Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality |
SAROJ AMAR |
- Acetylcholinesterase (AchE) Inhibition
|
- Sensory axonal peripheral neuropathy
- Increased Mortality
|
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
- Increase, Oxygen-evolving complex damage
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway |
Fei Li |
- Activation, PARP1
- ROS formation
|
|
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Ksenia Groh |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
|
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants |
Erwin L Roggen |
|
|
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. |
Evangelos-Panagiotis Daskalopoulos |
|
|
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Kristie Sullivan |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
|
Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Karen Watanabe |
- Acetylcholinesterase (AchE) Inhibition
|
|
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release |
Travis Karschnik |
- Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
|
- Impairment, Learning and memory
|
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis |
Travis Karschnik |
- Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
|
- Impairment, Learning and memory
|
Activation of reactive oxygen species leading the atherosclerosis |
Hiromi Ohara |
|
|
Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation |
Barbara Viviani |
- Activation, estrogen receptor alpha
|
- Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
|
Adverse outcome pathway of PM-induced respiratory toxicity |
li qing |
- Non-coding RNA expression profile alteration
|
- Chronic obstructive pulmonary disease
|
Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity |
Yue Zhang |
- Increased, Reactive oxygen species
- Disruption, Estrogen receptor
- Antagonism, Androgen receptor
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
- anogenital distance (AGD), decreased
- Malformation, cryptorchidism - maldescended testis
- Decrease, Reproduction
|
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Prakash Patel |
|
- Cognitive Function, Decreased
|
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Prakash Patel |
|
- Cognitive Function, Decreased
|
AhR activation leading to liver fibrosis |
Xavier COUMOUL |
|
|
Alcohol dehydrogenase leading to reproductive dysfunction |
Donggon Yoo |
- Increase, Alcohol dehydrogenase
|
|
Alkylation of DNA leading to reduced sperm count |
Carole Yauk |
|
|
An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects |
Liang Chen |
|
|
Androgen receptor (AR) antagonism leading to hypospadias in male offspring |
Terje Svingen |
- Antagonism, Androgen receptor
|
|
Androgen receptor activation leading to prostate cancer |
Jianxiang Li |
- Activation, Androgen receptor
|
|
Androgen receptor agonism leading to reproduction dysfunction (in zebrafish) |
Hongling Liu |
- Agonism, Androgen receptor
- Increased, gene expression of AR
|
- Decreased, Population trajectory
|
Androgen receptor antagonism leading to testicular cancer |
Chander K. Negi |
- Antagonism, Androgen receptor
|
|
AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation |
Fei Li |
- Increased, Hepatic thyroid hormone uptake/transport
|
|
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Nathalia Pereira Souza |
- N/A, Mitochondrial dysfunction 1
|
|
AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. |
Hailin Xu |
- Increase, Reactive oxygen species
|
- Increased incidence of respiratory disease
- Dysfunction of respiratory system
|
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway |
Dianke Yu |
|
|
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway |
Dianke Yu |
|
|
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Frederic Y. Bois |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
|
Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation |
Jessica Resnick |
- Influenza A Virus (IAV) binds sialic acid glycan receptor
|
- Influenza A Virus (IAV) shedding and transmission
|
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) |
Laure-Alix Clerbaux |
|
|
Binding to the extracellular protein laminin leading to decreased cognitive function |
Eliska Kuchovska |
- Binding, extracellular matrix protein laminin
|
- Cognitive Function, Decreased
|
Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses |
Xiaoyun Wu |
|
|
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits |
Julia Meerman |
- Activation of metabotropic glutamate receptor
- Inositol triphosphate receptor activation
- Overactivation, NMDARs
- Inhibition GABAA receptor
- Opening, voltage-gated calcium channels
|
- Parkinsonian motor deficits
|
Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death |
Young Jun Kim |
|
|
Ceramide synthase inhibition leading to neural tube defects |
Lola Bajard |
- Inhibition of Ceramide Synthase
|
|
Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms |
Karine Audouze |
- Ryanodine receptor activation
- Inositol triphosphate receptor activation
|
- Impairment, Learning and memory
- decreased, Intellectual Quotient
- increased, socio-economic burden
|
combined unhealthy lifestyle factors leading to metabolic syndrome |
Gillina Bezemer |
|
|
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Binding, Thyroid binding globulin in serum
|
- Altered, Amphibian metamorphosis
|
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Binding, Transthyretin in serum
|
- Altered, Amphibian metamorphosis
|
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects |
Job Berkhout |
|
|
CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Jelle Broeders |
- CYP2E1 Activation
- Protein Adduct Formation
|
|
Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Katy Goyak |
- Inhibition, cytochrome oxidase
|
- Increase, Site of Contact Nasal Tumors
|
Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) stem Leydig cells leads to Hypospadias, increased |
John Frisch |
|
|
Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) stem Leydig cells leads to Impaired, Spermatogenesis |
John Frisch |
|
- Impaired, Spermatogenesis
|
Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis |
John Frisch |
|
|
Demethylation of PPAR promotor leading to vascular disrupting effects |
Yanhong Wei |
- peroxisome proliferator activated receptor promoter demethylation
|
- Increase, Vascular disrupting effects
|
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia |
Dag Anders Brede |
|
|
Deposition of Energy Leading to Learning and Memory Impairment |
Vinita Chauhan |
|
- Impairment, Learning and memory
|
Deposition of energy leading to occurrence of bone loss |
Vinita Chauhan |
|
|
Deposition of energy leading to occurrence of cataracts |
Vinita Chauhan |
|
|
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis |
You Song |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis |
Knut Erik Tollefsen |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Deposition of energy leads to vascular remodeling |
Vinita Chauhan |
|
- Occurrence, Vascular Remodeling
|
Deposition of ionising energy leading to population decline via programmed cell death |
Knut Erik Tollefsen |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionising energy leading to population decline via mitochondrial dysfunction |
Knut Erik Tollefsen |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis |
Knut Erik Tollefsen |
|
|
Deposition of ionising energy leads to population decline via pollen abnormal |
Li Xie |
|
- Decrease, Reproduction
- Decreased, Population trajectory
|
Deposition of ionizing energy leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionizing energy leads to population decline via impaired meiosis |
Erica Maremonti |
- Deposition of Ionizing Energy
|
- Decrease of egg production and cummulative fecundity
- Decrease, Reproduction
- Decreased, Population size
|
DNA adduct formation leading to kidney failure |
Manoe Janssen |
|
|
DNA methyltransferase inhibition leading to population decline (3) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Doda decarboxylase leading to mortality |
Donggon Yoo |
|
|
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) |
Gillina Bezemer |
- Prolonged TLR9 activation
|
- Multi Organ Failure involving Acute Respiratory Distress Syndrome
- Increased Mortality
|
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Gillina Bezemer |
- Toll Like Receptor (TLR) Dysregulation
|
|
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Christopher Goodchild |
|
|
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Christopher Goodchild |
|
|
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Jon Doering |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin |
Danielle Beaton |
|
- Decrease, Growth
- Decreased, Reproductive Success
|
ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity |
Min Ji Kim |
- Estrogen receptor alpha inactivation
|
- Metabolically unhealthy Obesity
|
ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome |
Min Ji Kim |
- Estrogen receptor alpha inactivation
|
- Insulin resistance
- Metabolic syndrome
|
Essential element imbalance leads to reproductive failure via oxidative stress |
Travis Karschnik |
- Increased, essential element imbalance
|
- Decreased, Viable Offspring
|
Estrogen antagonism leading to increased risk of autism-like behavior |
Kanglong Cui |
- Antagonism, Estrogen receptor
|
|
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction |
John Hoang |
- Activation, estrogen receptor alpha
|
|
Excessive iron accumulation leading to neurological disorders |
Young Jun Kim |
- Increased intracelluar Iron accumulation
|
|
Excessive reactive oxygen species production leading to mortality (1) |
You Song |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (2) |
You Song |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (3) |
You Song |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (4) |
You Song |
- Increase, Reactive Oxygen Species production
|
|
Formation of DNA photoproducts leading to growth inhibition (1) |
You Song |
- Increase, Formation of DNA photoproducts
|
|
Formation of DNA photoproducts leading to growth inhibition (2) |
You Song |
|
|
Formation of DNA photoproducts leading to growth inhibition (3) |
You Song |
|
|
Frustrated phagocytosis leads to malignant mesothelioma |
Penny Nymark |
|
|
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects |
Fei Li |
- protein-coupled estrogen receptor 1 (GPER) activation
|
|
Glucocorticoid Receptor activation leading to hepatic steatosis |
Chander K. Negi |
- Activation, Glucocorticoid Receptor
|
- Increased, Liver Steatosis
|
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Carlie LaLone |
- Activation, Glucocorticoid Receptor
|
- Increased, Disease susceptibility
|
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Alexander Cole |
- Activation, Glucocorticoid Receptor
|
- Decrease, Population growth rate
|
Glutathione conjugation leading to reproductive dysfunction via oxidative stress |
Leonardo Vieira |
|
|
Gluten intake leading to celiac disease example test - under development |
Pablo Rodriguez Fernandez |
|
|
GSK3beta inactivation leading to increased mortality via defects in developing inner ear |
Vid Modic |
|
- Increased Mortality
- Decrease, Population growth rate
|
hERG channel blockade leading to sudden cardiac death |
Egemen Bilgin |
|
|
Histone deacetylase inhibition leads to impeded craniofacial development |
Marvin Martens |
- Histone deacetylase inhibition
|
- Facial cartilage structures are reduced in size and morphologically distorted
|
Histone deacetylase inhibition leads to neural tube defects |
Marvin Martens |
- Histone deacetylase inhibition
|
|
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Young Jun Kim |
- Hyperactivation of ACE/Ang-II/AT1R axis
|
|
IKK complex inhibition leading to liver injury |
Nanette Vrijenhoek |
|
- Necrotic Tissue
- Liver Injury
|
Imbalance in redox homeostasis leading to structural damage to tissues |
Fei Li |
|
|
Immune mediated hepatitis |
Jung-Hwa Oh |
- benzoquinone imine and acylglucuronide metabolites
|
- Immune mediated hepatitis
|
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males |
Terje Svingen |
- Increased (ectopic) all-trans retinoic acid concentration
|
|
Increased LCN2/iron complex leading to neurological disorders |
Young Jun Kim |
- Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
|
|
Increased reactive oxygen species production leading to decreased cognitive function |
Eliska Kuchovska |
- Increase, Reactive Oxygen Species production
|
- Cognitive Function, Decreased
|
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) |
Qi Wang |
|
- Gestational diabetes mellitus
|
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Bérénice COLLET |
- Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
|
- Malformation, cryptorchidism - maldescended testis
|
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Marvin Martens |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Chemical induced Fanconi syndrome
|
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Young Jun Kim |
- Inhibition of cystathionine beta-synthase
|
- Impaired,anterior-posterior axis development
|
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) |
Vid Modic |
|
- Increased Mortality
- Decrease, Population growth rate
|
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Stefan Scholz |
- Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
|
- Growth, reduction
- Decreased, survival
|
Inhibition of N-linked glycosylation leads to liver injury |
Marvin Martens |
- Inhibition of N-linked glycosylation
|
|
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries |
Gina Mennen |
- Inhibition of ALDH1A (RALDH)
|
- transposition of the great arteries
|
Inhibition of voltage-gated sodium channels leading to decreased cognition |
Eliska Kuchovska |
- Binding to voltage-gated sodium channel
|
- Cognitive Function, Decreased
|
Interaction with lung resident cell membrane components leads to lung cancer |
Penny Nymark |
- Substance interaction with the lung resident cell membrane components
|
|
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability |
Deborah Oughton |
- Deposition of Energy
- Increase in reactive oxygen and nitrogen species (RONS)
- Increase, DNA damage
|
- Decrease, Population growth rate
|
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation |
Olivier ARMANT |
|
- Increase risk, microcephaly
|
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways |
Yann GUEGUEN |
|
- Increased, Kidney Failure
|
Knickkopf leading to mortality |
Donggon Yoo |
- Decrease, 20-hydroxyecdysone
|
|
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Marvin Martens |
- Activation, Latent Transforming Growth Factor Beta 1
|
|
Liver X Receptor (LXR) activation leads to liver steatosis |
John Frisch |
|
- Increased, Liver Steatosis
|
Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Young Jun Kim |
|
- Decline, Population trajectory
|
Metabolic Syndrome leading to Toll Like Receptor dysregulation |
Gillina Bezemer |
|
|
Microtubule interacting drugs lead to peripheral neuropathy |
Marvin Martens |
- Binding of microtubule stabilizing agents (MSA) to microtubules
|
- Sensory axonal peripheral neuropathy
|
Mitochondrial complex inhibition leading to liver injury |
Wanda van der Stel |
- Increase, Mitochondrial complex III antagonism
- Mitochondrial Complex IV inhibition
- Mitochondrial Complex V inhibition
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
- Inhibition, NADH-ubiquinone oxidoreductase (complex I)
- Binding of inhibitor to mitochondrial complex III
- Binding of inhibitor to mitochondrial complex IV
- Binding of inhibitor to mitochondrial complex V
|
- Necrotic Tissue
- Liver Injury
|
Mitochondrial dysfunction to metabolic diseases |
Chander K. Negi |
|
|
Na+ /K+ -ATPase inhibition leading to hypertension |
Michelle Angrish |
- Decreased Na/K ATPase activity
|
|
Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction |
Yanhong Wei |
|
- Increase, Vascular disrupting effects
|
Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway |
Yanhong Wei |
|
- Increase, Vascular disrupting effects
|
Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway |
Yanhong Wei |
|
- Increase, Vascular disrupting effects
|
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function |
SAROJ AMAR |
- Acetylcholinesterase (AchE) Inhibition
|
- Cognitive Function, Decreased
|
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure |
Zarin Hossain |
- Oxidation, Glutathione (To be considered with MIE)
|
|
Oxidative stress Leading to Decreased Lung Function |
Karsta Luettich |
|
|
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction |
Karsta Luettich |
|
|
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 |
Karsta Luettich |
|
|
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
You Song |
|
|
Photosystem II antagonism leading to growth inhibition via oxidative damage |
You Song |
|
|
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
You Song |
|
|
PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV |
Hui Li |
|
|
PM-related Adverse outcome pathway frameworks on various systems |
Tianyu Li |
|
|
PM2.5-related AOP frameworks on liver diseases |
Zhou Du |
|
|
PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone |
Jennifer Olker |
|
- Decreased, Viable Offspring
- Decrease, Population growth rate
|
PPARG activation leading to intrahepatic cholestasis |
Yuan Jin |
|
|
Pregnane X Receptor (PXR) activation leads to liver steatosis |
John Frisch |
- Activation, Pregnane-X receptor, NR1l2
|
- Increased, Liver Steatosis
|
Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway |
John Frisch |
- Increased, Reactive oxygen species
|
|
Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway |
John Frisch |
- Increased, Reactive oxygen species
|
|
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population |
ruiyang Ding |
|
|
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality |
Yu Yang |
|
|
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population |
ruiyang Ding |
|
|
Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level |
Ana-Andreea Cioca |
|
|
Reduced environmental pH leading to thinner shells in Mytilus edulis |
James Ducker |
|
|
Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory |
Diana Lupu |
|
|
Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Knut Erik Tollefsen |
- Increase, Uncoupling of photophosphorylation
|
|
Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory |
Diana Lupu |
- Agonism, Retinoic acid receptor
|
- Impairment, Learning and memory
|
Retinoic acid receptor agonism during neurodevelopment leading to microcephaly |
Diana Lupu |
- Agonism, Retinoic acid receptor
|
- Increase risk, microcephaly
|
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality |
ruiyang Ding |
|
|
S-adenosylmethionine depletion leading to population decline (1) |
You Song |
- Inhibition, Chitin synthase 1
|
|
S-adenosylmethionine depletion leading to population decline (2) |
You Song |
- Increase, Sulfonylurea receptor binding
|
|
SARS-CoV-2 infection leading to hyperinflammation |
Hasmik Yepiskoposyan |
|
|
SARS-CoV-2 infection leading to pyroptosis |
Hasmik Yepiskoposyan |
|
|
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. |
Evangelos-Panagiotis Daskalopoulos |
|
|
Sensitization induction of the intestinal tract by food proteins |
Erwin L Roggen |
|
|
Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine |
Simon Thomas |
- Succinate dehydrogenase, inhibited
|
- Insulin resistance, increased
|
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level |
Ana-Andreea Cioca |
- Inhibition of Sulfotransferase E1 (SULT1E1)
|
|
TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Jinsoo Lee |
|
- Anomalies, Congenital cardiac conotruncal
|
test AOP |
Kevin Crofton |
|
|
The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects |
Yanhong Wei |
- Increase, Reactive Oxygen Species production
|
- Increase, Vascular disrupting effects
|
The AOP framwork on silica nanopariticles induced hepatoxicity |
Tianyu Li |
|
|
Thermal stress leading to population decline (1) |
You Song |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thermal stress leading to population decline (2) |
You Song |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thermal stress leading to population decline (3) |
You Song |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition |
Eliska Kuchovska |
- Antagonism, Thyroid Receptor
|
- Cognitive Function, Decreased
|
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain |
Katherine (Katie) O'Shaughnessy |
- Thyroperoxidase, Inhibition
|
- Periventricular heterotopia formation
- Increase, seizure
|
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Seokjoo Yoon |
- Toll-like receptor 4 activation
- Inactivation of PPARγ
|
|
Unknown MIE altering cholesterol metabolism leading to decreased cognition |
Eliska Kuchovska |
|
- Cognitive Function, Decreased
|
Various neuronal effects induced by elavl3, sox10, and mbp |
Donggon Yoo |
- Increase, CNS Neural cell death
|
- impaired, Learning and memory
- Encephalitis
- Parkinsonian motor deficits
- Increase, seizure
- Increased, epilepsy
- Increase, Mortality
- Inhibition, Feeding
|
Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation |
Julija Filipovska |
|
|
α-diketone-induced bronchiolitis obliterans |
Marvin Martens |
- Interaction of α-diketones with arginine residues
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