AOP-Wiki

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All Key Events

Showing 1926 to 1939 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

60	Induction, Chitin degradation and resorption Short Name	0		Nov 29, 2016	Nov 29, 2016	None
64	Reduction, Ionotropic GABA receptor chloride channel conductance Short Name	1	Cellular	Nov 29, 2016	Feb 6, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
66	Activation, ChREBP Short Name Activation, ChREBP	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
68	Increase, Collagen accumulation Short Name Increase, Collagen accumulation	1	Tissue	Nov 29, 2016	Feb 11, 2026	12 AOPs 38: Protein Alkylation leading to Liver Fibrosis 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
75	N/A, Covalent binding to protein, possibly lysine residue Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
52	Decreased, Calcium influx Short Name Decreased, Calcium influx	1	Cellular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
78	Reduction, Cumulative fecundity and spawning Short Name	1	Individual	Nov 29, 2016	Mar 20, 2017	17 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
79	Inhibition, Cyclooxygenase activity Short Name Inhibition, Cyclooxygenase activity	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 28: Cyclooxygenase inhibition leading reproductive failure 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
80	Up Regulation, CYP1A1 Short Name Up Regulation, CYP1A1	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 57: AhR activation leading to hepatic steatosis 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
84	Up Regulation, CYP1B1 Short Name Up Regulation, CYP1B1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
87	Release, Cytokine Short Name Release, Cytokine	1	Cellular	Nov 29, 2016	Sep 16, 2017	5 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 303: Frustrated phagocytosis-induced lung cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
89	Synthesis, De Novo Fatty Acid (FA) Short Name Synthesis, De Novo Fatty Acid (FA)	1	Cellular	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
97	Alkylation, DNA Short Name Alkylation, DNA	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 141: Alkylation of DNA leading to cancer 2 322: Alkylation of DNA leading to decreased sperm count
103	Increase, Ecdysone receptor hyperactivation Short Name Increase, EcR hyperactivation	1	Molecular	Nov 29, 2016	Sep 29, 2025	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade