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Showing 201 to 225 of 1922 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
1691 Antagonism,LH receptor
0 Molecular Oct 3, 2019 Oct 3, 2019 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1692 Reduction, Progesterone synthesis
0 Cellular Oct 3, 2019 Oct 3, 2019 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1693 Decreased, Progesterone levels
0 Tissue Oct 3, 2019 Apr 8, 2025 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1696 Decrease of egg production and cummulative fecundity
0 Individual Oct 3, 2019 Oct 3, 2019
1697 Increase, DNA methyltransferase expression
0 Molecular Oct 30, 2019 Oct 30, 2019 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1698 Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor
0 Molecular Oct 30, 2019 Oct 30, 2019 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1699 Decrease, expression of gonadotropin releasing hormone receptor
0 Molecular Oct 30, 2019 Oct 30, 2019 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1701 Suppression of NF-kB
0 Molecular Nov 17, 2019 Nov 17, 2019 None
1580 Binding of microtubule stabilizing agents (MSA) to microtubules
0 Molecular Jan 29, 2019 Jan 29, 2019 279: Microtubule interacting drugs lead to peripheral neuropathy
1567 Suppressed DC activation
0 Organ Dec 24, 2018 Dec 24, 2018 None
1568 Impaired antigen presentation
0 Organ Dec 24, 2018 Dec 24, 2018 None
1569 Impaired T cell activation
0 Cellular Dec 24, 2018 Jun 25, 2019 None
1570 Blocking of IL-1R
0 Molecular Dec 24, 2018 Jun 1, 2019 None
1571 Decreased IL-1 production
0 Cellular Dec 24, 2018 Jun 24, 2019 None
1572 Impaired IL-1 signaling
0 Molecular Dec 24, 2018 Jun 24, 2019 None
1573 Suppressed MyD88
0 Cellular Jan 6, 2019 Mar 17, 2019 None
1574 Inhibition, IKK complex
0 Molecular Jan 7, 2019 Jan 7, 2019 278: IKK complex inhibition leading to liver injury
1575 Activation, Caspase 8 pathway
0 Molecular Jan 7, 2019 Mar 7, 2019 278: IKK complex inhibition leading to liver injury
1576 Activation, Tissue resident cells (Kuppfer cells)
0 Cellular Jan 7, 2019 Jan 7, 2019 278: IKK complex inhibition leading to liver injury
1577 Increased, proinflammatory mediators (TNFalpha)
0 Molecular Jan 7, 2019 Jan 7, 2019 None
1578 Increase, Necrotic tissue
0 Tissue Jan 7, 2019 Jan 7, 2019 None
1579 Increase, proinflammatory mediators (TNFalpha)
0 Molecular Jan 7, 2019 Jan 7, 2019 278: IKK complex inhibition leading to liver injury
1566 Suppressed NF-kB
0 Cellular Dec 24, 2018 Dec 24, 2018 None
1581 Disturbance in microtubule dynamic instability
0 Cellular Jan 29, 2019 Jan 29, 2019 279: Microtubule interacting drugs lead to peripheral neuropathy
1582 Impaired axonial transport
0 Cellular Jan 29, 2019 Jan 29, 2019