AOP-Wiki

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All Key Events

Showing 1751 to 1775 of 1946 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

402	Cognitive function, decreased Short Name Cognitive function, decreased	2	Individual	Nov 29, 2016	Jul 25, 2024	15 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 486: Binding to the extracellular protein laminin leading to decreased cognitive function 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
451	Inhibition, Mitochondrial fatty acid beta-oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis
450	Decrease, Very low-density lipoprotein export capacity Short Name Decrease, VLDL export capacity	1	Cellular	Nov 29, 2016	Feb 12, 2026	57: AhR activation leading to hepatic steatosis
447	Reduction, Cholesterol transport in mitochondria Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males
446	Reduction, fetal/adult testosterone Short Name Reduction of testosterone	1	Tissue	Nov 29, 2016	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
445	Respiratory distress/arrest Short Name Respiratory distress/arrest	1	Organ	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 94: Sodium channel inhibition leading to congenital malformations
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
442	Decreased, Population trajectory Short Name Decreased, Population trajectory	1	Population	Nov 29, 2016	Apr 18, 2017	3 AOPs 435: Deposition of ionising energy leads to population decline via pollen abnormal 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
429	Cellular Proliferation and Clonal Expansion of Mutant Cells (Pre-neoplastic Foci), Alteration of cellular growth homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
382	Aberrant, Dendritic morphology Short Name Aberrant, Dendritic morphology	1	Cellular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
401	Increase, Biliary excretion TH glucuronide Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	None
398	Activation, Dendritic Cells Short Name Activation, Dendritic Cells	2	Cellular	Nov 29, 2016	Dec 3, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
397	Response, Keratinocytes Short Name Response, Keratinocytes	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
396	Covalent Binding, Protein Short Name Covalent Binding, Protein	1	Molecular	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
389	Increased, Intracellular Calcium overload Short Name	1	Cellular	Nov 29, 2016	Jun 26, 2020	7 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 535: Binding and activation of GPER leading to learning and memory impairments 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
388	Overactivation, NMDARs Short Name Overactivation, NMDARs	2	Cellular	Nov 29, 2016	Jul 14, 2024	5 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
387	Binding of agonist, NMDARs Short Name Binding of agonist, NMDARs	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
386	Decrease of neuronal network function Short Name Neuronal network function, Decreased	1	Organ	Nov 29, 2016	May 28, 2018	13 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 501: Excessive iron accumulation leading to neurological disorders 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 522: Estrogen antagonism leading to increased risk of autism-like behavior 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
385	Decrease of synaptogenesis Short Name Synaptogenesis, Decreased	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
384	Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
383	Reduced, Presynaptic release of glutamate Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
360	Decrease, Population growth rate Short Name Decrease, Population growth rate	1	Population	Nov 29, 2016	Jan 3, 2023	61 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 29: Estrogen receptor agonism leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 292: Inhibition of tyrosinase leads to decreased population in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 289: Inhibition of 5α-reductase leading to decreased population growth rate via impaired fecundity in female fish 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 376: Androgen receptor agonism leading to male-biased sex ratio 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
381	Reduced levels of BDNF Short Name BDNF, Reduced	2	Molecular	Nov 29, 2016	Apr 4, 2019	9 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 375: test AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
380	Activation, Pre-MIE: Metabolism of AFB1 Short Name Activation, Pre-MIE: Metabolism of AFB1	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
378	Tumorigenesis, Hepatocellular carcinoma Short Name Tumorigenesis, Hepatocellular carcinoma	1	Individual	Nov 29, 2016	Nov 29, 2016	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)