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All Key Events

Showing 76 to 100 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

826	Activation, Keratinocytes Short Name Activation, Keratinocytes	2	Cellular	Nov 29, 2016	Sep 16, 2017	40: Covalent Protein binding leading to Skin Sensitisation
779	Increase, Papillomas/carcinomas (squamous cells) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
773	Increase, Endometrial adenocarcinomas Short Name Increase, Endometrial adenocarcinomas	2	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
772	Increase, Hyperplasia (glandular epithelial cells of endometrium) Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	3 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
813	Increased, Serum creatinine Short Name Increased, Serum creatinine	2	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
800	Decreased, Aromatase (Cyp19a1) mRNA Short Name Decreased, Aromatase (Cyp19a1) mRNA	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
853	Changes/Inhibition, Cellular Homeostasis and Apoptosis Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
850	Induction, CYP1A2/CYP1A5 Short Name Induction, CYP1A2/CYP1A5	2	Molecular	Nov 29, 2016	May 30, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
797	Increase, Adenomas/carcinomas (urothelial) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
799	Increased, HIF-1 heterodimer Short Name Increased, HIF-1 heterodimer	2	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
856	Formation, Hepatocellular and Bile duct tumors Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
870	Increase, Cell Proliferation Short Name Increase, Cell Proliferation	2	Cellular	Nov 29, 2016	Dec 10, 2024	9 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 303: Frustrated phagocytosis-induced lung cancer 272: Deposition of energy leading to lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 451: Interaction with lung resident cell membrane components leads to lung cancer 478: Deposition of energy leading to occurrence of cataracts 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
868	Increase, Tissue Degeneration, Necrosis & Atrophy Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
862	Not Increased, Circulating Ketone Bodies Short Name	2	Tissue	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
421	Increased, glomerular rupture and renal hemorrhaging Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
454	Increased, Triglyceride formation Short Name Increased, Triglyceride formation	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
457	Activation, SREBF1 Short Name Activation, SREBF1	2	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 62: AKT2 activation leading to hepatic steatosis
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
527	Decreased, Decreased fecundity Short Name Decreased, Decreased fecundity	2	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
531	Decreased, LH Surge Short Name Decreased, LH Surge	2	Cellular	Nov 29, 2016	Jan 13, 2025	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 512: Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
406	decreased, Fertility Short Name decreased, Fertility	2	Individual	Nov 29, 2016	Dec 17, 2024	13 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle