| 2312 |
Increased, nasal lesions
Short Name
Increased, nasal lesions
|
1 |
Organ |
Mar 5, 2025 |
Mar 19, 2025 |
368: Cytochrome oxidase inhibition leading to increased nasal lesions
|
| 2155 |
Inhibition of Sulfotransferase E1 (SULT1E1)
Short Name
SULT1E1 inhibition
|
1 |
Molecular |
Jul 28, 2023 |
Feb 21, 2025 |
504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
|
| 2193 |
Influenza A Virus (IAV) budding
Short Name
IAV budding
|
1 |
Cellular |
Oct 2, 2023 |
Jan 29, 2024 |
506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
| 2158 |
Influenza A Virus (IAV) binds sialic acid glycan receptor
Short Name
IAV binds receptor
|
1 |
Molecular |
Jul 31, 2023 |
Aug 2, 2023 |
506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
| 2194 |
Influenza A Virus (IAV) shedding and transmission
Short Name
infection proliferation
|
1 |
Individual |
Oct 2, 2023 |
Oct 2, 2023 |
506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
| 2199 |
Increased, Expression of LXR activated genes
Short Name
Increased, Expression of LXR activated genes
|
1 |
Molecular |
Dec 7, 2023 |
Mar 29, 2024 |
518: Liver X Receptor (LXR) activation leads to liver steatosis
|
| 2402 |
Increased, estradiol (E2) production in ovaries
Short Name
Increased, E2 production in ovaries
|
1 |
Tissue |
Jan 29, 2026 |
Apr 6, 2026 |
4 AOPs
|
| 2418 |
Increased, phenotypic female-biased sex ratio
Short Name
Increased, female-biased sex ratio
|
1 |
Population |
Apr 17, 2026 |
Apr 17, 2026 |
641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
|
| 2417 |
Increased, differentiation to ovaries
Short Name
Increased, differentiation to ovaries
|
1 |
Individual |
Apr 17, 2026 |
Apr 17, 2026 |
641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
|
| 2413 |
Increased, uterine weight
Short Name
Increased, uterine weight
|
1 |
Organ |
Mar 13, 2026 |
Mar 13, 2026 |
637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining
|
| 2414 |
COL3A1 Signaling Pathway
Short Name
COL3A1 Signaling Pathway
|
1 |
Molecular |
Mar 25, 2026 |
Jun 4, 2026 |
638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
|
| 2415 |
Precocious puberty
Short Name
Precocious puberty
|
1 |
Individual |
Mar 26, 2026 |
Mar 26, 2026 |
639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
|
| 2257 |
Celiac disease
Short Name
Celiac disease
|
1 |
Individual |
Aug 13, 2024 |
Dec 2, 2024 |
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
|
| 2236 |
Decreased, Sodium uptake in gills
Short Name
Decreased, sodium uptake in gills
|
1 |
Cellular |
Jul 8, 2024 |
Dec 3, 2024 |
539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
| 2237 |
Decreased, Plasma sodium concentrations
Short Name
Decreased, Plasma sodium concentrations
|
1 |
Tissue |
Jul 8, 2024 |
Dec 3, 2024 |
539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
| 2238 |
Increased, Blood viscosity
Short Name
Increased, Blood viscosity
|
1 |
Tissue |
Jul 8, 2024 |
Dec 3, 2024 |
539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
| 2239 |
Increased, Cardiac stress
Short Name
Increased, Cardiac stress
|
1 |
Organ |
Jul 8, 2024 |
Dec 3, 2024 |
539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
| 2206 |
Increased, histomorphological alteration of testis
Short Name
Increased, histomorphological alteration of testis
|
1 |
Tissue |
Jan 24, 2024 |
Apr 10, 2024 |
521: Essential element imbalance leads to reproductive failure via oxidative stress
|
| 2227 |
Disrupted PPAR isoform nuclear signaling
Short Name
Disrupted PPAR isoform nuclear signaling
|
1 |
Molecular |
May 14, 2024 |
May 22, 2024 |
529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
|
| 2226 |
Stressor binding PPAR isoforms
Short Name
Binding PPAR isoforms
|
1 |
Molecular |
May 8, 2024 |
May 22, 2024 |
529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
|
| 2225 |
Disrupted Lipid Storage
Short Name
Disrupted Lipid Storage
|
1 |
Cellular |
May 8, 2024 |
May 23, 2024 |
529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
|
| 2224 |
Dysregulation of transcriptional expression within PPAR signaling network
Short Name
Dysregulation of transcriptional expression within PPAR signaling network
|
1 |
Molecular |
May 8, 2024 |
May 23, 2024 |
529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
|
| 2244 |
Altered Stress Response Signaling
Short Name
Altered Stress Response Signaling
|
1 |
Molecular |
Jul 24, 2024 |
Nov 15, 2024 |
2 AOPs
|
| 2256 |
Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
Short Name
Activation of gluten- and TG2-reactive B cells
|
1 |
Cellular |
Aug 13, 2024 |
Jan 4, 2025 |
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
|
| 2255 |
Innate immune response, activation
Short Name
Activation of the innate immune response
|
1 |
Cellular |
Aug 13, 2024 |
Apr 3, 2025 |
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
|