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All Key Events

Showing 26 to 50 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2426	Hepatic BSEP (ABCB11), decreased Short Name BSEP (ABCB11), decreased	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2427	Bile acid composition in bile and intestine, altered Short Name Bile acid composition, altered	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2428	Gut derived PAMPs, increased Short Name PAMPs, increased	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2429	Instability/dysfunction of INSIG1 Short Name Instability of INSIG1	0	Molecular	Jun 9, 2026	Jun 9, 2026	None
2383	Increase, Hemopericardium Short Name Increase, Hemopericardium	0	Organ	Oct 29, 2025	Oct 29, 2025	3 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
2374	Increase, Ecdysone receptor antagonism Short Name Increase, EcR antagonism	0	Molecular	Sep 29, 2025	Sep 29, 2025	2 AOPs 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2375	Decrease, Mis-timed ecdysone receptor-responsive nuclear receptor cascade Short Name	0	Cellular	Sep 29, 2025	Sep 29, 2025	2 AOPs 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2373	Increase, Mis-timed ecdysone receptor-responsive nuclear receptor cascade Short Name	0	Cellular	Sep 29, 2025	Sep 29, 2025	342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
2376	Inhibition, organic anion-transporting polypeptide 1C1 (OATP1C1) Short Name Inhibition, OATP1C1	0	Molecular	Oct 8, 2025	Oct 8, 2025	610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2377	Decrease, neural network maturation Short Name neural network formation	0	Tissue	Oct 8, 2025	Oct 8, 2025	610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2378	Impaired axonal insulation Short Name Impaired axonal insulation	0	Tissue	Oct 8, 2025	Oct 8, 2025	610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2379	Disruption of the regulatory function of dopamine signaling components. Short Name	0	Molecular	Oct 19, 2025	Oct 19, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2380	Increase, transcription of the dopamine transporter (SLC6A3) gene Short Name Increase, dopamine transporter gene	0	Molecular	Oct 19, 2025	Oct 19, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2381	Increase, transcription of the dopamine receptor (drd) gene. Short Name Increase, dopamine receptor gene	0	Molecular	Oct 19, 2025	Oct 19, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2382	Increase, nerve spasm Short Name Increase, nerve spasm	0	Individual	Oct 20, 2025	Oct 20, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2369	Granulosa cell damage Short Name Granulosa cell damage	0	Cellular	Sep 9, 2025	Sep 9, 2025	595: Emerging OPFRS reproductive outcome pathway
2385	Suppression of Keap1 cysteine oxidation Short Name Suppression of Keap1 cysteine oxidation	0	Molecular	Nov 4, 2025	Nov 4, 2025	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
2368	immature oocyte Short Name immature oocyte	0	Cellular	Sep 9, 2025	Sep 9, 2025	None
2367	Steroidogenesis Dysregulation Short Name Steroidogenesis Dysregulation	0	Cellular	Sep 9, 2025	Sep 9, 2025	595: Emerging OPFRS reproductive outcome pathway
2366	ovarian retardation Short Name ovarian retardation	0	Organ	Sep 9, 2025	Sep 9, 2025	595: Emerging OPFRS reproductive outcome pathway
2365	Anogenital distance (AGD), increased Short Name AGD, increased	0	Tissue	Sep 5, 2025	Dec 8, 2025	547: Androgen receptor agonism leading to long anogenital distance in female offspring
2386	Lipid-peroxidation overload Short Name Lipid-peroxidation overload	0	Cellular	Nov 4, 2025	Nov 4, 2025	None
2387	MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition. Short Name	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2388	MIE-B: Photoactivation / photoproduct formation leading to ROS generation Short Name photoproducts generate ROS	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2389	KE1: Altered steroidogenesis (gene/protein level) Short Name Altered steroidogenesis	0	Cellular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways