AOP-Wiki

API

All Key Events

Showing 51 to 75 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

10	Acetylcholine accumulation in synapses Short Name ACh Synaptic Accumulation	1	Cellular	Nov 29, 2016	Jun 26, 2020	5 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 471: Neuron defect induced early behavioral change
9	Activation, 5HT2c Short Name Activation, 5HT2c	1	Molecular	Nov 29, 2016	Sep 16, 2017	33: Kidney toxicity induced by activation of 5HT2C
8	Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Short Name	1	Tissue	Nov 29, 2016	Nov 29, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
140	Decreased, HSD17B10 expression Short Name Decreased, HSD17B10 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
142	Hyperplasia, Hyperplasia Short Name Hyperplasia, Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
145	Induction, IKB inhibitory protein Short Name Induction, IKB inhibitory protein	1	Cellular	Nov 29, 2016	Sep 16, 2017	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
166	Decreased, Long-term potentiation (LTP) Short Name Decreased, Long-term potentiation (LTP)	1	Organ	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
183	Abnormal, Morphogenesis Short Name Abnormal, Morphogenesis	0		Nov 29, 2016	Nov 29, 2016	None
179	Decrease, Fatty acid beta-oxidation Short Name Decrease, Fatty acid β-oxidation	1	Cellular	Nov 29, 2016	May 23, 2025	7 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
178	Mitochondrial electron transport chain, disrupted Short Name	1	Cellular	Nov 29, 2016	Jan 7, 2026	4 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
177	Increase, Mitochondrial dysfunction Short Name Increase, Mitochondrial dysfunction	1	Cellular	Nov 29, 2016	Feb 11, 2026	42 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 144: Endocytic lysosomal uptake leading to liver fibrosis 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 200: Estrogen receptor activation leading to breast cancer 273: Mitochondrial complex inhibition leading to liver injury 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 205: AOP from chemical insult to cell death 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 362: Immune mediated hepatitis 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 34: LXR activation leading to hepatic steatosis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 595: Emerging OPFRS reproductive outcome pathway 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) 472: DNA adduct formation leading to kidney failure
173	N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
169	Disruption, Membrane integrity Short Name Disruption, Membrane integrity	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
168	Decreased, Lymphocytes Short Name Decreased, Lymphocytes	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
167	Activation, LXR Short Name Activation, LXR	2	Molecular	Nov 29, 2016	May 21, 2024	3 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
149	Increase, Inflammation Short Name Increase, Inflammation	1	Cellular	Nov 29, 2016	Feb 28, 2024	9 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 439: Activation of the AhR leading to metastatic breast cancer 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 577: AhR activation leading to endometriosis 472: DNA adduct formation leading to kidney failure
165	Activation, Long term AHR receptor driven direct and indirect gene expression changes Short Name	1	Cellular	Nov 29, 2016	Dec 2, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
164	Induction, Liver “Dysfunctional” Changes by CGA 330050 Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
161	Increase, Liver and splenic hemosiderosis Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
158	N/A, Interferences with SH-/selen-proteins Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
155	Inadequate DNA repair Short Name Inadequate DNA repair	1	Cellular	Nov 29, 2016	Mar 8, 2024	13 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to reduced sperm count 397: Bulky DNA adducts leading to mutations 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
152	Suppression, Inflammatory cytokines Short Name Suppression, Inflammatory cytokines	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
151	Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Short Name	2	Molecular	Nov 29, 2016	Nov 5, 2020	None