AOP-Wiki

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All Key Events

Showing 1876 to 1900 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2125	Increased fat mass Short Name Increased fat mass	0	Organ	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2126	Estrogen receptor alpha inactivation Short Name ERa inactivation	0	Molecular	Apr 5, 2023	Apr 10, 2023	2 AOPs 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
1871	olfactory sensory neurons, decrease Short Name olfacotry neurons, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1855	Increased Sodium-sensitive hypertension Short Name Increased Sodium-sensitive hypertension	0	Tissue	Apr 7, 2021	Apr 7, 2021	384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1856	Imbalanced salty and sweet taste responses Short Name Sodium inhibition, Sweet enhancement	0	Tissue	Apr 7, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1857	Platelet-neutrophil interactions, Increased Short Name	0	Cellular	Apr 8, 2021	Apr 8, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation
1876	ACE2 shedding effects on viral entry Short Name Hyunjoon Kong	0	Cellular	Apr 28, 2021	Apr 28, 2021	None
1875	Cerebrovascular disease (stroke) Short Name stroke	0	Organ	Apr 27, 2021	Mar 30, 2022	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1874	blood brain barrier disruption Short Name BBB disruption	0	Cellular	Apr 27, 2021	Apr 27, 2021	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1873	impaired olfactory function (anosmia) Short Name anosmia	0	Organ	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1872	Olfactory epithelium degeneration Short Name Olfactory epithelium degeneration	0	Tissue	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1862	Decrease, Photosystem II efficiency Short Name Decrease, Photosystem II efficiency	0	Cellular	Apr 11, 2021	Jan 16, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1870	Sustentacular cells, decrease Short Name Sustentacular cells, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1858	Increased viral transcription and replication Short Name	0	Cellular	Apr 9, 2021	Apr 9, 2021	None
1859	Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1860	Increase, Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1861	Increase, D1 protein deactivation Short Name D1 protein deactivation	0	Cellular	Apr 11, 2021	Apr 11, 2021	386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1865	Increase, Oxygen-evolving complex damage Short Name Increase, OEC damage	0	Molecular	Apr 11, 2021	Apr 11, 2021	389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1864	Increase, Programmed cell death Short Name Increase, Programmed cell death	0	Cellular	Apr 11, 2021	Apr 12, 2021	388: Deposition of ionising energy leading to population decline via programmed cell death
1863	Decrease, Reproduction Short Name Decrease, Reproduction	0	Individual	Apr 11, 2021	Apr 11, 2021	9 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
1925	Increased，Vascular smooth muscle cell activation Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1920	Altered gene expression, TGF-β dependent fibrosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
1926	Increased，Vascular fibrosis Short Name Increased，Vascular fibrosis	0	Tissue	Aug 19, 2021	Sep 1, 2021	None
1927	Increased，Vascular endothelial cell autophagy dysfunction Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1928	increased，Vascular endothelial dysfunction Short Name	0	Tissue	Aug 19, 2021	Sep 1, 2021	6 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways