AOP-Wiki

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All Key Events

Showing 176 to 200 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
678	Reduced, Pheromone release Short Name Reduced, Pheromone release	1	Individual	Nov 29, 2016	Dec 3, 2016	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	Decline, Population trajectory Short Name Decline, Population trajectory	1	Population	Nov 29, 2016	Dec 3, 2016	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
693	Increased, cyclic adenosine monophosphate Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 558: Phosphodiesterase inhibition leading to heart failure
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
726	Increased, Induction of pyruvate dehydrogenase (PDH) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
748	Increased, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	465: Alcohol dehydrogenase leading to reproductive dysfunction
765	Decreased, population 1 Short Name Decreased, population 1	1	Population	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
798	Inhibition, Prolyl hydroxylases Short Name Inhibition, Prolyl hydroxylases	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
799	Increased, HIF-1 heterodimer Short Name Increased, HIF-1 heterodimer	2	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
801	modulation, Unknown Short Name modulation, Unknown	1	Molecular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
769	Increase, Oxidative metabolism Short Name Increase, Oxidative metabolism	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
766	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
760	Activation, Glutamate-gated chloride channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
828	Inhibition, Phospholipase A Short Name Inhibition, Phospholipase A	1	Molecular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
825	Decreased, Renal ability to dilute urine Short Name	1	Organ	Nov 29, 2016	Dec 3, 2016	128: Kidney dysfunction by decreased thyroid hormone
805	Decreased, mevalonate Short Name Decreased, mevalonate	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility
829	Damage, Lipid bilayer Short Name Damage, Lipid bilayer	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
802	Increased, HIF-1 alpha transcription Short Name Increased, HIF-1 alpha transcription	1	Cellular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
838	Induction, Microvesicular fat Short Name Induction, Microvesicular fat	1	Tissue	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
839	Formation, Mallory body Short Name Formation, Mallory body	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
849	Inhibition, Antgonism of NE receptor Short Name Inhibition, Antgonism of NE receptor	1	Molecular	Nov 29, 2016	Dec 3, 2016	126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
972	Decreased fertility, Reduced number of oocytes ovulated Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats