Recently added AOPs

Title Point of Contact MIE AO
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen 1865: Increase, Oxygen-evolving complex damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen 1941: Memory loss
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation Julija Filipovska 1739: ACE2 binding to viral S-protein
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos 1739: ACE2 binding to viral S-protein 1535: Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
Adverse outcome pathway of PM-induced respiratory toxicity li qing
Alkylation of DNA leading to reduced sperm count Carole Yauk 97: Alkylation, DNA 1757: Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen 26: Antagonism, Androgen receptor 972: Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen 26: Antagonism, Androgen receptor 1786: increase, retained nipples in males
Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve 25: Agonism, Androgen receptor 360: Decrease, Population trajectory
Androgen receptor antagonism leading to testicular cancer Chander K. Negi 26: Antagonism, Androgen receptor 1839: Testicular Cancer
AOP for thyroid disorder caused by triphenyl phosphate Fei Li
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza 1261: Mitochondrial impairment 1763: Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez 36: Inhibition, Aromatase 360: Decrease, Population trajectory
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu 18: Activation, AhR 1250: Decrease, lung function
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu 18: Activation, AhR 1250: Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu 18: Activation, AhR 1276: Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu 18: Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
Bulky DNA adducts leading to mutations Carole Yauk 1879: Bulky DNA adducts, increase 185: Increase, Mutations
Ceramide synthase inhibition leading to neural tube defects Lola Bajard
combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders 1508: CYP2E1 Activation and 1509: Protein Adduct Formation 1514: Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak 1840: Inhibition, cytochrome oxidase 872: Increase, Site of Contact Nasal Tumors
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen 1194: Increase, DNA damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionising energy leads to population decline via pollen abnormal Li Xie 1686: Deposition of Energy 1863: Decrease, Reproduction and 442: Decreased, Population trajectory
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti 1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage 1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size
DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga
DNA methyltransferase inhibition leading to population decline (3) You Song 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer 1842: Prolonged TLR9 activation 1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer 1848: Toll Like Receptor (TLR) Dysregulation
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering 18: Activation, AhR 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang
Excessive reactive oxygen species production leading to mortality (1) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1) You Song 1765: Increase, Formation of DNA photoproducts 350: Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2) You Song
Formation of DNA photoproducts leading to growth inhibition (3) You Song
From activation of the AhR leading to breast cancer related death Louise Benoit
Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark 1668: Frustrated phagoytosis 1090: Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Fei Li
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi 122: Activation, Glucocorticoid Receptor 459: Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole 122: Activation, Glucocorticoid Receptor 360: Decrease, Population trajectory
GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic 1647: GSK3beta inactivation 351: Increased Mortality and 360: Decrease, Population trajectory
hERG inhibition leading to cardiac toxicity Egemen Bilgin 1956: Binding to hERG channel and 1957: hERG channel biogenesis interference 1964: Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects Marvin Martens 1502: Histone deacetylase inhibition 1561: Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
Hypothalamic estrogen receptors inhibition leading to ovarian cancer Kalyan Gayen
IKK complex inhibition leading to liver injury Nanette Vrijenhoek 1574: Inhibition, IKK complex 1548: Necrotic Tissue and 1549: Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues Fei Li
Immune mediated hepatitis Jung-Hwa Oh 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang 1950: Increase, TNF 1953: Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic 1884: Inhibition of Fyna 351: Increased Mortality and 360: Decrease, Population trajectory
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts 1467: Growth, reduction and 636: Decreased, survival
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen
Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development Andrea Terron
Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim 1691: Antagonism,LH receptor 679: Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel 1542, 1543, 1544, 888, 887, 1653, 1654, 1655 1548: Necrotic Tissue and 1549: Liver Injury
Mitochondrial dysfunction to metabolic diseases Chander K. Negi
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain 351: Increased Mortality
Oxidative stress Leading to Decreased Lung Function Karsta Luettich 1392: Oxidative Stress 1250: Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich 1392: Oxidative Stress 1250: Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich 1392: Oxidative Stress 1250: Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song
PM-related Adverse outcome pathway frameworks on various systems Tianyu Li
PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson 227: Activation, PPARα
PPARG activation leading to intrahepatic cholestasis Yuan Jin
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population ruiyang Ding
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality ruiyang Ding
S-adenosylmethionine depletion leading to population decline (1) You Song 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2) You Song 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan 1739: ACE2 binding to viral S-protein 1868: Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan 1739: ACE2 binding to viral S-protein 1967: Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos 1739: ACE2 binding to viral S-protein 1934: Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins Erwin L Roggen
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
test AOP Kevin Crofton
Thermal stress leading to population decline (1) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (2) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (3) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon 1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ 1458: Pulmonary fibrosis
α-diketone-induced bronchiolitis obliterans Marvin Martens 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans