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All Key Events

Showing 126 to 150 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2219	Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha Short Name Binding of (ant)agonist to PPAR alpha	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2220	Antagonism, Glucocorticoid hormone receptor Short Name GR antagonism	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2221	Altered Liver X receptor activity Short Name LXR activity, altered	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2222	Altered peroxisome proliferator–activated receptor alpha activity Short Name PPAR alpha activity, altered	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2223	Reduced number of oligodendrocytes Short Name Reduced number of oligodendrocytes	0	Cellular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2190	Cardiomyocyte differentiation inhibition Short Name	0	Cellular	Sep 16, 2023	Sep 16, 2023	None
2229	Cerebellar neuronal differentiation. Decreased Short Name	0	Organ	Jun 6, 2024	Jun 6, 2024	532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2230	Cerebellar hypoplasia Short Name Cerebellar hypoplasia	0	Tissue	Jun 6, 2024	Jun 6, 2024	532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2231	Locomotor function. Impaired Short Name Impaired locomotor function	0	Population	Jun 6, 2024	Jun 6, 2024	2 AOPs 532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2232	Antagonism, Retinoic acid receptors Short Name RAR antagonism	0	Molecular	Jun 6, 2024	Jun 6, 2024	533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
2233	Decreased, ERαβ heterodimers Short Name Decreased, ERαβ heterodimers	0	Molecular	Jun 19, 2024	Jun 19, 2024	535: Binding and activation of GPER leading to learning and memory impairments
2234	Malignant transformation of cells Short Name Malignant transformation of cells	0	Cellular	Jun 26, 2024	Jun 26, 2024	None
2235	Increased incidence and mortality of liver diseases among children Short Name	0	Population	Jun 26, 2024	Jun 26, 2024	None
2240	The NO synthase pathway activation Short Name The NO synthase pathway activation	0	Cellular	Jul 9, 2024	Jul 9, 2024	538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
2241	Ferroptosis related pathways activation Short Name Ferroptosis related pathways activation	0	Cellular	Jul 9, 2024	Jul 9, 2024	538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
2243	Succinate Accumulation Short Name Succinate Accumulation	0	Cellular	Jul 18, 2024	Jul 18, 2024	2 AOPs 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
2202	Altered expression of cell cycle genes Short Name Altered expression of cell cycle genes	0	Molecular	Jan 14, 2024	Mar 7, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
2195	Increase, CNS Neural cell death Short Name Increase, CNS Neural cell death	0	Cellular	Oct 17, 2023	Oct 17, 2023	2 AOPs 471: Neuron defect induced early behavioral change 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2196	Decrease, elavl3 Short Name Decrease, elavl3	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2197	Decrease, sox10 Short Name Decrease, sox10	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2198	Decrease, mbp Short Name Decrease, mbp	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2200	decline, neural progenitor cells Short Name decline, neural progenitor cells	0	Organ	Jan 10, 2024	Jan 10, 2024	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2201	Agonism, Retinoic acid receptor Short Name RAR agonism	0	Molecular	Jan 14, 2024	Jan 24, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2203	Decreased proliferation of cortical neural progenitor cells Short Name	0	Cellular	Jan 14, 2024	Jan 29, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
2204	Altered brain morphology Short Name Altered brain morphology	0	Organ	Jan 14, 2024	Jan 14, 2024	520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory