AOP-Wiki

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All Key Events

Showing 126 to 150 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
532	Delayed, Ovulation Short Name Delayed, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
527	Decreased, Decreased fecundity Short Name Decreased, Decreased fecundity	2	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
460	Increased, Fatty acid uptake Short Name Increased, Fatty acid uptake	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
422	Increased, nephropathy Short Name Increased, nephropathy	1	Individual	Nov 29, 2016	Dec 3, 2016	53: ER agonism leading to reduced survival due to renal failure
561	Reduced, Food storage Short Name Reduced, Food storage	1	Population	Nov 29, 2016	Dec 3, 2016	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
564	Abnormal, Roll change within caste Short Name Abnormal, Roll change within caste	0	Population	Nov 29, 2016	Dec 3, 2016	4 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
565	Reduced, Brood care Short Name Reduced, Brood care	2	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
566	impaired, Larval development Short Name impaired, Larval development	1	Population	Nov 29, 2016	Dec 3, 2016	5 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
568	impaired, Hive thermoregulation Short Name impaired, Hive thermoregulation	1	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
571	Accelerated, Aging Short Name Accelerated, Aging	1	Individual	Nov 29, 2016	Dec 3, 2016	80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
572	Decrease, Number of worker bees Short Name Decrease, Number of worker bees	1	Population	Nov 29, 2016	Dec 3, 2016	4 AOPs 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
573	Increase, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
574	Increased, Appetite and hunger Short Name Increased, Appetite and hunger	1	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
576	Increased, Viral susceptibility Short Name Increased, Viral susceptibility	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
577	impaired, Development Short Name impaired, Development	1	Individual	Nov 29, 2016	Dec 3, 2016	84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
580	Reduced, Antiseptic incorporated in food Short Name	0	Population	Nov 29, 2016	Dec 3, 2016	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
583	impaired, Thoracic shivering Short Name impaired, Thoracic shivering	0	Individual	Nov 29, 2016	Dec 3, 2016	None
588	Increased, predation Short Name Increased, predation	1	Population	Nov 29, 2016	Dec 3, 2016	5 AOPs 93: sodium channel inhibition leading to increased predation 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 99: Histamine (H2) receptor antagonism leading to reduced survival
590	N/A, hypoxia Short Name N/A, hypoxia	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 94: Sodium channel inhibition leading to congenital malformations 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
591	Increased, amputations Short Name Increased, amputations	1	Individual	Nov 29, 2016	Dec 3, 2016	94: Sodium channel inhibition leading to congenital malformations