Recently added AOPs


Title Point of Contact MIE AO
5 alpha reductase leading to fish reproduction failulare Young Jun Kim
Acetylcholinesterase Inhibition Leading to Neurodegeneration Kendra Conrow
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
Chitin synthase inhibition leading to premature molting associated mortality You Song
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
D1 protein blockage leading to apoptosis associated growth inhibition You Song
D1 protein blockage leading to photosystem II (PSII)-inhibition associated growth reduction You Song
Direct deposition of ionizing energy onto DNA leading to lung cancer Vinita Chauhan
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline Knut Erik Tollefsen
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
Inhibition of IL-1 signaling Yutaka Kimura
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
Mitochondrila Complex III inhibition leading to ATP depletion associated mortality You Song
Mitochondrila Complex III inhibition leading to oxidative stress associated mortality You Song
Reactive oxygen species generated form photoreactive chemicals leading to phototoxic reactions Satomi Onoue
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally
Renal protein alkylation leading to kidney toxicity Angela Mally
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen
Sensitization induction of the intestinal tract by food proteins Erwin Roggen
Sulfonylurea receptor binding leading to premature molting associated mortality You Song
Uncoupling of oxidative phosphorylation leading to mortality You Song
Uncoupling of oxidative phosphorylation leading to reproduction decline You Song
Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen
α-diketone-induced bronchiolitis obliterans Marvin Martens