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All Key Events

Showing 151 to 175 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

592	Reduced, survival Short Name Reduced, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
620	Increased, serotonin (5-HT) 1 1 Short Name Increased, serotonin (5-HT) 1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
622	Increased, locomotion Short Name Increased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
623	Increase, predation Short Name Increase, predation	1	Population	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
624	Increased, foot detachment Short Name Increased, foot detachment	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
627	Decreased, anxiety Short Name Decreased, anxiety	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
629	Decreased, sheltering Short Name Decreased, sheltering	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
634	N/A, sedation Short Name N/A, sedation	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
635	Decreased, locomotion Short Name Decreased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
636	Decreased, survival Short Name Decreased, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 99: Histamine (H2) receptor antagonism leading to reduced survival 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
637	impaired, Learning and memory Short Name impaired, Learning and memory	0	Individual	Nov 29, 2016	Dec 3, 2016	471: Neuron defect induced early behavioral change
644	Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
646	Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis Short Name	1	Organ	Nov 29, 2016	Dec 3, 2016	69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
650	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
651	Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
652	Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
654	Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
655	Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	4 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome 74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	2 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
659	Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
661	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
662	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
671	Reduced, Prostaglandin F2alpha concentration, plasma Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
673	Reduced, Spawning behavior Short Name Reduced, Spawning behavior	1	Individual	Nov 29, 2016	Dec 3, 2016	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
674	Reduced, Ability to attract spawning mates Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release