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All Key Events

Showing 1826 to 1850 of 1936 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

565	Reduced, Brood care Short Name Reduced, Brood care	2	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
573	Increase, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
584	Inhibition, sodium channel Short Name Inhibition, sodium channel	2	Molecular	Nov 29, 2016	Sep 16, 2017	5 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations 197: Sodium channel (Nav1.1) inhibition leading to population decline 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Short Name	2	Molecular	Nov 29, 2016	Feb 24, 2025	6 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
650	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	2 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
660	decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
663	Desensitization, Nicotinic acetylcholine receptor Short Name	2	Molecular	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
739	Increase, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
741	Increase, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
753	Increase, Thyroid-stimulating hormone (TSH) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
402	Cognitive function, decreased Short Name Cognitive function, decreased	2	Individual	Nov 29, 2016	Jul 25, 2024	15 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 486: Binding to the extracellular protein laminin leading to decreased cognitive function 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
406	decreased, Fertility Short Name decreased, Fertility	2	Individual	Nov 29, 2016	Dec 17, 2024	13 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Short Name	2	Cellular	Nov 29, 2016	May 28, 2021	7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
531	Decreased, LH Surge Short Name Decreased, LH Surge	2	Cellular	Nov 29, 2016	Jan 13, 2025	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 512: Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation