AOP-Wiki

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All Key Events

Showing 1901 to 1925 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

18	Activation, AhR Short Name Activation, AhR	2	Molecular	Nov 29, 2016	May 31, 2025	22 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 57: AhR activation leading to hepatic steatosis 131: Aryl hydrocarbon receptor activation leading to uroporphyria 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression 577: AhR activation leading to endometriosis
17	Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway Short Name	0	Molecular	Nov 29, 2016	Aug 19, 2021	2 AOPs 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
12	Acetylcholinesterase (AchE) Inhibition Short Name AchE Inhibition	1	Cellular	Nov 29, 2016	Apr 29, 2020	7 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
10	Acetylcholine accumulation in synapses Short Name ACh Synaptic Accumulation	1	Cellular	Nov 29, 2016	Jun 26, 2020	5 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 471: Neuron defect induced early behavioral change
9	Activation, 5HT2c Short Name Activation, 5HT2c	1	Molecular	Nov 29, 2016	Sep 16, 2017	33: Kidney toxicity induced by activation of 5HT2C
8	Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
106	Reduction, Eggshell thickness Short Name Reduction, Eggshell thickness	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
105	Inhibition, Mitochondrial Electron Transport Chain Complexes Short Name	0	Molecular	Nov 29, 2016	Mar 22, 2023	4 AOPs 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
110	Impairment, Endothelial network Short Name Impairment, Endothelial network	1	Cellular	Nov 29, 2016	Jan 18, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
111	Agonism, Estrogen receptor Short Name Agonism, Estrogen receptor	2	Molecular	Nov 29, 2016	Sep 11, 2025	8 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 200: Estrogen receptor activation leading to breast cancer 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
112	Antagonism, Estrogen receptor Short Name Antagonism, Estrogen receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 30: Estrogen receptor antagonism leading to reproductive dysfunction 443: DNA damage and mutations leading to Metastatic Breast Cancer 522: Estrogen antagonism leading to increased risk of autism-like behavior 595: Emerging OPFRS reproductive outcome pathway
115	Increase, Fatty acid influx Short Name Increase, FA influx	1	Cellular	Nov 29, 2016	Feb 11, 2026	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
116	Activation, FAS Short Name Activation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
118	Formation, Formation of hemoglobin adducts Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
119	N/A, Gap Short Name N/A, Gap	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
122	Increase, Glucocorticoid receptor activation Short Name Increase, GR activation	1	Molecular	Nov 29, 2016	Feb 12, 2026	11 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 214: Network of SSRIs (selective serotonin reuptake inhibitors) 318: Glucocorticoid Receptor activation leading to hepatic steatosis 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
129	Reduction, Gonadotropins, circulating concentrations Short Name	2	Organ	Nov 29, 2016	May 9, 2018	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
130	Depletion, GSH Short Name Depletion, GSH	1	Cellular	Nov 29, 2016	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
131	Down Regulation, Gulcose-6-phosphate dehydrogenase Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
134	Increase, Kupffer cell activation Short Name Increase, Kupffer cell activation	1	Cellular	Nov 29, 2016	Feb 11, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
77	Production, Critical Metabolites (CGA 330050 and CGA 265307) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
54	Up Regulation, CD36 Short Name Up Regulation, CD36	1	Molecular	Nov 29, 2016	Mar 26, 2024	5 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
55	Increase, Cell injury/death Short Name Cell injury/death	1	Cellular	Nov 29, 2016	May 27, 2024	29 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 38: Protein Alkylation leading to Liver Fibrosis 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 144: Endocytic lysosomal uptake leading to liver fibrosis 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 278: IKK complex inhibition leading to liver injury 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 273: Mitochondrial complex inhibition leading to liver injury 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 494: AhR activation leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
57	Proliferation, Cell proliferation in the absence of cytotoxicity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
59	Inhibition of Apoptosis in Altered Hepatic Foci, Changes in Cellular Growth Homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None