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All Key Events

Showing 226 to 250 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

424	Inhibition, Na+/I- symporter (NIS) Short Name Inhibition, Na+/I- symporter (NIS)	1	Molecular	Nov 29, 2016	Apr 27, 2026	5 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
423	Increased, Clonal Expansion / Cell Proliferation to Form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
422	Increased, nephropathy Short Name Increased, nephropathy	1	Individual	Nov 29, 2016	Dec 3, 2016	53: ER agonism leading to reduced survival due to renal failure
421	Increased, glomerular rupture and renal hemorrhaging Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
419	Increased, renal vitellogenin deposition Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
526	Inhibition, Inhibition of Dopamine-beta-hydroxylase Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
527	Decreased, Decreased fecundity Short Name Decreased, Decreased fecundity	2	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
528	Decreased, Synthesis of NE Short Name Decreased, Synthesis of NE	1	Cellular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
529	Decreased, GnRH cfos activity Short Name Decreased, GnRH cfos activity	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
530	Decreased, GnRH pulsatility/release Short Name Decreased, GnRH pulsatility/release	1	Cellular	Nov 29, 2016	Jan 28, 2026	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
531	Decreased, LH Surge Short Name Decreased, LH Surge	2	Cellular	Nov 29, 2016	Jan 13, 2025	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 512: Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
532	Delayed, Ovulation Short Name Delayed, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
533	Decreased, Cortical granule release/distribution upon fertilization Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
534	Altered, Formation of cortical envelope Short Name Altered, Formation of cortical envelope	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
535	Abnormal, Sperm penetration (polyspermy) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
536	Altered, Chromosome number (polyploid) zygote Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
484	Activation, AKT2 Short Name Activation, AKT2	1	Molecular	Nov 29, 2016	Sep 16, 2017	62: AKT2 activation leading to hepatic steatosis
472	Down Regulation, CPT1A Short Name Down Regulation, CPT1A	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
474	Down Regulation, HMGCS2 Short Name Down Regulation, HMGCS2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
477	Decreased, Ketogenesis Short Name Decreased, Ketogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis