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All Key Events

Showing 1876 to 1900 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1825	Increase, Cell death Short Name Increase, Cell death	2	Cellular	Dec 4, 2020	Nov 27, 2024	12 AOPs 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 368: Cytochrome oxidase inhibition leading to increased nasal lesions 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 482: Deposition of energy leading to occurrence of bone loss 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function 472: DNA adduct formation leading to kidney failure
1690	Decrease, circulating testosterone levels Short Name	2	Tissue	Aug 30, 2019	Mar 20, 2026	12 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 124: HMG-CoA reductase inhibition leading to decreased fertility 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 595: Emerging OPFRS reproductive outcome pathway
1867	Bradykinin system, hyperactivated Short Name Bradykinin, activated	3	Molecular	Apr 20, 2021	Jan 24, 2022	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
1846	Thrombosis and Disseminated Intravascular Coagulation Short Name Thrombosis and DIC	3	Individual	Mar 25, 2021	Nov 25, 2022	3 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
854	Alterations, Cellular proliferation / hyperplasia Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 41: Sustained AhR Activation leading to Rodent Liver Tumours 495: Androgen receptor activation leading to prostate cancer
764	N/A, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	113: Glutamate-gated chloride channel activation leading to acute mortality
807	Decreased, cholesterol Short Name Decreased, cholesterol	3	Tissue	Nov 29, 2016	May 24, 2022	2 AOPs 124: HMG-CoA reductase inhibition leading to decreased fertility 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
602	Increased, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 96: Axonal sodium channel modulation leading to acute mortality 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
667	Binding at picrotoxin site, iGABAR chloride channel Short Name	3	Molecular	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1134	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	3	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1132	Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	3	Cellular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1446	Decrease, Coupling of oxidative phosphorylation Short Name Decrease, Coupling of OXPHOS	3	Cellular	Jun 29, 2017	Nov 7, 2025	15 AOPs 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1495	Substance interaction with the lung resident cell membrane components Short Name Interaction with the lung cell membrane	3	Molecular	Jan 2, 2018	May 17, 2023	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1238	Activation of oxidative stress pathway Short Name Oxidation	3	Molecular	Nov 29, 2016	Jun 19, 2017	594: Micro plastic effect on reproduction
1235	Non-neuronal production of IL-8/CXCL1, Epithelial irritation Short Name	3	Tissue	Nov 29, 2016	Dec 3, 2016	None
1243	Altered, Ca2+-calmodulin activated signal transduction Short Name	3	Cellular	Nov 29, 2016	Jun 7, 2018	4 AOPs 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
2308	Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors Short Name	3	Organ	Jan 14, 2025	Feb 13, 2025	568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
2159	Influenza A virus (IAV) cell entry Short Name IAV cell entry	3	Cellular	Aug 11, 2023	Oct 3, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2118	Succinate dehydrogenase, inhibited Short Name SDH, inhibited	3	Molecular	Apr 3, 2023	May 4, 2023	5 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits
2078	Loss of drebrin Short Name Loss of drebrin	3	Cellular	Dec 11, 2022	Apr 3, 2025	2 AOPs 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	3	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2090	Increase, Bone Remodeling Short Name Bone Remodeling	3	Tissue	Jan 11, 2023	Aug 13, 2024	482: Deposition of energy leading to occurrence of bone loss
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function