AOP-Wiki

API

All Key Events

Showing 251 to 275 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

478	Activation, NRF2 Short Name Activation, NRF2	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
479	Activation, NR1H4 Short Name Activation, NR1H4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
480	Activation, SHP Short Name Activation, SHP	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
482	Decreased, DHB4/HSD17B4 Short Name Decreased, DHB4/HSD17B4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
483	Activation, LXR alpha Short Name Activation, LXR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
486	systemic inflammation leading to hepatic steatosis Short Name inflammation	1	Organ	Nov 29, 2016	Feb 24, 2017	62: AKT2 activation leading to hepatic steatosis
488	Decrease, Ovulation Short Name Decrease, Ovulation	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
494	Glucocorticoid Receptor Agonist, Activation Short Name GR Agonist, Activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
495	Repressed expression of steroidogenic enzymes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 595: Emerging OPFRS reproductive outcome pathway
496	Increased apoptosis, decreased fetal/adult Leydig Cells Short Name Decreased Leydig Cells	1	Cellular	Nov 29, 2016	May 17, 2023	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
559	Activation, Nicotinic acetylcholine receptor Short Name	1	Molecular	Nov 29, 2016	Jun 7, 2018	9 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
560	Abnormal, Foraging activity and behavior Short Name	1	Individual	Nov 29, 2016	Jun 7, 2018	9 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
561	Reduced, Food storage Short Name Reduced, Food storage	1	Population	Nov 29, 2016	Dec 3, 2016	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
563	Death/Failure, Colony Short Name Death/Failure, Colony	1	Population	Nov 29, 2016	Jun 7, 2018	21 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 179: Varroa mite infestation increases virus levels leading to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 181: Weather event contributes to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure 185: Queen egg-laying decrease leads to colony loss/failure
564	Abnormal, Roll change within caste Short Name Abnormal, Roll change within caste	0	Population	Nov 29, 2016	Dec 3, 2016	4 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
565	Reduced, Brood care Short Name Reduced, Brood care	2	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
566	impaired, Larval development Short Name impaired, Larval development	1	Population	Nov 29, 2016	Dec 3, 2016	5 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
568	impaired, Hive thermoregulation Short Name impaired, Hive thermoregulation	1	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
570	Accumulation, Damaged mitochondrial DNA Short Name Accumulation, Damaged mitochondrial DNA	1	Cellular	Nov 29, 2016	Sep 16, 2017	80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
571	Accelerated, Aging Short Name Accelerated, Aging	1	Individual	Nov 29, 2016	Dec 3, 2016	80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
572	Decrease, Number of worker bees Short Name Decrease, Number of worker bees	1	Population	Nov 29, 2016	Dec 3, 2016	4 AOPs 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
573	Increase, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure