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All Key Events

Showing 201 to 225 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

461	Suppression, HNF4alpha Short Name Suppression, HNF4alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	59: HNF4alpha suppression leading to hepatic steatosis
462	Up Regulation, SCD-1 Short Name Up Regulation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
463	Up Regulation, FAS Short Name Up Regulation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
465	Increased, Fatty acid influx Short Name Increased, FA Influx	1	Cellular	Nov 29, 2016	Feb 24, 2026	6 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
466	Up Regulation, LDLR (low density lipoprotein receptor) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
467	Increased, LDL uptake Short Name Increased, LDL uptake	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 57: AhR activation leading to hepatic steatosis 462: Activation of reactive oxygen species leading the atherosclerosis
468	Inhibition, PPAR alpha Short Name Inhibition, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
470	Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
471	Inhibition, FoxA2 Short Name Inhibition, FoxA2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
429	Cellular Proliferation and Clonal Expansion of Mutant Cells (Pre-neoplastic Foci), Alteration of cellular growth homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
442	Decreased, Population trajectory Short Name Decreased, Population trajectory	1	Population	Nov 29, 2016	Apr 18, 2017	3 AOPs 435: Deposition of ionising energy leads to population decline via pollen abnormal 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
402	Cognitive function, decreased Short Name Cognitive function, decreased	2	Individual	Nov 29, 2016	Jul 25, 2024	15 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 486: Binding to the extracellular protein laminin leading to decreased cognitive function 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
405	disrupted, ovarian cycle Short Name disrupted, ovarian cycle	1	Individual	Nov 29, 2016	Dec 17, 2024	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
406	decreased, Fertility Short Name decreased, Fertility	2	Individual	Nov 29, 2016	Dec 17, 2024	13 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Short Name	2	Cellular	Nov 29, 2016	May 28, 2021	7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
409	Metabolism of AFB1, Production of Reactive Electrophiles Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
413	Reduction, Testosterone synthesis in Leydig cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
414	Increase, Luteinizing hormone (LH) Short Name Increase, Luteinizing hormone (LH)	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
415	Hyperplasia, Leydig cell Short Name Hyperplasia, Leydig cell	1	Cellular	Nov 29, 2016	Sep 27, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
416	Increase proliferation, Leydig cell Short Name Increase proliferation, Leydig cell	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
418	Increased, Vitellogenin synthesis Short Name Increased, Vitellogenin synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
417	skewed, sex ratio Short Name skewed, sex ratio	1	Population	Nov 29, 2016	Dec 3, 2016	52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
428	Delay, Developmental GABA shift Short Name Delay, Developmental GABA shift	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
427	Down Regulation, K-Cl co-transporter 2 (KCC2) Short Name	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
425	Decrease of Thyroidal iodide Short Name Thyroidal Iodide, Decreased	1	Cellular	Nov 29, 2016	Apr 4, 2019	4 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis