Recently added AOPs

Title Point of Contact MIE AO
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR
  • Acetylcholinesterase (AchE) Inhibition
  • Sensory axonal peripheral neuropathy
  • Increased Mortality
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
  • Increase, Oxygen-evolving complex damage
  • Decrease, Reproduction
  • Decrease, Population growth rate
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li
  • Activation, PARP1
  • ROS formation
  • Apoptotic cell death
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen
  • Memory Loss
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation Julija Filipovska
  • Binding to ACE2
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos
  • Binding to ACE2
  • Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe
  • Acetylcholinesterase (AchE) Inhibition
  • N/A, Neurodegeneration
Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara
Activation of the AhR leading to breast cancer Louise Benoit
  • Activation, AhR
  • N/A, Breast Cancer
Adverse outcome pathway of PM-induced respiratory toxicity li qing
  • Non-coding RNA expression profile alteration
  • Chronic obstructive pulmonary disease
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel
Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo
  • Increase, Alcohol dehydrogenase
Alkylation of DNA leading to reduced sperm count Carole Yauk
  • Alkylation, DNA
  • Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen
  • Antagonism, Androgen receptor
  • Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen
  • Antagonism, Androgen receptor
  • Nipple retention in male offspring, increased
Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
Androgen receptor antagonism leading to testicular cancer Chander K. Negi
  • Antagonism, Androgen receptor
  • Testicular Cancer
Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds
  • Antagonism, Smoothened receptor
  • Ororofacial clefting
AOP for thyroid disorder caused by triphenyl phosphate Fei Li
  • Increased, Hepatic thyroid hormone uptake/transport
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza
  • Mitochondrial impairment
  • Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez
  • Inhibition, Aromatase
  • Decrease, Population growth rate
Aryl hydrocarbon receptor activation leading to early life stage mortality via cardiovascular toxicity Prarthana Shankar
  • Activation, AhR
  • Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to early life stage mortality via impeded craniofacial development Prarthana Shankar
  • Activation, AhR
  • Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu
  • Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu
  • Activation, AhR
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu
  • Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Chronic kidney disease
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux
  • Binding to ACE2
  • Increase, the risk of acute respiratory failure
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman
  • Activation of metabotropic glutamate receptor
  • Inositol triphosphate receptor activation
  • Overactivation, NMDARs
  • Inhibition GABAA receptor
  • Parkinsonian motor deficits
Ceramide synthase inhibition leading to neural tube defects Lola Bajard
  • Inhibition of Ceramide Synthase
  • Neural tube defects
combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman
  • Binding, Thyroid binding globulin in serum
  • Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman
  • Binding, Transthyretin in serum
  • Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
  • CYP2E1 Activation
  • Protein Adduct Formation
  • Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak
  • Inhibition, cytochrome oxidase
  • Increase, Site of Contact Nasal Tumors
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede
  • Deposition of Energy
  • Acute Myeloid Leukemia
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leads to vascular remodeling Vinita Chauhan
  • Deposition of Energy
  • Occurrence, Vascular Remodeling
Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen
Deposition of ionising energy leads to population decline via pollen abnormal Li Xie
  • Deposition of Energy
  • Decrease, Reproduction
  • Decreased, Population trajectory
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti
  • Deposition of Ionizing Energy
  • Decrease of egg production and cummulative fecundity
  • Decrease, Reproduction
  • Decreased, Population size
DNA adduct formation leading to kidney failure Manoe Janssen
DNA methyltransferase inhibition leading to population decline (3) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
Doda decarboxylase leading to mortality Donggon Yoo
  • Decrease, Tyrosine
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer
  • Prolonged TLR9 activation
  • Multi Organ Failure involving Acute Respiratory Distress Syndrome
  • Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer
  • Toll Like Receptor (TLR) Dysregulation
elavl3, sox10, mbp neurogene Donggon Yoo
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering
  • Activation, AhR
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Energy deposition from internalized Ra-226 decay leads to altered ventilation behavior and slower growth in Lymnaea stagnalis due to apparent hypoxia from decreased hemocyanin oxygen binding capacity Danielle Beaton
  • Deposition of Energy
  • Decrease, Growth
  • Decreased, Reproductive Success
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang
  • Activation, estrogen receptor alpha
  • Impaired, Reproduction
Excessive reactive oxygen species production leading to mortality (1) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1) You Song
  • Increase, Formation of DNA photoproducts
  • Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2) You Song
Formation of DNA photoproducts leading to growth inhibition (3) You Song
Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark
  • Frustrated phagocytosis
  • Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Fei Li
  • protein-coupled estrogen receptor 1 (GPER) activation
  • N/A, Steatohepatisis
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi
  • Activation, Glucocorticoid Receptor
  • Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone
  • Activation, Glucocorticoid Receptor
  • Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole
  • Activation, Glucocorticoid Receptor
  • Decrease, Population growth rate
GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic
  • GSK3beta inactivation
  • Increased Mortality
  • Decrease, Population growth rate
hERG inhibition leading to cardiac toxicity Egemen Bilgin
  • Binding to hERG channel
  • hERG channel biogenesis interference
  • Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
  • Histone deacetylase inhibition
  • Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
  • Histone deacetylase inhibition
  • Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim
  • Hyperactivation of ACE/Ang-II/AT1R axis
  • Chronic kidney disease
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
  • Inhibition, IKK complex
  • Necrotic Tissue
  • Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues Fei Li
Immune mediated hepatitis Jung-Hwa Oh
  • benzoquinone imine and acylglucuronide metabolites
  • Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen
  • Increased (ectopic) all-trans retinoic acid concentration
  • Reduce, Sperm count
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang
  • Increase, TNF
  • Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
  • Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
  • Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim
  • Inhibition of cystathionine beta-synthase
  • Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic
  • Inhibition of Fyna
  • Increased Mortality
  • Decrease, Population growth rate
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
  • Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
  • Growth, reduction
  • Decreased, survival
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Occurrence, Kidney toxicity
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
  • Inhibition of N-linked glycosylation
  • Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen
  • Inhibition of ALDH1A (RALDH)
  • transposition of the great arteries
Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark
  • Substance interaction with the lung resident cell membrane components
  • Lung cancer
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton
  • Deposition of Energy
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Decrease, Population growth rate
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT
  • Deposition of Energy
  • Increase risk, microcephaly
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN
  • Increased, Kidney Failure
Knickkopf leading to mortality Donggon Yoo
  • Decrease, 20-hydroxyecdysone
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
  • Activation, Latent Transforming Growth Factor Beta 1
  • Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim
  • Antagonism,LH receptor
  • Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
  • Binding of microtubule stabilizing agents (MSA) to microtubules
  • Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
  • Increase, Mitochondrial complex III antagonism
  • Mitochondrial Complex IV inhibition
  • Mitochondrial Complex V inhibition
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Inhibition, NADH-ubiquinone oxidoreductase (complex I)
  • Binding of inhibitor to mitochondrial complex III
  • Binding of inhibitor to mitochondrial complex IV
  • Binding of inhibitor to mitochondrial complex V
  • Necrotic Tissue
  • Liver Injury
Mitochondrial dysfunction to metabolic diseases Chander K. Negi
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR
  • Acetylcholinesterase (AchE) Inhibition
  • Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain
  • Oxidation, Glutathione (To be considered with MIE)
  • Increased Mortality
Oxidative stress Leading to Decreased Lung Function Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song
PM-related Adverse outcome pathway frameworks on various systems Tianyu Li
PM2.5-related AOP frameworks on liver diseases Zhou Du
PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson
  • Activation, PPARα
  • Viable offspring, decreased
  • Decrease, Population growth rate
PPARG activation leading to intrahepatic cholestasis Yuan Jin
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population ruiyang Ding
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population ruiyang Ding
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen
  • Increase, Uncoupling of photophosphorylation
  • Decrease, Growth
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality ruiyang Ding
S-adenosylmethionine depletion leading to population decline (1) You Song
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2) You Song
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan
  • Binding to ACE2
  • Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan
  • Binding to ACE2
  • Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos
  • Binding to ACE2
  • Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins Erwin L Roggen
Succinate dehydrogenase inactivation leading to cancer Sylvie Bortoli
Superoxide dismutase inhibition leading to increased insulin resistance Simon Thomas
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee
  • Inhibition, TBX1
  • Anomalies, Congenital cardiac conotruncal
test AOP Kevin Crofton
The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li
Thermal stress leading to population decline (1) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thermal stress leading to population decline (2) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thermal stress leading to population decline (3) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon
  • Toll-like receptor 4 activation
  • Inactivation of PPARγ
  • Pulmonary fibrosis
α-diketone-induced bronchiolitis obliterans Marvin Martens
  • Interaction of α-diketones with arginine residues
  • Bronchiolitis obliterans