AOP-Wiki

API

All Key Events

Showing 151 to 175 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1282	Activation, JAK/STAT pathway Short Name Activation, JAK/STAT pathway	2	Cellular	Feb 15, 2017	Sep 16, 2017	208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
1286	Down Regulation, GSS and GSTs gene Short Name Down Regulation, GSS and GSTs gene	2	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1320	Increased, extracellular serotonin Short Name Increased, extracellular serotonin	2	Molecular	Apr 13, 2017	Feb 13, 2025	8 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1497	Increased, recruitment of inflammatory cells Short Name Recruitment of inflammatory cells	2	Tissue	Jan 3, 2018	May 12, 2023	8 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 303: Frustrated phagocytosis-induced lung cancer 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1202	Suppression, IL-2 and IL-4 production Short Name Suppression, IL-2 and IL-4 production	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1130	Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1133	Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1169	Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1151	Osteoporosis and vascular calcification, Bone deterioration Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1208	Increased, Male offspring Short Name Increased, Male offspring	2	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1138	Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1116	Decreased, Triiodothyronine (T3) in tissues Short Name	2	Tissue	Nov 29, 2016	Sep 1, 2020	2 AOPs 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
2401	Male preputial separation, failed/delayed Short Name Male PPS, failed/delayed	2	Tissue	Dec 15, 2025	Feb 6, 2026	619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
2393	Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced Short Name	2	Cellular	Dec 3, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
2371	Increased cortisol Short Name Increased cortisol	2	Cellular	Sep 11, 2025	Oct 31, 2025	604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
2251	Estradiol availability, increased Short Name Increased E2 availability	2	Tissue	Aug 9, 2024	Nov 21, 2024	4 AOPs 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
2245	Altered Cell Differentiation Signaling Short Name Altered cell differentiation signaling	2	Molecular	Jul 24, 2024	Apr 18, 2025	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2300	Disruption, Glucolipid metabolism Short Name Disruption, Glucolipid metabolism	2	Cellular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2266	Demyelination, increased Short Name Demyelination, increased	2	Cellular	Oct 1, 2024	Oct 1, 2024	3 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2275	Gluten reactive adaptive T-cells with antigen presenting cells, co-localization Short Name	2	Cellular	Nov 12, 2024	Dec 20, 2024	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2271	Increased, plasma low-density lipoprotein (LDL) cholesterol Short Name Increased, plasma LDL cholesterol	1	Tissue	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2294	Plasma estradiol, increased Short Name Plasma E2, increased	1	Cellular	Nov 22, 2024	Apr 6, 2026	5 AOPs 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2293	Aromatase, induction Short Name Aromatase, induction	1	Molecular	Nov 22, 2024	Feb 21, 2025	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2258	Inhibition, monocarboxylate transporter 8 (MCT8) Short Name	1	Molecular	Aug 28, 2024	Nov 24, 2025	610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2298	Decrease, intratesticular testosterone levels Short Name Decrease, intratesticular testosterone	1	Organ	Dec 12, 2024	Mar 20, 2026	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring