AOP-Wiki

API

All Key Events

Showing 1801 to 1825 of 1946 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

352	N/A, Neurodegeneration Short Name N/A, Neurodegeneration	1	Tissue	Nov 29, 2016	Feb 23, 2021	7 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 471: Neuron defect induced early behavioral change
357	Cholestasis, Pathology Short Name Cholestasis, Pathology	1	Individual	Nov 29, 2016	Dec 3, 2016	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
358	Increase, Pericardial edema Short Name Increase, Pericardial edema	1	Organ	Nov 29, 2016	Sep 16, 2017	None
320	Increase, Curved body axis Short Name Increase, Curved body axis	0		Nov 29, 2016	Nov 29, 2016	None
319	Loss, Cochlear function Short Name Loss, Cochlear function	1	Organ	Nov 29, 2016	Sep 16, 2017	8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
317	Altered, Cardiovascular development/function Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
315	Decreased, Body length Short Name Decreased, Body length	0		Nov 29, 2016	Nov 29, 2016	None
313	Increase, Allergic Respiratory Hypersensitivity Response Short Name	1	Organ	Nov 29, 2016	Feb 7, 2023	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
312	N/A, Allergic contact dermatitis on challenge Short Name	0	Individual	Nov 29, 2016	Nov 29, 2016	None
288	Activation of specific nuclear receptors, Transcriptional change Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
286	Altered, Transcription of genes by the androgen receptor Short Name	1	Tissue	Nov 29, 2016	Mar 20, 2026	14 AOPs 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 495: Androgen receptor activation leading to prostate cancer 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 372: Androgen receptor antagonism leading to testicular cancer 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
289	Decrease, Translocator protein (TSPO) Short Name Decrease, Translocator protein (TSPO)	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
291	Accumulation, Triglyceride Short Name Accumulation, Triglyceride	1	Cellular	Nov 29, 2016	Mar 26, 2024	8 AOPs 34: LXR activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
294	N/A, Unknown Short Name N/A, Unknown	0	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 33: Kidney toxicity induced by activation of 5HT2C 1: Uncharacterized liver damage leading to hepatocellular carcinoma
295	Induction, Upregulation of glucuronyltransferase activity Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
298	Insufficiency, Vascular Short Name Insufficiency, Vascular	2	Molecular	Nov 29, 2016	Jul 20, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
301	Binding, VEGF-A Short Name Binding, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
302	Production, VEGF-A Short Name Production, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
304	Decreased, VegfR2 Short Name Decreased, VegfR2	0		Nov 29, 2016	Nov 29, 2016	None
305	Inhibition, VegfR2 Short Name Inhibition, VegfR2	2	Molecular	Nov 29, 2016	Jan 17, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
307	Increase, Vitellogenin synthesis in liver Short Name	1	Tissue	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
310	Alteration, Wnt pathway Short Name Alteration, Wnt pathway	1	Cellular	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
145	Induction, IKB inhibitory protein Short Name Induction, IKB inhibitory protein	1	Cellular	Nov 29, 2016	Sep 16, 2017	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility