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Showing 76 to 100 of 1922 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
1168 Undercarboxylation of osteocalcin , Affects bone formation (osteoblast-osteoclast interaction, bone resorption) and glucose and lipid hoemostasis
0 Nov 29, 2016 Nov 29, 2016 None
1178 Decreased, Chloride conductance
0 Nov 29, 2016 Nov 29, 2016 None
1180 Estrogen receptor activation,
0 Nov 29, 2016 Nov 29, 2016 None
1184 Dysfunction, Mitochondrial Dynamics
0 Nov 29, 2016 Nov 29, 2016 None
1199 Binding of FK506 to FKBP12,
0 Nov 29, 2016 Nov 29, 2016 None
1200 Binding of FK506 to FKBP12, Formation
0 Nov 29, 2016 Nov 29, 2016 None
1207 Induction, Male traits formation in embryos
0 Nov 29, 2016 Nov 29, 2016 None
1216 Influx of Ca2+, Excitation of trigeminal nerves
0 Nov 29, 2016 Nov 29, 2016 None
1219 Release of Substance P (SP), Substance P increase in circulation
0 Nov 29, 2016 Nov 29, 2016 None
1221 Cough, Dyspnea, Sneezing, Acute respiratory effect
0 Nov 29, 2016 Nov 29, 2016 None
1227 TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/NEK293 fibroblast cells
0 Nov 29, 2016 Nov 29, 2016 None
1228 TRPA1 activation, Classic receptor binding / HEK 293 cells (fibroclast), cho cells (ovary), noncovalently linkked)
0 Nov 29, 2016 Nov 29, 2016 None
1229 TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/ HEK293 fibroblast cells
0 Nov 29, 2016 Nov 29, 2016 None
1231 Oxidization of biomolecules, Lipid bilayer and cellular proteins
0 Nov 29, 2016 Nov 29, 2016 None
1232 Production of nerve growth factor ,
0 Nov 29, 2016 Nov 29, 2016 None
1233 Production, Nerve growth factor
0 Nov 29, 2016 Nov 29, 2016 None
1244 Mucus hypersecretion,
0 Nov 29, 2016 Nov 29, 2016 None
1245 Mucus , Hypersecretion
0 Nov 29, 2016 Nov 29, 2016 None
1246 Lung function, Decrease
0 Nov 29, 2016 Nov 29, 2016 None
1247 EGFR , PPAR-alpha activation
0 Nov 29, 2016 Nov 29, 2016 None
1248 EGFR , Activation
0 Nov 29, 2016 Nov 29, 2016 None
165 Activation, Long term AHR receptor driven direct and indirect gene expression changes
1 Cellular Nov 29, 2016 Dec 2, 2016 41: Sustained AhR Activation leading to Rodent Liver Tumours
323 Increased, Disease susceptibility
1 Individual Nov 29, 2016 Dec 3, 2016 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
337 N/A, Impairment of reproductive capacity
1 Individual Nov 29, 2016 Dec 3, 2016 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
357 Cholestasis, Pathology
1 Individual Nov 29, 2016 Dec 3, 2016 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)