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All Key Events

Showing 126 to 150 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

948	reduced production, VEGF Short Name reduced production, VEGF	2	Cellular	Nov 29, 2016	Mar 28, 2018	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
962	Increase, Mucin production Short Name Increase, Mucin production	2	Cellular	Nov 29, 2016	Mar 9, 2023	148: EGFR Activation Leading to Decreased Lung Function
1000	stabilization, PPAR alpha co-repressor Short Name stabilization, PPAR alpha co-repressor	2	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
973	KE5 : Decrease, AKT/eNOS activity Short Name Decrease, AKT/eNOS activity	2	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
981	Reduction, NFAT/AP-1 complex formation Short Name Reduction, NFAT/AP-1 complex formation	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
980	Inhibition, Calcineurin Activity Short Name Inhibition, Calcineurin Activity	2	Molecular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1825	Increase, Cell death Short Name Increase, Cell death	2	Cellular	Dec 4, 2020	Nov 27, 2024	12 AOPs 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 368: Cytochrome oxidase inhibition leading to increased nasal lesions 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 482: Deposition of energy leading to occurrence of bone loss 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function 472: DNA adduct formation leading to kidney failure
1670	Lung cancer Short Name Lung cancer	2	Organ	Jul 3, 2019	Aug 13, 2019	5 AOPs 303: Frustrated phagocytosis-induced lung cancer 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 451: Interaction with lung resident cell membrane components leads to lung cancer
1690	Decrease, circulating testosterone levels Short Name	2	Tissue	Aug 30, 2019	Mar 20, 2026	12 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 124: HMG-CoA reductase inhibition leading to decreased fertility 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 595: Emerging OPFRS reproductive outcome pathway
1234	Production of nerve growth factor , Epithelial irritation Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	None
1226	Increased Respiratory irritability and Chronic Cough, Short Name Respiratory irritability	2	Organ	Nov 29, 2016	Sep 24, 2018	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1225	Immune system inflammation Short Name Leukocyte infiltration	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1224	Non-neuronal production of TNF, Epithelial irritation Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	None
1024	Increased, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	None
1026	Increased Apoptosis, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1065	Activation, estrogen receptor alpha Short Name Activation, ERα	2	Molecular	Nov 29, 2016	Jan 28, 2026	11 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
1068	Endometrial squamous metaplasia, Increase Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1070	Increased, adenosquamous carcinomas of endometrium Short Name	2	Tissue	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1075	prolonged, estrus cycle Short Name prolonged, estrus cycle	2	Individual	Nov 29, 2016	Oct 3, 2025	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1079	Increased, Adenomas/carcinomas (mammary) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1081	Increased, lactotroph hyperplasia and hypertrophy Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1093	Decreased, Thyroxine (T4) in tissues Short Name Decreased, Thyroxine (T4) in tissues	2	Tissue	Nov 29, 2016	Sep 3, 2020	None
1101	Altered, Amphibian metamorphosis Short Name Altered, Amphibian metamorphosis	2	Organ	Nov 29, 2016	Sep 2, 2020	11 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1110	Increased, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	183: Nosema infection increases energetic demands leading to colony loss/failure
1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Short Name	2	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans