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All Key Events

Showing 176 to 200 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

360	Decrease, Population growth rate Short Name Decrease, Population growth rate	1	Population	Nov 29, 2016	Jan 3, 2023	61 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 29: Estrogen receptor agonism leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 292: Inhibition of tyrosinase leads to decreased population in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 376: Androgen receptor agonism leading to male-biased sex ratio 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
381	Reduced levels of BDNF Short Name BDNF, Reduced	2	Molecular	Nov 29, 2016	Apr 4, 2019	5 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 375: test AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
380	Activation, Pre-MIE: Metabolism of AFB1 Short Name Activation, Pre-MIE: Metabolism of AFB1	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
378	Tumorigenesis, Hepatocellular carcinoma Short Name Tumorigenesis, Hepatocellular carcinoma	1	Individual	Nov 29, 2016	Nov 29, 2016	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
377	Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered Hepatic Foci (AHF)) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
376	Increased, Induced Mutations in Critical Genes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
373	Formation, Pro-mutagenic DNA Adducts Short Name Formation, Pro-mutagenic DNA Adducts	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) 472: DNA adduct formation leading to kidney failure
369	Uroporphyria Short Name Uroporphyria	1	Individual	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
366	Increased, Structural malformations Short Name Increased, Structural malformations	0		Nov 29, 2016	Nov 29, 2016	None
364	Impaired development of, Reproductive organs Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 616: organic UV filter and its Photoproducts reproductive toxicity pathways
363	Altered, Reproductive behaviour Short Name Altered, Reproductive behaviour	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 616: organic UV filter and its Photoproducts reproductive toxicity pathways
361	Decline, Population Short Name Decline, Population	1	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
459	Increase, Liver steatosis Short Name Increase, Liver steatosis	1	Organ	Nov 29, 2016	Feb 11, 2026	21 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis 62: AKT2 activation leading to hepatic steatosis 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) 285: Inhibition of N-linked glycosylation leads to liver injury 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 232: NFE2/Nrf2 repression to steatosis 57: AhR activation leading to hepatic steatosis 494: AhR activation leading to liver fibrosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
445	Respiratory distress/arrest Short Name Respiratory distress/arrest	1	Organ	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 94: Sodium channel inhibition leading to congenital malformations
446	Reduction, fetal/adult testosterone Short Name Reduction of testosterone	1	Tissue	Nov 29, 2016	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
447	Reduction, Cholesterol transport in mitochondria Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males
450	Decrease, Very low-density lipoprotein export capacity Short Name Decrease, VLDL export capacity	1	Cellular	Nov 29, 2016	Feb 12, 2026	57: AhR activation leading to hepatic steatosis
451	Inhibition, Mitochondrial fatty acid beta-oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis
454	Increased, Triglyceride formation Short Name Increased, Triglyceride formation	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
456	Suppression, Constitutive androstane receptor, NR1I3 Short Name	1	Molecular	Nov 29, 2016	May 25, 2026	58: NR1I3 (CAR) suppression leading to hepatic steatosis
457	Activation, SREBF1 Short Name Activation, SREBF1	2	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 62: AKT2 activation leading to hepatic steatosis
458	Increased, De Novo FA synthesis Short Name Increased, De Novo FA synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis
403	Suppression, Immune system Short Name Suppression, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
460	Increased, Fatty acid uptake Short Name Increased, Fatty acid uptake	0	Cellular	Nov 29, 2016	Dec 3, 2016	None