AOP-Wiki

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All Key Events

Showing 26 to 50 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

68	Increase, Collagen accumulation Short Name Increase, Collagen accumulation	1	Tissue	Nov 29, 2016	Feb 11, 2026	12 AOPs 38: Protein Alkylation leading to Liver Fibrosis 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
75	N/A, Covalent binding to protein, possibly lysine residue Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
77	Production, Critical Metabolites (CGA 330050 and CGA 265307) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
78	Reduction, Cumulative fecundity and spawning Short Name	1	Individual	Nov 29, 2016	Mar 20, 2017	17 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
79	Inhibition, Cyclooxygenase activity Short Name Inhibition, Cyclooxygenase activity	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 28: Cyclooxygenase inhibition leading reproductive failure 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
80	Up Regulation, CYP1A1 Short Name Up Regulation, CYP1A1	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
84	Up Regulation, CYP1B1 Short Name Up Regulation, CYP1B1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
89	Synthesis, De Novo Fatty Acid (FA) Short Name Synthesis, De Novo Fatty Acid (FA)	1	Cellular	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
28	Reduction, Angiogenesis Short Name Reduction, Angiogenesis	1	Molecular	Nov 29, 2016	Jul 20, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
51	Inhibition, Ca++ ATPase Short Name Inhibition, Ca++ ATPase	1	Molecular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
50	Increase, Ca++ (intracellular) Short Name Increase, Ca++ (intracellular)	1	Cellular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
49	Reduction, Ca and HCO3 transport to shell gland Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
46	Accumulation, Biological membranes Short Name Accumulation, Biological membranes	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
41	Inhibition, Bile Salt Export Pump (ABCB11) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
40	Mitochondrial ATP production, decreased Short Name Mitochondrial ATP production, decreased	1	Cellular	Nov 29, 2016	Oct 16, 2025	7 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 258: Renal protein alkylation leading to kidney toxicity 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
39	Increased Cholinergic Signaling Short Name Increased Cholinergic Signaling	3	Organ	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
36	Inhibition, Aromatase Short Name Inhibition, Aromatase	1	Molecular	Nov 29, 2016	May 27, 2026	3 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
29	Reduction in, Angiogenic sprouts Short Name Reduction in, Angiogenic sprouts	0		Nov 29, 2016	Nov 29, 2016	None
3	Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Short Name	1	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 595: Emerging OPFRS reproductive outcome pathway
26	Antagonism, Androgen receptor Short Name Antagonism, Androgen receptor	1	Molecular	Nov 29, 2016	Mar 20, 2026	9 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 595: Emerging OPFRS reproductive outcome pathway 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
25	Agonism, Androgen receptor Short Name Agonism, Androgen receptor	1	Molecular	Nov 29, 2016	Nov 5, 2024	6 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 547: Androgen receptor agonism leading to long anogenital distance in female offspring 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 495: Androgen receptor activation leading to prostate cancer
21	Altered regulation, Alpha hemoglobin Short Name Altered regulation, Alpha hemoglobin	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
18	Activation, AhR Short Name Activation, AhR	2	Molecular	Nov 29, 2016	May 31, 2025	22 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 57: AhR activation leading to hepatic steatosis 131: Aryl hydrocarbon receptor activation leading to uroporphyria 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression 577: AhR activation leading to endometriosis
17	Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway Short Name	0	Molecular	Nov 29, 2016	Aug 19, 2021	2 AOPs 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
12	Acetylcholinesterase (AchE) Inhibition Short Name AchE Inhibition	1	Cellular	Nov 29, 2016	Apr 29, 2020	7 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias