| Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
1865: Increase, Oxygen-evolving complex damage |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway |
Fei Li |
|
|
| 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Ksenia Groh |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
588: Increased, predation |
| ACE2 dysregulation leading to microvascular disfunction |
Julija Filipovska |
1739: ACE2 binding to viral S-protein |
|
| Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Kristie Sullivan |
12: Acetylcholinesterase (AchE) Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Karen Watanabe |
12: Acetylcholinesterase (AchE) Inhibition |
352: N/A, Neurodegeneration |
| Alkylation of DNA leading to reduced sperm count |
Carole Yauk |
97: Alkylation, DNA |
1757: Reduce, Sperm count |
| Androgen receptor (AR) antagonism leading to decreased fertility in females |
Terje Svingen |
26: Antagonism, Androgen receptor |
972: Decreased fertility, Reduced number of oocytes ovulated |
| Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Terje Svingen |
26: Antagonism, Androgen receptor |
1786: increase, retained nipples in males |
| Androgen receptor agonism leading to male-biased sex ratio |
Dan Villeneuve |
25: Agonism, Androgen receptor |
360: Decrease, Population trajectory |
| Androgen receptor antagonism leading to testicular cancer |
Chander K. Negi |
26: Antagonism, Androgen receptor |
1839: Testicular Cancer |
| Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Young Jun Kim |
1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) |
1276: Lung fibrosis |
| AOP for thyroid disorder caused by triphenyl phosphate |
Fei Li |
|
|
| AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Nathalia Pereira Souza |
1261: Mitochondrial impairment |
1763: Urothelial Tumor |
| Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Kelvin Santana Rodriguez |
36: Inhibition, Aromatase |
360: Decrease, Population trajectory |
| Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway |
Dianke Yu |
|
|
| Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway |
Dianke Yu |
|
|
| Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Frederic Y. Bois |
1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress |
1603: Chronic kidney disease |
| Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Anna Price |
1739: ACE2 binding to viral S-protein |
1841: Encephalitis |
| Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Magda Sachana |
1739: ACE2 binding to viral S-protein |
1875: Cerebrovascular disease (stroke) |
| Binding of SARS-CoV-2 to ACE2 in enterocytes leads to increased intestinal permeability resulting in GI disorders |
Laure-Alix Clerbaux |
|
|
| Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
1739: ACE2 binding to viral S-protein |
351: Increased Mortality |
| Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Young Jun Kim |
1739: ACE2 binding to viral S-protein |
1850: dysgeusia |
| Bulky DNA adducts leading to mutations |
Carole Yauk |
1879: Bulky DNA adducts, increase |
185: Increase, Mutations |
| Chitinase inhibition leading to mortality |
Simon Schmid |
1806: Increase, Chitinase inhibition |
350: Increase, Mortality |
| Chitobiase inhibition leading to mortality |
Simon Schmid |
1807: Increase, Chitobiase inhibition |
350: Increase, Mortality |
| combined unhealthy lifestyle factors leading to metabolic syndrome |
Gillina Bezemer |
|
|
| Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Jonathan Haselman |
1831: Binding, Thyroid binding globulin in serum |
1101: Altered, Amphibian metamorphosis |
| Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Jonathan Haselman |
957: Binding, Transthyretin in serum |
1101: Altered, Amphibian metamorphosis |
| CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Jelle Broeders |
1508: CYP2E1 Activation and 1509: Protein Adduct Formation |
1514: Neurodegeneration |
| Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Katy Goyak |
1840: Inhibition, cytochrome oxidase |
872: Increase, Site of Contact Nasal Tumors |
| Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Penny Nymark |
1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated |
1868: Hyperinflammation |
| Deposition of ionizing energy leads to population decline via impaired meiosis |
Erica Maremonti |
1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage |
1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size |
| DNA damage leading to population decline via programmed cell death |
Knut Erik Tollefsen |
1194: Increase, DNA damage |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| DNA methyltransferase inhibition leading to population decline (3) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) |
Gillina Bezemer |
1842: Prolonged TLR9 activation |
1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality |
| Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Gillina Bezemer |
|
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Christopher Goodchild |
|
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Christopher Goodchild |
|
|
| Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Jon Doering |
18: Activation, AhR |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
| Excessive reactive oxygen species production leading to mortality (1) |
You Song |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (2) |
You Song |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (3) |
You Song |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (4) |
You Song |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to population decline via lipid peroxidation |
Knut Erik Tollefsen |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction |
You Song |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Formation of DNA photoproducts leading to growth inhibition (1) |
You Song |
1765: Increase, Formation of DNA photoproducts |
350: Increase, Mortality |
| Formation of DNA photoproducts leading to growth inhibition (2) |
You Song |
|
|
| Formation of DNA photoproducts leading to growth inhibition (3) |
You Song |
|
|
| Frustrated phagocytosis leads to malignant mesothelioma |
Nureddin Mansour |
|
|
| G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect |
Fei Li |
|
|
| Glucocorticoid Receptor activation leading to hepatic steatosis |
Chander K. Negi |
122: Activation, Glucocorticoid Receptor |
459: Increased, Liver Steatosis |
| Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Carlie LaLone |
122: Activation, Glucocorticoid Receptor |
323: Increased, Disease susceptibility |
| Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Alexander Cole |
122: Activation, Glucocorticoid Receptor |
360: Decrease, Population trajectory |
| Histone deacetylase inhibition leads to impeded craniofacial development |
Marvin Martens |
1502: Histone deacetylase inhibition |
1559: Facial cartilage structures are reduced in size and morphologically distorted |
| Histone deacetylase inhibition leads to neural tube defects |
Marvin Martens |
1502: Histone deacetylase inhibition |
1561: Neural tube defects |
| Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Young Jun Kim |
1853: Hyperactivation of ACE/Ang-II/AT1R axis |
1603: Chronic kidney disease |
| IKK complex inhibition leading to liver injury |
Nanette Vrijenhoek |
1574: Inhibition, IKK complex |
1548: Necrotic Tissue and 1549: Liver Injury |
| Imbalance in redox homeostasis leading to structural damage to tissues |
Fei Li |
|
|
| Immune mediated hepatitis |
Jung-Hwa Oh |
1814: benzoquinone imine and acylglucuronide metabolites |
1820: Immune mediated hepatitis |
| Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males |
Terje Svingen |
1888: Increased (ectopic) all-trans retinoic acid concentration |
1757: Reduce, Sperm count |
| Increased reactive oxygen species production leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
257: Increase, Reactive Oxygen Species production |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Increased reactive oxygen species production leading to population decline via mitochondrial dysfunction |
Knut Erik Tollefsen |
257: Increase, Reactive Oxygen Species production |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation |
Shihori Tanabe |
1738: Increased susceptibility to viral entry |
1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation |
| Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Young Jun Kim |
1796: 11β-hydroxylase inhibition |
360: Decrease, Population trajectory |
| Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Young Jun Kim |
1799: Inhibition of 11β-HSD |
360: Decrease, Population trajectory |
| Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Bérénice COLLET |
1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity |
1616: Malformation, cryptorchidism - maldescended testis |
| Inhibition of ALDH1A2 (RALDH2) causing reduced all-trans retinoic acid levels leading to decreased fertility, females |
Terje Svingen |
1880: Inhibition of ALDH1A2 (RALDH2) |
972: Decreased fertility, Reduced number of oocytes ovulated |
| Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Young Jun Kim |
1740: ACE2 inhibition |
344: N/A, Liver fibrosis |
| Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis |
Young Jun Kim |
1740: ACE2 inhibition |
1276: Lung fibrosis |
| Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Marvin Martens |
888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) |
1564: Chemical induced Fanconi syndrome |
| Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Young Jun Kim |
1657: Inhibition of cystathionine beta-synthase |
1667: Impaired,anterior-posterior axis development |
| Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) |
Vid Modic |
1884: Inhibition of Fyna |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Stefan Scholz |
1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts |
1467: Growth, reduction and 636: Decreased, survival |
| Inhibition of N-linked glycosylation leads to liver injury |
Marvin Martens |
1604: Inhibition of N-linked glycosylation |
1549: Liver Injury |
| Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Marvin Martens |
1468: Activation, Latent Transforming Growth Factor Beta 1 |
1458: Pulmonary fibrosis |
| Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Young Jun Kim |
1691: Antagonism,LH receptor |
679: Decline, Population trajectory |
| Metabolic Syndrome leading to Toll Like Receptor dysregulation |
Gillina Bezemer |
|
|
| Microtubule interacting drugs lead to peripheral neuropathy |
Marvin Martens |
1580: Binding of microtubule stabilizing agents (MSA) to microtubules |
1583: Sensory axonal peripheral neuropathy |
| Mitochondrial complex inhibition leading to liver injury |
Wanda van der Stel |
1542, 1543, 1544, 888, 887, 1653, 1654, 1655 |
1548: Necrotic Tissue and 1549: Liver Injury |
| Mitochondrial dysfunction to metabolic diseases |
Chander K. Negi |
|
|
| Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function |
SAROJ AMAR |
12: Acetylcholinesterase (AchE) Inhibition |
402: Cognitive Function, Decreased |
| Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure |
Zarin Hossain |
|
|
| Oxidative stress [MIE] Leading to Decreased Lung Function [AO] |
Karsta Luettich |
|
|
| Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
You Song |
|
|
| Photosystem II antagonism leading to growth inhibition via oxidative damage |
You Song |
|
|
| Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
You Song |
|
|
| PPARalpha Agonism Impairs Fish Reproduction |
Ashley Kittelson |
227: Activation, PPARα |
|
| PPARG activation leading to intrahepatic cholestasis |
Yuan Jin |
|
|
| Reduced environmental pH leading to thinner shells in Mytilus edulis |
James Ducker |
|
|
| Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Knut Erik Tollefsen |
1471: Increase, Uncoupling of photophosphorylation |
1521: Decrease, Growth |
| Repression of Gbx2 expression leads to defects in developing inner ear and consequently to increased mortality |
Vid Modic |
|
|
| S-adenosylmethionine depletion leading to population decline (1) |
You Song |
1522: Inhibition, Chitin synthase 1 |
350: Increase, Mortality |
| S-adenosylmethionine depletion leading to population decline (2) |
You Song |
1525: Increase, Sulfonylurea receptor binding |
350: Increase, Mortality |
| SARS-CoV-2 infection leading to hyperinflammation |
Hasmik Yepiskoposyan |
|
|
| Sars-cov-2 infection leading to impaired olfactory function (anosmia) |
Sandra Coecke |
1739: ACE2 binding to viral S-protein |
1873: impaired olfactory function (anosmia) |
| SARS-CoV-2 infection leading to pyroptosis |
Hasmik Yepiskoposyan |
|
|
| SARS-CoV-2 infection leading to thromboinflammation |
Luigi Margiotta-Casaluci |
|
|
| Sensitization induction of the intestinal tract by food proteins |
Erwin Roggen |
|
|
| Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
1525: Increase, Sulfonylurea receptor binding |
350: Increase, Mortality |
| TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Jinsoo Lee |
1680: Inhibition, TBX1 |
1685: Anomalies, Congenital cardiac conotruncal |
| test AOP |
Kevin Crofton |
|
|
| Thermal stress leading to population decline (1) |
You Song |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thermal stress leading to population decline (2) |
You Song |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thermal stress leading to population decline (3) |
You Song |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain |
Katherine (Katie) O'Shaughnessy |
|
|
| Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning |
Lucia Vergauwen |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Thyroperoxidase inhibition leading to increased mortality via altered retinal layer structure |
Lucia Vergauwen |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Thyroperoxidase inhibition leading to increased mortality via decreased eye size |
Lucia Vergauwen |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Seokjoo Yoon |
1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ |
1458: Pulmonary fibrosis |
| α-diketone-induced bronchiolitis obliterans |
Marvin Martens |
1584: Interaction of α-diketones with arginine residues |
1588: Bronchiolitis obliterans |