AOP-Wiki

API

All Key Events

Showing 1826 to 1850 of 1946 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

142	Hyperplasia, Hyperplasia Short Name Hyperplasia, Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
140	Decreased, HSD17B10 expression Short Name Decreased, HSD17B10 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Short Name	1	Tissue	Nov 29, 2016	Nov 29, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
243	Reduction, Prostaglandin E2 concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
228	peroxisome proliferator activated receptor promoter demethylation Short Name demethylation, PPARg promoter	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 72: Epigenetic modification of PPARG leading to adipogenesis 510: Demethylation of PPAR promotor leading to vascular disrupting effects
231	Decreased, PPAR-alpha activation Short Name Decreased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
232	Decreased, PPAR-beta activation Short Name Decreased, PPAR-beta activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
233	Decreased, PPAR-gamma activation Short Name Decreased, PPAR-gamma activation	1	Molecular	Nov 29, 2016	Oct 30, 2023	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
234	Activation, PPARα & PPARγ Short Name Activation, PPARα & PPARγ	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
238	Induction, Pre-mature molting Short Name Induction, Pre-mature molting	0		Nov 29, 2016	Nov 29, 2016	None
239	Activation, Pregnane-X receptor, NR1I2 Short Name Activation, Pregnane-X receptor, NR1I2	1	Molecular	Nov 29, 2016	May 25, 2026	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
240	Feminisation or incomplete development, Primary and accessory male sex organs Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
227	Activation, PPARα Short Name Activation, PPARα	1	Molecular	Nov 29, 2016	Dec 28, 2020	9 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 61: NFE2L2/FXR activation leading to hepatic steatosis 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
244	Alkylation, Protein Short Name Alkylation, Protein	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 258: Renal protein alkylation leading to kidney toxicity
245	Activation, PXR/SXR Short Name Activation, PXR/SXR	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 11: Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
246	Increase, RBC congestion in liver Short Name Increase, RBC congestion in liver	2	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
250	Damaging, Red blood cells; hemolysis Short Name Damaging, Red blood cells; hemolysis	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
252	Increase, Renal pathology due to VTG deposition Short Name	1	Organ	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
253	N/A, Reproductive failure Short Name N/A, Reproductive failure	1	Individual	Nov 29, 2016	Dec 3, 2016	28: Cyclooxygenase inhibition leading reproductive failure
258	Activation, SCD-1 Short Name Activation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
261	Binding, SH-/selen-proteins Short Name Binding, SH-/selen-proteins	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
209	Peptide Oxidation Short Name Peptide Oxidation	1	Molecular	Nov 29, 2016	Nov 13, 2017	4 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 149: Peptide Oxidation Leading to Hypertension 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
186	Altered, Neuroanatomy Short Name Altered, Neuroanatomy	1	Organ	Nov 29, 2016	Sep 16, 2017	65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
188	Neuroinflammation Short Name Neuroinflammation	2	Tissue	Nov 29, 2016	Jul 15, 2022	10 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 471: Neuron defect induced early behavioral change 535: Binding and activation of GPER leading to learning and memory impairments 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
191	Neuronal dysfunction Short Name Neuronal dysfunction	1	Cellular	Nov 29, 2016	Apr 7, 2022	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 471: Neuron defect induced early behavioral change