848 decreased CHEBI CHEBI:18357 (R)-noradrenaline GO GO:0051380 norepinephrine binding Aop:126 Event:849 decreased PR PR:000001186 alpha-2A adrenergic receptor GO GO:0023052 signaling Aop:126 Event:529 decreased PR PR:P01101 proto-oncogene c-Fos (mouse) GO GO:0023052 signaling Aop:126 Event:530 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:126 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0033684 regulation of luteinizing hormone secretion Aop:126 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:126 Event:532 delayed MP MP:0001928 abnormal ovulation Aop:126 Event:533 decreased GO GO:0060473 cortical granule GO GO:0046903 secretion Aop:126 Event:534 abnormal GO GO:0060387 fertilization envelope Aop:126 Event:535 abnormal GO GO:0035037 sperm entry Aop:126 Event:536 increased MP MP:0004023 abnormal chromosome number Aop:126 Event:527 decreased MESH D005298 fertility Aop:126 Event:527 decreased MESH D005298 fertility MP MP:0001921 reduced fertility Aop:128 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:128 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:128 Event:819 decreased GO GO:0003094 glomerular filtration Aop:128 Event:820 decreased VT VT:0005524 kidney plasma flow trait Aop:128 Event:821 decreased CHEBI CHEBI:29101 sodium(1+) GO GO:0070293 renal absorption Aop:128 Event:813 increased CHEBI CHEBI:16737 creatinine Aop:128 Event:813 increased MP MP:0005332 abnormal amino acid level Aop:128 Event:823 occurrence UBERON UBERON:0009773 renal tubule MESH D004106 Dilatation Aop:128 Event:824 occurrence MP MP:0011899 podocyte vacuolization Aop:128 Event:818 occurrence UBERON UBERON:0009773 renal tubule GO GO:0048102 autophagic cell death Aop:128 Event:825 decreased UBERON UBERON:0002113 kidney MI MI:0613 function Aop:128 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:130 Event:828 decreased PR PR:Q53H76 phospholipase A1 member A (human) GO GO:0004620 phospholipase activity Aop:130 Event:829 functional change FMA FMA:67514 Lipid bilayer of wall of lysosome Aop:130 Event:831 functional change GO GO:0005764 lysosome Aop:130 Event:833 occurrence GO GO:0048102 autophagic cell death Aop:130 Event:835 occurrence GO GO:0048102 autophagic cell death Aop:130 Event:837 occurrence GO GO:0048102 autophagic cell death Aop:130 Event:838 increased HP HP:0001414 Microvesicular hepatic steatosis Aop:130 Event:839 occurrence MP MP:0014045 Mallory bodies Aop:130 Event:840 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:130 Event:836 occurrence GO GO:0048102 autophagic cell death Aop:130 Event:177 functional change GO GO:0005739 mitochondrion Aop:131 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:131 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:131 Event:844 increased CHEBI CHEBI:27258 uroporphyrinogen Aop:131 Event:845 decreased PR PR:000017134 uroporphyrinogen decarboxylase GO GO:0003824 catalytic activity Aop:131 Event:846 increased CHEBI CHEBI:26214 porphyrins Aop:131 Event:369 increased MP MP:0005654 porphyria Aop:131 Event:850 increased PR PR:000006102 cytochrome P450 1A2 GO GO:0010467 gene expression Aop:131 Event:850 increased PR PR:P79761 cytochrome P450 1A5 (chicken) GO GO:0010467 gene expression Aop:134 Event:424 decreased PR PR:000015171 sodium/iodide cotransporter GO GO:0008507 sodium:iodide symporter activity Aop:134 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:134 Event:425 decreased CHEBI CHEBI:16382 iodide GO GO:0015705 iodide transport Aop:134 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:134 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:134 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:134 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:134 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:134 Event:402 decreased GO GO:0007611 learning or memory Aop:134 Event:402 decreased GO GO:0050890 cognition Aop:136 Event:867 decreased GO GO:0051453 regulation of intracellular pH Aop:136 Event:868 increased UBERON UBERON:0001997 olfactory epithelium MESH D001284 atrophy Aop:136 Event:868 increased GO GO:0070265 necrotic cell death Aop:136 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:136 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:136 Event:869 increased MESH D008679 Metaplasia Aop:136 Event:768 increased GO GO:0008219 cell death Aop:136 Event:768 increased GO GO:0001909 leukocyte mediated cytotoxicity Aop:136 Event:872 increased UBERON UBERON:0005386 olfactory segment of nasal mucosa MP MP:0002006 neoplasm Aop:136 Event:876 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:138 Event:877 decreased PR PR:000014993 solute carrier family 22 member 6 GO GO:0023052 signaling Aop:138 Event:1096 increased CHEBI CHEBI:27226 uric acid Aop:138 Event:1097 occurrence MP MP:0004154 renal tubular necrosis Aop:138 Event:1098 increased CHEBI CHEBI:26216 potassium atom Aop:138 Event:351 increased MESH D009026 mortality Aop:138 Event:1102 increased CHEBI CHEBI:27226 uric acid Aop:138 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:138 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:138 Event:1392 increased MP MP:0003674 oxidative stress Aop:139 Event:97 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006305 DNA alkylation Aop:139 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:139 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:139 Event:885 increased MESH D009369 Neoplasms Aop:141 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:141 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:141 Event:885 increased MESH D009369 Neoplasms Aop:141 Event:97 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006305 DNA alkylation Aop:144 Event:177 functional change GO GO:0005739 mitochondrion Aop:144 Event:55 increased GO GO:0008219 cell death Aop:144 Event:1539 increased GO GO:0005765 lysosomal membrane GO GO:0006897 endocytosis Aop:144 Event:898 occurrence GO GO:0005764 lysosome GO GO:1903008 organelle disassembly Aop:144 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:144 Event:1494 increased CL CL:0000738 leukocyte GO GO:0002263 cell activation involved in immune response Aop:144 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:144 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:144 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:148 Event:941 occurrence PR PR:000006933 epidermal growth factor receptor GO GO:0005006 epidermal growth factor-activated receptor activity Aop:148 Event:941 increased PR PR:000006933 epidermal growth factor receptor GO GO:0016310 phosphorylation Aop:148 Event:962 increased PR PR:000031343 mucin-5AC GO GO:0010467 gene expression Aop:148 Event:962 increased PR PR:000031343 mucin-5AC GO GO:0006412 translation Aop:148 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:148 Event:2117 increased CL CL:0000160 goblet cell Aop:149 Event:209 increased MP MP:0003674 oxidative stress Aop:149 Event:927 increased PR PR:000011328 nitric oxide synthase, endothelial GO GO:0010731 protein glutathionylation Aop:149 Event:927 increased CHEBI CHEBI:32460 cysteine residue GO GO:0010731 protein glutathionylation Aop:149 Event:935 decreased PR PR:000007893 GTP cyclohydrolase 1 GO GO:1903009 proteasome complex disassembly Aop:149 Event:934 decreased CHEBI CHEBI:15372 5,6,7,8-tetrahydrobiopterin GO GO:0009058 biosynthetic process Aop:149 Event:932 functional change PR PR:000011328 nitric oxide synthase, endothelial Aop:149 Event:933 decreased CHEBI CHEBI:16480 nitric oxide GO GO:0006809 nitric oxide biosynthetic process Aop:149 Event:937 abnormal UBERON UBERON:0001981 blood vessel GO GO:0042311 vasodilation Aop:149 Event:951 increased MP MP:0004878 increased systemic vascular resistance Aop:149 Event:952 increased MP MP:0000231 hypertension Aop:149 Event:973 decreased PR PR:000011328 nitric oxide synthase, endothelial GO GO:0003824 catalytic activity Aop:149 Event:973 decreased PR PR:000029189 AKT kinase GO GO:0003824 catalytic activity Aop:150 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:150 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:150 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:150 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:150 Event:945 decreased PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0046983 protein dimerization activity Aop:150 Event:945 decreased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:150 Event:110 abnormal GO GO:0003158 endothelium development Aop:150 Event:317 morphological change MP MP:0001544 abnormal cardiovascular system physiology Aop:150 Event:317 abnormal UBERON UBERON:0004535 cardiovascular system GO GO:0072358 cardiovascular system development Aop:150 Event:947 increased MP MP:0008762 embryonic lethality Aop:150 Event:947 increased MESH D009026 mortality Aop:150 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A GO GO:0010467 gene expression Aop:150 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A MP MP:0008469 abnormal protein level Aop:151 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:151 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:151 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:151 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:151 Event:945 decreased PR PR:000008555 hypoxia-inducible factor 1-alpha GO GO:0046983 protein dimerization activity Aop:151 Event:945 decreased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:151 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A GO GO:0010467 gene expression Aop:151 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A MP MP:0008469 abnormal protein level Aop:152 Event:957 increased PR PR:000016801 transthyretin GO GO:0005488 binding Aop:152 Event:958 increased CHEBI CHEBI:30660 thyroxine Aop:152 Event:959 increased CHEBI CHEBI:30660 thyroxine Aop:152 Event:960 increased CHEBI CHEBI:30660 thyroxine GO GO:0006810 transport Aop:152 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:152 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:152 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:152 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:152 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:152 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:152 Event:402 decreased GO GO:0007611 learning or memory Aop:152 Event:402 decreased GO GO:0050890 cognition Aop:153 Event:964 decreased PR PR:000006100 aromatase GO GO:0023052 signaling Aop:153 Event:968 decreased CHEBI CHEBI:80304 Metastin GO GO:0007269 neurotransmitter secretion Aop:153 Event:969 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:153 Event:970 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0032275 luteinizing hormone secretion Aop:153 Event:971 abnormal GO GO:0042698 ovulation cycle Aop:153 Event:972 decreased VT VT:1000294 egg quantity Aop:153 Event:1056 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:153 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:153 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:154 Event:979 increased PR PR:000003112 NFAT protein MI MI:0254 genetic interference Aop:154 Event:981 decreased PR PR:000011161 NFAT activation molecule 1 GO GO:0002534 cytokine production involved in inflammatory response Aop:154 Event:981 increased GO GO:0001775 cell activation Aop:154 Event:984 increased IDO IDO:0000610 Immunosuppression Aop:154 Event:1202 decreased PR PR:000001379 interleukin-2 GO GO:0032623 interleukin-2 production Aop:154 Event:1202 decreased PR PR:000001391 interleukin-4 GO GO:0032633 interleukin-4 production Aop:154 Event:980 increased PR PR:000007535 FK506-binding protein 15 GO GO:0005488 binding Aop:154 Event:980 increased TAIR TAIR:AT5G64350 FKBP12 (Arabidopsis thaliana) GO GO:0005488 binding Aop:155 Event:1002 decreased PR PR:000006481 type II iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:155 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:155 Event:1004 decreased UBERON UBERON:2001278 posterior chamber swim bladder GO GO:0048798 swim bladder inflation Aop:155 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:155 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:155 Event:351 increased MESH D009026 mortality Aop:156 Event:1002 decreased PR PR:000006481 type II iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:156 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:156 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:156 Event:1007 decreased UBERON UBERON:2001277 anterior chamber swim bladder GO GO:0048798 swim bladder inflation Aop:156 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:156 Event:351 increased MESH D009026 mortality Aop:157 Event:1009 decreased PR PR:000006480 type I iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:157 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:157 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:157 Event:1004 decreased UBERON UBERON:2001278 posterior chamber swim bladder GO GO:0048798 swim bladder inflation Aop:157 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:157 Event:351 increased MESH D009026 mortality Aop:158 Event:1009 decreased PR PR:000006480 type I iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:158 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:158 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:158 Event:1007 decreased UBERON UBERON:2001277 anterior chamber swim bladder GO GO:0048798 swim bladder inflation Aop:158 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:158 Event:351 increased MESH D009026 mortality Aop:159 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:159 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:159 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:159 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:159 Event:1007 decreased UBERON UBERON:2001277 anterior chamber swim bladder GO GO:0048798 swim bladder inflation Aop:159 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:159 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:159 Event:351 increased MESH D009026 mortality Aop:160 Event:351 increased MESH D009026 mortality Aop:160 Event:762 decreased CHEBI CHEBI:17996 chloride GO GO:0022851 GABA-gated chloride ion channel activity Aop:160 Event:1012 increased GO GO:0060080 inhibitory postsynaptic potential Aop:160 Event:1014 increased MP MP:0000753 paralysis Aop:160 Event:761 increased CHEBI CHEBI:17996 chloride GO GO:1902476 chloride transmembrane transport Aop:160 Event:1015 decreased GO GO:1902710 GABA receptor complex GO GO:0050805 negative regulation of synaptic transmission Aop:160 Event:1016 decreased NBO NBO:0000079 feeding behavior Aop:161 Event:351 increased MESH D009026 mortality Aop:161 Event:1015 decreased GO GO:1902710 GABA receptor complex GO GO:0050805 negative regulation of synaptic transmission Aop:161 Event:1012 increased GO GO:0060080 inhibitory postsynaptic potential Aop:161 Event:1016 decreased NBO NBO:0000079 feeding behavior Aop:161 Event:761 increased CHEBI CHEBI:17996 chloride GO GO:1902476 chloride transmembrane transport Aop:161 Event:1018 increased PR PR:Q94900 glutamate-gated chloride channel (fruit fly) GO GO:0005254 chloride channel activity Aop:161 Event:1019 increased MP MP:0000753 paralysis Aop:162 Event:1023 increased CHEBI CHEBI:81567 Thyroid stimulating hormone Aop:162 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:162 Event:741 increased MESH D000236 Adenoma Aop:162 Event:741 increased MESH D002277 Carcinoma Aop:162 Event:740 increased CL CL:0002258 thyroid follicular cell MESH D006965 hyperplasia Aop:162 Event:739 increased CL CL:0002258 thyroid follicular cell GO GO:0008283 cell proliferation Aop:162 Event:739 increased CL CL:0002258 thyroid follicular cell MESH D006984 hypertrophy Aop:162 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0015020 glucuronosyltransferase activity Aop:162 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0003824 catalytic activity Aop:162 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:163 Event:1028 decreased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:163 Event:1029 increased GO GO:0045444 fat cell differentiation Aop:163 Event:1032 increased PR PR:000036194 eukaryotic protein GO GO:0046903 secretion Aop:163 Event:1033 increased CL CL:0008019 mesenchymal cell GO GO:0010463 mesenchymal cell proliferation Aop:163 Event:1034 increased PR PR:Q3U4N7 IGF-like family receptor 1 (mouse) GO GO:0010467 gene expression Aop:163 Event:1035 increased MESH D005354 Fibrosarcoma Aop:163 Event:1036 increased MESH D008080 liposarcoma Aop:163 Event:1037 increased MESH D006394 hemangiosarcoma Aop:164 Event:1038 increased PR PR:000001193 beta-2 adrenergic receptor GO GO:0031698 beta-2 adrenergic receptor binding Aop:164 Event:1039 increased PR PR:000001193 beta-2 adrenergic receptor GO GO:0004941 beta2-adrenergic receptor activity Aop:164 Event:1040 increased GO GO:0044557 relaxation of smooth muscle Aop:164 Event:1042 increased CL CL:0000192 smooth muscle cell GO GO:0008283 cell proliferation Aop:164 Event:1043 increased UBERON UBERON:0001135 smooth muscle tissue MESH D006984 hypertrophy Aop:164 Event:1044 increased MESH D007889 leiomyoma Aop:165 Event:1045 decreased CHEBI CHEBI:23965 estradiol Aop:165 Event:1046 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:165 Event:1047 increased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:165 Event:1049 decreased CHEBI CHEBI:81569 Follicle stimulating hormone GO GO:0046884 follicle-stimulating hormone secretion Aop:165 Event:1050 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0032275 luteinizing hormone secretion Aop:165 Event:1051 increased CL CL:0002132 stromal cell of ovary MESH D006965 hyperplasia Aop:165 Event:1052 increased UBERON UBERON:0004911 epithelium of female gonad MESH D006965 hyperplasia Aop:165 Event:1053 increased MESH D000236 Adenoma Aop:165 Event:1054 increased MESH D016586 Granular Cell Tumor Aop:165 Event:1056 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:166 Event:1057 decreased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:166 Event:1058 decreased UBERON UBERON:0001970 bile Aop:166 Event:1059 occurrence MESH D002779 cholestasis Aop:166 Event:1060 abnormal GO GO:0006629 lipid metabolic process Aop:166 Event:1061 increased PR PR:000005110 cholecystokinin Aop:166 Event:1062 increased CL CL:0000622 acinar cell GO GO:0008283 cell proliferation Aop:166 Event:1063 increased MESH D002277 Carcinoma Aop:167 Event:1066 increased PR PR:000014896 homeobox protein SIX1 GO GO:0008283 cell proliferation Aop:167 Event:1068 increased FMA FMA:66769 Squamous cell MESH D008679 Metaplasia Aop:167 Event:1068 increased UBERON UBERON:0004811 endometrium epithelium MESH D008679 Metaplasia Aop:167 Event:1070 increased MESH D018196 adenosquamous carcinoma Aop:167 Event:1070 increased MESH D018196 adenosquamous carcinoma HP HP:0012114 Endometrial carcinoma Aop:167 Event:2329 increased PR PR:000014896 homeobox protein SIX1 GO GO:0010467 gene expression Aop:167 Event:2330 increased PR PR:000014896 homeobox protein SIX1 GO GO:0006412 translation Aop:167 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:167 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:167 Event:772 increased CL CL:0002656 glandular cell of endometrium MP MP:0009092 endometrium hyperplasia Aop:167 Event:772 increased CL CL:0000150 glandular epithelial cell MESH D006965 hyperplasia Aop:168 Event:1071 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:168 Event:1072 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:168 Event:1074 disrupted MP MP:0001928 abnormal ovulation Aop:168 Event:1075 increased MP MP:0009006 prolonged estrous cycle Aop:168 Event:1075 increased MP MP:0009017 prolonged estrus Aop:168 Event:1076 increased CHEBI CHEBI:50114 estrogen Aop:168 Event:1077 increased PR PR:000013246 prolactin Aop:168 Event:1078 increased MP MP:0000630 mammary gland hyperplasia Aop:168 Event:1079 increased MESH D000236 Adenoma Aop:168 Event:1079 increased MESH D002277 Carcinoma Aop:168 Event:1080 increased MP MP:0010307 abnormal tumor latency Aop:169 Event:1071 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:169 Event:1072 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:169 Event:1075 increased MP MP:0009006 prolonged estrous cycle Aop:169 Event:1075 increased MP MP:0009017 prolonged estrus Aop:169 Event:1074 disrupted MP MP:0001928 abnormal ovulation Aop:169 Event:1076 increased CHEBI CHEBI:50114 estrogen Aop:169 Event:1081 increased CL CL:0000439 prolactin secreting cell MESH D006965 hyperplasia Aop:169 Event:1081 increased CL CL:0000439 prolactin secreting cell MESH D006984 hypertrophy Aop:169 Event:1082 increased MESH D000236 Adenoma HP HP:0002893 Pituitary adenoma Aop:170 Event:1083 increased CL CL:0000700 dopaminergic neuron GO GO:0001963 synaptic transmission, dopaminergic Aop:170 Event:1084 increased PR PR:000013246 prolactin GO GO:0070459 prolactin secretion Aop:170 Event:1085 increased UBERON UBERON:0001911 mammary gland MESH D006965 hyperplasia Aop:170 Event:1080 increased MP MP:0010307 abnormal tumor latency Aop:170 Event:1079 increased MESH D000236 Adenoma Aop:170 Event:1079 increased MESH D002277 Carcinoma Aop:171 Event:1086 increased UBERON UBERON:0000977 pleura GO GO:0008219 cell death Aop:171 Event:1087 increased GO GO:0006954 inflammatory response Aop:171 Event:1032 increased PR PR:000036194 eukaryotic protein GO GO:0046903 secretion Aop:171 Event:1089 increased UBERON UBERON:0001136 mesothelium GO GO:0008283 cell proliferation Aop:171 Event:1090 increased MESH D008654 mesothelioma HP HP:0100001 Malignant mesothelioma Aop:171 Event:1392 increased MP MP:0003674 oxidative stress Aop:173 Event:1495 increased GO GO:0002221 pattern recognition receptor signaling pathway Aop:173 Event:1495 increased PR PR:000001096 Toll-like receptor GO GO:0002224 toll-like receptor signaling pathway Aop:173 Event:1495 increased PR PR:000001155 Toll-like receptor 4 GO GO:0034142 toll-like receptor 4 signaling pathway Aop:173 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:173 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:173 Event:1496 increased GO GO:0006956 complement activation Aop:173 Event:1496 increased FMA FMA:86578 Interleukin Aop:173 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:173 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:173 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:175 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:175 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:175 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:175 Event:1101 delayed GO GO:0007552 metamorphosis Aop:175 Event:1101 increased GO GO:0007552 metamorphosis Aop:176 Event:424 decreased PR PR:000015171 sodium/iodide cotransporter GO GO:0008507 sodium:iodide symporter activity Aop:176 Event:425 decreased CHEBI CHEBI:16382 iodide GO GO:0015705 iodide transport Aop:176 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:176 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:176 Event:1101 delayed GO GO:0007552 metamorphosis Aop:176 Event:1101 increased GO GO:0007552 metamorphosis Aop:177 Event:1104 decreased CHEBI CHEBI:15553 prostaglandin F2alpha Aop:177 Event:1105 occurrence UBERON UBERON:0002113 kidney MESH D007511 ischemia Aop:177 Event:1097 occurrence MP MP:0004154 renal tubular necrosis Aop:177 Event:1098 increased CHEBI CHEBI:26216 potassium atom Aop:177 Event:351 increased MESH D009026 mortality Aop:177 Event:1103 decreased PR PR:000013427 prostaglandin G/H synthase 1 GO GO:0004666 prostaglandin-endoperoxide synthase activity Aop:177 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:177 Event:1096 increased CHEBI CHEBI:27226 uric acid Aop:177 Event:1102 increased CHEBI CHEBI:27226 uric acid Aop:177 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:177 Event:1392 increased MP MP:0003674 oxidative stress Aop:178 Event:559 increased FMA FMA:61796 Nicotinic acetylcholine receptor GO GO:0015464 acetylcholine receptor activity Aop:178 Event:177 functional change GO GO:0005739 mitochondrion Aop:178 Event:1107 increased MESH D056631 colony collapse Aop:178 Event:563 increased MESH D056631 colony collapse Aop:179 Event:1109 increased MESH D019562 Viral load Aop:179 Event:1107 increased MESH D056631 colony collapse Aop:179 Event:563 increased MESH D056631 colony collapse Aop:180 Event:560 abnormal GO GO:0060756 foraging behavior Aop:180 Event:1107 increased MESH D056631 colony collapse Aop:180 Event:563 increased MESH D056631 colony collapse Aop:181 Event:1107 increased MESH D056631 colony collapse Aop:181 Event:563 increased MESH D056631 colony collapse Aop:182 Event:560 abnormal GO GO:0060756 foraging behavior Aop:182 Event:1107 increased MESH D056631 colony collapse Aop:182 Event:563 increased MESH D056631 colony collapse Aop:183 Event:1110 increased MP MP:0004889 increased energy expenditure Aop:183 Event:1110 increased MESH D013312 Stress, Physiological Aop:183 Event:560 abnormal GO GO:0060756 foraging behavior Aop:183 Event:1107 increased MESH D056631 colony collapse Aop:183 Event:563 increased MESH D056631 colony collapse Aop:184 Event:1108 abnormal MESH D012380 role Aop:184 Event:1107 increased MESH D056631 colony collapse Aop:184 Event:563 increased MESH D056631 colony collapse Aop:185 Event:1107 increased MESH D056631 colony collapse Aop:185 Event:563 increased MESH D056631 colony collapse Aop:186 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:186 Event:1097 occurrence MP MP:0004154 renal tubular necrosis Aop:186 Event:1098 increased CHEBI CHEBI:26216 potassium atom Aop:186 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:186 Event:351 increased MESH D009026 mortality Aop:186 Event:1392 increased MP MP:0003674 oxidative stress Aop:187 Event:1122 abnormal GO GO:0007599 hemostasis Aop:187 Event:1130 increased MP MP:0001914 hemorrhage Aop:187 Event:1130 abnormal GO GO:0042060 wound healing Aop:187 Event:1131 decreased PR PR:000007299 prothrombin MI MI:1139 carboxylation reaction Aop:187 Event:1131 decreased PR PR:P70375 coagulation factor VII (mouse) MI MI:1139 carboxylation reaction Aop:187 Event:1131 decreased PR PR:P16294 coagulation factor IX (mouse) MI MI:1139 carboxylation reaction Aop:187 Event:1131 decreased PR PR:O88947 coagulation factor X (mouse) MI MI:1139 carboxylation reaction Aop:187 Event:1132 decreased CHEBI CHEBI:33284 nutrient GO GO:0006810 transport Aop:187 Event:1132 abnormal GO GO:1990748 cellular detoxification Aop:187 Event:1132 occurrence MP MP:0001577 anemia Aop:187 Event:1133 decreased MESH D001779 blood coagulation factors Aop:187 Event:1133 decreased GO GO:0007599 hemostasis Aop:187 Event:1134 abnormal CHEBI CHEBI:28384 vitamin K GO GO:0042373 vitamin K metabolic process Aop:187 Event:1134 decreased PR PR:000004191 androgen receptor GO GO:0023052 signaling Aop:187 Event:1134 decreased MESH D064417 Vitamin K Epoxide Reductases GO GO:0003824 catalytic activity Aop:187 Event:1135 increased MP MP:0003031 acidosis Aop:187 Event:1135 increased MP MP:0010128 hypovolemia Aop:187 Event:1135 functional change UBERON UBERON:0000062 organ Aop:187 Event:1135 decreased VT VT:1000152 wellness/fitness trait Aop:187 Event:1135 increased MESH D009026 mortality Aop:187 Event:1136 decreased PCO PCO:0000008 population growth rate Aop:187 Event:1138 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:187 Event:1138 increased GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:187 Event:1151 increased MP MP:0000066 osteoporosis Aop:187 Event:1151 increased UBERON UBERON:0002049 vasculature MESH D061205 vascular calcification Aop:187 Event:1169 abnormal PR PR:000030444 osteocalcin GO GO:0043687 post-translational protein modification Aop:187 Event:1169 decreased PR PR:P19788 matrix Gla protein (mouse) MI MI:1139 carboxylation reaction Aop:188 Event:1152 decreased PR PR:Q6PHW0 iodotyrosine deiodinase 1 (human) GO GO:0003824 catalytic activity Aop:188 Event:425 decreased CHEBI CHEBI:16382 iodide GO GO:0015705 iodide transport Aop:188 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:188 Event:1101 delayed GO GO:0007552 metamorphosis Aop:188 Event:1101 increased GO GO:0007552 metamorphosis Aop:188 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:189 Event:1009 decreased PR PR:000006480 type I iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:189 Event:1116 increased CHEBI CHEBI:18258 3,3',5-triiodo-L-thyronine Aop:189 Event:1116 decreased CHEBI CHEBI:18258 3,3',5-triiodo-L-thyronine Aop:189 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:189 Event:1101 delayed GO GO:0007552 metamorphosis Aop:189 Event:1101 increased GO GO:0007552 metamorphosis Aop:190 Event:1002 decreased PR PR:000006481 type II iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:190 Event:1116 increased CHEBI CHEBI:18258 3,3',5-triiodo-L-thyronine Aop:190 Event:1116 decreased CHEBI CHEBI:18258 3,3',5-triiodo-L-thyronine Aop:190 Event:1101 delayed GO GO:0007552 metamorphosis Aop:190 Event:1101 increased GO GO:0007552 metamorphosis Aop:190 Event:1023 increased CHEBI CHEBI:81567 Thyroid stimulating hormone Aop:191 Event:1153 decreased PR PR:000006482 type III iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:191 Event:1154 decreased CHEBI CHEBI:18258 3,3',5-triiodo-L-thyronine Aop:191 Event:1101 delayed GO GO:0007552 metamorphosis Aop:191 Event:1101 increased GO GO:0007552 metamorphosis Aop:192 Event:1155 decreased PR PR:000015039 pendrin GO GO:0023052 signaling Aop:192 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:192 Event:1101 delayed GO GO:0007552 metamorphosis Aop:192 Event:1101 increased GO GO:0007552 metamorphosis Aop:192 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:193 Event:1156 decreased PR PR:000006727 dual oxidase 1 GO GO:0003824 catalytic activity Aop:193 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:193 Event:1101 delayed GO GO:0007552 metamorphosis Aop:193 Event:1101 increased GO GO:0007552 metamorphosis Aop:193 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:194 Event:1157 increased PR PR:000000001 protein GO GO:0023052 signaling Aop:194 Event:1158 increased CHEBI CHEBI:60311 thyroid hormone GO GO:0006810 transport Aop:194 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0015020 glucuronosyltransferase activity Aop:194 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0003824 catalytic activity Aop:194 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:194 Event:1101 delayed GO GO:0007552 metamorphosis Aop:194 Event:1101 increased GO GO:0007552 metamorphosis Aop:194 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:195 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:195 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:195 Event:626 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0001820 serotonin secretion Aop:195 Event:1161 increased CL CL:0000300 gamete GO GO:0048469 cell maturation Aop:195 Event:1164 increased PCO PCO:0000001 population of organisms Aop:195 Event:1255 premature MESH C82476 spawning Aop:195 Event:1142 increased UBERON UBERON:0003978 valve GO GO:0050881 musculoskeletal movement Aop:195 Event:1163 increased GO GO:0022414 reproductive process Aop:196 Event:1215 increased PR PR:000001065 transient receptor potential cation channel TRPV1 GO GO:0023052 signaling Aop:196 Event:1218 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:196 Event:1220 decreased UBERON UBERON:0001759 vagus nerve GO GO:0043179 rhythmic excitation Aop:196 Event:1222 increased CHEBI CHEBI:80308 Substance P GO GO:0005184 neuropeptide hormone activity Aop:196 Event:1223 increased UBERON UBERON:0001645 trigeminal nerve GO GO:0060004 reflex Aop:196 Event:1223 increased MESH D003371 cough Aop:196 Event:1223 increased MESH D012130 Respiratory Hypersensitivity Aop:196 Event:1223 increased MESH D004417 Dyspnea Aop:196 Event:1226 increased UBERON UBERON:0001004 respiratory system GO GO:0006954 inflammatory response Aop:196 Event:1226 increased MESH D003371 cough Aop:196 Event:1433 increased CHEBI CHEBI:80337 Calcitonin gene-related peptide 1 GO GO:0005184 neuropeptide hormone activity Aop:196 Event:1434 increased MESH D012912 sneezing GO GO:0060004 reflex Aop:196 Event:1435 increased CHEBI CHEBI:80311 Neurokinin A GO GO:0005184 neuropeptide hormone activity Aop:197 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:197 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0023052 signaling Aop:197 Event:1176 decreased CHEBI CHEBI:29101 sodium(1+) GO GO:0006810 transport Aop:197 Event:1179 decreased CHEBI CHEBI:16865 gamma-aminobutyric acid GO GO:0006810 transport Aop:200 Event:1182 increased GO GO:0008283 cell proliferation Aop:200 Event:1183 decreased GO GO:0006915 apoptotic process Aop:200 Event:177 functional change GO GO:0005739 mitochondrion Aop:200 Event:1187 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0030331 estrogen receptor binding Aop:200 Event:1188 increased PR PR:000016261 serotransferrin GO GO:0030331 estrogen receptor binding Aop:200 Event:1189 increased GO GO:0001935 endothelial cell proliferation Aop:200 Event:1190 increased GO GO:0043542 endothelial cell migration Aop:200 Event:1191 increased GO GO:0023052 signaling Aop:200 Event:1192 increased MESH D006965 hyperplasia Aop:200 Event:1193 pathological MESH D001943 Breast Neoplasms Aop:200 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:200 Event:1195 morphological change GO GO:0031012 extracellular matrix Aop:200 Event:1196 increased CL CL:0000066 epithelial cell Aop:200 Event:1197 decreased GO GO:0001775 cell activation Aop:200 Event:1198 decreased GO GO:0042116 macrophage activation Aop:200 Event:1213 increased GO GO:0001525 angiogenesis Aop:200 Event:1239 abnormal GO GO:0010467 gene expression Aop:200 Event:1240 abnormal PR PR:000000001 protein GO GO:0006412 translation Aop:200 Event:1241 increased GO GO:0048870 cell motility Aop:200 Event:1242 increased GO GO:0019932 second-messenger-mediated signaling Aop:200 Event:1392 increased MP MP:0003674 oxidative stress Aop:200 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:200 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:201 Event:1205 increased CHEBI CHEBI:24943 juvenile hormone GO GO:0023052 signaling Aop:201 Event:1206 increased PR PR:P23023 protein doublesex (fruit fly) GO GO:0010467 gene expression Aop:201 Event:1208 increased VT VT:1000189 offspring quantity Aop:201 Event:1208 increased UBERON UBERON:0003101 male organism Aop:201 Event:1209 increased UBERON UBERON:0003135 male reproductive organ Aop:201 Event:361 decreased PCO PCO:0000008 population growth rate Aop:201 Event:1210 abnormal MESH D020387 Food Chain Aop:202 Event:1252 abnormal GO GO:0061505 DNA topoisomerase II activity Aop:202 Event:1253 occurrence MESH D014178 Translocation, Genetic Aop:203 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:203 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:203 Event:1142 increased UBERON UBERON:0003978 valve GO GO:0050881 musculoskeletal movement Aop:203 Event:626 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0001820 serotonin secretion Aop:203 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:204 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:204 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:204 Event:1142 increased UBERON UBERON:0003978 valve GO GO:0050881 musculoskeletal movement Aop:204 Event:1163 increased GO GO:0022414 reproductive process Aop:204 Event:1164 increased PCO PCO:0000001 population of organisms Aop:204 Event:626 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0001820 serotonin secretion Aop:205 Event:1258 abnormal GO GO:0016043 cellular component organization Aop:205 Event:1260 decreased GO GO:0005739 mitochondrion MI MI:0613 function Aop:205 Event:1259 abnormal GO GO:0007009 plasma membrane organization Aop:205 Event:1262 increased GO GO:0006915 apoptotic process Aop:205 Event:1263 increased GO GO:0070265 necrotic cell death Aop:205 Event:177 functional change GO GO:0005739 mitochondrion Aop:206 Event:149 increased GO GO:0006954 inflammatory response Aop:206 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:207 Event:1174 increased MESH D019255 NADPH Oxidase GO GO:0023052 signaling Aop:207 Event:1277 decreased GO GO:0000003 reproduction Aop:207 Event:1279 increased MP MP:0003674 oxidative stress Aop:207 Event:1279 increased PR PR:000003106 map kinase p38 GO GO:0023052 signaling Aop:207 Event:1280 increased PR PR:G5EGD2 hypoxia-inducible factor 1 (Caenorhabditis elegans) GO GO:0023052 signaling Aop:207 Event:1281 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:207 Event:1262 increased GO GO:0006915 apoptotic process Aop:207 Event:177 functional change GO GO:0005739 mitochondrion Aop:207 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:208 Event:1282 increased PR PR:000025748 Janus kinase GO GO:0023052 signaling Aop:208 Event:1282 increased PR PR:000001933 signal transducer and transcription activator STAT GO GO:0023052 signaling Aop:208 Event:1283 increased PR PR:000000046 TGF-beta GO GO:0023052 signaling Aop:208 Event:1277 decreased GO GO:0000003 reproduction Aop:209 Event:1284 increased PR PR:000021564 sterol regulatory element-binding protein 2 proteolytic cleavage product GO GO:0010467 gene expression Aop:209 Event:1285 increased CHEBI CHEBI:27208 unsaturated fatty acid GO GO:0006636 unsaturated fatty acid biosynthetic process Aop:209 Event:1286 decreased PR PR:000008293 glutathione synthetase GO GO:0004363 glutathione synthase activity Aop:209 Event:1286 decreased PR PR:000029945 glutathione S-transferase GO GO:0004364 glutathione transferase activity Aop:209 Event:1287 decreased CHEBI CHEBI:16856 glutathione GO GO:0006750 glutathione biosynthetic process Aop:209 Event:1288 decreased PR PR:000008774 3-hydroxyacyl-CoA dehydrogenase type-2 GO GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Aop:209 Event:1289 abnormal CHEBI CHEBI:16113 cholesterol Aop:209 Event:1290 abnormal CHEBI CHEBI:16856 glutathione Aop:210 Event:209 increased MP MP:0003674 oxidative stress Aop:210 Event:1292 increased MESH D048031 JNK Mitogen-Activated Protein Kinases GO GO:0023052 signaling Aop:210 Event:1293 increased PR PR:O16850 forkhead box protein O (Caenorhabditis elegans) GO GO:0023052 signaling Aop:210 Event:1294 abnormal GO GO:1990909 Wnt signalosome GO GO:0023052 signaling Aop:210 Event:1295 abnormal GO GO:0009790 embryo development Aop:210 Event:1277 decreased GO GO:0000003 reproduction Aop:212 Event:1502 decreased PR PR:000008478 histone deacetylase 1 GO GO:0004857 enzyme inhibitor activity Aop:212 Event:1503 increased CHEBI CHEBI:15358 histone GO GO:0031399 regulation of protein modification process Aop:212 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:212 Event:1262 increased GO GO:0006915 apoptotic process Aop:212 Event:1506 increased FMA FMA:7210 Testis HP HP:0000029 Testicular atrophy Aop:212 Event:1515 decreased CL CL:0000017 spermatocyte Aop:213 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:213 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:214 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:214 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:214 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:214 Event:1339 increased CHEBI CHEBI:29108 calcium(2+) VT VT:0010499 calcium amount Aop:215 Event:1350 increased CHEBI CHEBI:29985 L-glutamate(1-) GO GO:0035249 synaptic transmission, glutamatergic Aop:215 Event:1353 disrupted GO GO:0005248 voltage-gated sodium channel activity Aop:216 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:216 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:216 Event:78 decreased VT VT:1000294 egg quantity Aop:216 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:217 Event:1376 increased GO GO:1990150 VEGF-A complex HP HP:0003002 Breast carcinoma Aop:218 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:219 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:220 Event:1392 increased MP MP:0003674 oxidative stress Aop:220 Event:1394 increased GO GO:0034599 cellular response to oxidative stress Aop:220 Event:1394 increased CL CL:0000235 macrophage GO GO:0002281 macrophage activation involved in immune response Aop:220 Event:1394 decreased PR PR:000008555 hypoxia-inducible factor 1-alpha MP MP:0005039 hypoxia Aop:220 Event:1394 decreased PR PR:000017294 von Hippel-Lindau disease tumor suppressor MP MP:0005039 hypoxia Aop:221 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:221 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:222 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:222 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:223 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:223 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:224 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:224 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:225 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:225 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:226 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:226 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:226 Event:1339 increased CHEBI CHEBI:29108 calcium(2+) VT VT:0010499 calcium amount Aop:230 Event:1350 increased CHEBI CHEBI:29985 L-glutamate(1-) GO GO:0035249 synaptic transmission, glutamatergic Aop:230 Event:1353 disrupted GO GO:0005248 voltage-gated sodium channel activity Aop:232 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:233 Event:763 increased GO GO:0060081 membrane hyperpolarization Aop:235 Event:763 increased GO GO:0060081 membrane hyperpolarization Aop:237 Event:1438 increased N/A N/A Acute phase proteins GO GO:0006953 acute-phase response Aop:237 Event:1439 increased N/A N/A Acute phase proteins GO GO:0006953 acute-phase response Aop:237 Event:1443 increased HP HP:0002621 Atherosclerosis Aop:237 Event:1495 increased GO GO:0002221 pattern recognition receptor signaling pathway Aop:237 Event:1495 increased PR PR:000001096 Toll-like receptor GO GO:0002224 toll-like receptor signaling pathway Aop:237 Event:1495 increased PR PR:000001155 Toll-like receptor 4 GO GO:0034142 toll-like receptor 4 signaling pathway Aop:237 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:237 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:237 Event:1496 increased GO GO:0006956 complement activation Aop:237 Event:1496 increased FMA FMA:86578 Interleukin Aop:238 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:238 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:238 Event:78 decreased VT VT:1000294 egg quantity Aop:238 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:241 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:241 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:242 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:242 Event:636 decreased VT VT:0005372 life span trait Aop:245 Event:1472 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:245 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:245 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:256 Event:709 increased CL CL:1000507 kidney tubule cell GO GO:0008219 cell death Aop:256 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:256 Event:177 functional change GO GO:0005739 mitochondrion Aop:257 Event:831 functional change GO GO:0005764 lysosome Aop:257 Event:898 occurrence GO GO:0005764 lysosome GO GO:1903008 organelle disassembly Aop:257 Event:709 increased CL CL:1000507 kidney tubule cell GO GO:0008219 cell death Aop:257 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:258 Event:244 increased GO GO:0008213 protein alkylation Aop:258 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:258 Event:709 increased CL CL:1000507 kidney tubule cell GO GO:0008219 cell death Aop:258 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:258 Event:177 functional change GO GO:0005739 mitochondrion Aop:260 Event:1513 increased MP MP:0006042 increased apoptosis Aop:260 Event:1392 increased MP MP:0003674 oxidative stress Aop:261 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:263 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:263 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:263 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:263 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:263 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:263 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:264 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:264 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:264 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:264 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:264 Event:55 increased GO GO:0008219 cell death Aop:264 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:265 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:265 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:265 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:265 Event:55 increased GO GO:0008219 cell death Aop:265 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:266 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:266 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:266 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:266 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:266 Event:1562 decreased GO GO:0005890 sodium:potassium-exchanging ATPase complex GO GO:0005391 sodium:potassium-exchanging ATPase activity Aop:266 Event:55 increased GO GO:0008219 cell death Aop:266 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:267 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:267 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:267 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:267 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:267 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:268 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:268 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:268 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:268 Event:55 increased GO GO:0008219 cell death Aop:268 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:271 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:271 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:271 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:271 Event:221 decreased MESH D014819 vitellogenins Aop:271 Event:78 decreased VT VT:1000294 egg quantity Aop:272 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:272 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:272 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:272 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:272 Event:1636 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:272 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:272 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:273 Event:1542 decreased GO GO:0005750 mitochondrial respiratory chain complex III HP HP:0011924 Decreased activity of mitochondrial complex III Aop:273 Event:888 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0006120 mitochondrial electron transport, NADH to ubiquinone Aop:273 Event:887 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0008137 NADH dehydrogenase (ubiquinone) activity Aop:273 Event:889 abnormal CHEBI CHEBI:36080 protein MESH D057165 Proteostasis deficiencies Aop:273 Event:55 increased GO GO:0008219 cell death Aop:273 Event:177 functional change GO GO:0005739 mitochondrion Aop:273 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:274 Event:1502 decreased PR PR:000008478 histone deacetylase 1 GO GO:0004857 enzyme inhibitor activity Aop:275 Event:1502 decreased PR PR:000008478 histone deacetylase 1 GO GO:0004857 enzyme inhibitor activity Aop:275 Event:1503 increased CHEBI CHEBI:15358 histone GO GO:0031399 regulation of protein modification process Aop:275 Event:1239 abnormal GO GO:0010467 gene expression Aop:275 Event:1560 abnormal GO GO:0005623 cell GO GO:0030154 cell differentiation Aop:276 Event:888 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0006120 mitochondrial electron transport, NADH to ubiquinone Aop:276 Event:887 decreased PR PR:000031316 NADH-ubiquinone oxidoreductase chain 1 GO GO:0008137 NADH dehydrogenase (ubiquinone) activity Aop:276 Event:1562 decreased GO GO:0005890 sodium:potassium-exchanging ATPase complex GO GO:0005391 sodium:potassium-exchanging ATPase activity Aop:277 Event:1700 decreased PR PR:000001363 interleukin-1 receptor type I GO GO:0004908 interleukin-1 receptor activity Aop:277 Event:1702 decreased CL CL:0000084 T cell GO GO:0002286 T cell activation involved in immune response Aop:277 Event:202 decreased PR PR:000001753 transcription factor NF-kappa-B subunit GO GO:0007249 I-kappaB kinase/NF-kappaB signaling Aop:277 Event:984 increased IDO IDO:0000610 Immunosuppression Aop:278 Event:202 decreased PR PR:000001753 transcription factor NF-kappa-B subunit GO GO:0007249 I-kappaB kinase/NF-kappaB signaling Aop:278 Event:55 increased GO GO:0008219 cell death Aop:280 Event:149 increased GO GO:0006954 inflammatory response Aop:280 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:281 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:281 Event:10 increased CHEBI CHEBI:15355 acetylcholine Aop:281 Event:1602 increased PR PR:000001488 muscarinic acetylcholine receptor GO GO:0031789 G-protein coupled acetylcholine receptor binding Aop:281 Event:388 increased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:281 Event:388 morphological change GO GO:0032591 dendritic spine membrane MP MP:0011267 abnormal excitatory postsynaptic current amplitude Aop:281 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:281 Event:55 increased GO GO:0008219 cell death Aop:281 Event:1623 occurrence CL CL:0000540 neuron HP HP:0011185 EEG with focal epileptiform discharges Aop:281 Event:352 increased MP MP:0002229 neurodegeneration Aop:281 Event:1788 occurrence UBERON UBERON:0000955 brain NBO NBO:0000703 secondary generalized seizure Aop:281 Event:1350 increased CHEBI CHEBI:29985 L-glutamate(1-) GO GO:0035249 synaptic transmission, glutamatergic Aop:282 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:284 Event:926 abnormal CHEBI CHEBI:16856 glutathione GO GO:0016209 antioxidant activity Aop:284 Event:1392 increased MP MP:0003674 oxidative stress Aop:284 Event:178 disrupted GO GO:0005746 mitochondrial respiratory chain Aop:284 Event:768 increased GO GO:0008219 cell death Aop:284 Event:768 increased GO GO:0001909 leukocyte mediated cytotoxicity Aop:285 Event:1262 increased GO GO:0006915 apoptotic process Aop:285 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:286 Event:1542 decreased GO GO:0005750 mitochondrial respiratory chain complex III HP HP:0011924 Decreased activity of mitochondrial complex III Aop:286 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:286 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:286 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:287 Event:1542 decreased GO GO:0005750 mitochondrial respiratory chain complex III HP HP:0011924 Decreased activity of mitochondrial complex III Aop:287 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:287 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:287 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:287 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:288 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:288 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:288 Event:1615 abnormal UBERON UBERON:0000991 gonad GO GO:0048513 animal organ development Aop:288 Event:1616 abnormal GO GO:0048513 animal organ development Aop:288 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:288 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:289 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:289 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:289 Event:221 decreased MESH D014819 vitellogenins Aop:289 Event:78 decreased VT VT:1000294 egg quantity Aop:289 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:290 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:290 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:290 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:291 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:291 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:291 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:291 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:292 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:293 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:293 Event:1193 pathological MESH D001943 Breast Neoplasms Aop:293 Event:1492 increased GO GO:0002263 cell activation involved in immune response Aop:293 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:293 Event:1494 increased CL CL:0000738 leukocyte GO GO:0002263 cell activation involved in immune response Aop:293 Event:1182 increased GO GO:0008283 cell proliferation Aop:293 Event:1192 increased MESH D006965 hyperplasia Aop:293 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:294 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:294 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:294 Event:1193 pathological MESH D001943 Breast Neoplasms Aop:294 Event:1182 increased GO GO:0008283 cell proliferation Aop:294 Event:1492 increased GO GO:0002263 cell activation involved in immune response Aop:294 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:294 Event:1494 increased CL CL:0000738 leukocyte GO GO:0002263 cell activation involved in immune response Aop:294 Event:1192 increased MESH D006965 hyperplasia Aop:296 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:296 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:296 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:296 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:296 Event:1636 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:297 Event:1643 functional change UBERON UBERON:0000970 eye VT VT:0002090 vision trait Aop:297 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:298 Event:1651 occurrence GO GO:2001038 regulation of cellular response to drug Aop:298 Event:1754 increased PR PR:000030936 protein-serine O-palmitoleoyltransferase porcupine GO GO:0061355 Wnt protein secretion Aop:298 Event:1755 occurrence GO GO:1990907 beta-catenin-TCF complex GO GO:1904863 regulation of beta-catenin-TCF complex assembly Aop:298 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:298 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:299 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:299 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:299 Event:78 decreased VT VT:1000294 egg quantity Aop:299 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:299 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:300 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:300 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:300 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:300 Event:402 decreased GO GO:0007611 learning or memory Aop:300 Event:402 decreased GO GO:0050890 cognition Aop:302 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:303 Event:1668 decreased CL CL:0000235 macrophage GO GO:0006909 phagocytosis Aop:303 Event:87 increased FMA FMA:84050 Cytokine GO GO:0050663 cytokine secretion Aop:303 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:303 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:303 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:303 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:303 Event:1669 increased MESH D009154 mutation Aop:303 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:303 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:303 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:303 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:303 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:303 Event:1670 increased UBERON UBERON:0002048 lung HP HP:0100526 Neoplasm of the lung Aop:303 Event:1670 increased UBERON UBERON:0002048 lung MP MP:0008014 increased lung tumor incidence Aop:305 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:305 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:305 Event:1688 disrupted FMA FMA:264621 Musculature of male perineum GO GO:0030521 androgen receptor signaling pathway Aop:305 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:306 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:306 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:306 Event:1688 disrupted FMA FMA:264621 Musculature of male perineum GO GO:0030521 androgen receptor signaling pathway Aop:306 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:307 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:307 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:307 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:307 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:307 Event:1688 disrupted FMA FMA:264621 Musculature of male perineum GO GO:0030521 androgen receptor signaling pathway Aop:307 Event:2298 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:309 Event:1695 decreased FMA FMA:67343 Ovum GO GO:0030728 ovulation Aop:309 Event:679 decreased PCO PCO:0000008 population growth rate Aop:310 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:310 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:310 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:310 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:310 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:310 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:310 Event:221 decreased MESH D014819 vitellogenins Aop:310 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:310 Event:309 decreased GO GO:0001555 oocyte growth Aop:310 Event:309 decreased GO GO:0048599 oocyte development Aop:310 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:310 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:310 Event:78 decreased VT VT:1000294 egg quantity Aop:310 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:311 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:311 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:311 Event:78 decreased VT VT:1000294 egg quantity Aop:311 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:311 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:312 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:312 Event:10 increased CHEBI CHEBI:15355 acetylcholine Aop:312 Event:39 increased MP MP:0001393 ataxia Aop:312 Event:39 increased MP MP:0001399 hyperactivity Aop:312 Event:39 increased MP MP:0000753 paralysis Aop:312 Event:351 increased MESH D009026 mortality Aop:312 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:315 Event:1715 decreased PR PR:000009198 tyrosine-protein kinase JAK3 GO GO:0051098 regulation of binding Aop:315 Event:1716 decreased PR PR:000001933 signal transducer and transcription activator STAT GO GO:0006470 protein dephosphorylation Aop:315 Event:1717 decreased GO GO:0032993 protein-DNA complex GO GO:0043392 negative regulation of DNA binding Aop:315 Event:1718 decreased PR PR:000001391 interleukin-4 GO GO:0032633 interleukin-4 production Aop:315 Event:1719 decreased GO GO:0002286 T cell activation involved in immune response Aop:318 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:318 Event:860 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:318 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:318 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:319 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:319 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:319 Event:1172 increased GO GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Aop:319 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:319 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:319 Event:1496 increased GO GO:0006956 complement activation Aop:319 Event:1496 increased FMA FMA:86578 Interleukin Aop:319 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0009299 mRNA transcription Aop:319 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0004180 carboxypeptidase activity Aop:319 Event:1854 decreased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0034394 protein localization to cell surface Aop:319 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 Aop:320 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:320 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:320 Event:1496 increased GO GO:0006956 complement activation Aop:320 Event:1496 increased FMA FMA:86578 Interleukin Aop:320 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:320 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:320 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:320 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:320 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:320 Event:351 increased MESH D009026 mortality Aop:320 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:320 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:320 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:320 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:320 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:320 Event:1901 decreased PR PR:000024938 interferon alpha GO GO:0060337 type I interferon signaling pathway Aop:320 Event:1901 decreased PR PR:000024939 interferon beta GO GO:0060337 type I interferon signaling pathway Aop:320 Event:1901 occurrence GO GO:0019022 RNA viral genome GO GO:0071360 cellular response to exogenous dsRNA Aop:322 Event:97 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006305 DNA alkylation Aop:322 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:322 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:323 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:323 Event:807 decreased CHEBI CHEBI:16113 cholesterol GO GO:0006695 cholesterol biosynthetic process Aop:323 Event:807 decreased CHEBI CHEBI:16113 cholesterol GO GO:0030301 cholesterol transport Aop:323 Event:807 decreased CHEBI CHEBI:17002 cholesteryl ester GO GO:0030301 cholesterol transport Aop:323 Event:1756 decreased CHEBI CHEBI:34133 11-Keto-testosterone GO GO:0006702 androgen biosynthetic process Aop:323 Event:1758 abnormal FMA FMA:67338 Mature sperm cell HP HP:0008669 Abnormal spermatogenesis Aop:323 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:323 Event:2147 decreased GO GO:0019953 sexual reproduction Aop:323 Event:2147 decreased VT VT:1000181 viable offspring quantity Aop:324 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:324 Event:1392 increased MP MP:0003674 oxidative stress Aop:324 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:324 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:324 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:324 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:324 Event:55 increased GO GO:0008219 cell death Aop:324 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:325 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:325 Event:1392 increased MP MP:0003674 oxidative stress Aop:325 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:325 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:325 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:325 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:325 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:326 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:326 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:326 Event:1392 increased MP MP:0003674 oxidative stress Aop:326 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:326 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:326 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:326 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:326 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:327 Event:350 increased MESH D009026 mortality Aop:327 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:328 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:328 Event:350 increased MESH D009026 mortality Aop:328 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:329 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:329 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:329 Event:350 increased MESH D009026 mortality Aop:329 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:330 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:330 Event:350 increased MESH D009026 mortality Aop:330 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:331 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:331 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:331 Event:1392 increased MP MP:0003674 oxidative stress Aop:331 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:331 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:331 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:331 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:331 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:331 Event:55 increased GO GO:0008219 cell death Aop:332 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:332 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:332 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:332 Event:1392 increased MP MP:0003674 oxidative stress Aop:332 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:332 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:332 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:332 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:333 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:333 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:333 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:333 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:333 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:333 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:333 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:333 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:333 Event:1392 increased MP MP:0003674 oxidative stress Aop:334 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:334 Event:1761 decreased CL CL:0000354 blastemal cell GO GO:0031101 fin regeneration Aop:334 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:334 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:334 Event:2245 abnormal GO GO:0030154 cell differentiation Aop:334 Event:2245 increased GO GO:0007166 cell surface receptor signaling pathway Aop:334 Event:2089 decreased GO GO:0001649 osteoblast differentiation Aop:334 Event:2089 increased GO GO:0030316 osteoclast differentiation Aop:335 Event:795 increased CL CL:0000731 urothelial cell GO GO:0008283 cell proliferation Aop:335 Event:796 increased CL CL:0000731 urothelial cell MESH D006965 hyperplasia Aop:335 Event:177 functional change GO GO:0005739 mitochondrion Aop:336 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:337 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:338 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:339 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:340 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:341 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:342 Event:103 increased GO GO:0008230 ecdysone receptor holocomplex GO GO:0035076 ecdysone receptor-mediated signaling pathway Aop:342 Event:988 decreased GO GO:0008255 ecdysis-triggering hormone activity Aop:342 Event:1266 decreased PR PR:Q9VCW0 cardioactive peptide (fruit fly) GO GO:0002790 peptide secretion Aop:342 Event:1267 decreased CL CL:0000100 motor neuron GO GO:0019226 transmission of nerve impulse Aop:342 Event:993 increased GO GO:0006936 muscle contraction Aop:342 Event:990 increased CHEBI CHEBI:17029 chitin GO GO:0006031 chitin biosynthetic process Aop:342 Event:350 increased MESH D009026 mortality Aop:343 Event:988 decreased GO GO:0008255 ecdysis-triggering hormone activity Aop:343 Event:1266 decreased PR PR:Q9VCW0 cardioactive peptide (fruit fly) GO GO:0002790 peptide secretion Aop:343 Event:1267 decreased CL CL:0000100 motor neuron GO GO:0019226 transmission of nerve impulse Aop:343 Event:993 increased GO GO:0006936 muscle contraction Aop:343 Event:990 increased CHEBI CHEBI:17029 chitin GO GO:0006031 chitin biosynthetic process Aop:343 Event:350 increased MESH D009026 mortality Aop:344 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:344 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:344 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:345 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:345 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:345 Event:1800 decreased CL CL:0000501 granulosa cell GO GO:0001541 ovarian follicle development Aop:345 Event:405 disrupted UBERON UBERON:0001305 ovarian follicle GO GO:0042698 ovulation cycle Aop:345 Event:406 decreased MESH D005298 fertility Aop:345 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:345 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:346 Event:36 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:346 Event:1789 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:346 Event:1790 increased UBERON UBERON:2005272 immature gonad GO GO:0008584 male gonad development Aop:346 Event:1791 increased PCO PCO:0000001 population of organisms GO GO:0046661 male sex differentiation Aop:346 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:347 Event:1292 increased MESH D048031 JNK Mitogen-Activated Protein Kinases GO GO:0023052 signaling Aop:347 Event:1283 increased PR PR:000000046 TGF-beta GO GO:0023052 signaling Aop:347 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:348 Event:1756 decreased CHEBI CHEBI:34133 11-Keto-testosterone GO GO:0006702 androgen biosynthetic process Aop:348 Event:1758 abnormal FMA FMA:67338 Mature sperm cell HP HP:0008669 Abnormal spermatogenesis Aop:348 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:348 Event:406 decreased MESH D005298 fertility Aop:348 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:349 Event:1756 decreased CHEBI CHEBI:34133 11-Keto-testosterone GO GO:0006702 androgen biosynthetic process Aop:349 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:349 Event:406 decreased MESH D005298 fertility Aop:349 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:358 Event:1524 decreased GO GO:0018990 ecdysis, chitin-based cuticle Aop:358 Event:350 increased MESH D009026 mortality Aop:359 Event:1524 decreased GO GO:0018990 ecdysis, chitin-based cuticle Aop:359 Event:350 increased MESH D009026 mortality Aop:360 Event:1522 decreased GO GO:0004100 chitin synthase activity Aop:360 Event:1523 decreased UBERON UBERON:0001002 cuticle GO GO:0042335 cuticle development Aop:360 Event:1524 decreased GO GO:0018990 ecdysis, chitin-based cuticle Aop:360 Event:350 increased MESH D009026 mortality Aop:361 Event:1523 decreased UBERON UBERON:0001002 cuticle GO GO:0042335 cuticle development Aop:361 Event:1524 decreased GO GO:0018990 ecdysis, chitin-based cuticle Aop:361 Event:350 increased MESH D009026 mortality Aop:362 Event:177 functional change GO GO:0005739 mitochondrion Aop:363 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:363 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:363 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:363 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:363 Event:351 increased MESH D009026 mortality Aop:363 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:363 Event:1877 morphological change UBERON UBERON:0000966 retina GO GO:0010842 retina layer formation Aop:363 Event:1643 functional change UBERON UBERON:0000970 eye VT VT:0002090 vision trait Aop:364 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:364 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:364 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:364 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:364 Event:1878 decreased UBERON UBERON:0000970 eye MP MP:0001297 microphthalmia Aop:364 Event:351 increased MESH D009026 mortality Aop:364 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:364 Event:1643 functional change UBERON UBERON:0000970 eye VT VT:0002090 vision trait Aop:365 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:365 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:365 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:365 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:365 Event:351 increased MESH D009026 mortality Aop:365 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:365 Event:1643 functional change UBERON UBERON:0000970 eye VT VT:0002090 vision trait Aop:366 Event:957 increased PR PR:000016801 transthyretin GO GO:0005488 binding Aop:366 Event:959 increased CHEBI CHEBI:30660 thyroxine Aop:366 Event:1158 increased CHEBI CHEBI:60311 thyroid hormone GO GO:0006810 transport Aop:366 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:366 Event:1101 delayed GO GO:0007552 metamorphosis Aop:366 Event:1101 increased GO GO:0007552 metamorphosis Aop:366 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:367 Event:959 increased CHEBI CHEBI:30660 thyroxine Aop:367 Event:1158 increased CHEBI CHEBI:60311 thyroid hormone GO GO:0006810 transport Aop:367 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:367 Event:1101 delayed GO GO:0007552 metamorphosis Aop:367 Event:1101 increased GO GO:0007552 metamorphosis Aop:367 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:368 Event:1840 decreased GO GO:0005739 mitochondrion GO GO:0004129 cytochrome-c oxidase activity Aop:368 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:368 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:368 Event:2312 increased FMA FMA:46472 Nose MP MP:0013027 wounding Aop:372 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:372 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:372 Event:1616 abnormal GO GO:0048513 animal organ development Aop:372 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:374 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:374 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:374 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:374 Event:352 increased MP MP:0002229 neurodegeneration Aop:375 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0010467 gene expression Aop:375 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0046903 secretion Aop:376 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:376 Event:1790 increased UBERON UBERON:2005272 immature gonad GO GO:0008584 male gonad development Aop:376 Event:1791 increased PCO PCO:0000001 population of organisms GO GO:0046661 male sex differentiation Aop:376 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:377 Event:351 increased MESH D009026 mortality Aop:377 Event:1895 increased GO GO:0072559 NLRP3 inflammasome complex GO GO:0044546 NLRP3 inflammasome complex assembly Aop:377 Event:1392 increased MP MP:0003674 oxidative stress Aop:377 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0034599 cellular response to oxidative stress Aop:377 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0000302 response to reactive oxygen species Aop:377 Event:1869 decreased GO GO:0034599 cellular response to oxidative stress Aop:377 Event:55 increased GO GO:0008219 cell death Aop:377 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:377 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:377 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:377 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:377 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:377 Event:1496 increased GO GO:0006956 complement activation Aop:377 Event:1496 increased FMA FMA:86578 Interleukin Aop:377 Event:1868 increased GO GO:0002544 chronic inflammatory response Aop:377 Event:1868 increased GO GO:0002676 regulation of chronic inflammatory response Aop:377 Event:1868 increased PR PR:000001393 interleukin-6 GO GO:0032635 interleukin-6 production Aop:377 Event:1868 increased PR PR:000001136 interleukin-1 beta GO GO:0032611 interleukin-1 beta production Aop:377 Event:1868 increased PR PR:000000134 tumor necrosis factor alpha GO GO:1990774 tumor necrosis factor secretion Aop:377 Event:1868 increased HP HP:0012649 Increased inflammatory response Aop:377 Event:1868 increased CHEBI CHEBI:82594 Ferritin HP HP:0003281 Increased serum ferritin Aop:377 Event:1868 increased GO GO:0004457 lactate dehydrogenase activity Aop:377 Event:1868 increased PR PR:000005897 C-reactive protein HP HP:0011227 Elevated C-reactive protein level Aop:377 Event:1868 decreased CL CL:0000542 lymphocyte HP HP:0001888 Lymphopenia Aop:377 Event:87 increased FMA FMA:84050 Cytokine GO GO:0050663 cytokine secretion Aop:377 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:377 Event:759 increased MP MP:0003606 kidney failure Aop:377 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:377 Event:1172 increased GO GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Aop:377 Event:902 occurrence MP MP:0001860 liver inflammation Aop:377 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:377 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:377 Event:177 functional change GO GO:0005739 mitochondrion Aop:377 Event:1846 increased CL CL:0000233 platelet HP HP:0004936 Venous thrombosis Aop:377 Event:1846 decreased GO GO:0042730 fibrinolysis Aop:377 Event:1846 increased CHEBI CHEBI:5054 Fibrin GO GO:0072378 blood coagulation, fibrin clot formation Aop:379 Event:1845 occurrence UBERON UBERON:0000178 blood MP MP:0002551 abnormal blood coagulation Aop:379 Event:1846 increased CL CL:0000233 platelet HP HP:0004936 Venous thrombosis Aop:379 Event:1846 decreased GO GO:0042730 fibrinolysis Aop:379 Event:1846 increased CHEBI CHEBI:5054 Fibrin GO GO:0072378 blood coagulation, fibrin clot formation Aop:379 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:379 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:379 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:379 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:379 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:379 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:379 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:379 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:379 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:379 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0034599 cellular response to oxidative stress Aop:379 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0000302 response to reactive oxygen species Aop:379 Event:1869 decreased GO GO:0034599 cellular response to oxidative stress Aop:379 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:379 Event:1901 decreased PR PR:000024938 interferon alpha GO GO:0060337 type I interferon signaling pathway Aop:379 Event:1901 decreased PR PR:000024939 interferon beta GO GO:0060337 type I interferon signaling pathway Aop:379 Event:1901 occurrence GO GO:0019022 RNA viral genome GO GO:0071360 cellular response to exogenous dsRNA Aop:381 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:382 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:382 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:382 Event:1496 increased GO GO:0006956 complement activation Aop:382 Event:1496 increased FMA FMA:86578 Interleukin Aop:382 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:382 Event:1172 increased GO GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Aop:382 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:383 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:383 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:384 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:385 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:385 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0009299 mRNA transcription Aop:385 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0004180 carboxypeptidase activity Aop:385 Event:1854 decreased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0034394 protein localization to cell surface Aop:385 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 Aop:385 Event:2096 functional change CL CL:0000071 blood vessel endothelial cell Aop:385 Event:2096 functional change CL CL:0000669 pericyte cell Aop:385 Event:2096 functional change CL CL:0000192 smooth muscle cell Aop:385 Event:2096 disrupted GO GO:0010496 intercellular transport Aop:386 Event:1472 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:386 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:386 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:386 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:387 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:387 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:387 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:387 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:387 Event:1472 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:388 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:388 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:388 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:389 Event:1472 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:389 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:392 Event:1866 increased GO GO:0051918 negative regulation of fibrinolysis Aop:392 Event:1866 decreased GO GO:0030195 negative regulation of blood coagulation Aop:392 Event:1867 increased MP MP:0003070 increased vascular permeability Aop:392 Event:1867 increased GO GO:0042311 vasodilation Aop:392 Event:1867 increased MP MP:0001863 vascular inflammation Aop:392 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:392 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:392 Event:1496 increased GO GO:0006956 complement activation Aop:392 Event:1496 increased FMA FMA:86578 Interleukin Aop:392 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:392 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:392 Event:1868 increased GO GO:0002544 chronic inflammatory response Aop:392 Event:1868 increased GO GO:0002676 regulation of chronic inflammatory response Aop:392 Event:1868 increased PR PR:000001393 interleukin-6 GO GO:0032635 interleukin-6 production Aop:392 Event:1868 increased PR PR:000001136 interleukin-1 beta GO GO:0032611 interleukin-1 beta production Aop:392 Event:1868 increased PR PR:000000134 tumor necrosis factor alpha GO GO:1990774 tumor necrosis factor secretion Aop:392 Event:1868 increased HP HP:0012649 Increased inflammatory response Aop:392 Event:1868 increased CHEBI CHEBI:82594 Ferritin HP HP:0003281 Increased serum ferritin Aop:392 Event:1868 increased GO GO:0004457 lactate dehydrogenase activity Aop:392 Event:1868 increased PR PR:000005897 C-reactive protein HP HP:0011227 Elevated C-reactive protein level Aop:392 Event:1868 decreased CL CL:0000542 lymphocyte HP HP:0001888 Lymphopenia Aop:393 Event:1158 increased CHEBI CHEBI:60311 thyroid hormone GO GO:0006810 transport Aop:393 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:393 Event:1262 increased GO GO:0006915 apoptotic process Aop:394 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:394 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:394 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:394 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:394 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:394 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:394 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:394 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:394 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:394 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:395 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:395 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:395 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:395 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:395 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:395 Event:1846 increased CL CL:0000233 platelet HP HP:0004936 Venous thrombosis Aop:395 Event:1846 decreased GO GO:0042730 fibrinolysis Aop:395 Event:1846 increased CHEBI CHEBI:5054 Fibrin GO GO:0072378 blood coagulation, fibrin clot formation Aop:396 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:396 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:396 Event:752 abnormal GO GO:0005694 chromosome GO GO:0051305 chromosome movement towards spindle pole Aop:396 Event:406 decreased MESH D005298 fertility Aop:396 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:396 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:396 Event:1392 increased MP MP:0003674 oxidative stress Aop:397 Event:1879 increased CHEBI CHEBI:16991 deoxyribonucleic acid Aop:397 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:397 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:398 Event:1880 decreased PR PR:000003920 retinal dehydrogenase 1 GO GO:0002138 retinoic acid biosynthetic process Aop:398 Event:1881 decreased CHEBI CHEBI:15367 all-trans-retinoic acid GO GO:0002138 retinoic acid biosynthetic process Aop:398 Event:1882 disrupted CL CL:0000023 oocyte GO GO:0007127 meiosis I Aop:398 Event:1883 decreased UBERON UBERON:0001305 ovarian follicle GO GO:0001541 ovarian follicle development Aop:398 Event:406 decreased MESH D005298 fertility Aop:398 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:398 Event:405 disrupted UBERON UBERON:0001305 ovarian follicle GO GO:0042698 ovulation cycle Aop:399 Event:1884 decreased PR PR:Q6EWH2 tyrosine-protein kinase fyna (zebrafish) GO GO:0004713 protein tyrosine kinase activity Aop:399 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:399 Event:1878 decreased UBERON UBERON:0000970 eye MP MP:0001297 microphthalmia Aop:399 Event:351 increased MESH D009026 mortality Aop:399 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:399 Event:1643 functional change UBERON UBERON:0000970 eye VT VT:0002090 vision trait Aop:400 Event:406 decreased MESH D005298 fertility Aop:400 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:401 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:401 Event:472 decreased PR PR:000005835 carnitine O-palmitoyltransferase 1, liver isoform GO GO:0010467 gene expression Aop:401 Event:1284 increased PR PR:000021564 sterol regulatory element-binding protein 2 proteolytic cleavage product GO GO:0010467 gene expression Aop:401 Event:462 increased PR PR:000014497 acyl-CoA desaturase GO GO:0010467 gene expression Aop:402 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:402 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:402 Event:771 decreased CHEBI CHEBI:30660 thyroxine Aop:405 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:405 Event:10 increased CHEBI CHEBI:15355 acetylcholine Aop:405 Event:39 increased MP MP:0001393 ataxia Aop:405 Event:39 increased MP MP:0001399 hyperactivity Aop:405 Event:39 increased MP MP:0000753 paralysis Aop:405 Event:386 decreased GO GO:0099536 synaptic signaling Aop:405 Event:402 decreased GO GO:0007611 learning or memory Aop:405 Event:402 decreased GO GO:0050890 cognition Aop:406 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:406 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:406 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:406 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:406 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:406 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:406 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:406 