AOP-Wiki

API

All Key Events

Showing 126 to 150 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

310	Alteration, Wnt pathway Short Name Alteration, Wnt pathway	1	Cellular	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
307	Increase, Vitellogenin synthesis in liver Short Name	1	Tissue	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
305	Inhibition, VegfR2 Short Name Inhibition, VegfR2	2	Molecular	Nov 29, 2016	Jan 17, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
304	Decreased, VegfR2 Short Name Decreased, VegfR2	0		Nov 29, 2016	Nov 29, 2016	None
302	Production, VEGF-A Short Name Production, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
298	Insufficiency, Vascular Short Name Insufficiency, Vascular	2	Molecular	Nov 29, 2016	Jul 20, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
295	Induction, Upregulation of glucuronyltransferase activity Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
294	N/A, Unknown Short Name N/A, Unknown	0	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 33: Kidney toxicity induced by activation of 5HT2C 1: Uncharacterized liver damage leading to hepatocellular carcinoma
291	Accumulation, Triglyceride Short Name Accumulation, Triglyceride	1	Cellular	Nov 29, 2016	Mar 26, 2024	8 AOPs 34: LXR activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
289	Decrease, Translocator protein (TSPO) Short Name Decrease, Translocator protein (TSPO)	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
301	Binding, VEGF-A Short Name Binding, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
337	N/A, Impairment of reproductive capacity Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
339	Altered, Larval development Short Name Altered, Larval development	1	Individual	Nov 29, 2016	Dec 3, 2016	29: Estrogen receptor agonism leading to reproductive dysfunction
341	Impairment, Learning and memory Short Name Impairment, Learning and memory	2	Individual	Nov 29, 2016	Apr 27, 2026	22 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 99: Histamine (H2) receptor antagonism leading to reduced survival 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 483: Deposition of Energy Leading to Learning and Memory Impairment 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 535: Binding and activation of GPER leading to learning and memory impairments 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
342	Increased, Lethality Short Name Increased, Lethality	0		Nov 29, 2016	Nov 29, 2016	None
344	Increase, Liver fibrosis Short Name Increase, Liver fibrosis	1	Organ	Nov 29, 2016	Feb 11, 2026	11 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 494: AhR activation leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
345	N/A, Liver Steatosis Short Name N/A, Liver Steatosis	1	Organ	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
347	Formation, Liver tumor Short Name Formation, Liver tumor	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
348	Malformation, Male reproductive tract Short Name Malformation, Male reproductive tract	1	Organ	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
350	Increase, Mortality Short Name Increase, Mortality	1	Individual	Nov 29, 2016	Oct 26, 2020	16 AOPs 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 465: Alcohol dehydrogenase leading to reproductive dysfunction 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality 471: Neuron defect induced early behavioral change 330: Excessive reactive oxygen species production leading to mortality (4) 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
351	Increased Mortality Short Name Increased Mortality	1	Population	Nov 29, 2016	Jul 8, 2022	28 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 96: Axonal sodium channel modulation leading to acute mortality 104: Altered ion channel activity leading impaired heart function 113: Glutamate-gated chloride channel activation leading to acute mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
352	N/A, Neurodegeneration Short Name N/A, Neurodegeneration	1	Tissue	Nov 29, 2016	Feb 23, 2021	7 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 471: Neuron defect induced early behavioral change
357	Cholestasis, Pathology Short Name Cholestasis, Pathology	1	Individual	Nov 29, 2016	Dec 3, 2016	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
358	Increase, Pericardial edema Short Name Increase, Pericardial edema	1	Organ	Nov 29, 2016	Sep 16, 2017	None