AOP-Wiki

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All Key Events

Showing 1 to 25 of 1922 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1868	Hyperinflammation Short Name Hyperinflammation	10	Tissue	Apr 20, 2021	Dec 29, 2021	4 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 406: SARS-CoV-2 infection leading to hyperinflammation 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2180	Immune mechanisms antagonized by viral proteins Short Name immune mechanisms antagonized	5	Molecular	Aug 23, 2023	Dec 13, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
1847	Increased SARS-CoV-2 production Short Name SARS-CoV-2 production	5	Cellular	Mar 25, 2021	Jun 14, 2022	8 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1669	Increased, DNA damage and mutation Short Name Increased, DNA damage and mutation	5	Cellular	Jul 3, 2019	Aug 13, 2019	6 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1135	Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Short Name	5	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1131	Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) Short Name	4	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1394	Induction, persistent proliferation/sustained proliferation Short Name Sustained proliferation	4	Cellular	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1496	Increased, secretion of proinflammatory mediators Short Name Increased proinflammatory mediators	4	Cellular	Jan 2, 2018	May 17, 2023	11 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response 319: Binding to ACE2 leading to lung fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1223	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea Short Name	4	Tissue	Nov 29, 2016	Sep 24, 2018	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1738	SARS-CoV-2 cell entry Short Name SARS-CoV-2 cell entry	4	Cellular	Mar 1, 2020	Apr 4, 2023	10 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1854	Dysregulation, ACE2 expression and activity Short Name ACE2 dysregulation	4	Molecular	Mar 31, 2021	Feb 18, 2023	3 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis 319: Binding to ACE2 leading to lung fibrosis
1972	Increased, Steroidogenic acute regulatory protein (StAR) Short Name	4	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
2096	Occurrence, (Micro)vascular dysfunction Short Name (Micro)vascular dysfunction	4	Tissue	Jan 23, 2023	Jul 31, 2023	385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
2399	Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced Short Name	4	Cellular	Dec 11, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2192	Influenza A Virus production increased Short Name IAV production increased	4	Molecular	Oct 2, 2023	Jan 29, 2024	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2242	Abnormality, dendritic spine morphology Short Name Dendritic spine abnormality	4	Cellular	Jul 14, 2024	Mar 12, 2025	475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
854	Alterations, Cellular proliferation / hyperplasia Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 41: Sustained AhR Activation leading to Rodent Liver Tumours 495: Androgen receptor activation leading to prostate cancer
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
602	Increased, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 96: Axonal sodium channel modulation leading to acute mortality 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
667	Binding at picrotoxin site, iGABAR chloride channel Short Name	3	Molecular	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
807	Decreased, cholesterol Short Name Decreased, cholesterol	3	Tissue	Nov 29, 2016	May 24, 2022	2 AOPs 124: HMG-CoA reductase inhibition leading to decreased fertility 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
764	N/A, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	113: Glutamate-gated chloride channel activation leading to acute mortality
1867	Bradykinin system, hyperactivated Short Name Bradykinin, activated	3	Molecular	Apr 20, 2021	Jan 24, 2022	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation