AOP-Wiki

API

All Key Events

Showing 151 to 175 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

336	Increase, Heritable mutations in offspring Short Name	1	Individual	Nov 29, 2016	Nov 29, 2016	15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
334	Promotion, Hepatocelluar carcinoma Short Name Promotion, Hepatocelluar carcinoma	1	Individual	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
330	Decrease, Fertility Short Name Decrease, Fertility	1	Individual	Nov 29, 2016	Jun 29, 2017	124: HMG-CoA reductase inhibition leading to decreased fertility
328	Decrease, Fecundity Short Name Decrease, Fecundity	0	Individual	Nov 29, 2016	Jun 12, 2018	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
327	Accumulation, Fatty acid Short Name Accumulation, Fatty acid	1	Organ	Nov 29, 2016	Sep 16, 2017	5 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
323	Increased, Disease susceptibility Short Name Increased, Disease susceptibility	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
321	N/A, Cyanosis occurs Short Name N/A, Cyanosis occurs	1	Individual	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
320	Increase, Curved body axis Short Name Increase, Curved body axis	0		Nov 29, 2016	Nov 29, 2016	None
319	Loss, Cochlear function Short Name Loss, Cochlear function	1	Organ	Nov 29, 2016	Sep 16, 2017	8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
317	Altered, Cardiovascular development/function Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
315	Decreased, Body length Short Name Decreased, Body length	0		Nov 29, 2016	Nov 29, 2016	None
313	Increase, Allergic Respiratory Hypersensitivity Response Short Name	1	Organ	Nov 29, 2016	Feb 7, 2023	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
312	N/A, Allergic contact dermatitis on challenge Short Name	0	Individual	Nov 29, 2016	Nov 29, 2016	None
382	Aberrant, Dendritic morphology Short Name Aberrant, Dendritic morphology	1	Cellular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
401	Increase, Biliary excretion TH glucuronide Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	None
398	Activation, Dendritic Cells Short Name Activation, Dendritic Cells	2	Cellular	Nov 29, 2016	Dec 3, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
397	Response, Keratinocytes Short Name Response, Keratinocytes	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
396	Covalent Binding, Protein Short Name Covalent Binding, Protein	1	Molecular	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
389	Increased, Intracellular Calcium overload Short Name	1	Cellular	Nov 29, 2016	Jun 26, 2020	7 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 535: Binding and activation of GPER leading to learning and memory impairments 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
388	Overactivation, NMDARs Short Name Overactivation, NMDARs	2	Cellular	Nov 29, 2016	Jul 14, 2024	5 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
387	Binding of agonist, NMDARs Short Name Binding of agonist, NMDARs	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
386	Decrease of neuronal network function Short Name Neuronal network function, Decreased	1	Organ	Nov 29, 2016	May 28, 2018	13 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 501: Excessive iron accumulation leading to neurological disorders 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 522: Estrogen antagonism leading to increased risk of autism-like behavior 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
385	Decrease of synaptogenesis Short Name Synaptogenesis, Decreased	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
384	Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
383	Reduced, Presynaptic release of glutamate Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities