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All Key Events

Showing 176 to 200 of 1937 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2299	Altered, Redox Homeostasis Short Name Altered, Redox Homeostasis	1	Molecular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2276	Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) Short Name Increased, PCSK9 protein expression	1	Cellular	Nov 13, 2024	Feb 10, 2025	548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2274	Androgen receptor activation, increased Short Name Androgen receptor activation, increased	1	Tissue	Nov 2, 2024	Nov 2, 2024	547: Androgen receptor agonism leading to long anogenital distance in female offspring
2273	Dihydrotestosterone (DHT) levels, increased Short Name	1	Tissue	Nov 2, 2024	Nov 2, 2024	None
2272	Testosterone levels, increased Short Name Testosterone levels, increased	1	Tissue	Nov 2, 2024	Nov 2, 2024	None
2270	Increased, cholesterol synthesis enzymes Short Name	1	Cellular	Oct 22, 2024	Feb 10, 2025	545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis
2269	Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression Short Name Increased, SREBP2 protein expression	1	Cellular	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2268	Decreased, insulin-induced gene 1 (INSIG1) protein activity Short Name Decreased, INSIG1 protein activity	1	Cellular	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2301	Abnormal, Behavior Short Name Abnormal, Behavior	1	Individual	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2265	Oligodendrocyte death, increased Short Name Oligodendrocyte death, increased	1	Cellular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2263	Lysolecithin, increased Short Name LPS, increased	1	Cellular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2262	Neuropathy target esterase, inhibited Short Name NTE, inhibited	1	Molecular	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
2261	Decreased, blood plasma volume Short Name Decreased, blood plasma volume	1	Tissue	Sep 20, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2260	Gluten-reactive CD4+ T cells, activation Short Name	1	Cellular	Sep 13, 2024	Jan 4, 2025	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2306	Persistent vaginal cornification Short Name Persistent vaginal cornification	1	Tissue	Jan 13, 2025	Jan 29, 2026	2 AOPs 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2400	Preputial epithelial morphogenesis, disrupted Short Name	1	Cellular	Dec 15, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
2384	Decrease, Vascular integrity Short Name Decrease, Vascular integrity	1	Tissue	Oct 29, 2025	Nov 7, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
2372	Squamous metaplasia, Increase Short Name Squamous metaplasia, Increase	1	Cellular	Sep 12, 2025	Sep 16, 2025	None
2370	Agonism binding, α1-Adrenoreceptor Short Name A1AR Agonism	1	Molecular	Sep 11, 2025	May 28, 2026	604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
2363	Elevated mitochondrial ROS and dysfunction Short Name Mito ROS dysfunction	1	Cellular	Sep 5, 2025	Oct 3, 2025	2 AOPs 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons 616: organic UV filter and its Photoproducts reproductive toxicity pathways
2330	Sine oculis homeobox 1 protein expression, increased Short Name SIX1 protein expression, increased	1	Molecular	Jul 8, 2025	Dec 17, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2329	Sine oculis homeobox 1 gene expression, increased Short Name SIX1 gene expression, increased	1	Molecular	Jul 8, 2025	Sep 11, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2305	Premature ovarian Insufficiency Short Name POI	1	Organ	Jan 12, 2025	May 7, 2025	563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2317	Loss of olfactory function Short Name Loss of olfactory function	1	Organ	Mar 13, 2025	Mar 25, 2025	574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
2316	Increased, pulmonary edema Short Name Increased, pulmonary edema	1	Organ	Mar 12, 2025	Mar 24, 2025	573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema