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All Key Events

Showing 1901 to 1925 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1929	Increased incidence of cardiovascular morbidity and mortality in the general population Short Name	0	Population	Aug 21, 2021	Aug 21, 2021	519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
1932	Gastrointestinal disorders Short Name GI disorders	0	Individual	Sep 2, 2021	Sep 8, 2021	None
1933	Increased, Interleukin-6 production Short Name Increased IL-6 production	0	Cellular	Sep 20, 2021	Sep 20, 2021	416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1934	Myocardial Infarction Short Name Heart attack	0	Organ	Oct 15, 2021	Oct 15, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1935	Angiotensin (1-7) levels diminished Short Name Ang (1-7) levels reduced	0	Molecular	Oct 15, 2021	Oct 15, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1936	Angiotensin II degradation reduced Short Name Degradation of Ang-II reduced	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1937	ADAM17 expression induction Short Name ADAM17 induction	0	Cellular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1938	ACE2 increased shedding Short Name ACE2 increased shedding	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1924	Increased，Cardiac fibrosis Short Name Increased，Cardiac fibrosis	0	Organ	Aug 19, 2021	Sep 1, 2021	550: Increased LMNA gene mutation leading to heart failure
1923	Altered gene expression, P53 dependent apoptosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
1922	Increased, Reactive metabolites production Short Name Increased, metabolites	0	Cellular	Aug 19, 2021	Aug 26, 2021	417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
1921	Altered gene expression, NF-kB dependent Interleukin-6 pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	2 AOPs 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1919	Increased，Cardiac Dysregulation Short Name Increased，Cardiac dysfunction	0	Tissue	Aug 18, 2021	Sep 1, 2021	None
1918	Increased，Myocardial apoptosis Short Name Increased，Myocardial apoptosis	0	Cellular	Aug 18, 2021	Sep 1, 2021	None
1917	Altered gene expression, NRF2 dependent antioxidant pathway Short Name	0	Molecular	Aug 17, 2021	Aug 19, 2021	3 AOPs 421: PPARG activation leading to intrahepatic cholestasis 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1916	Thromboinflammation, Increased Short Name Thromboinflammation, Increased	0	Organ	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1915	Neutrophil activation, Increased Short Name Neutrophil activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1914	Platelet activation, Increased Short Name Platelet activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1913	Endothelial cell dysfunction Short Name Endothelial cell dysfunction	0	Cellular	Aug 4, 2021	Aug 4, 2021	2 AOPs 412: Endothelial cell dysfunction leading to thromboinflammation 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1905	eya1 expression, inhibited Short Name eya1 expression, inhibited	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1904	six1b expression, increased Short Name six1b expression, increased	0	Molecular	Jul 14, 2021	Aug 12, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1903	foxi1 expression, increased Short Name foxi1 expression, increased	0	Molecular	Jul 14, 2021	Oct 28, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1902	Repression of Gbx2 expression Short Name Repression of Gbx2 expression	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1900	increased platelet surface TLR9 expression Short Name increased platelet tlr9 expression	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1899	formation of neutrophil extracellular traps (NETs) Short Name NETosis	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)