AOP-Wiki

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All Key Events

Showing 201 to 225 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

964	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
994	Decreased, Synthesis of molting fluid proteases Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
970	Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
997	Decreased, Population size Short Name Decreased, Population size	0	Population	Nov 29, 2016	Dec 3, 2016	396: Deposition of ionizing energy leads to population decline via impaired meiosis
1040	relaxation, smooth muscle Short Name relaxation, smooth muscle	1	Tissue	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1043	Hypertrophy/hyperplasia, smooth muscle Short Name Hypertrophy/hyperplasia, smooth muscle	1	Cellular	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1049	Increased, secrection of FSH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1050	Increased, secretion of LH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1053	Promotion, ovarian adenomas Short Name Promotion, ovarian adenomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1054	Promotion, ovarian granular cell tumors Short Name Promotion, ovarian granular cell tumors	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1072	Decreased, LH Surge from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1074	interruption, Ovulation Short Name interruption, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1076	Increased, circulating estrogen levels Short Name Increased, circulating estrogen levels	1	Organ	Nov 29, 2016	Dec 3, 2016	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
1077	Increased, prolactin exposure Short Name Increased, prolactin exposure	1	Tissue	Nov 29, 2016	Dec 3, 2016	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1080	Increased, latency period Short Name Increased, latency period	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1083	Decreased, Dopaminergic activity Short Name Decreased, Dopaminergic activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1084	Increased, prolactin secretion Short Name Increased, prolactin secretion	1	Tissue	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1087	Increased, inflammation Short Name Increased, inflammation	1	Cellular	Nov 29, 2016	Dec 3, 2016	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1090	Increased, mesotheliomas Short Name Increased, mesotheliomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 409: Frustrated phagocytosis leads to malignant mesothelioma
1102	Occurrence, tophi (urate) deposition Short Name Occurrence, tophi (urate) deposition	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1103	Inhibition, Cyclooxygenase 1 activity Short Name Inhibition, Cyclooxygenase 1 activity	1	Molecular	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1105	Occurrence, renal ischemia Short Name Occurrence, renal ischemia	1	Tissue	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1109	Increased, Deformed Wing Virus levels Short Name Increased, Deformed Wing Virus levels	1	Individual	Nov 29, 2016	Dec 3, 2016	179: Varroa mite infestation increases virus levels leading to colony loss/failure
1110	Increased, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	183: Nosema infection increases energetic demands leading to colony loss/failure
1114	Unknown, MIE Short Name Unknown, MIE	0	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 186: unknown MIE leading to renal failure and mortality 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition