Recently added AOPs


Title Point of Contact MIE AO
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
Acetylcholinesterase Inhibition Leading to Neurodegeneration Kendra Conrow
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
Chitin synthase inhibition leading to premature molting associated mortality You Song
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
D1 protein blockage leading to apoptosis associated growth inhibition You Song
D1 protein blockage leading to photosystem II (PSII)-inhibition associated growth reduction You Song
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen
Direct deposition of ionizing energy onto DNA leading to lung cancer Vinita Chauhan
DNA methyltransferase inhibition leading to reduced fecundity associated population decline You Song
DNA methyltransferase inhibition leading to transgenerational DNA methylation associated population decline You Song
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline Knut Erik Tollefsen
Frustrated phagocytosis-induced lung cancer Carole Seidel
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
Increased DNA damage leading to increased risk of breast cancer Jessica Helm
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
Inhibition of 5α-reductase leading to impaired fertility in female fish Young Jun Kim
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim
Inhibition of IL-1 signaling Yutaka Kimura
Inhibition of JAK3 leading to impairment of TDAR Hajime Kojima
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim
Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park
Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
Lung surfactant function disruption leading to acute inhalation toxicity Jorid Birkelund Sørli
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
Mitochondrila Complex III inhibition leading to ATP depletion associated mortality You Song
Mitochondrila Complex III inhibition leading to oxidative stress associated mortality You Song
Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk
Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Satomi Onoue
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally
Renal protein alkylation leading to kidney toxicity Angela Mally
S-adenosylmethionine depletion leading to reduced fecundity You Song
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen
Sensitization induction of the intestinal tract by food proteins Erwin Roggen
Sulfonylurea receptor binding leading to premature molting associated mortality You Song
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton
Uncoupling of oxidative phosphorylation leading to mortality You Song
Uncoupling of oxidative phosphorylation leading to reproduction decline You Song
Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen
Wnt ligand stimulation and Wnt signalling activation lead to cancer malignancy Shihori Tanabe
α-diketone-induced bronchiolitis obliterans Marvin Martens