All AOPs With OECD Status With SAAOP Status

Recently added AOPs


Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 5-HTT increased predation
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
ACE2 inhibition leading to lung fibrosis Young Jun Kim
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe
Alkylation of DNA leading to reduced sperm count Carole Yauk
Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim
Chitin synthase inhibition leading to mortality You Song
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
DNA methyltransferase inhibition leading to population decline (#3) You Song
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering
Excessive reactive oxygen species production leading to lipid peroxidation-associated reproduction decrease You Song
Excessive reactive oxygen species production leading to mortality (#1) You Song
Excessive reactive oxygen species production leading to mortality (#2) You Song
Excessive reactive oxygen species production leading to mortality (#3) You Song
Excessive reactive oxygen species production leading to mortality (#4) You Song
Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline Knut Erik Tollefsen
Formation of DNA photoproducts leading to mortality You Song
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone GR increased disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
Inhibition of 11β-HSD leading to impaired spermatogenesis in fish Young Jun Kim
Inhibition of 11β-hydroxylase leading to male infertility in fish Young Jun Kim
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
Mitochondrial complex inhibition leading to mortality You Song
Mitochondrial complex inhibition leading to reproduction decline You Song
Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk
PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Renal protein alkylation leading to kidney toxicity Angela Mally
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen
Sensitization induction of the intestinal tract by food proteins Erwin Roggen
Sulfonylurea receptor binding leading to mortality You Song
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee
Thermal stress leading to growth arrest You Song
Thermal stress leading to mortality You Song
Thermal stress leading to reproductive decline You Song
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma activation leading to pulmonary fibrosis Seokjoo Yoon
Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen
α-diketone-induced bronchiolitis obliterans Marvin Martens