AOP-Wiki

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All Key Events

Showing 176 to 200 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1855	Increased Sodium-sensitive hypertension Short Name Increased Sodium-sensitive hypertension	0	Tissue	Apr 7, 2021	Apr 7, 2021	384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1865	Increase, Oxygen-evolving complex damage Short Name Increase, OEC damage	0	Molecular	Apr 11, 2021	Apr 11, 2021	389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1852	Increased Ang II type 1 receptor (AT1R) Short Name Increased Ang II type 1 receptor (AT1R)	0	Tissue	Mar 30, 2021	Mar 30, 2021	2 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1851	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Short Name	0	Molecular	Mar 30, 2021	Mar 30, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
1850	dysgeusia Short Name taste impairment	0	Organ	Mar 28, 2021	Apr 26, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1849	Impaired gustatory nerve Short Name Impaired gustatory nerve	0	Tissue	Mar 28, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1848	Toll Like Receptor (TLR) Dysregulation Short Name TLR Activation/Dysregulation	0	Molecular	Mar 26, 2021	Nov 23, 2021	3 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 378: Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
1841	Encephalitis Short Name Encephalitis	0	Organ	Feb 23, 2021	Feb 23, 2021	2 AOPs 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
1844	systemic inflammatory response syndrome Short Name SIRS	0	Individual	Mar 19, 2021	Mar 19, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1843	Multi Organ Failure involving Acute Respiratory Distress Syndrome Short Name ARDS and MODS	0	Individual	Mar 19, 2021	Nov 19, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1842	Prolonged TLR9 activation Short Name TLR9 activation	0	Molecular	Mar 19, 2021	Mar 26, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1705	Impaired coordination and movement Short Name Impaired coordination and movement	0	Individual	Dec 20, 2019	Dec 20, 2019	312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
1720	Trypsin inhibition Short Name Inhibition, trypsin	0	Molecular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1714	Exacerbation of systemic lupus erythematosus (SLE) Short Name Exacerbation of SLE	0	Individual	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1713	Increase of anti-DNA antibody from autoreactive B cell Short Name Increase of autoantibody production	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1712	Increase of Th2 cells producing IL-4 Short Name Increase of Th2 cells producing IL-4	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1711	Induction of GATA3 expression Short Name Induction of GATA3 expression	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1710	Binding to estrogen receptor (ER)-α in immune cells Short Name Binding to estrogen receptor (ER)-α	0	Molecular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1709	Psoriatic skin disease Short Name Skin disease	0	Individual	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1708	Th17 cell migration and inflammation induction Short Name	0	Cellular	Dec 27, 2019	Nov 23, 2020	2 AOPs 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1707	Increase, IL-23 from matured dendritic cells Short Name Increase of IL-23	0	Cellular	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1706	Stimulation, TLR7/8 Short Name Stimulation of TLR7/8	0	Molecular	Dec 27, 2019	Nov 21, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1704	testJF Short Name test	0	Molecular	Dec 5, 2019	Dec 5, 2019	None
1703	Dysregulation of heart rate and vascular tone Short Name Cardiovascular dysregulation	0	Organ	Nov 25, 2019	Dec 20, 2019	16: Acetylcholinesterase inhibition leading to acute mortality
1694	Reduction, progesterone uptake, decresed maturation Short Name	0	Cellular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction