Recently added AOPs

Title Point of Contact MIE AO
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen 1865: Increase, Oxygen-evolving complex damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation
ACE2 dysregulation leading to microvascular disfunction Julija Filipovska 1739: ACE2 binding to viral S-protein
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
Alkylation of DNA leading to reduced sperm count Carole Yauk 97: Alkylation, DNA 1757: Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen 26: Antagonism, Androgen receptor 972: Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen 26: Antagonism, Androgen receptor 1786: increase, retained nipples in males
Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve 25: Agonism, Androgen receptor 360: Decrease, Population trajectory
Androgen receptor antagonism leading to testicular cancer Chander K. Negi 26: Antagonism, Androgen receptor 1839: Testicular Cancer
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis
AOP for thyroid disorder caused by triphenyl phosphate Fei Li
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza 1261: Mitochondrial impairment 1763: Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez 36: Inhibition, Aromatase 360: Decrease, Population trajectory
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price 1739: ACE2 binding to viral S-protein 1841: Encephalitis
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana 1739: ACE2 binding to viral S-protein 1875: Cerebrovascular disease (stroke)
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to increased intestinal permeability resulting in GI disorders Laure-Alix Clerbaux
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim 1739: ACE2 binding to viral S-protein 351: Increased Mortality
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim 1739: ACE2 binding to viral S-protein 1850: dysgeusia
Bulky DNA adducts leading to mutations Carole Yauk 1879: Bulky DNA adducts, increase 185: Increase, Mutations
Chitinase inhibition leading to mortality Simon Schmid 1806: Increase, Chitinase inhibition 350: Increase, Mortality
Chitobiase inhibition leading to mortality Simon Schmid 1807: Increase, Chitobiase inhibition 350: Increase, Mortality
combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders 1508: CYP2E1 Activation and 1509: Protein Adduct Formation 1514: Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak 1840: Inhibition, cytochrome oxidase 872: Increase, Site of Contact Nasal Tumors
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark 1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated 1868: Hyperinflammation
Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti 1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage 1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size
DNA damage leading to population decline via programmed cell death Knut Erik Tollefsen 1194: Increase, DNA damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
DNA methyltransferase inhibition leading to population decline (3) You Song 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Gillina Bezemer 1842: Prolonged TLR9 activation 1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering 18: Activation, AhR 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
Excessive reactive oxygen species production leading to mortality (1) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4) You Song 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to population decline via lipid peroxidation Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction You Song 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Formation of DNA photoproducts leading to growth inhibition (1) You Song 1765: Increase, Formation of DNA photoproducts 350: Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2) You Song
Formation of DNA photoproducts leading to growth inhibition (3) You Song
Frustrated phagocytosis leads to malignant mesothelioma Nureddin Mansour
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Fei Li
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi 122: Activation, Glucocorticoid Receptor 459: Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole 122: Activation, Glucocorticoid Receptor 360: Decrease, Population trajectory
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects Marvin Martens 1502: Histone deacetylase inhibition 1561: Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
IKK complex inhibition leading to liver injury Nanette Vrijenhoek 1574: Inhibition, IKK complex 1548: Necrotic Tissue and 1549: Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues Fei Li
Immune mediated hepatitis Jung-Hwa Oh 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
Increased reactive oxygen species production leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Increased reactive oxygen species production leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe 1738: Increased susceptibility to viral entry 1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation
Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim 1796: 11β-hydroxylase inhibition 360: Decrease, Population trajectory
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim 1799: Inhibition of 11β-HSD 360: Decrease, Population trajectory
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
Inhibition of ALDH1A2 (RALDH2) causing reduced all-trans retinoic acid levels leading to decreased fertility, females Terje Svingen 1880: Inhibition of ALDH1A2 (RALDH2) 972: Decreased fertility, Reduced number of oocytes ovulated
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim 1740: ACE2 inhibition 344: N/A, Liver fibrosis
Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Young Jun Kim 1740: ACE2 inhibition 1276: Lung fibrosis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic 1884: Inhibition of Fyna 351: Increased Mortality and 360: Decrease, Population trajectory
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts 1467: Growth, reduction and 636: Decreased, survival
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim 1691: Antagonism,LH receptor 679: Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel 1542, 1543, 1544, 888, 887, 1653, 1654, 1655 1548: Necrotic Tissue and 1549: Liver Injury
Mitochondrial dysfunction to metabolic diseases Chander K. Negi
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain
Oxidative stress [MIE] Leading to Decreased Lung Function [AO] Karsta Luettich
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song
PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson 227: Activation, PPARα
PPARG activation leading to intrahepatic cholestasis Yuan Jin
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
Repression of Gbx2 expression leads to defects in developing inner ear and consequently to increased mortality Vid Modic
S-adenosylmethionine depletion leading to population decline (1) You Song 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2) You Song 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan
Sars-cov-2 infection leading to impaired olfactory function (anosmia) Sandra Coecke 1739: ACE2 binding to viral S-protein 1873: impaired olfactory function (anosmia)
SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan
SARS-CoV-2 infection leading to thromboinflammation Luigi Margiotta-Casaluci
Sensitization induction of the intestinal tract by food proteins Erwin Roggen
Sulfonylureareceptor binding leading to mortality Simon Schmid 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
test AOP Kevin Crofton
Thermal stress leading to population decline (1) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (2) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (3) You Song 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy
Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to increased mortality via altered retinal layer structure Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to increased mortality via decreased eye size Lucia Vergauwen 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon 1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ 1458: Pulmonary fibrosis
α-diketone-induced bronchiolitis obliterans Marvin Martens 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans