AOP-Wiki

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All Key Events

Showing 101 to 125 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

246	Increase, RBC congestion in liver Short Name Increase, RBC congestion in liver	2	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
250	Damaging, Red blood cells; hemolysis Short Name Damaging, Red blood cells; hemolysis	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
252	Increase, Renal pathology due to VTG deposition Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
253	N/A, Reproductive failure Short Name N/A, Reproductive failure	1	Individual	Nov 29, 2016	Dec 3, 2016	28: Cyclooxygenase inhibition leading reproductive failure
258	Activation, SCD-1 Short Name Activation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
261	Binding, SH-/selen-proteins Short Name Binding, SH-/selen-proteins	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
209	Peptide Oxidation Short Name Peptide Oxidation	1	Molecular	Nov 29, 2016	Nov 13, 2017	4 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 149: Peptide Oxidation Leading to Hypertension 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
186	Altered, Neuroanatomy Short Name Altered, Neuroanatomy	1	Organ	Nov 29, 2016	Sep 16, 2017	65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
188	Neuroinflammation Short Name Neuroinflammation	2	Tissue	Nov 29, 2016	Jul 15, 2022	10 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 471: Neuron defect induced early behavioral change 535: Binding and activation of GPER leading to learning and memory impairments 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
191	Neuronal dysfunction Short Name Neuronal dysfunction	1	Cellular	Nov 29, 2016	Apr 7, 2022	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 471: Neuron defect induced early behavioral change
192	Altered, Neurophysiology Short Name Altered, Neurophysiology	1	Organ	Nov 29, 2016	Sep 16, 2017	65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
193	Decreased, Nitric Oxide Short Name Decreased, Nitric Oxide	1	Cellular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
195	Inhibition, NMDARs Short Name Inhibition, NMDARs	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 522: Estrogen antagonism leading to increased risk of autism-like behavior
201	Binding of antagonist, NMDA receptors Short Name Binding of antagonist, NMDA receptors	0	Molecular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
202	Inhibition, Nuclear factor kappa B (NF-kB) Short Name	1	Molecular	Nov 29, 2016	Mar 2, 2023	5 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 278: IKK complex inhibition leading to liver injury 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 618: PPARgamma activation leads to a diminished vaccine response
185	Increase, Mutations Short Name Increase, Mutations	1	Molecular	Nov 29, 2016	May 15, 2023	10 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 397: Bulky DNA adducts leading to mutations 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts
213	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
214	Bile accumulation, Pathological condition Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
216	Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	57: AhR activation leading to hepatic steatosis
219	Reduction, Plasma 17beta-estradiol concentrations Short Name	1	Organ	Nov 29, 2016	Sep 26, 2017	11 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
220	Increase, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	4 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
221	Reduction, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	May 27, 2026	11 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
222	Elimination of (high doses), Posterior cardinal vein Short Name	0		Nov 29, 2016	Nov 29, 2016	None
288	Activation of specific nuclear receptors, Transcriptional change Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
286	Altered, Transcription of genes by the androgen receptor Short Name	1	Tissue	Nov 29, 2016	Mar 20, 2026	14 AOPs 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 495: Androgen receptor activation leading to prostate cancer 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 372: Androgen receptor antagonism leading to testicular cancer 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring