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All Key Events

Showing 51 to 75 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2040	Decrease, GLI1/2 target gene expression Short Name Decrease, GLI1/2 target gene expression	2	Cellular	Jul 25, 2022	Apr 2, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
1944	Synaptic dysfunction Short Name Dysfunctional synapses	2	Organ	Oct 26, 2021	Aug 4, 2025	3 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
1866	Fibrinolysis, decreased Short Name Hypofibrinolysis	2	Molecular	Apr 20, 2021	Oct 19, 2021	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
49	Reduction, Ca and HCO3 transport to shell gland Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
18	Activation, AhR Short Name Activation, AhR	2	Molecular	Nov 29, 2016	May 31, 2025	22 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 57: AhR activation leading to hepatic steatosis 131: Aryl hydrocarbon receptor activation leading to uroporphyria 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression 577: AhR activation leading to endometriosis
272	Activation/Proliferation, T-cells Short Name Activation/Proliferation, T-cells	2	Organ	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
285	Reduction, Vitellogenin synthesis in liver Short Name	2	Tissue	Nov 29, 2016	May 27, 2026	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
111	Agonism, Estrogen receptor Short Name Agonism, Estrogen receptor	2	Molecular	Nov 29, 2016	Sep 11, 2025	8 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 200: Estrogen receptor activation leading to breast cancer 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
118	Formation, Formation of hemoglobin adducts Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
79	Inhibition, Cyclooxygenase activity Short Name Inhibition, Cyclooxygenase activity	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 28: Cyclooxygenase inhibition leading reproductive failure 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
129	Reduction, Gonadotropins, circulating concentrations Short Name	2	Organ	Nov 29, 2016	May 9, 2018	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
77	Production, Critical Metabolites (CGA 330050 and CGA 265307) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
188	Neuroinflammation Short Name Neuroinflammation	2	Tissue	Nov 29, 2016	Jul 15, 2022	10 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 471: Neuron defect induced early behavioral change 535: Binding and activation of GPER leading to learning and memory impairments 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
246	Increase, RBC congestion in liver Short Name Increase, RBC congestion in liver	2	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
151	Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Short Name	2	Molecular	Nov 29, 2016	Nov 5, 2020	None
167	Activation, LXR Short Name Activation, LXR	2	Molecular	Nov 29, 2016	May 21, 2024	3 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
295	Induction, Upregulation of glucuronyltransferase activity Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
298	Insufficiency, Vascular Short Name Insufficiency, Vascular	2	Molecular	Nov 29, 2016	Jul 20, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
317	Altered, Cardiovascular development/function Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
305	Inhibition, VegfR2 Short Name Inhibition, VegfR2	2	Molecular	Nov 29, 2016	Jan 17, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
341	Impairment, Learning and memory Short Name Impairment, Learning and memory	2	Individual	Nov 29, 2016	Apr 27, 2026	22 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 99: Histamine (H2) receptor antagonism leading to reduced survival 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 483: Deposition of Energy Leading to Learning and Memory Impairment 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 535: Binding and activation of GPER leading to learning and memory impairments 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
398	Activation, Dendritic Cells Short Name Activation, Dendritic Cells	2	Cellular	Nov 29, 2016	Dec 3, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
388	Overactivation, NMDARs Short Name Overactivation, NMDARs	2	Cellular	Nov 29, 2016	Jul 14, 2024	5 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
381	Reduced levels of BDNF Short Name BDNF, Reduced	2	Molecular	Nov 29, 2016	Apr 4, 2019	5 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 375: test AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
768	Increase, Cytotoxicity Short Name Increase, Cytotoxicity	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease