AOP-Wiki

API

All Key Events

Showing 1 to 25 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2429	Instability/dysfunction of INSIG1 Short Name Instability of INSIG1	0	Molecular	Jun 9, 2026	Jun 9, 2026	None
1195	modulation, Extracellular Matrix Composition Short Name	1	Cellular	Nov 29, 2016	Jun 4, 2026	2 AOPs 200: Estrogen receptor activation leading to breast cancer 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
2414	COL3A1 Signaling Pathway Short Name COL3A1 Signaling Pathway	1	Molecular	Mar 25, 2026	Jun 4, 2026	638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
2370	Agonism binding, α1-Adrenoreceptor Short Name A1AR Agonism	1	Molecular	Sep 11, 2025	May 28, 2026	604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
285	Reduction, Vitellogenin synthesis in liver Short Name	2	Tissue	Nov 29, 2016	May 27, 2026	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
221	Reduction, Plasma vitellogenin concentrations Short Name	1	Organ	Nov 29, 2016	May 27, 2026	11 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
36	Inhibition, Aromatase Short Name Inhibition, Aromatase	1	Molecular	Nov 29, 2016	May 27, 2026	3 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3	Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Short Name	1	Cellular	Nov 29, 2016	May 27, 2026	9 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 595: Emerging OPFRS reproductive outcome pathway
456	Suppression, Constitutive androstane receptor, NR1I3 Short Name	1	Molecular	Nov 29, 2016	May 25, 2026	58: NR1I3 (CAR) suppression leading to hepatic steatosis
239	Activation, Pregnane-X receptor, NR1I2 Short Name Activation, Pregnane-X receptor, NR1I2	1	Molecular	Nov 29, 2016	May 25, 2026	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
1505	Increase, Cell cycle disruption Short Name Cell cycle disruption	1	Cellular	Jan 21, 2018	May 19, 2026	8 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 396: Deposition of ionizing energy leads to population decline via impaired meiosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption
341	Impairment, Learning and memory Short Name Impairment, Learning and memory	2	Individual	Nov 29, 2016	Apr 27, 2026	22 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 99: Histamine (H2) receptor antagonism leading to reduced survival 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 483: Deposition of Energy Leading to Learning and Memory Impairment 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 535: Binding and activation of GPER leading to learning and memory impairments 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
424	Inhibition, Na+/I- symporter (NIS) Short Name Inhibition, Na+/I- symporter (NIS)	1	Molecular	Nov 29, 2016	Apr 27, 2026	5 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
1656	Antagonism, Thyroid Receptor Short Name TR Antagnoism	0	Molecular	Jun 8, 2019	Apr 27, 2026	4 AOPs 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1889	Increased premature meiotic initiation in fetal male germ cells Short Name premature meiosis, male germ cells	0	Cellular	May 29, 2021	Apr 24, 2026	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
2428	Gut derived PAMPs, increased Short Name PAMPs, increased	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2427	Bile acid composition in bile and intestine, altered Short Name Bile acid composition, altered	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2426	Hepatic BSEP (ABCB11), decreased Short Name BSEP (ABCB11), decreased	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2425	Intrahepatic bile acid burden, increased Short Name Intrahepatic bile acids, increased	0	Cellular	Apr 23, 2026	Apr 23, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2420	Increased, Retinoic Acid Receptor Activation Short Name Increased, RAR activation	0	Tissue	Apr 22, 2026	Apr 23, 2026	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
2419	Decreased, Retinoic Acid Receptor Activation Short Name Decreased, RAR activation	0	Tissue	Apr 22, 2026	Apr 23, 2026	398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
2424	Hepatic CYP7A1, increased Short Name Hepatic CYP7A1, increased	0	Cellular	Apr 22, 2026	Apr 22, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2423	Hepatic SHP, decreased Short Name Hepatic SHP, decreased	0	Cellular	Apr 22, 2026	Apr 22, 2026	232: NFE2/Nrf2 repression to steatosis
2422	Ileal FGF15/FGF19 secretion, decreased Short Name Decreased FGF15/FGF19	0	Cellular	Apr 22, 2026	Apr 22, 2026	642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation