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All Key Events

Showing 26 to 50 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
173	N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
39	Increased Cholinergic Signaling Short Name Increased Cholinergic Signaling	3	Organ	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
2308	Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors Short Name	3	Organ	Jan 14, 2025	Feb 13, 2025	568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
2159	Influenza A virus (IAV) cell entry Short Name IAV cell entry	3	Cellular	Aug 11, 2023	Oct 3, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
1235	Non-neuronal production of IL-8/CXCL1, Epithelial irritation Short Name	3	Tissue	Nov 29, 2016	Dec 3, 2016	None
1238	Activation of oxidative stress pathway Short Name Oxidation	3	Molecular	Nov 29, 2016	Jun 19, 2017	594: Micro plastic effect on reproduction
1243	Altered, Ca2+-calmodulin activated signal transduction Short Name	3	Cellular	Nov 29, 2016	Jun 7, 2018	4 AOPs 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1132	Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	3	Cellular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1134	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	3	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1495	Substance interaction with the lung resident cell membrane components Short Name Interaction with the lung cell membrane	3	Molecular	Jan 2, 2018	Jun 22, 2026	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1446	Decrease, Coupling of oxidative phosphorylation Short Name Decrease, Coupling of OXPHOS	3	Cellular	Jun 29, 2017	Nov 7, 2025	15 AOPs 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	3	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2090	Increase, Bone Remodeling Short Name Bone Remodeling	3	Tissue	Jan 11, 2023	Aug 13, 2024	482: Deposition of energy leading to occurrence of bone loss
2118	Succinate dehydrogenase, inhibited Short Name SDH, inhibited	3	Molecular	Apr 3, 2023	May 4, 2023	5 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function
1867	Bradykinin system, hyperactivated Short Name Bradykinin, activated	3	Molecular	Apr 20, 2021	Jan 24, 2022	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
1901	Interferon-I antiviral response, antagonized by SARS-CoV-2 Short Name IFN-I response, antagonized	3	Cellular	Jul 9, 2021	Dec 15, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2078	Loss of drebrin Short Name Loss of drebrin	3	Cellular	Dec 11, 2022	Apr 3, 2025	2 AOPs 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
2089	Altered Bone Cell Homeostasis Short Name Altered Bone Cell Homeostasis	2	Cellular	Jan 11, 2023	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2091	Occurrence, Bone Loss Short Name Bone Loss	2	Organ	Jan 11, 2023	Aug 23, 2024	482: Deposition of energy leading to occurrence of bone loss
2147	Decreased, Viable Offspring Short Name Decreased, Viable Offspring	2	Individual	Jun 2, 2023	Apr 10, 2024	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
2028	Decrease, GLI1/2 translocation to nucleus Short Name Decrease, GLI1/2 translocation	2	Molecular	Jul 15, 2022	Oct 28, 2022	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2042	Increase, Orofacial clefting Short Name orofacial cleft	2	Individual	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2041	Decrease, facial prominence outgrowth Short Name Decrease, facial prominence outgrowth	2	Tissue	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting