AOP-Wiki

API

All Key Events

Showing 1876 to 1900 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2082	Hypospadias, increased Short Name Hypospadias	1	Organ	Dec 18, 2022	Mar 20, 2026	4 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
26	Antagonism, Androgen receptor Short Name Antagonism, Androgen receptor	1	Molecular	Nov 29, 2016	Mar 20, 2026	9 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 595: Emerging OPFRS reproductive outcome pathway 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
1617	Inhibition, 5α-reductase Short Name Inhibition, 5α-reductase	0	Molecular	Apr 18, 2019	Mar 20, 2026	5 AOPs 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1613	Decrease, dihydrotestosterone (DHT) levels Short Name Decrease, DHT level	1	Tissue	Apr 10, 2019	Mar 20, 2026	6 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1614	Decrease, androgen receptor activation Short Name Decrease, AR activation	1	Tissue	Apr 10, 2019	Mar 20, 2026	13 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
286	Altered, Transcription of genes by the androgen receptor Short Name	1	Tissue	Nov 29, 2016	Mar 20, 2026	14 AOPs 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 495: Androgen receptor activation leading to prostate cancer 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 372: Androgen receptor antagonism leading to testicular cancer 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
2298	Decrease, intratesticular testosterone levels Short Name Decrease, intratesticular testosterone	1	Organ	Dec 12, 2024	Mar 20, 2026	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
1690	Decrease, circulating testosterone levels Short Name	2	Tissue	Aug 30, 2019	Mar 20, 2026	12 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 124: HMG-CoA reductase inhibition leading to decreased fertility 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 595: Emerging OPFRS reproductive outcome pathway
1786	Nipple retention (NR), increased Short Name nipple retention, increased	0	Individual	May 11, 2020	Mar 21, 2026	3 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
2415	Precocious puberty Short Name Precocious puberty	1	Individual	Mar 26, 2026	Mar 26, 2026	639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
2416	human amyotrophic lateral sclerosis (ALS) Short Name ALS	0	Individual	Mar 30, 2026	Mar 30, 2026	636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
968	Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons Short Name	1	Cellular	Nov 29, 2016	Apr 6, 2026	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1986	Decreased, Gonadotropins Short Name Decreased, Gonadotropins	1	Tissue	Apr 5, 2022	Apr 6, 2026	2 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1985	Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV) Short Name Increased Kisspeptin levels in AVPV	1	Cellular	Apr 5, 2022	Apr 6, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1047	Increased, secretion of GnRH from hypothalamus Short Name	1	Cellular	Nov 29, 2016	Apr 6, 2026	6 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2137	Increase, Gonadotropins concentration in plasma Short Name	1	Cellular	May 16, 2023	Apr 6, 2026	5 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2402	Increased, estradiol (E2) production in ovaries Short Name Increased, E2 production in ovaries	1	Tissue	Jan 29, 2026	Apr 6, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2294	Plasma estradiol, increased Short Name Plasma E2, increased	1	Cellular	Nov 22, 2024	Apr 6, 2026	5 AOPs 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2417	Increased, differentiation to ovaries Short Name Increased, differentiation to ovaries	1	Individual	Apr 17, 2026	Apr 17, 2026	641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
2418	Increased, phenotypic female-biased sex ratio Short Name Increased, female-biased sex ratio	1	Population	Apr 17, 2026	Apr 17, 2026	641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
957	Binding, Transthyretin in serum Short Name Binding, Transthyretin in serum	1	Molecular	Nov 29, 2016	Apr 22, 2026	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
2421	Inhibition, Intestinal FXR Short Name FXR inhibition	0	Molecular	Apr 22, 2026	Apr 22, 2026	2 AOPs 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation 232: NFE2/Nrf2 repression to steatosis
2422	Ileal FGF15/FGF19 secretion, decreased Short Name Decreased FGF15/FGF19	0	Cellular	Apr 22, 2026	Apr 22, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2423	Hepatic SHP, decreased Short Name Hepatic SHP, decreased	0	Cellular	Apr 22, 2026	Apr 22, 2026	232: NFE2/Nrf2 repression to steatosis
2424	Hepatic CYP7A1, increased Short Name Hepatic CYP7A1, increased	0	Cellular	Apr 22, 2026	Apr 22, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation