AOP-Wiki

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All Key Events

Showing 101 to 125 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

321	N/A, Cyanosis occurs Short Name N/A, Cyanosis occurs	1	Individual	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
339	Altered, Larval development Short Name Altered, Larval development	1	Individual	Nov 29, 2016	Dec 3, 2016	29: Estrogen receptor agonism leading to reproductive dysfunction
347	Formation, Liver tumor Short Name Formation, Liver tumor	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
363	Altered, Reproductive behaviour Short Name Altered, Reproductive behaviour	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 616: organic UV filter and its Photoproducts reproductive toxicity pathways
364	Impaired development of, Reproductive organs Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 616: organic UV filter and its Photoproducts reproductive toxicity pathways
593	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
804	Inhibition, HMG-CoA reductase Short Name Inhibition, HMG-CoA reductase	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility
978	Activation, Suppression of NFAT activation and hindrance of nuclear localization Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
985	Relief, Relief of atopic dermatitis Short Name Relief, Relief of atopic dermatitis	0	Individual	Nov 29, 2016	Dec 3, 2016	None
983	Suppression, Suppression of T-cell dependent antibody response (TDAR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
982	Suppression, Suppression in mixed lymphocyte reaction (MLR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
976	Formation, The binding of FK506 with FKBP12 Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
1203	Suppression, Suppression of production of cytotoxic T-cells Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
1204	Suppression, Suppression of T-cell dependent antibody production Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
361	Decline, Population Short Name Decline, Population	1	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
270	Induction, Sustained Hepatotoxicity Short Name Induction, Sustained Hepatotoxicity	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
152	Suppression, Inflammatory cytokines Short Name Suppression, Inflammatory cytokines	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
168	Decreased, Lymphocytes Short Name Decreased, Lymphocytes	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
84	Up Regulation, CYP1B1 Short Name Up Regulation, CYP1B1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
234	Activation, PPARα & PPARγ Short Name Activation, PPARα & PPARγ	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
253	N/A, Reproductive failure Short Name N/A, Reproductive failure	1	Individual	Nov 29, 2016	Dec 3, 2016	28: Cyclooxygenase inhibition leading reproductive failure
216	Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	57: AhR activation leading to hepatic steatosis
213	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
403	Suppression, Immune system Short Name Suppression, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
417	skewed, sex ratio Short Name skewed, sex ratio	1	Population	Nov 29, 2016	Dec 3, 2016	52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males