| 2286 |
Inhibition of Na⁺/K⁺-ATPase
Short Name
Na⁺/K⁺-ATPase
|
0 |
Molecular |
Nov 21, 2024 |
Nov 21, 2024 |
None
|
| 2313 |
Increased, Cardiovascular fibrosis
Short Name
Increased, Cardiovascular fibrosis
|
0 |
Organ |
Mar 11, 2025 |
Mar 11, 2025 |
None
|
| 2295 |
HCN Channel Inhibition
Short Name
HCN Channel Inhibition
|
0 |
Molecular |
Nov 24, 2024 |
Nov 24, 2024 |
562: HCN Channel Inhibition leading to Arrhythmias
|
| 2296 |
Reduced Pacemaker Activity in SA Node
Short Name
Reduced Pacemaker Activity in SA Node
|
0 |
Cellular |
Nov 24, 2024 |
Nov 25, 2024 |
562: HCN Channel Inhibition leading to Arrhythmias
|
| 2297 |
Serum bile acid levels, Altered
Short Name
Bile acid alterations
|
0 |
Cellular |
Nov 25, 2024 |
Nov 25, 2024 |
None
|
| 2285 |
Increased the delayed and early afterdepolarizations
Short Name
the delayed and early afterdepolarizations
|
0 |
Cellular |
Nov 21, 2024 |
Nov 26, 2024 |
554: β-adrenergic receptor agonists leading to arrhythmias.
|
| 2284 |
Increased Intracellular cAMP Levels
Short Name
Intracellular cAMP
|
0 |
Cellular |
Nov 21, 2024 |
Nov 21, 2024 |
554: β-adrenergic receptor agonists leading to arrhythmias.
|
| 2283 |
Increased the early premature depolarizations during repolarization
Short Name
Early premature depolarizations
|
0 |
Cellular |
Nov 21, 2024 |
Nov 26, 2024 |
2 AOPs
|
| 2282 |
Cardiac ion channels blockade
Short Name
Cardiac ion channels (e.g., potassium, sodium, calcium)
|
0 |
Molecular |
Nov 21, 2024 |
Nov 21, 2024 |
519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
|
| 2280 |
Increased delay in heart electrical conduction
Short Name
Prolonged atrioventricular (AV)
|
0 |
Organ |
Nov 20, 2024 |
Nov 26, 2024 |
2 AOPs
|
| 2302 |
Increase, Malformations
Short Name
Increase, Malformations
|
0 |
Population |
Dec 24, 2024 |
Jan 20, 2025 |
564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
|
| 2303 |
Increased plasma estradiol to progesterone ratio (estrogen dominance/unopposed estrogen)
Short Name
Plasma estradiol/progesterone ratio, increase
|
0 |
Organ |
Jan 3, 2025 |
Jan 3, 2025 |
566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
|
| 2279 |
Structural changes in lamin A/C
Short Name
Structural changes in lamin A/C
|
0 |
Cellular |
Nov 20, 2024 |
Nov 20, 2024 |
550: Increased LMNA gene mutation leading to heart failure
|
| 2278 |
Increased LMNA Mutation
Short Name
LMNA Mutation
|
0 |
Molecular |
Nov 20, 2024 |
Dec 2, 2024 |
550: Increased LMNA gene mutation leading to heart failure
|
| 2307 |
Binding of plastoquinone B (QB) within D1 protein of Photosystem II
Short Name
Binding to the QB site D1 protein
|
0 |
Molecular |
Jan 14, 2025 |
Feb 4, 2026 |
567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
|
| 2277 |
Inhibition, aromatase activity in plasma
Short Name
Inhibition, plasma aromatase activity
|
0 |
Tissue |
Nov 16, 2024 |
Nov 16, 2024 |
549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
|
| 2309 |
Decreased DNA methylation of FAM50B/PTCHD3
Short Name
FAM50B/PTCHD3 methylation
|
0 |
Molecular |
Mar 2, 2025 |
Mar 2, 2025 |
569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
|
| 2310 |
Elevated gene expression of FAM50B/PTCHD3
Short Name
FAM50B/PTCHD3 expression
|
0 |
Molecular |
Mar 2, 2025 |
Mar 2, 2025 |
569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
|
| 2311 |
Inhibition of PI3K-Akt pathway
Short Name
PI3K-Akt pathway
|
0 |
Molecular |
Mar 2, 2025 |
Mar 2, 2025 |
569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
|
| 2228 |
Cerebellar gene expression. Altered
Short Name
Altered cerebellar gene expression
|
0 |
Molecular |
Jun 6, 2024 |
Jun 6, 2024 |
532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
| 2211 |
Microcephaly
Short Name
Microcephalus
|
0 |
Organ |
Feb 2, 2024 |
Feb 2, 2024 |
581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
|
| 2215 |
Decrease Left Ventricular function
Short Name
Decrease LV function
|
0 |
Organ |
Apr 3, 2024 |
Apr 3, 2024 |
2 AOPs
|
| 2216 |
Binding of antagonist to thyroid hormone receptor
Short Name
Binding of antagonist to thyroid hormone receptor
|
0 |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
| 2217 |
Binding of antagonist to glucocorticoid hormone receptor
Short Name
Binding of antagonist to glucocorticoid hormone receptor
|
0 |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
| 2218 |
Binding of (ant)agonist to liver X receptor
Short Name
Binding of (ant)agonist to liver X receptor
|
0 |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|