All AOPs With OECD Status With SAAOP Status

Recently added AOPs

Title	Point of Contact	MIE	AO
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality	SAROJ AMAR	Acetylcholinesterase (AchE) Inhibition	Sensory axonal peripheral neuropathy Increased Mortality
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis	Knut Erik Tollefsen	Increase, Oxygen-evolving complex damage	Decrease, Reproduction Decrease, Population growth rate
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway	Fei Li	Activation, PARP1 ROS formation	Apoptotic cell death
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation	Ksenia Groh	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants	Erwin L Roggen		Memory Loss
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation	Julija Filipovska	Binding to ACE2
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.	Evangelos-Panagiotis Daskalopoulos	Binding to ACE2	Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement	Kristie Sullivan	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate
Acetylcholinesterase Inhibition Leading to Neurodegeneration	Karen Watanabe	Acetylcholinesterase (AchE) Inhibition	N/A, Neurodegeneration
Activation of reactive oxygen species leading the atherosclerosis	Hiromi Ohara
Activation of the AhR leading to breast cancer	Louise Benoit	Activation, AhR	N/A, Breast Cancer
Adverse outcome pathway of PM-induced respiratory toxicity	li qing	Non-coding RNA expression profile alteration	Chronic obstructive pulmonary disease
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Prakash Patel
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Prakash Patel
Alcohol dehydrogenase leading to reproductive dysfunction	Donggon Yoo	Increase, Alcohol dehydrogenase
Alkylation of DNA leading to reduced sperm count	Carole Yauk	Alkylation, DNA	Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females	Terje Svingen	Antagonism, Androgen receptor	Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Terje Svingen	Antagonism, Androgen receptor	Nipple retention in male offspring, increased
Androgen receptor agonism leading to male-biased sex ratio	Dan Villeneuve	Agonism, Androgen receptor	Decrease, Population growth rate
Androgen receptor antagonism leading to testicular cancer	Chander K. Negi	Antagonism, Androgen receptor	Testicular Cancer
Antagonism of Smoothened receptor leading to orofacial clefting	Jacob Reynolds	Antagonism, Smoothened receptor	Ororofacial clefting
AOP for thyroid disorder caused by triphenyl phosphate	Fei Li	Increased, Hepatic thyroid hormone uptake/transport
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment	Nathalia Pereira Souza	Mitochondrial impairment	Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	Kelvin Santana Rodriguez	Inhibition, Aromatase	Decrease, Population growth rate
Aryl hydrocarbon receptor activation leading to early life stage mortality via cardiovascular toxicity	Prarthana Shankar	Activation, AhR	Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to early life stage mortality via impeded craniofacial development	Prarthana Shankar	Activation, AhR	Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway	Dianke Yu
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway	Dianke Yu		Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway	Dianke Yu	Activation, AhR	Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway	Dianke Yu	Activation, AhR	Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway	Dianke Yu	Activation, AhR
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway	Dianke Yu	Activation, AhR	Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway	Dianke Yu	Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease	Frederic Y. Bois	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Chronic kidney disease
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)	Laure-Alix Clerbaux	Binding to ACE2	Increase, the risk of acute respiratory failure
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits	Julia Meerman	Activation of metabotropic glutamate receptor Inositol triphosphate receptor activation Overactivation, NMDARs Inhibition GABAA receptor	Parkinsonian motor deficits
Ceramide synthase inhibition leading to neural tube defects	Lola Bajard	Inhibition of Ceramide Synthase	Neural tube defects
combined unhealthy lifestyle factors leading to metabolic syndrome	Gillina Bezemer
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis	Jonathan Haselman	Binding, Thyroid binding globulin in serum	Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis	Jonathan Haselman	Binding, Transthyretin in serum	Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects	Job Berkhout
CYP2E1 activation and formation of protein adducts leading to neurodegeneration	Jelle Broeders	CYP2E1 Activation Protein Adduct Formation	Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions	Katy Goyak	Inhibition, cytochrome oxidase	Increase, Site of Contact Nasal Tumors
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia	Dag Anders Brede	Deposition of Energy	Acute Myeloid Leukemia
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis	You Song	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis	Knut Erik Tollefsen	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Deposition of energy leads to vascular remodeling	Vinita Chauhan	Deposition of Energy	Occurrence, Vascular Remodeling
Deposition of ionising energy leading to population decline via programmed cell death	Knut Erik Tollefsen	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionising energy leading to population decline via mitochondrial dysfunction	Knut Erik Tollefsen	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis	Knut Erik Tollefsen
Deposition of ionising energy leads to population decline via pollen abnormal	Li Xie	Deposition of Energy	Decrease, Reproduction Decreased, Population trajectory
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis	Knut Erik Tollefsen	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionizing energy leads to population decline via impaired meiosis	Erica Maremonti	Deposition of Ionizing Energy	Decrease of egg production and cummulative fecundity Decrease, Reproduction Decreased, Population size
DNA adduct formation leading to kidney failure	Manoe Janssen
DNA methyltransferase inhibition leading to population decline (3)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
Doda decarboxylase leading to mortality	Donggon Yoo	Decrease, Tyrosine
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)	Gillina Bezemer	Prolonged TLR9 activation	Multi Organ Failure involving Acute Respiratory Distress Syndrome Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load	Gillina Bezemer	Toll Like Receptor (TLR) Dysregulation
elavl3, sox10, mbp neurogene	Donggon Yoo
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development	Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity	Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR	Jon Doering	Activation, AhR	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Energy deposition from internalized Ra-226 decay leads to altered ventilation behavior and slower growth in Lymnaea stagnalis due to apparent hypoxia from decreased hemocyanin oxygen binding capacity	Danielle Beaton	Deposition of Energy	Decrease, Growth Decreased, Reproductive Success
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction	John Hoang	Activation, estrogen receptor alpha	Impaired, Reproduction
Excessive reactive oxygen species production leading to mortality (1)	You Song	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2)	You Song	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3)	You Song	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4)	You Song	Increase, Reactive Oxygen Species production	Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1)	You Song	Increase, Formation of DNA photoproducts	Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2)	You Song
Formation of DNA photoproducts leading to growth inhibition (3)	You Song
Frustrated phagocytosis leads to malignant mesothelioma	Penny Nymark	Frustrated phagocytosis	Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect	Fei Li	protein-coupled estrogen receptor 1 (GPER) activation	N/A, Steatohepatisis
Glucocorticoid Receptor activation leading to hepatic steatosis	Chander K. Negi	Activation, Glucocorticoid Receptor	Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility	Carlie LaLone	Activation, Glucocorticoid Receptor	Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration	Alexander Cole	Activation, Glucocorticoid Receptor	Decrease, Population growth rate
GSK3beta inactivation leading to increased mortality via defects in developing inner ear	Vid Modic	GSK3beta inactivation	Increased Mortality Decrease, Population growth rate
hERG inhibition leading to cardiac toxicity	Egemen Bilgin	Binding to hERG channel hERG channel biogenesis interference	Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development	Marvin Martens	Histone deacetylase inhibition	Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects	Marvin Martens	Histone deacetylase inhibition	Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease	Young Jun Kim	Hyperactivation of ACE/Ang-II/AT1R axis	Chronic kidney disease
IKK complex inhibition leading to liver injury	Nanette Vrijenhoek	Inhibition, IKK complex	Necrotic Tissue Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues	Fei Li
Immune mediated hepatitis	Jung-Hwa Oh	benzoquinone imine and acylglucuronide metabolites	Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males	Terje Svingen	Increased (ectopic) all-trans retinoic acid concentration	Reduce, Sperm count
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)	Qi Wang	Increase, TNF	Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)	Bérénice COLLET	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity	Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome	Marvin Martens	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis	Young Jun Kim	Inhibition of cystathionine beta-synthase	Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)	Vid Modic	Inhibition of Fyna	Increased Mortality Decrease, Population growth rate
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity	Stefan Scholz	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts	Growth, reduction Decreased, survival
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity	Baki Sadi	Inhibition, Mitochondrial Electron Transport Chain Complexes	Occurrence, Kidney toxicity
Inhibition of N-linked glycosylation leads to liver injury	Marvin Martens	Inhibition of N-linked glycosylation	Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries	Gina Mennen	Inhibition of ALDH1A (RALDH)	transposition of the great arteries
Interaction with lung resident cell membrane components leads to lung cancer	Penny Nymark	Substance interaction with the lung resident cell membrane components	Lung cancer
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability	Deborah Oughton	Deposition of Energy Increase in reactive oxygen and nitrogen species (RONS) Increase, DNA damage	Decrease, Population growth rate
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation	Olivier ARMANT	Deposition of Energy	Increase risk, microcephaly
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways	Yann GUEGUEN		Increased, Kidney Failure
Knickkopf leading to mortality	Donggon Yoo	Decrease, 20-hydroxyecdysone
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis	Marvin Martens	Activation, Latent Transforming Growth Factor Beta 1	Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction	Young Jun Kim	Antagonism,LH receptor	Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation	Gillina Bezemer
Microtubule interacting drugs lead to peripheral neuropathy	Marvin Martens	Binding of microtubule stabilizing agents (MSA) to microtubules	Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury	Wanda van der Stel	Increase, Mitochondrial complex III antagonism Mitochondrial Complex IV inhibition Mitochondrial Complex V inhibition Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Inhibition, NADH-ubiquinone oxidoreductase (complex I) Binding of inhibitor to mitochondrial complex III Binding of inhibitor to mitochondrial complex IV Binding of inhibitor to mitochondrial complex V	Necrotic Tissue Liver Injury
Mitochondrial dysfunction to metabolic diseases	Chander K. Negi
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function	SAROJ AMAR	Acetylcholinesterase (AchE) Inhibition	Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure	Zarin Hossain	Oxidation, Glutathione (To be considered with MIE)	Increased Mortality
Oxidative stress Leading to Decreased Lung Function	Karsta Luettich	Oxidative Stress	Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Karsta Luettich	Oxidative Stress	Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1	Karsta Luettich	Oxidative Stress	Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone	You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage	You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis	You Song
PM-related Adverse outcome pathway frameworks on various systems	Tianyu Li
PM2.5-related AOP frameworks on liver diseases	Zhou Du
PPARalpha Agonism Impairs Fish Reproduction	Ashley Kittelson	Activation, PPARα	Viable offspring, decreased Decrease, Population growth rate
PPARG activation leading to intrahepatic cholestasis	Yuan Jin
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population	ruiyang Ding
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality	Yu Yang
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population	ruiyang Ding
Reduced environmental pH leading to thinner shells in Mytilus edulis	James Ducker
Reduction in photophosphorylation leading to growth inhibition in aquatic plants	Knut Erik Tollefsen	Increase, Uncoupling of photophosphorylation	Decrease, Growth
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality	ruiyang Ding
S-adenosylmethionine depletion leading to population decline (1)	You Song	Inhibition, Chitin synthase 1	Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2)	You Song	Increase, Sulfonylurea receptor binding	Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation	Hasmik Yepiskoposyan	Binding to ACE2	Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis	Hasmik Yepiskoposyan	Binding to ACE2	Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.	Evangelos-Panagiotis Daskalopoulos	Binding to ACE2	Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins	Erwin L Roggen
Succinate dehydrogenase inactivation leading to cancer	Sylvie Bortoli
Superoxide dismutase inhibition leading to increased insulin resistance	Simon Thomas
TBX1 inhibition leading to congenital cardiac conotruncal anomalies	Jinsoo Lee	Inhibition, TBX1	Anomalies, Congenital cardiac conotruncal
test AOP	Kevin Crofton
The AOP framwork on silica nanopariticles induced hepatoxicity	Tianyu Li
Thermal stress leading to population decline (1)	You Song	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thermal stress leading to population decline (2)	You Song	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thermal stress leading to population decline (3)	You Song	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain	Katherine (Katie) O'Shaughnessy
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis	Seokjoo Yoon	Toll-like receptor 4 activation Inactivation of PPARγ	Pulmonary fibrosis
α-diketone-induced bronchiolitis obliterans	Marvin Martens	Interaction of α-diketones with arginine residues	Bronchiolitis obliterans