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:406 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:406 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:406 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0034599 cellular response to oxidative stress Aop:406 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0000302 response to reactive oxygen species Aop:406 Event:1869 decreased GO GO:0034599 cellular response to oxidative stress Aop:406 Event:1895 increased GO GO:0072559 NLRP3 inflammasome complex GO GO:0044546 NLRP3 inflammasome complex assembly Aop:406 Event:1868 increased GO GO:0002544 chronic inflammatory response Aop:406 Event:1868 increased GO GO:0002676 regulation of chronic inflammatory response Aop:406 Event:1868 increased PR PR:000001393 interleukin-6 GO GO:0032635 interleukin-6 production Aop:406 Event:1868 increased PR PR:000001136 interleukin-1 beta GO GO:0032611 interleukin-1 beta production Aop:406 Event:1868 increased PR PR:000000134 tumor necrosis factor alpha GO GO:1990774 tumor necrosis factor secretion Aop:406 Event:1868 increased HP HP:0012649 Increased inflammatory response Aop:406 Event:1868 increased CHEBI CHEBI:82594 Ferritin HP HP:0003281 Increased serum ferritin Aop:406 Event:1868 increased GO GO:0004457 lactate dehydrogenase activity Aop:406 Event:1868 increased PR PR:000005897 C-reactive protein HP HP:0011227 Elevated C-reactive protein level Aop:406 Event:1868 decreased CL CL:0000542 lymphocyte HP HP:0001888 Lymphopenia Aop:407 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:407 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:407 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:407 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:407 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:407 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:407 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:407 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:407 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:407 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:407 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0034599 cellular response to oxidative stress Aop:407 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0000302 response to reactive oxygen species Aop:407 Event:1869 decreased GO GO:0034599 cellular response to oxidative stress Aop:407 Event:1895 increased GO GO:0072559 NLRP3 inflammasome complex GO GO:0044546 NLRP3 inflammasome complex assembly Aop:409 Event:1668 decreased CL CL:0000235 macrophage GO GO:0006909 phagocytosis Aop:409 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:409 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:409 Event:1496 increased GO GO:0006956 complement activation Aop:409 Event:1496 increased FMA FMA:86578 Interleukin Aop:409 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:409 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:409 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:409 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:409 Event:1669 increased MESH D009154 mutation Aop:409 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:409 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:409 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:409 Event:1896 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:409 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:409 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:409 Event:1090 increased MESH D008654 mesothelioma HP HP:0100001 Malignant mesothelioma Aop:410 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:410 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:410 Event:1930 abnormal GO GO:0030916 otic vesicle formation Aop:410 Event:1008 decreased GO GO:0007605 sensory perception of sound Aop:410 Event:351 increased MESH D009026 mortality Aop:410 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:411 Event:1908 occurrence GO GO:0031514 motile cilium HP HP:0012262 Abnormal ciliary motility Aop:411 Event:1909 decreased VT VT:0001947 mucociliary clearance trait Aop:411 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:411 Event:1392 increased MP MP:0003674 oxidative stress Aop:412 Event:87 increased FMA FMA:84050 Cytokine GO GO:0050663 cytokine secretion Aop:413 Event:926 abnormal CHEBI CHEBI:16856 glutathione GO GO:0016209 antioxidant activity Aop:413 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:413 Event:759 increased MP MP:0003606 kidney failure Aop:413 Event:351 increased MESH D009026 mortality Aop:413 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:414 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:414 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:414 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:415 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:415 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:415 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:416 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:416 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:416 Event:1670 increased UBERON UBERON:0002048 lung HP HP:0100526 Neoplasm of the lung Aop:416 Event:1670 increased UBERON UBERON:0002048 lung MP MP:0008014 increased lung tumor incidence Aop:416 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:416 Event:1669 increased MESH D009154 mutation Aop:416 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:416 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:416 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:416 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:417 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:417 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:417 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:417 Event:1669 increased MESH D009154 mutation Aop:417 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:417 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:417 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:417 Event:1670 increased UBERON UBERON:0002048 lung HP HP:0100526 Neoplasm of the lung Aop:417 Event:1670 increased UBERON UBERON:0002048 lung MP MP:0008014 increased lung tumor incidence Aop:418 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:418 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:418 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:418 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:418 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:418 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:419 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:419 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:419 Event:1262 increased GO GO:0006915 apoptotic process Aop:419 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:420 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:420 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:420 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:420 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:420 Event:1670 increased UBERON UBERON:0002048 lung HP HP:0100526 Neoplasm of the lung Aop:420 Event:1670 increased UBERON UBERON:0002048 lung MP MP:0008014 increased lung tumor incidence Aop:422 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:422 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:422 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:422 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:422 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:422 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:422 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:422 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:422 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:422 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:422 Event:1931 disrupted CL CL:0000073 barrier epithelial cell Aop:422 Event:1901 decreased PR PR:000024938 interferon alpha GO GO:0060337 type I interferon signaling pathway Aop:422 Event:1901 decreased PR PR:000024939 interferon beta GO GO:0060337 type I interferon signaling pathway Aop:422 Event:1901 occurrence GO GO:0019022 RNA viral genome GO GO:0071360 cellular response to exogenous dsRNA Aop:423 Event:177 functional change GO GO:0005739 mitochondrion Aop:423 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:423 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:424 Event:1906 decreased GO GO:0005254 chloride channel activity Aop:424 Event:1392 increased MP MP:0003674 oxidative stress Aop:424 Event:1907 decreased UBERON UBERON:0035963 epithelial lining fluid Aop:424 Event:1909 decreased VT VT:0001947 mucociliary clearance trait Aop:424 Event:1908 occurrence GO GO:0031514 motile cilium HP HP:0012262 Abnormal ciliary motility Aop:424 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:425 Event:1392 increased MP MP:0003674 oxidative stress Aop:425 Event:1911 decreased PR PR:000007628 forkhead box protein J1 Aop:425 Event:1912 decreased GO GO:0031514 motile cilium Aop:425 Event:1908 occurrence GO GO:0031514 motile cilium HP HP:0012262 Abnormal ciliary motility Aop:425 Event:1909 decreased VT VT:0001947 mucociliary clearance trait Aop:425 Event:1250 decreased VT VT:0002327 respiratory function trait Aop:426 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:426 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:426 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:426 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:426 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:426 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:427 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:427 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:428 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:428 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0009299 mRNA transcription Aop:428 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0004180 carboxypeptidase activity Aop:428 Event:1854 decreased PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0034394 protein localization to cell surface Aop:428 Event:1854 increased PR PR:000003622 angiotensin-converting enzyme 2 Aop:429 Event:1392 increased MP MP:0003674 oxidative stress Aop:429 Event:386 decreased GO GO:0099536 synaptic signaling Aop:429 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:429 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:429 Event:1944 decreased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0003990 decreased neurotransmitter release Aop:429 Event:1944 increased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0002916 increased synaptic depression Aop:430 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:430 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:430 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:430 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:430 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:430 Event:1901 decreased PR PR:000024938 interferon alpha GO GO:0060337 type I interferon signaling pathway Aop:430 Event:1901 decreased PR PR:000024939 interferon beta GO GO:0060337 type I interferon signaling pathway Aop:430 Event:1901 occurrence GO GO:0019022 RNA viral genome GO GO:0071360 cellular response to exogenous dsRNA Aop:430 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:430 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:430 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:430 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:430 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:430 Event:1939 increased GO GO:0019076 viral release from host cell Aop:432 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:432 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:432 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:432 Event:876 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:432 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:432 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:432 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:432 Event:403 increased UBERON UBERON:0002405 immune system GO GO:0044414 suppression of host defenses Aop:435 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:435 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:435 Event:752 abnormal GO GO:0005694 chromosome GO GO:0051305 chromosome movement towards spindle pole Aop:435 Event:442 decreased PCO PCO:0000008 population growth rate Aop:436 Event:1880 decreased PR PR:000003920 retinal dehydrogenase 1 GO GO:0002138 retinoic acid biosynthetic process Aop:436 Event:1881 decreased CHEBI CHEBI:15367 all-trans-retinoic acid GO GO:0002138 retinoic acid biosynthetic process Aop:437 Event:709 increased CL CL:1000507 kidney tubule cell GO GO:0008219 cell death Aop:437 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:437 Event:177 functional change GO GO:0005739 mitochondrion Aop:437 Event:1392 increased MP MP:0003674 oxidative stress Aop:439 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:439 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:439 Event:149 increased GO GO:0006954 inflammatory response Aop:439 Event:1262 increased GO GO:0006915 apoptotic process Aop:439 Event:1241 increased GO GO:0048870 cell motility Aop:439 Event:1190 increased GO GO:0043542 endothelial cell migration Aop:439 Event:1196 increased CL CL:0000066 epithelial cell Aop:439 Event:1376 increased GO GO:1990150 VEGF-A complex HP HP:0003002 Breast carcinoma Aop:439 Event:1971 increased GO GO:0070531 BRCA1-A complex HP HP:0003002 Breast carcinoma Aop:440 Event:1046 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:440 Event:1047 increased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:440 Event:1050 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0032275 luteinizing hormone secretion Aop:440 Event:1972 increased PR PR:000015718 StAR-related lipid transfer protein 3 MP MP:0005133 increased luteinizing hormone level Aop:440 Event:1972 increased PR PR:000015719 StAR-related lipid transfer protein 4 MP MP:0005133 increased luteinizing hormone level Aop:440 Event:1972 increased PR PR:000015720 StAR-related lipid transfer protein 5 MP MP:0005133 increased luteinizing hormone level Aop:440 Event:1972 increased PR PR:000015721 StAR-related lipid transfer protein 6 MP MP:0005133 increased luteinizing hormone level Aop:440 Event:1973 increased FMA FMA:83376 Estrogen GO GO:0035937 estrogen secretion Aop:440 Event:1076 increased CHEBI CHEBI:50114 estrogen Aop:440 Event:1052 increased UBERON UBERON:0004911 epithelium of female gonad MESH D006965 hyperplasia Aop:440 Event:1053 increased MESH D000236 Adenoma Aop:440 Event:2092 increased CHEBI CHEBI:17263 estrone GO GO:0038002 endocrine signaling Aop:441 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:441 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:441 Event:1262 increased GO GO:0006915 apoptotic process Aop:442 Event:1353 disrupted GO GO:0005248 voltage-gated sodium channel activity Aop:442 Event:1977 functional change GO GO:0001518 voltage-gated sodium channel complex GO GO:0005272 sodium channel activity Aop:442 Event:1983 disrupted GO GO:0001508 action potential Aop:442 Event:2005 disrupted GO GO:0045202 synapse Aop:442 Event:757 morphological change UBERON UBERON:0002421 hippocampal formation GO GO:0007420 brain development Aop:442 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:442 Event:402 decreased GO GO:0007611 learning or memory Aop:442 Event:402 decreased GO GO:0050890 cognition Aop:443 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:443 Event:1669 increased MESH D009154 mutation Aop:443 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:443 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:443 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:443 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:443 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:443 Event:1172 increased GO GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Aop:443 Event:112 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:443 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:444 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:444 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:444 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:444 Event:1392 increased MP MP:0003674 oxidative stress Aop:445 Event:1985 increased CHEBI CHEBI:80304 Metastin GO GO:0007269 neurotransmitter secretion Aop:445 Event:1986 decreased UBERON UBERON:0001009 circulatory system HP HP:0030339 Decreased circulating gonadotropin level Aop:445 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:445 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:447 Event:202 decreased PR PR:000001753 transcription factor NF-kappa-B subunit GO GO:0007249 I-kappaB kinase/NF-kappaB signaling Aop:447 Event:1097 occurrence MP MP:0004154 renal tubular necrosis Aop:447 Event:814 occurrence UBERON UBERON:0002113 kidney MESH Q000633 toxicity Aop:447 Event:759 increased MP MP:0003606 kidney failure Aop:447 Event:177 functional change GO GO:0005739 mitochondrion Aop:447 Event:1392 increased MP MP:0003674 oxidative stress Aop:449 Event:1502 decreased PR PR:000008478 histone deacetylase 1 GO GO:0004857 enzyme inhibitor activity Aop:450 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:450 Event:352 increased MP MP:0002229 neurodegeneration Aop:450 Event:618 decreased GO GO:0099536 synaptic signaling Aop:450 Event:351 increased MESH D009026 mortality Aop:450 Event:1392 increased MP MP:0003674 oxidative stress Aop:451 Event:1495 increased GO GO:0002221 pattern recognition receptor signaling pathway Aop:451 Event:1495 increased PR PR:000001096 Toll-like receptor GO GO:0002224 toll-like receptor signaling pathway Aop:451 Event:1495 increased PR PR:000001155 Toll-like receptor 4 GO GO:0034142 toll-like receptor 4 signaling pathway Aop:451 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:451 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:451 Event:1496 increased GO GO:0006956 complement activation Aop:451 Event:1496 increased FMA FMA:86578 Interleukin Aop:451 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:451 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:451 Event:780 increased CL CL:0000066 epithelial cell GO GO:0008219 cell death Aop:451 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:451 Event:2006 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:451 Event:1669 increased GO GO:0090734 site of DNA damage GO GO:0042769 DNA damage response, detection of DNA damage Aop:451 Event:1669 increased MESH D009154 mutation Aop:451 Event:1669 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:451 Event:1669 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:451 Event:1669 increased GO GO:1990391 DNA repair complex MP MP:0008058 abnormal DNA repair Aop:451 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:451 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:451 Event:1670 increased UBERON UBERON:0002048 lung HP HP:0100526 Neoplasm of the lung Aop:451 Event:1670 increased UBERON UBERON:0002048 lung MP MP:0008014 increased lung tumor incidence Aop:452 Event:1262 increased GO GO:0006915 apoptotic process Aop:452 Event:1392 increased MP MP:0003674 oxidative stress Aop:452 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:454 Event:2119 increased HP HP:0000855 Insulin resistance Aop:455 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:455 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:455 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:455 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:455 Event:2020 decreased GO GO:0010467 gene expression Aop:455 Event:947 increased MP MP:0008762 embryonic lethality Aop:455 Event:947 increased MESH D009026 mortality Aop:455 Event:2021 increased GO GO:0010467 gene expression Aop:456 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:456 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:456 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:456 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:456 Event:2020 decreased GO GO:0010467 gene expression Aop:456 Event:2021 increased GO GO:0010467 gene expression Aop:456 Event:317 morphological change MP MP:0001544 abnormal cardiovascular system physiology Aop:456 Event:317 abnormal UBERON UBERON:0004535 cardiovascular system GO GO:0072358 cardiovascular system development Aop:456 Event:947 increased MP MP:0008762 embryonic lethality Aop:456 Event:947 increased MESH D009026 mortality Aop:457 Event:2118 decreased GO GO:0000104 succinate dehydrogenase activity Aop:457 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0046443 FAD metabolic process Aop:457 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0006105 succinate metabolic process Aop:457 Event:2119 increased HP HP:0000855 Insulin resistance Aop:457 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:457 Event:2120 increased CHEBI CHEBI:18421 superoxide GO GO:0022904 respiratory electron transport chain Aop:457 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:457 Event:1392 increased MP MP:0003674 oxidative stress Aop:458 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:458 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:458 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0015020 glucuronosyltransferase activity Aop:458 Event:295 increased PR PR:000001325 beta-1,3-glucuronyltransferase GO GO:0003824 catalytic activity Aop:458 Event:961 increased CHEBI CHEBI:30660 thyroxine GO GO:0008152 metabolic process Aop:458 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:458 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:458 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:458 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:458 Event:402 decreased GO GO:0007611 learning or memory Aop:458 Event:402 decreased GO GO:0050890 cognition Aop:459 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:459 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:459 Event:850 increased PR PR:000006102 cytochrome P450 1A2 GO GO:0010467 gene expression Aop:459 Event:850 increased PR PR:P79761 cytochrome P450 1A5 (chicken) GO GO:0010467 gene expression Aop:459 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:459 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:459 Event:280 decreased CHEBI CHEBI:30660 thyroxine GO GO:0010817 regulation of hormone levels Aop:459 Event:756 abnormal UBERON UBERON:0002421 hippocampal formation GO GO:0010468 regulation of gene expression Aop:459 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:459 Event:402 decreased GO GO:0007611 learning or memory Aop:459 Event:402 decreased GO GO:0050890 cognition Aop:459 Event:1392 increased MP MP:0003674 oxidative stress Aop:460 Event:2027 decreased PR PR:000015288 smoothened GO GO:0010469 regulation of receptor activity Aop:460 Event:2028 decreased PR PR:000008026 zinc finger protein GLI1 GO GO:0000060 protein import into nucleus, translocation Aop:460 Event:2028 decreased PR PR:000008027 zinc finger protein GLI2 GO GO:0000060 protein import into nucleus, translocation Aop:460 Event:2040 decreased PR PR:000008026 zinc finger protein GLI1 GO GO:0010467 gene expression Aop:460 Event:2040 decreased PR PR:000008027 zinc finger protein GLI2 GO GO:0010467 gene expression Aop:460 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:460 Event:2041 increased UBERON UBERON:0005620 primary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:460 Event:2041 increased UBERON UBERON:0001716 secondary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:460 Event:2042 increased HP HP:0000175 Cleft palate Aop:460 Event:2042 increased MP MP:0005170 cleft upper lip Aop:460 Event:2043 decreased PR PR:000014841 sonic hedgehog protein GO GO:0019932 second-messenger-mediated signaling Aop:460 Event:2044 decreased PR PR:000015288 smoothened GO GO:0061512 protein localization to cilium Aop:460 Event:1262 increased GO GO:0006915 apoptotic process Aop:462 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:462 Event:1392 increased MP MP:0003674 oxidative stress Aop:462 Event:2068 increased GO GO:0072577 endothelial cell apoptotic process Aop:462 Event:901 increased GO GO:0006954 inflammatory response Aop:462 Event:1198 decreased GO GO:0042116 macrophage activation Aop:462 Event:467 increased CHEBI CHEBI:39026 low-density lipoprotein GO GO:0006898 receptor-mediated endocytosis Aop:464 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:464 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:464 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:464 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:464 Event:388 increased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:464 Event:388 morphological change GO GO:0032591 dendritic spine membrane MP MP:0011267 abnormal excitatory postsynaptic current amplitude Aop:464 Event:1392 increased MP MP:0003674 oxidative stress Aop:464 Event:177 functional change GO GO:0005739 mitochondrion Aop:465 Event:748 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:465 Event:350 increased MESH D009026 mortality Aop:466 Event:990 increased CHEBI CHEBI:17029 chitin GO GO:0006031 chitin biosynthetic process Aop:466 Event:350 increased MESH D009026 mortality Aop:467 Event:990 increased CHEBI CHEBI:17029 chitin GO GO:0006031 chitin biosynthetic process Aop:467 Event:350 increased MESH D009026 mortality Aop:468 Event:1739 occurrence PR PR:000003622 angiotensin-converting enzyme 2 GO GO:0005102 receptor binding Aop:468 Event:1738 occurrence PR PR:000016456 transmembrane protease serine 2 GO GO:0061025 membrane fusion Aop:468 Event:1738 occurrence PR PR:P07711 cathepsin L1 (human) GO GO:0075509 endocytosis involved in viral entry into host cell Aop:468 Event:1738 occurrence GO GO:0019015 viral genome GO GO:0046718 viral entry into host cell Aop:468 Event:1738 occurrence PR PR:000036197 viral protein GO GO:0046718 viral entry into host cell Aop:468 Event:1901 decreased PR PR:000024938 interferon alpha GO GO:0060337 type I interferon signaling pathway Aop:468 Event:1901 decreased PR PR:000024939 interferon beta GO GO:0060337 type I interferon signaling pathway Aop:468 Event:1901 occurrence GO GO:0019022 RNA viral genome GO GO:0071360 cellular response to exogenous dsRNA Aop:468 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039694 viral RNA genome replication Aop:468 Event:1847 increased GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0039690 positive stranded viral RNA replication Aop:468 Event:1847 increased GO GO:0072516 viral assembly compartment GO GO:0019074 viral RNA genome packaging Aop:468 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0009299 mRNA transcription Aop:468 Event:1847 increased GO GO:0019024 ssRNA viral genome GO GO:0019081 viral translation Aop:468 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:468 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:468 Event:1496 increased FMA FMA:84050 Cytokine GO GO:0002534 cytokine production involved in inflammatory response Aop:468 Event:1496 increased FMA FMA:241981 Chemokine GO GO:0090195 chemokine secretion Aop:468 Event:1496 increased GO GO:0006956 complement activation Aop:468 Event:1496 increased FMA FMA:86578 Interleukin Aop:468 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:468 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:468 Event:1868 increased GO GO:0002544 chronic inflammatory response Aop:468 Event:1868 increased GO GO:0002676 regulation of chronic inflammatory response Aop:468 Event:1868 increased PR PR:000001393 interleukin-6 GO GO:0032635 interleukin-6 production Aop:468 Event:1868 increased PR PR:000001136 interleukin-1 beta GO GO:0032611 interleukin-1 beta production Aop:468 Event:1868 increased PR PR:000000134 tumor necrosis factor alpha GO GO:1990774 tumor necrosis factor secretion Aop:468 Event:1868 increased HP HP:0012649 Increased inflammatory response Aop:468 Event:1868 increased CHEBI CHEBI:82594 Ferritin HP HP:0003281 Increased serum ferritin Aop:468 Event:1868 increased GO GO:0004457 lactate dehydrogenase activity Aop:468 Event:1868 increased PR PR:000005897 C-reactive protein HP HP:0011227 Elevated C-reactive protein level Aop:468 Event:1868 decreased CL CL:0000542 lymphocyte HP HP:0001888 Lymphopenia Aop:470 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:470 Event:1392 increased MP MP:0003674 oxidative stress Aop:470 Event:1493 increased GO GO:0002526 acute inflammatory response Aop:470 Event:2067 functional change UBERON UBERON:0001986 endothelium GO GO:0033484 nitric oxide homeostasis Aop:470 Event:2068 increased GO GO:0072577 endothelial cell apoptotic process Aop:470 Event:2069 occurrence UBERON UBERON:0001981 blood vessel GO GO:0001974 blood vessel remodeling Aop:470 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:470 Event:2244 increased GO GO:0007166 cell surface receptor signaling pathway Aop:471 Event:352 increased MP MP:0002229 neurodegeneration Aop:471 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:471 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:471 Event:618 decreased GO GO:0099536 synaptic signaling Aop:471 Event:10 increased CHEBI CHEBI:15355 acetylcholine Aop:471 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:471 Event:1944 decreased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0003990 decreased neurotransmitter release Aop:471 Event:1944 increased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0002916 increased synaptic depression Aop:471 Event:388 increased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:471 Event:388 morphological change GO GO:0032591 dendritic spine membrane MP MP:0011267 abnormal excitatory postsynaptic current amplitude Aop:471 Event:191 increased GO GO:0036475 neuron death in response to oxidative stress Aop:471 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:471 Event:2078 decreased PR PR:000006296 drebrin GO GO:0098974 postsynaptic actin cytoskeleton organization Aop:471 Event:2078 decreased GO GO:0015629 actin cytoskeleton GO GO:0060997 dendritic spine morphogenesis Aop:471 Event:2078 increased GO GO:0015629 actin cytoskeleton GO GO:1904621 regulation of actin-dependent ATPase activity Aop:471 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:471 Event:2151 decreased CHEBI CHEBI:25512 neurotransmitter GO GO:0023052 signaling Aop:471 Event:350 increased MESH D009026 mortality Aop:471 Event:1018 increased PR PR:Q94900 glutamate-gated chloride channel (fruit fly) GO GO:0005254 chloride channel activity Aop:471 Event:1016 decreased NBO NBO:0000079 feeding behavior Aop:471 Event:1012 increased GO GO:0060080 inhibitory postsynaptic potential Aop:471 Event:1014 increased MP MP:0000753 paralysis Aop:471 Event:1015 decreased GO GO:1902710 GABA receptor complex GO GO:0050805 negative regulation of synaptic transmission Aop:471 Event:1392 increased MP MP:0003674 oxidative stress Aop:473 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:473 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:474 Event:2118 decreased GO GO:0000104 succinate dehydrogenase activity Aop:474 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0046443 FAD metabolic process Aop:474 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0006105 succinate metabolic process Aop:474 Event:1457 occurrence FMA FMA:66768 Epithelial cell GO GO:0001837 epithelial to mesenchymal transition Aop:474 Event:885 increased MESH D009369 Neoplasms Aop:475 Event:875 increased GO GO:0008328 ionotropic glutamate receptor complex GO GO:0004970 ionotropic glutamate receptor activity Aop:475 Event:388 increased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:475 Event:388 morphological change GO GO:0032591 dendritic spine membrane MP MP:0011267 abnormal excitatory postsynaptic current amplitude Aop:475 Event:2078 decreased PR PR:000006296 drebrin GO GO:0098974 postsynaptic actin cytoskeleton organization Aop:475 Event:2078 decreased GO GO:0015629 actin cytoskeleton GO GO:0060997 dendritic spine morphogenesis Aop:475 Event:2078 increased GO GO:0015629 actin cytoskeleton GO GO:1904621 regulation of actin-dependent ATPase activity Aop:475 Event:1944 decreased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0003990 decreased neurotransmitter release Aop:475 Event:1944 increased CL CL:0000117 CNS neuron (sensu Vertebrata) MP MP:0002916 increased synaptic depression Aop:475 Event:341 decreased GO GO:0007612 learning Aop:475 Event:341 decreased GO GO:0007613 memory Aop:475 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:475 Event:386 decreased GO GO:0099536 synaptic signaling Aop:475 Event:2242 pathological GO GO:0098871 postsynaptic actin cytoskeleton GO GO:0031914 negative regulation of synaptic plasticity Aop:475 Event:2242 decreased PR PR:000006296 drebrin HP HP:0000726 Dementia Aop:475 Event:2242 decreased PR PR:000006296 drebrin GO GO:0060292 long term synaptic depression Aop:475 Event:2242 increased PR PR:000006296 drebrin MP MP:0002207 abnormal long term potentiation Aop:476 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:476 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:476 Event:496 increased GO GO:0006915 apoptotic process Aop:476 Event:1262 increased GO GO:0006915 apoptotic process Aop:476 Event:446 decreased CHEBI CHEBI:17347 testosterone Aop:476 Event:520 decreased VT VT:0002673 sperm quantity Aop:476 Event:520 morphological change CL CL:0000019 sperm Aop:476 Event:520 decreased MESH D005298 fertility Aop:476 Event:520 decreased CL CL:0000019 sperm Aop:476 Event:1688 disrupted FMA FMA:264621 Musculature of male perineum GO GO:0030521 androgen receptor signaling pathway Aop:476 Event:1616 abnormal GO GO:0048513 animal organ development Aop:476 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:476 Event:177 functional change GO GO:0005739 mitochondrion Aop:476 Event:1392 increased MP MP:0003674 oxidative stress Aop:477 Event:2082 abnormal UBERON UBERON:0000989 penis GO GO:0048568 embryonic organ development Aop:477 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:477 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:477 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:478 Event:2081 increased GO GO:0036211 protein modification process Aop:478 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:478 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:478 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:478 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:478 Event:185 increased CHEBI CHEBI:16991 deoxyribonucleic acid MESH D009154 mutation Aop:478 Event:1636 increased GO GO:0005694 chromosome GO GO:0031052 chromosome breakage Aop:478 Event:870 increased CL CL:0000066 epithelial cell GO GO:0008283 cell proliferation Aop:478 Event:870 increased CL CL:0000077 mesothelial cell GO GO:0008283 cell proliferation Aop:478 Event:2083 increased FMA FMA:58241 Lens MP MP:0009859 eye opacity Aop:478 Event:1392 increased MP MP:0003674 oxidative stress Aop:479 Event:177 functional change GO GO:0005739 mitochondrion Aop:479 Event:1392 increased MP MP:0003674 oxidative stress Aop:479 Event:55 increased GO GO:0008219 cell death Aop:480 Event:177 functional change GO GO:0005739 mitochondrion Aop:480 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:481 Event:1392 increased MP MP:0003674 oxidative stress Aop:481 Event:1198 decreased GO GO:0042116 macrophage activation Aop:481 Event:1197 decreased GO GO:0001775 cell activation Aop:481 Event:177 functional change GO GO:0005739 mitochondrion Aop:481 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:482 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:482 Event:1392 increased MP MP:0003674 oxidative stress Aop:482 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:482 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:482 Event:2089 decreased GO GO:0001649 osteoblast differentiation Aop:482 Event:2089 increased GO GO:0030316 osteoclast differentiation Aop:482 Event:2090 decreased GO GO:0030282 bone mineralization Aop:482 Event:2090 occurrence GO GO:0045780 positive regulation of bone resorption Aop:482 Event:2090 occurrence MP MP:0002998 abnormal bone remodeling Aop:482 Event:2091 occurrence MP MP:0010879 decreased trabecular bone volume Aop:482 Event:2091 occurrence MP MP:0000063 decreased bone mineral density Aop:482 Event:2245 abnormal GO GO:0030154 cell differentiation Aop:482 Event:2245 increased GO GO:0007166 cell surface receptor signaling pathway Aop:483 Event:1686 increased RBO RBO:00015021 energy deposition event Aop:483 Event:1392 increased MP MP:0003674 oxidative stress Aop:483 Event:1492 increased GO GO:0002263 cell activation involved in immune response Aop:483 Event:2097 increased GO GO:0006954 inflammatory response Aop:483 Event:2098 decreased GO GO:0022008 neurogenesis Aop:483 Event:2098 increased MP MP:0000921 demyelination Aop:483 Event:2098 increased GO GO:0070997 neuron death Aop:483 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:483 Event:341 decreased GO GO:0007612 learning Aop:483 Event:341 decreased GO GO:0007613 memory Aop:483 Event:2244 increased GO GO:0007166 cell surface receptor signaling pathway Aop:485 Event:402 decreased GO GO:0007611 learning or memory Aop:485 Event:402 decreased GO GO:0050890 cognition Aop:486 Event:402 decreased GO GO:0007611 learning or memory Aop:486 Event:402 decreased GO GO:0050890 cognition Aop:487 Event:402 decreased GO GO:0007611 learning or memory Aop:487 Event:402 decreased GO GO:0050890 cognition Aop:488 Event:402 decreased GO GO:0007611 learning or memory Aop:488 Event:402 decreased GO GO:0050890 cognition Aop:488 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0034599 cellular response to oxidative stress Aop:488 Event:1869 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:0000302 response to reactive oxygen species Aop:488 Event:1869 decreased GO GO:0034599 cellular response to oxidative stress Aop:488 Event:1392 increased MP MP:0003674 oxidative stress Aop:488 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:489 Event:1353 disrupted GO GO:0005248 voltage-gated sodium channel activity Aop:489 Event:1977 functional change GO GO:0001518 voltage-gated sodium channel complex GO GO:0005272 sodium channel activity Aop:489 Event:402 decreased GO GO:0007611 learning or memory Aop:489 Event:402 decreased GO GO:0050890 cognition Aop:490 Event:1350 increased CHEBI CHEBI:29985 L-glutamate(1-) GO GO:0035249 synaptic transmission, glutamatergic Aop:490 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:490 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:490 Event:758 abnormal GO GO:0045202 synapse GO GO:0007268 chemical synaptic transmission Aop:490 Event:341 decreased GO GO:0007612 learning Aop:490 Event:341 decreased GO GO:0007613 memory Aop:490 Event:2124 increased PR PR:000002193 apoptosis regulator BAX Aop:490 Event:55 increased GO GO:0008219 cell death Aop:491 Event:2040 decreased PR PR:000008026 zinc finger protein GLI1 GO GO:0010467 gene expression Aop:491 Event:2040 decreased PR PR:000008027 zinc finger protein GLI2 GO GO:0010467 gene expression Aop:491 Event:2043 decreased PR PR:000014841 sonic hedgehog protein GO GO:0019932 second-messenger-mediated signaling Aop:491 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:491 Event:2041 increased UBERON UBERON:0005620 primary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:491 Event:2041 increased UBERON UBERON:0001716 secondary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:491 Event:2042 increased HP HP:0000175 Cleft palate Aop:491 Event:2042 increased MP MP:0005170 cleft upper lip Aop:491 Event:1262 increased GO GO:0006915 apoptotic process Aop:492 Event:130 decreased CHEBI CHEBI:16856 glutathione MP MP:0012603 abnormal glutathione level Aop:492 Event:2131 increased CHEBI CHEBI:24335 glutathione conjugate GO GO:0043295 glutathione binding Aop:492 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:492 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:492 Event:406 decreased MESH D005298 fertility Aop:492 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:493 Event:1497 increased CL CL:0009002 inflammatory cell GO GO:0006954 inflammatory response Aop:493 Event:1497 increased CL CL:0000235 macrophage GO GO:0042116 macrophage activation Aop:493 Event:2119 increased HP HP:0000855 Insulin resistance Aop:494 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:494 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:494 Event:55 increased GO GO:0008219 cell death Aop:494 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:494 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:494 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:495 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:495 Event:1183 decreased GO GO:0006915 apoptotic process Aop:495 Event:854 abnormal FMA FMA:63179 Liver cell GO GO:0008283 cell proliferation Aop:495 Event:854 increased CL CL:0002196 hepatic oval stem cell MESH D006965 hyperplasia Aop:495 Event:854 increased CL CL:0002538 intrahepatic bile duct epithelial cell MESH D006965 hyperplasia Aop:495 Event:1196 increased CL CL:0000066 epithelial cell Aop:495 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:496 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:496 Event:2137 increased CL CL:0011111 gonadotropin releasing neuron GO GO:0046879 hormone secretion Aop:496 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:496 Event:221 decreased MESH D014819 vitellogenins Aop:496 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:496 Event:309 decreased GO GO:0001555 oocyte growth Aop:496 Event:309 decreased GO GO:0048599 oocyte development Aop:496 Event:78 decreased VT VT:1000294 egg quantity Aop:496 Event:442 decreased PCO PCO:0000008 population growth rate Aop:496 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:496 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:496 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:497 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:497 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:497 Event:177 functional change GO GO:0005739 mitochondrion Aop:497 Event:2119 increased HP HP:0000855 Insulin resistance Aop:497 Event:1392 increased MP MP:0003674 oxidative stress Aop:498 Event:191 increased GO GO:0036475 neuron death in response to oxidative stress Aop:499 Event:2146 increased CL CL:0000127 astrocyte GO GO:0016301 kinase activity Aop:499 Event:1339 increased CHEBI CHEBI:29108 calcium(2+) VT VT:0010499 calcium amount Aop:499 Event:341 decreased GO GO:0007612 learning Aop:499 Event:341 decreased GO GO:0007613 memory Aop:499 Event:2151 decreased CHEBI CHEBI:25512 neurotransmitter GO GO:0023052 signaling Aop:500 Event:2146 increased CL CL:0000127 astrocyte GO GO:0016301 kinase activity Aop:500 Event:1339 increased CHEBI CHEBI:29108 calcium(2+) VT VT:0010499 calcium amount Aop:500 Event:341 decreased GO GO:0007612 learning Aop:500 Event:341 decreased GO GO:0007613 memory Aop:500 Event:352 increased MP MP:0002229 neurodegeneration Aop:500 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:500 Event:1262 increased GO GO:0006915 apoptotic process Aop:500 Event:177 functional change GO GO:0005739 mitochondrion Aop:501 Event:386 decreased GO GO:0099536 synaptic signaling Aop:501 Event:1392 increased MP MP:0003674 oxidative stress Aop:502 Event:2042 increased HP HP:0000175 Cleft palate Aop:502 Event:2042 increased MP MP:0005170 cleft upper lip Aop:502 Event:2041 increased UBERON UBERON:0005620 primary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:502 Event:2041 increased UBERON UBERON:0001716 secondary palate MP MP:0009888 palatal shelves fail to meet at midline Aop:502 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:502 Event:2043 decreased PR PR:000014841 sonic hedgehog protein GO GO:0019932 second-messenger-mediated signaling Aop:502 Event:1262 increased GO GO:0006915 apoptotic process Aop:502 Event:2040 decreased PR PR:000008026 zinc finger protein GLI1 GO GO:0010467 gene expression Aop:502 Event:2040 decreased PR PR:000008027 zinc finger protein GLI2 GO GO:0010467 gene expression Aop:502 Event:2028 decreased PR PR:000008026 zinc finger protein GLI1 GO GO:0000060 protein import into nucleus, translocation Aop:502 Event:2028 decreased PR PR:000008027 zinc finger protein GLI2 GO GO:0000060 protein import into nucleus, translocation Aop:503 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:503 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:503 Event:772 increased CL CL:0002656 glandular cell of endometrium MP MP:0009092 endometrium hyperplasia Aop:503 Event:772 increased CL CL:0000150 glandular epithelial cell MESH D006965 hyperplasia Aop:503 Event:1896 increased GO GO:0005694 chromosome MP MP:0008866 chromosomal instability Aop:504 Event:2155 decreased PR PR:000032783 estrogen sulfotransferase GO GO:0008146 sulfotransferase activity Aop:504 Event:2251 increased CHEBI CHEBI:23965 estradiol Aop:504 Event:2251 increased FMA FMA:86488 Glandular part of endometrium GO GO:0035938 estradiol secretion Aop:504 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:504 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:505 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:505 Event:1392 increased MP MP:0003674 oxidative stress Aop:505 Event:149 increased GO GO:0006954 inflammatory response Aop:505 Event:1513 increased MP MP:0006042 increased apoptosis Aop:505 Event:885 increased MESH D009369 Neoplasms Aop:506 Event:2158 occurrence GO GO:0005102 receptor binding Aop:506 Event:2159 occurrence GO GO:0030665 clathrin-coated vesicle membrane GO GO:0036010 protein localization to endosome Aop:506 Event:2159 occurrence PR PR:000049750 influenzavirus hemagglutinin GO GO:0006898 receptor-mediated endocytosis Aop:506 Event:2159 occurrence GO GO:0012506 vesicle membrane GO GO:0061025 membrane fusion Aop:506 Event:2180 decreased PR PR:000044794 influenzavirus NS gene translation product GO GO:0034154 toll-like receptor 7 signaling pathway Aop:506 Event:2180 decreased PR PR:000044794 influenzavirus NS gene translation product GO GO:0034138 toll-like receptor 3 signaling pathway Aop:506 Event:2180 occurrence GO GO:0046775 suppression by virus of host cytokine production Aop:506 Event:2180 occurrence GO GO:0009616 virus induced gene silencing Aop:506 Event:2180 occurrence GO GO:0075528 modulation by virus of host immune response Aop:506 Event:2192 occurrence GO GO:0031381 viral RNA-directed RNA polymerase complex GO GO:0006606 protein import into nucleus Aop:506 Event:2192 occurrence GO GO:0019017 segmented viral genome GO GO:0001172 transcription, RNA-templated Aop:506 Event:2192 occurrence GO GO:0046784 viral mRNA export from host cell nucleus Aop:506 Event:2192 occurrence GO GO:0019075 virus maturation Aop:506 Event:2193 occurrence GO GO:0046761 viral budding from plasma membrane Aop:506 Event:2194 occurrence GO GO:0019089 transmission of virus Aop:507 Event:1392 increased MP MP:0003674 oxidative stress Aop:509 Event:177 functional change GO GO:0005739 mitochondrion Aop:509 Event:1392 increased MP MP:0003674 oxidative stress Aop:510 Event:228 increased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:510 Event:1392 increased MP MP:0003674 oxidative stress Aop:511 Event:932 functional change PR PR:000011328 nitric oxide synthase, endothelial Aop:511 Event:177 functional change GO GO:0005739 mitochondrion Aop:511 Event:1392 increased MP MP:0003674 oxidative stress Aop:511 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:512 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0033684 regulation of luteinizing hormone secretion Aop:512 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:513 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:513 Event:233 decreased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:513 Event:1060 abnormal GO GO:0006629 lipid metabolic process Aop:513 Event:1513 increased MP MP:0006042 increased apoptosis Aop:513 Event:885 increased MESH D009369 Neoplasms Aop:516 Event:1562 decreased GO GO:0005890 sodium:potassium-exchanging ATPase complex GO GO:0005391 sodium:potassium-exchanging ATPase activity Aop:516 Event:952 increased MP MP:0000231 hypertension Aop:517 Event:239 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:517 Event:54 increased PR PR:000001905 platelet glycoprotein 4 GO GO:0010467 gene expression Aop:517 Event:115 increased CHEBI CHEBI:35366 fatty acid GO GO:2000193 positive regulation of fatty acid transport Aop:517 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:517 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:518 Event:167 increased PR PR:000011394 oxysterols receptor LXR-beta GO GO:0023052 signaling Aop:518 Event:167 increased PR PR:000011395 oxysterols receptor LXR-alpha GO GO:0023052 signaling Aop:518 Event:2199 increased GO GO:0010467 gene expression Aop:518 Event:89 increased CHEBI CHEBI:35366 fatty acid GO GO:0006633 fatty acid biosynthetic process Aop:518 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:518 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:520 Event:341 decreased GO GO:0007612 learning Aop:520 Event:341 decreased GO GO:0007613 memory Aop:521 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:521 Event:1392 increased MP MP:0003674 oxidative stress Aop:521 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:521 Event:2206 increased FMA FMA:7210 Testis HP HP:0000035 Abnormality of the testis Aop:521 Event:1758 abnormal FMA FMA:67338 Mature sperm cell HP HP:0008669 Abnormal spermatogenesis Aop:521 Event:2147 decreased GO GO:0019953 sexual reproduction Aop:521 Event:2147 decreased VT VT:1000181 viable offspring quantity Aop:522 Event:112 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:522 Event:195 decreased GO GO:0017146 NMDA selective glutamate receptor complex GO GO:0004972 NMDA glutamate receptor activity Aop:522 Event:386 decreased GO GO:0099536 synaptic signaling Aop:524 Event:2252 occurrence FMA FMA:84795 Human leukocyte antigen complex VT VT:0001835 antigen presentation trait Aop:524 Event:2253 occurrence GO GO:0042105 alpha-beta T cell receptor complex GO GO:0035822 gene conversion Aop:524 Event:2254 occurrence GO GO:0019815 B cell receptor complex GO GO:0002206 gene conversion of immunoglobulin genes Aop:524 Event:2255 occurrence GO GO:0002376 immune system process Aop:524 Event:2256 occurrence CL CL:0000236 B cell GO GO:0002312 B cell activation involved in immune response Aop:524 Event:1931 disrupted CL CL:0000073 barrier epithelial cell Aop:524 Event:2257 pathological CL CL:0002563 intestinal epithelial cell HP HP:0002608 Celiac disease Aop:524 Event:2260 occurrence CL CL:0000084 T cell GO GO:0002286 T cell activation involved in immune response Aop:524 Event:2275 occurrence CL CL:0000084 T cell GO GO:0072678 T cell migration Aop:524 Event:2275 occurrence CL CL:0000145 professional antigen presenting cell GO GO:0036336 dendritic cell migration Aop:525 Event:341 decreased GO GO:0007612 learning Aop:525 Event:341 decreased GO GO:0007613 memory Aop:526 Event:656 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:526 Event:647 decreased GO GO:0050810 regulation of steroid biosynthetic process Aop:526 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:526 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:526 Event:2212 abnormal UBERON UBERON:0001301 epididymis GO GO:0048645 animal organ formation Aop:526 Event:1758 abnormal FMA FMA:67338 Mature sperm cell HP HP:0008669 Abnormal spermatogenesis Aop:527 Event:656 decreased PR PR:000011405 COUP transcription factor 2 GO GO:0035624 receptor transactivation Aop:527 Event:647 decreased GO GO:0050810 regulation of steroid biosynthetic process Aop:527 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:527 Event:2213 abnormal UBERON UBERON:0000057 urethra GO GO:0048645 animal organ formation Aop:527 Event:2082 abnormal UBERON UBERON:0000989 penis GO GO:0048568 embryonic organ development Aop:528 Event:2214 decreased GO GO:0010467 gene expression Aop:528 Event:1615 abnormal UBERON UBERON:0000991 gonad GO GO:0048513 animal organ development Aop:528 Event:1616 abnormal GO GO:0048513 animal organ development Aop:529 Event:327 increased CHEBI CHEBI:35366 fatty acid Aop:529 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:529 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:529 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:529 Event:2224 disrupted GO GO:0010468 regulation of gene expression Aop:529 Event:2225 disrupted GO GO:0019915 lipid storage Aop:529 Event:2226 occurrence GO GO:0005102 receptor binding Aop:529 Event:2227 disrupted GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:530 Event:1539 increased GO GO:0005765 lysosomal membrane GO GO:0006897 endocytosis Aop:530 Event:177 functional change GO GO:0005739 mitochondrion Aop:530 Event:55 increased GO GO:0008219 cell death Aop:530 Event:1931 disrupted CL CL:0000073 barrier epithelial cell Aop:530 Event:898 occurrence GO GO:0005764 lysosome GO GO:1903008 organelle disassembly Aop:533 Event:1239 abnormal GO GO:0010467 gene expression Aop:533 Event:851 abnormal MP MP:0002882 abnormal neuron morphology Aop:533 Event:385 decreased GO GO:0045202 synapse GO GO:0007416 synapse assembly Aop:533 Event:386 decreased GO GO:0099536 synaptic signaling Aop:533 Event:341 decreased GO GO:0007612 learning Aop:533 Event:341 decreased GO GO:0007613 memory Aop:534 Event:2118 decreased GO GO:0000104 succinate dehydrogenase activity Aop:534 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0046443 FAD metabolic process Aop:534 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0006105 succinate metabolic process Aop:534 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:534 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:534 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:534 Event:885 increased MESH D009369 Neoplasms Aop:534 Event:1392 increased MP MP:0003674 oxidative stress Aop:534 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:535 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:535 Event:1392 increased MP MP:0003674 oxidative stress Aop:535 Event:1262 increased GO GO:0006915 apoptotic process Aop:535 Event:2151 decreased CHEBI CHEBI:25512 neurotransmitter GO GO:0023052 signaling Aop:535 Event:188 pathological CL CL:0000129 microglial cell MP MP:0001847 brain inflammation Aop:535 Event:188 pathological CL CL:0000127 astrocyte MP MP:0001847 brain inflammation Aop:535 Event:341 decreased GO GO:0007612 learning Aop:535 Event:341 decreased GO GO:0007613 memory Aop:536 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:536 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:536 Event:307 increased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:536 Event:220 increased MESH D014819 vitellogenins Aop:536 Event:252 increased MESH D007674 Kidney Diseases Aop:536 Event:351 increased MESH D009026 mortality Aop:536 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:537 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:537 Event:111 increased PR PR:000007204 estrogen receptor GO GO:0048018 receptor agonist activity Aop:537 Event:307 increased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:537 Event:220 increased MESH D014819 vitellogenins Aop:537 Event:364 abnormal UBERON UBERON:0003133 reproductive organ GO GO:0032502 developmental process Aop:537 Event:78 decreased VT VT:1000294 egg quantity Aop:538 Event:1392 increased MP MP:0003674 oxidative stress Aop:539 Event:1562 decreased GO GO:0005890 sodium:potassium-exchanging ATPase complex GO GO:0005391 sodium:potassium-exchanging ATPase activity Aop:539 Event:2236 decreased UBERON UBERON:0002535 gill GO GO:0097369 sodium ion import Aop:539 Event:2237 decreased UBERON UBERON:0001969 blood plasma MP MP:0005634 decreased circulating sodium level Aop:539 Event:2238 increased UBERON UBERON:0000178 blood VT VT:3000004 blood viscosity trait Aop:539 Event:2239 increased UBERON UBERON:0000948 heart MESH D013312 Stress, Physiological Aop:539 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:539 Event:2261 decreased UBERON UBERON:0001969 blood plasma GO GO:0008015 blood circulation Aop:540 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:540 Event:1392 increased MP MP:0003674 oxidative stress Aop:540 Event:1262 increased GO GO:0006915 apoptotic process Aop:540 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:540 Event:285 decreased MESH D014819 vitellogenins GO GO:0010467 gene expression Aop:540 Event:285 decreased MESH D014819 vitellogenins GO GO:0009306 protein secretion Aop:540 Event:221 decreased MESH D014819 vitellogenins Aop:540 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:540 Event:309 decreased GO GO:0001555 oocyte growth Aop:540 Event:309 decreased GO GO:0048599 oocyte development Aop:540 Event:78 decreased VT VT:1000294 egg quantity Aop:540 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:543 Event:2262 decreased PR PR:000012946 neuropathy target esterase Aop:543 Event:2263 increased CHEBI CHEBI:60479 lysophosphatidylcholine Aop:543 Event:2265 increased CL CL:0000128 oligodendrocyte GO GO:0008219 cell death Aop:543 Event:2266 increased MP MP:0000921 demyelination Aop:543 Event:2266 increased HP HP:0007305 CNS demyelination Aop:544 Event:2262 decreased PR PR:000012946 neuropathy target esterase Aop:544 Event:2263 increased CHEBI CHEBI:60479 lysophosphatidylcholine Aop:544 Event:149 increased GO GO:0006954 inflammatory response Aop:544 Event:2265 increased CL CL:0000128 oligodendrocyte GO GO:0008219 cell death Aop:544 Event:2266 increased MP MP:0000921 demyelination Aop:544 Event:2266 increased HP HP:0007305 CNS demyelination Aop:545 Event:239 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:545 Event:2268 decreased PR PR:000009056 insulin-induced gene 1 protein MP MP:0005567 decreased circulating total protein level Aop:545 Event:2269 increased PR PR:000015612 sterol regulatory element-binding protein 2 MP MP:0005568 increased circulating total protein level Aop:545 Event:2270 increased GO GO:0006695 cholesterol biosynthetic process Aop:545 Event:2271 increased CHEBI CHEBI:47774 low-density lipoprotein cholesterol MP MP:0000182 increased circulating LDL cholesterol level Aop:546 Event:2118 decreased GO GO:0000104 succinate dehydrogenase activity Aop:546 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0046443 FAD metabolic process Aop:546 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0006105 succinate metabolic process Aop:546 Event:798 decreased MESH D064828 Prolyl hydroxylases GO GO:0003824 catalytic activity Aop:546 Event:590 decreased MP MP:0005039 hypoxia Aop:546 Event:885 increased MESH D009369 Neoplasms Aop:547 Event:2274 increased PR PR:000004191 androgen receptor GO GO:0060765 regulation of androgen receptor signaling pathway Aop:547 Event:25 increased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:548 Event:239 increased PR PR:000011397 nuclear receptor subfamily 1 group I member 2 GO GO:0023052 signaling Aop:548 Event:2268 decreased PR PR:000009056 insulin-induced gene 1 protein MP MP:0005567 decreased circulating total protein level Aop:548 Event:2269 increased PR PR:000015612 sterol regulatory element-binding protein 2 MP MP:0005568 increased circulating total protein level Aop:548 Event:2276 increased PR PR:000012440 proprotein convertase subtilisin/kexin type 9 MP MP:0005568 increased circulating total protein level Aop:548 Event:2271 increased CHEBI CHEBI:47774 low-density lipoprotein cholesterol MP MP:0000182 increased circulating LDL cholesterol level Aop:549 Event:36 decreased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:549 Event:219 decreased CHEBI CHEBI:16469 17beta-estradiol Aop:549 Event:221 decreased MESH D014819 vitellogenins Aop:549 Event:309 decreased MESH D014819 vitellogenins GO GO:0006898 receptor-mediated endocytosis Aop:549 Event:309 decreased GO GO:0001555 oocyte growth Aop:549 Event:309 decreased GO GO:0048599 oocyte development Aop:549 Event:78 decreased VT VT:1000294 egg quantity Aop:549 Event:442 decreased PCO PCO:0000008 population growth rate Aop:550 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:551 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:551 Event:1602 increased PR PR:000001488 muscarinic acetylcholine receptor GO GO:0031789 G-protein coupled acetylcholine receptor binding Aop:551 Event:1098 increased CHEBI CHEBI:26216 potassium atom Aop:551 Event:1983 disrupted GO GO:0001508 action potential Aop:552 Event:698 abnormal GO GO:0001508 action potential Aop:552 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:553 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0019871 sodium channel inhibitor activity Aop:553 Event:584 decreased PR PR:000002095 sodium channel protein type 1 subunit alpha GO GO:0023052 signaling Aop:553 Event:698 abnormal GO GO:0001508 action potential Aop:553 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:554 Event:1038 increased PR PR:000001193 beta-2 adrenergic receptor GO GO:0031698 beta-2 adrenergic receptor binding Aop:554 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:555 Event:593 decreased PR PR:Q12809 potassium voltage-gated channel subfamily H member 2 (human) GO GO:0019870 potassium channel inhibitor activity Aop:555 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:556 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:556 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:556 Event:1562 decreased GO GO:0005890 sodium:potassium-exchanging ATPase complex GO GO:0005391 sodium:potassium-exchanging ATPase activity Aop:557 Event:1039 increased PR PR:000001193 beta-2 adrenergic receptor GO GO:0004941 beta2-adrenergic receptor activity Aop:558 Event:389 increased CHEBI CHEBI:39124 calcium ion GO GO:0006816 calcium ion transport Aop:558 Event:1535 occurrence UBERON UBERON:0000948 heart HP HP:0001695 Cardiac arrest Aop:558 Event:693 increased CHEBI CHEBI:58165 3',5'-cyclic AMP(1-) Aop:559 Event:12 decreased PR PR:000003626 acetylcholinesterase GO GO:0003990 acetylcholinesterase activity Aop:559 Event:1602 increased PR PR:000001488 muscarinic acetylcholine receptor GO GO:0031789 G-protein coupled acetylcholine receptor binding Aop:559 Event:698 abnormal GO GO:0001508 action potential Aop:559 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:560 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:561 Event:2293 increased PR PR:000006100 aromatase GO GO:0070330 aromatase activity Aop:561 Event:1076 increased CHEBI CHEBI:50114 estrogen Aop:561 Event:2251 increased CHEBI CHEBI:23965 estradiol Aop:561 Event:2251 increased FMA FMA:86488 Glandular part of endometrium GO GO:0035938 estradiol secretion Aop:561 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:561 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:561 Event:2294 increased CHEBI CHEBI:16469 17beta-estradiol MP MP:0005182 increased circulating estradiol level Aop:562 Event:1106 increased MESH D001145 Arrhythmias, Cardiac Aop:563 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:563 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:563 Event:944 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0046983 protein dimerization activity Aop:563 Event:944 increased PR PR:000004303 aryl hydrocarbon receptor nuclear translocator GO GO:0046983 protein dimerization activity Aop:563 Event:2124 increased PR PR:000002193 apoptosis regulator BAX Aop:563 Event:1262 increased GO GO:0006915 apoptotic process Aop:563 Event:1883 decreased UBERON UBERON:0001305 ovarian follicle GO GO:0001541 ovarian follicle development Aop:563 Event:2305 decreased UBERON UBERON:0001305 ovarian follicle HP HP:0008209 Premature ovarian failure Aop:564 Event:2299 abnormal GO GO:0045454 cell redox homeostasis Aop:564 Event:178 disrupted GO GO:0005746 mitochondrial respiratory chain Aop:564 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:564 Event:2300 disrupted GO GO:0006006 glucose metabolic process Aop:564 Event:2300 disrupted MP MP:0013245 abnormal lipid metabolism Aop:564 Event:2151 decreased CHEBI CHEBI:25512 neurotransmitter GO GO:0023052 signaling Aop:564 Event:2301 abnormal GO GO:0007610 behavior Aop:564 Event:566 abnormal GO GO:0002164 larval development Aop:564 Event:351 increased MESH D009026 mortality Aop:564 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:565 Event:2251 increased CHEBI CHEBI:23965 estradiol Aop:565 Event:2251 increased FMA FMA:86488 Glandular part of endometrium GO GO:0035938 estradiol secretion Aop:565 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:565 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:566 Event:530 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:566 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0033684 regulation of luteinizing hormone secretion Aop:566 Event:531 decreased CHEBI CHEBI:81568 Luteinizing hormone GO GO:0046879 hormone secretion Aop:566 Event:1695 decreased FMA FMA:67343 Ovum GO GO:0030728 ovulation Aop:566 Event:2251 increased CHEBI CHEBI:23965 estradiol Aop:566 Event:2251 increased FMA FMA:86488 Glandular part of endometrium GO GO:0035938 estradiol secretion Aop:566 Event:2306 occurrence UBERON UBERON:0001344 epithelium of vagina GO GO:0070268 cornification Aop:567 Event:1472 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:567 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:568 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0098810 neurotransmitter reuptake Aop:568 Event:619 decreased PR PR:000015189 sodium-dependent serotonin transporter GO GO:0051610 serotonin uptake Aop:568 Event:1320 increased GO GO:0005576 extracellular region MP MP:0010069 increased serotonin level Aop:568 Event:1320 increased CHEBI CHEBI:28790 serotonin MP MP:0010069 increased serotonin level Aop:568 Event:2308 increased FMA FMA:86594 Surface of brain GO GO:0099589 serotonin receptor activity Aop:568 Event:2308 increased PR PR:000001161 5-hydroxytryptamine receptor 1A GO GO:0007210 serotonin receptor signaling pathway Aop:568 Event:2308 increased PR PR:000001168 5-hydroxytryptamine receptor 2C GO GO:0007210 serotonin receptor signaling pathway Aop:568 Event:1016 decreased NBO NBO:0000079 feeding behavior Aop:569 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:570 Event:2298 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:570 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:570 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:570 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:570 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:570 Event:2082 abnormal UBERON UBERON:0000989 penis GO GO:0048568 embryonic organ development Aop:571 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:571 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:571 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:571 Event:2082 abnormal UBERON UBERON:0000989 penis GO GO:0048568 embryonic organ development Aop:573 Event:1840 decreased GO GO:0005739 mitochondrion GO GO:0004129 cytochrome-c oxidase activity Aop:573 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:573 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:573 Event:2316 increased UBERON UBERON:0002048 lung HP HP:0100598 Pulmonary edema Aop:574 Event:1840 decreased GO GO:0005739 mitochondrion GO GO:0004129 cytochrome-c oxidase activity Aop:574 Event:1825 increased CL CL:0001035 bone cell GO GO:0008219 cell death Aop:574 Event:1825 increased GO GO:0005623 cell GO GO:0008219 cell death Aop:574 Event:2317 decreased FMA FMA:46472 Nose GO GO:1990834 response to odorant Aop:575 Event:2298 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:575 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:575 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:575 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:575 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:576 Event:1613 decreased CHEBI CHEBI:79436 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one GO GO:0042446 hormone biosynthetic process Aop:576 Event:1614 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:576 Event:286 decreased PR PR:000004191 androgen receptor GO GO:0010468 regulation of gene expression Aop:577 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:577 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:577 Event:149 increased GO GO:0006954 inflammatory response Aop:578 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0004874 aryl hydrocarbon receptor activity Aop:578 Event:18 increased PR PR:000003858 aryl hydrocarbon receptor GO GO:0017162 aryl hydrocarbon receptor binding Aop:578 Event:1971 increased GO GO:0070531 BRCA1-A complex HP HP:0003002 Breast carcinoma Aop:580 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:581 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:581 Event:402 decreased GO GO:0007611 learning or memory Aop:581 Event:402 decreased GO GO:0050890 cognition Aop:587 Event:177 functional change GO GO:0005739 mitochondrion Aop:587 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:587 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:587 Event:1542 decreased GO GO:0005750 mitochondrial respiratory chain complex III HP HP:0011924 Decreased activity of mitochondrial complex III Aop:588 Event:2118 decreased GO GO:0000104 succinate dehydrogenase activity Aop:588 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0046443 FAD metabolic process Aop:588 Event:2118 decreased GO GO:0045281 succinate dehydrogenase complex GO GO:0006105 succinate metabolic process Aop:588 Event:177 functional change GO GO:0005739 mitochondrion Aop:588 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:588 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:589 Event:177 functional change GO GO:0005739 mitochondrion Aop:589 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:589 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:590 Event:40 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:590 Event:889 abnormal CHEBI CHEBI:36080 protein MESH D057165 Proteostasis deficiencies Aop:590 Event:178 disrupted GO GO:0005746 mitochondrial respiratory chain Aop:591 Event:1194 functional change CHEBI CHEBI:16991 deoxyribonucleic acid Aop:591 Event:1293 increased PR PR:O16850 forkhead box protein O (Caenorhabditis elegans) GO GO:0023052 signaling Aop:591 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:591 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:591 Event:291 increased CHEBI CHEBI:17855 triglyceride Aop:591 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:592 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:592 Event:1281 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:592 Event:406 decreased MESH D005298 fertility Aop:592 Event:406 decreased MESH D005298 fertility GO GO:0009566 fertilization Aop:592 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:593 Event:2363 functional change GO GO:0005739 mitochondrion Aop:593 Event:890 increased MP MP:0003244 loss of dopaminergic neurons Aop:593 Event:896 occurrence MESH D020734 Parkinsonian disorders Aop:593 Event:889 abnormal CHEBI CHEBI:36080 protein MESH D057165 Proteostasis deficiencies Aop:594 Event:1238 increased GO GO:0005886 plasma membrane GO GO:0055114 oxidation-reduction process Aop:594 Event:1238 increased PR PR:000000001 protein GO GO:0055114 oxidation-reduction process Aop:594 Event:1238 increased CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0055114 oxidation-reduction process Aop:594 Event:1288 decreased PR PR:000008774 3-hydroxyacyl-CoA dehydrogenase type-2 GO GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Aop:594 Event:1277 decreased GO GO:0000003 reproduction Aop:595 Event:112 decreased PR PR:000007204 estrogen receptor GO GO:0030284 estrogen receptor activity Aop:595 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:595 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:595 Event:1392 increased MP MP:0003674 oxidative stress Aop:595 Event:1262 increased GO GO:0006915 apoptotic process Aop:595 Event:177 functional change GO GO:0005739 mitochondrion Aop:595 Event:495 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:595 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0042446 hormone biosynthetic process Aop:595 Event:1690 decreased CHEBI CHEBI:17347 testosterone GO GO:0061370 testosterone biosynthetic process Aop:595 Event:1758 abnormal FMA FMA:67338 Mature sperm cell HP HP:0008669 Abnormal spermatogenesis Aop:595 Event:520 decreased VT VT:0002673 sperm quantity Aop:595 Event:520 morphological change CL CL:0000019 sperm Aop:595 Event:520 decreased MESH D005298 fertility Aop:595 Event:520 decreased CL CL:0000019 sperm Aop:595 Event:3 decreased CHEBI CHEBI:16469 17beta-estradiol GO GO:0006703 estrogen biosynthetic process Aop:596 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:596 Event:1392 increased MP MP:0003674 oxidative stress Aop:596 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:596 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:596 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:596 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:596 Event:55 increased GO GO:0008219 cell death Aop:596 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:598 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:598 Event:1392 increased MP MP:0003674 oxidative stress Aop:598 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:598 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:598 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:598 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:598 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:598 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:599 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:599 Event:1392 increased MP MP:0003674 oxidative stress Aop:599 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:599 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:599 Event:55 increased GO GO:0008219 cell death Aop:599 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:600 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:600 Event:1392 increased MP MP:0003674 oxidative stress Aop:600 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:600 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:600 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:601 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:601 Event:1392 increased MP MP:0003674 oxidative stress Aop:601 Event:179 decreased CHEBI CHEBI:35366 fatty acid GO GO:0006635 fatty acid beta-oxidation Aop:601 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:601 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:601 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:602 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:602 Event:1392 increased MP MP:0003674 oxidative stress Aop:602 Event:1634 occurrence CHEBI CHEBI:26523 reactive oxygen species GO GO:1901031 regulation of response to reactive oxygen species Aop:602 Event:155 abnormal CHEBI CHEBI:16991 deoxyribonucleic acid GO GO:0006281 DNA repair Aop:602 Event:1635 increased FMA FMA:74412 Deoxyribonucleic acid NCI NCI:C25830 DNA Strand Break Aop:602 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:602 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:602 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:603 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:603 Event:1392 increased MP MP:0003674 oxidative stress Aop:603 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:603 Event:1821 decreased GO GO:0005623 cell GO GO:0008283 cell proliferation Aop:603 Event:1521 decreased UBERON UBERON:0000468 multicellular organism GO GO:0040007 growth Aop:604 Event:2370 decreased PR PR:000001183 alpha-1A adrenergic receptor GO GO:0007186 G-protein coupled receptor signaling pathway Aop:604 Event:2371 increased GO GO:0043043 peptide biosynthetic process Aop:604 Event:2371 occurrence GO GO:0005102 receptor binding Aop:605 Event:279 decreased PR PR:000016584 thyroid peroxidase GO GO:0004447 iodide peroxidase activity Aop:605 Event:277 decreased CHEBI CHEBI:60311 thyroid hormone GO GO:0006590 thyroid hormone generation Aop:605 Event:281 decreased CHEBI CHEBI:30660 thyroxine MP MP:0005475 abnormal circulating thyroxine level Aop:605 Event:1003 decreased CHEBI CHEBI:28774 3,3',5'-triiodothyronine MP MP:0005473 decreased triiodothyronine level Aop:605 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:605 Event:351 increased MESH D009026 mortality Aop:605 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:606 Event:1522 decreased GO GO:0004100 chitin synthase activity Aop:606 Event:1523 decreased UBERON UBERON:0001002 cuticle GO GO:0042335 cuticle development Aop:606 Event:1524 decreased GO GO:0018990 ecdysis, chitin-based cuticle Aop:606 Event:350 increased MESH D009026 mortality Aop:608 Event:1392 increased MP MP:0003674 oxidative stress Aop:608 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:608 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:608 Event:351 increased MESH D009026 mortality Aop:608 Event:360 decreased PCO PCO:0000001 population of organisms PCO PCO:0000008 population growth rate Aop:609 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:609 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:609 Event:968 decreased CHEBI CHEBI:80304 Metastin GO GO:0007269 neurotransmitter secretion Aop:609 Event:530 decreased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:609 Event:1986 decreased UBERON UBERON:0001009 circulatory system HP HP:0030339 Decreased circulating gonadotropin level Aop:609 Event:1075 increased MP MP:0009006 prolonged estrous cycle Aop:609 Event:1075 increased MP MP:0009017 prolonged estrus Aop:610 Event:2258 decreased PR PR:000014950 monocarboxylate transporter 8 GO GO:0070327 thyroid hormone transport Aop:610 Event:1505 disrupted PR PR:000029191 cell cycle-related cyclin GO GO:0051726 regulation of cell cycle Aop:610 Event:1002 decreased PR PR:000006481 type II iodothyronine deiodinase GO GO:0003824 catalytic activity Aop:610 Event:2266 increased MP MP:0000921 demyelination Aop:610 Event:2266 increased HP HP:0007305 CNS demyelination Aop:610 Event:386 decreased GO GO:0099536 synaptic signaling Aop:610 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0010467 gene expression Aop:610 Event:381 decreased PR PR:000004716 brain-derived neurotrophic factor GO GO:0046903 secretion Aop:610 Event:385 decreased GO GO:0045202 synapse GO GO:0007416 synapse assembly Aop:610 Event:341 decreased GO GO:0007612 learning Aop:610 Event:341 decreased GO GO:0007613 memory Aop:611 Event:746 increased GO GO:0001963 synaptic transmission, dopaminergic Aop:611 Event:602 increased MP MP:0001393 ataxia Aop:611 Event:602 increased MP MP:0001399 hyperactivity Aop:611 Event:602 increased MP MP:0000753 paralysis Aop:611 Event:1005 decreased NBO NBO:0000371 aquatic locomotion Aop:612 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:612 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:612 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:612 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:612 Event:1771 decreased CHEBI CHEBI:15422 ATP GO GO:0006754 ATP biosynthetic process Aop:612 Event:2384 increased GO GO:0043114 regulation of vascular permeability Aop:612 Event:947 increased MP MP:0008762 embryonic lethality Aop:612 Event:947 increased MESH D009026 mortality Aop:613 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:613 Event:1446 increased GO GO:0005739 mitochondrion GO GO:1901691 proton binding Aop:613 Event:1446 increased GO GO:0005739 mitochondrion GO GO:0017077 oxidative phosphorylation uncoupler activity Aop:613 Event:1446 decreased GO GO:0005739 mitochondrion GO GO:0051881 regulation of mitochondrial membrane potential Aop:613 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:613 Event:2384 increased GO GO:0043114 regulation of vascular permeability Aop:613 Event:947 increased MP MP:0008762 embryonic lethality Aop:613 Event:947 increased MESH D009026 mortality Aop:614 Event:227 increased PR PR:000013056 peroxisome proliferator-activated receptor alpha GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:614 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A GO GO:0010467 gene expression Aop:614 Event:948 decreased PR PR:000017284 vascular endothelial growth factor A MP MP:0008469 abnormal protein level Aop:614 Event:28 decreased GO GO:0001525 angiogenesis Aop:614 Event:947 increased MP MP:0008762 embryonic lethality Aop:614 Event:947 increased MESH D009026 mortality Aop:615 Event:902 occurrence MP MP:0001860 liver inflammation Aop:615 Event:1445 increased CHEBI CHEBI:26208 polyunsaturated fatty acid GO GO:0034440 lipid oxidation Aop:616 Event:1392 increased MP MP:0003674 oxidative stress Aop:616 Event:2363 functional change GO GO:0005739 mitochondrion Aop:616 Event:1262 increased GO GO:0006915 apoptotic process Aop:616 Event:363 abnormal GO GO:0019098 reproductive behavior Aop:616 Event:364 abnormal UBERON UBERON:0003133 reproductive organ GO GO:0032502 developmental process Aop:616 Event:971 abnormal GO GO:0042698 ovulation cycle Aop:618 Event:202 decreased PR PR:000001753 transcription factor NF-kappa-B subunit GO GO:0007249 I-kappaB kinase/NF-kappaB signaling Aop:618 Event:1028 decreased PR PR:000013058 peroxisome proliferator-activated receptor gamma GO GO:0035357 peroxisome proliferator activated receptor signaling pathway Aop:619 Event:26 decreased PR PR:000004191 androgen receptor GO GO:0004882 androgen receptor activity Aop:619 Event:2393 decreased PR PR:000004191 androgen receptor GO GO:0000060 protein import into nucleus, translocation Aop:619 Event:2393 decreased CHEBI CHEBI:50113 androgen GO GO:0051101 regulation of DNA binding Aop:619 Event:2399 decreased PR PR:000001449 fibroblast growth factor receptor 2 GO GO:0060638 mesenchymal-epithelial cell signaling Aop:619 Event:2399 decreased PR PR:000007480 fibroblast growth factor 10 GO GO:0060638 mesenchymal-epithelial cell signaling Aop:619 Event:2399 decreased PR PR:000007480 fibroblast growth factor 10 Aop:619 Event:2399 decreased PR PR:000007489 fibroblast growth factor 2 GO GO:0001775 cell activation Aop:619 Event:2400 disrupted UBERON UBERON:0011374 prepuce GO GO:0035261 external genitalia morphogenesis Aop:619 Event:2401 delayed UBERON UBERON:0001332 prepuce of penis MP MP:0008940 delayed balanopreputial separation Aop:619 Event:2401 arrested UBERON UBERON:0001332 prepuce of penis MP MP:0008940 delayed balanopreputial separation Aop:622 Event:1172 increased GO GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Aop:622 Event:1174 increased MESH D019255 NADPH Oxidase GO GO:0023052 signaling Aop:622 Event:1115 increased CHEBI CHEBI:26523 reactive oxygen species GO GO:1903409 reactive oxygen species biosynthetic process Aop:622 Event:1392 increased MP MP:0003674 oxidative stress Aop:622 Event:177 functional change GO GO:0005739 mitochondrion Aop:622 Event:1283 increased PR PR:000000046 TGF-beta GO GO:0023052 signaling Aop:622 Event:759 increased MP MP:0003606 kidney failure Aop:623 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030520 intracellular estrogen receptor signaling pathway Aop:623 Event:1065 increased PR PR:000027727 estrogen receptor alpha complex GO GO:0030284 estrogen receptor activity Aop:623 Event:1985 increased CHEBI CHEBI:80304 Metastin GO GO:0007269 neurotransmitter secretion Aop:623 Event:1047 increased MESH D007987 Gonadotropin Releasing Hormone GO GO:0046879 hormone secretion Aop:623 Event:2137 increased CL CL:0011111 gonadotropin releasing neuron GO GO:0046879 hormone secretion Aop:623 Event:2402 increased CHEBI CHEBI:16469 17beta-estradiol GO GO:0090030 regulation of steroid hormone biosynthetic process Aop:623 Event:2294 increased CHEBI CHEBI:16469 17beta-estradiol MP MP:0005182 increased circulating estradiol level Aop:623 Event:2306 occurrence UBERON UBERON:0001344 epithelium of vagina GO GO:0070268 cornification Aop:624 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:624 Event:2119 increased HP HP:0000855 Insulin resistance Aop:624 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:624 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:624 Event:177 functional change GO GO:0005739 mitochondrion Aop:624 Event:55 increased GO GO:0008219 cell death Aop:624 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:624 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:624 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:624 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:625 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:625 Event:2119 increased HP HP:0000855 Insulin resistance Aop:625 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:625 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:625 Event:1392 increased MP MP:0003674 oxidative stress Aop:625 Event:55 increased GO GO:0008219 cell death Aop:625 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:625 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:625 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:625 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:626 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:626 Event:2119 increased HP HP:0000855 Insulin resistance Aop:626 Event:465 increased CHEBI CHEBI:35366 fatty acid GO GO:0015908 fatty acid transport Aop:626 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:626 Event:55 increased GO GO:0008219 cell death Aop:626 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:626 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:626 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:626 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:627 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:627 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:627 Event:177 functional change GO GO:0005739 mitochondrion Aop:627 Event:55 increased GO GO:0008219 cell death Aop:627 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:627 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:627 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:627 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:628 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:628 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:628 Event:1392 increased MP MP:0003674 oxidative stress Aop:628 Event:55 increased GO GO:0008219 cell death Aop:628 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:628 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:628 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:628 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis Aop:629 Event:122 increased PR PR:000011406 glucocorticoid receptor GO GO:0004883 glucocorticoid receptor activity Aop:629 Event:459 increased HP HP:0001397 Hepatic steatosis Aop:629 Event:55 increased GO GO:0008219 cell death Aop:629 Event:134 increased CL CL:0000091 Kupffer cell GO GO:0042116 macrophage activation Aop:629 Event:265 increased CL CL:0000632 hepatic stellate cell GO GO:0035733 hepatic stellate cell activation Aop:629 Event:68 increased CHEBI CHEBI:3815 collagen GO GO:0032964 collagen biosynthetic process Aop:629 Event:344 occurrence UBERON UBERON:0002107 liver MP MP:0003333 liver fibrosis