AOP-Wiki

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All Key Events

Showing 151 to 175 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2205	Increased, essential element imbalance Short Name Increased, essential element imbalance	0	Molecular	Jan 24, 2024	May 9, 2024	521: Essential element imbalance leads to reproductive failure via oxidative stress
2207	inhibition, EKR1/2 signaling pathway Short Name inhibition, EKR1/2 signaling pathway	0	Cellular	Jan 25, 2024	Jan 25, 2024	522: Estrogen antagonism leading to increased risk of autism-like behavior
2208	Aberrant, synaptic formation and plasticity Short Name	0	Organ	Jan 25, 2024	Jan 25, 2024	2 AOPs 522: Estrogen antagonism leading to increased risk of autism-like behavior 535: Binding and activation of GPER leading to learning and memory impairments
2209	autism-like behavior Short Name autism-like behavior	0	Individual	Jan 25, 2024	Jan 25, 2024	522: Estrogen antagonism leading to increased risk of autism-like behavior
2191	Inhibition of the Wnt/β-catenin pathway Short Name	0	Cellular	Sep 18, 2023	Sep 18, 2023	None
2189	Development-related pathway alterations Short Name Development-related pathway alterations	0	Cellular	Sep 16, 2023	Sep 17, 2023	None
2210	Reduced cortical thickness Short Name Reduced cortical thickness	0	Tissue	Feb 2, 2024	Feb 2, 2024	523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
2246	Increased sympathetic nerve activity Short Name Increased sympathetic nerve activity	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2247	Increased incidence of cerebrovascular morbidility and mortality in the general population Short Name	0	Population	Jul 29, 2024	Jul 29, 2024	None
2248	Increased stress hormone Short Name Increased stress hormone	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2249	Activation of sensory receptors Short Name Activation of sensory receptors	0	Molecular	Jul 29, 2024	Jul 29, 2024	None
2250	17β-Hydroxysteroid dehydrogenase 2, inhibition Short Name HSD17B2 inhibition	0	Molecular	Aug 9, 2024	Aug 12, 2024	565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
2267	Delayed neuropathy, increased Short Name Delayed neuropathy, increased	0	Individual	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2264	Lysolecithin cell membrane integration, increased Short Name	0	Cellular	Oct 1, 2024	Oct 1, 2024	543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
2259	Altered, Microbial Bile Acid Metabolism Short Name Microbial Bile Acid Dysmetabolism	0	Molecular	Aug 29, 2024	Aug 29, 2024	None
1853	Hyperactivation of ACE/Ang-II/AT1R axis Short Name Hyperactivation of ACE/Ang-II/AT1R axis	0	Molecular	Mar 31, 2021	Mar 31, 2021	2 AOPs 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1864	Increase, Programmed cell death Short Name Increase, Programmed cell death	0	Cellular	Apr 11, 2021	Apr 12, 2021	388: Deposition of ionising energy leading to population decline via programmed cell death
1863	Decrease, Reproduction Short Name Decrease, Reproduction	0	Individual	Apr 11, 2021	Apr 11, 2021	9 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
1862	Decrease, Photosystem II efficiency Short Name Decrease, Photosystem II efficiency	0	Cellular	Apr 11, 2021	Jan 16, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1861	Increase, D1 protein deactivation Short Name D1 protein deactivation	0	Cellular	Apr 11, 2021	Apr 11, 2021	386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1860	Increase, Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1859	Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1858	Increased viral transcription and replication Short Name	0	Cellular	Apr 9, 2021	Apr 9, 2021	None
1857	Platelet-neutrophil interactions, Increased Short Name	0	Cellular	Apr 8, 2021	Apr 8, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation
1856	Imbalanced salty and sweet taste responses Short Name Sodium inhibition, Sweet enhancement	0	Tissue	Apr 7, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia