Recently added AOPs

Title Point of Contact MIE AO
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR
  • Acetylcholinesterase (AchE) Inhibition
  • Sensory axonal peripheral neuropathy
  • Increased Mortality
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
  • Increase, Oxygen-evolving complex damage
  • Decrease, Reproduction
  • Decrease, Population growth rate
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li
  • Activation, PARP1
  • ROS formation
  • Apoptotic cell death
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen
  • Memory Loss
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos
  • Binding to ACE2
  • Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe
  • Acetylcholinesterase (AchE) Inhibition
  • N/A, Neurodegeneration
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik
  • Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • Impairment, Learning and memory
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik
  • Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • Impairment, Learning and memory
Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara
Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani
  • Activation, estrogen receptor alpha
  • Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
Adverse outcome pathway of PM-induced respiratory toxicity li qing
  • Non-coding RNA expression profile alteration
  • Chronic obstructive pulmonary disease
Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang
  • Increased, Reactive oxygen species
  • Disruption, Estrogen receptor
  • Antagonism, Androgen receptor
  • Decreased sperm quantity or quality in the adult, Decreased fertility
  • anogenital distance (AGD), decreased
  • Malformation, cryptorchidism - maldescended testis
  • Decrease, Reproduction
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel
  • Activation, AhR
  • Cognitive Function, Decreased
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel
  • Activation, AhR
  • Cognitive Function, Decreased
AhR activation leading to liver fibrosis Xavier COUMOUL
  • Activation, AhR
  • N/A, Liver fibrosis
Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo
  • Increase, Alcohol dehydrogenase
Alkylation of DNA leading to reduced sperm count Carole Yauk
  • Alkylation, DNA
  • Reduce, Sperm count
An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen
Androgen receptor (AR) antagonism leading to hypospadias in male offspring Terje Svingen
  • Antagonism, Androgen receptor
  • Hypospadias, increased
Androgen receptor activation leading to prostate cancer Jianxiang Li
  • Activation, Androgen receptor
  • Prostate cancer
Androgen receptor agonism leading to reproduction dysfunction (in zebrafish) Hongling Liu
  • Agonism, Androgen receptor
  • Increased, gene expression of AR
  • Decreased, Population trajectory
Androgen receptor antagonism leading to testicular cancer Chander K. Negi
  • Antagonism, Androgen receptor
  • Testicular Cancer
AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation Fei Li
  • Increased, Hepatic thyroid hormone uptake/transport
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza
  • N/A, Mitochondrial dysfunction 1
  • Urothelial Tumor
AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu
  • Increase, Reactive oxygen species
  • Increased incidence of respiratory disease
  • Dysfunction of respiratory system
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu
  • Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu
  • Activation, AhR
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu
  • Activation, AhR
  • Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu
  • Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Chronic kidney disease
Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick
  • Influenza A Virus (IAV) binds sialic acid glycan receptor
  • Influenza A Virus (IAV) shedding and transmission
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux
  • Binding to ACE2
  • Hyperinflammation
Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska
  • Binding, extracellular matrix protein laminin
  • Cognitive Function, Decreased
Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman
  • Activation of metabotropic glutamate receptor
  • Inositol triphosphate receptor activation
  • Overactivation, NMDARs
  • Inhibition GABAA receptor
  • Opening, voltage-gated calcium channels
  • Parkinsonian motor deficits
Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death Young Jun Kim
Ceramide synthase inhibition leading to neural tube defects Lola Bajard
  • Inhibition of Ceramide Synthase
  • Neural tube defects
Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms Karine Audouze
  • Ryanodine receptor activation
  • Inositol triphosphate receptor activation
  • Impairment, Learning and memory
  • decreased, Intellectual Quotient
  • increased, socio-economic burden
combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman
  • Binding, Thyroid binding globulin in serum
  • Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman
  • Binding, Transthyretin in serum
  • Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
  • CYP2E1 Activation
  • Protein Adduct Formation
  • Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak
  • Inhibition, cytochrome oxidase
  • Increase, Site of Contact Nasal Tumors
Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) stem Leydig cells leads to Hypospadias, increased John Frisch
  • Hypospadias, increased
Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) stem Leydig cells leads to Impaired, Spermatogenesis John Frisch
  • Impaired, Spermatogenesis
Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch
Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei
  • peroxisome proliferator activated receptor promoter demethylation
  • Increase, Vascular disrupting effects
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede
  • Deposition of Energy
  • Acute Myeloid Leukemia
Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan
  • Deposition of Energy
  • Impairment, Learning and memory
Deposition of energy leading to occurrence of bone loss Vinita Chauhan
  • Deposition of Energy
  • Occurrence, Bone Loss
Deposition of energy leading to occurrence of cataracts Vinita Chauhan
  • Deposition of Energy
  • Occurrence of Cataracts
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leads to vascular remodeling Vinita Chauhan
  • Deposition of Energy
  • Occurrence, Vascular Remodeling
Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen
Deposition of ionising energy leads to population decline via pollen abnormal Li Xie
  • Deposition of Energy
  • Decrease, Reproduction
  • Decreased, Population trajectory
Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti
  • Deposition of Ionizing Energy
  • Decrease of egg production and cummulative fecundity
  • Decrease, Reproduction
  • Decreased, Population size
DNA adduct formation leading to kidney failure Manoe Janssen
DNA methyltransferase inhibition leading to population decline (3) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
Doda decarboxylase leading to mortality Donggon Yoo
  • Decrease, Tyrosine
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer
  • Prolonged TLR9 activation
  • Multi Organ Failure involving Acute Respiratory Distress Syndrome
  • Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer
  • Toll Like Receptor (TLR) Dysregulation
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering
  • Activation, AhR
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton
  • Deposition of Energy
  • Decrease, Growth
  • Decreased, Reproductive Success
ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim
  • Estrogen receptor alpha inactivation
  • Metabolically unhealthy Obesity
ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim
  • Estrogen receptor alpha inactivation
  • Insulin resistance
  • Metabolic syndrome
Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik
  • Increased, essential element imbalance
  • Decreased, Viable Offspring
Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui
  • Antagonism, Estrogen receptor
  • autism-like behavior
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang
  • Activation, estrogen receptor alpha
  • Impaired, Reproduction
Excessive iron accumulation leading to neurological disorders Young Jun Kim
  • Increased intracelluar Iron accumulation
  • Neurological disorder
Excessive reactive oxygen species production leading to mortality (1) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4) You Song
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1) You Song
  • Increase, Formation of DNA photoproducts
  • Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2) You Song
Formation of DNA photoproducts leading to growth inhibition (3) You Song
Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark
  • Frustrated phagocytosis
  • Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li
  • protein-coupled estrogen receptor 1 (GPER) activation
  • N/A, Steatohepatisis
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi
  • Activation, Glucocorticoid Receptor
  • Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone
  • Activation, Glucocorticoid Receptor
  • Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole
  • Activation, Glucocorticoid Receptor
  • Decrease, Population growth rate
Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira
  • Conjugation, GSH
  • impaired, Fertility
Gluten intake leading to celiac disease example test - under development Pablo Rodriguez Fernandez
GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic
  • GSK3beta inactivation
  • Increased Mortality
  • Decrease, Population growth rate
hERG channel blockade leading to sudden cardiac death Egemen Bilgin
  • hERG channel blockade
  • Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
  • Histone deacetylase inhibition
  • Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
  • Histone deacetylase inhibition
  • Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim
  • Hyperactivation of ACE/Ang-II/AT1R axis
  • Chronic kidney disease
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
  • Inhibition, IKK complex
  • Necrotic Tissue
  • Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues Fei Li
Immune mediated hepatitis Jung-Hwa Oh
  • benzoquinone imine and acylglucuronide metabolites
  • Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen
  • Increased (ectopic) all-trans retinoic acid concentration
  • Reduce, Sperm count
Increased LCN2/iron complex leading to neurological disorders Young Jun Kim
  • Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
  • Neurological disorder
Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska
  • Increase, Reactive Oxygen Species production
  • Cognitive Function, Decreased
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang
  • Increase, TNF
  • Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
  • Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
  • Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim
  • Inhibition of cystathionine beta-synthase
  • Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic
  • Inhibition of Fyna
  • Increased Mortality
  • Decrease, Population growth rate
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
  • Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
  • Growth, reduction
  • Decreased, survival
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
  • Inhibition of N-linked glycosylation
  • Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen
  • Inhibition of ALDH1A (RALDH)
  • transposition of the great arteries
Inhibition of voltage-gated sodium channels leading to decreased cognition Eliska Kuchovska
  • Binding to voltage-gated sodium channel
  • Cognitive Function, Decreased
Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark
  • Substance interaction with the lung resident cell membrane components
  • Lung cancer
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton
  • Deposition of Energy
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Decrease, Population growth rate
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT
  • Deposition of Energy
  • Increase risk, microcephaly
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN
  • Increased, Kidney Failure
Knickkopf leading to mortality Donggon Yoo
  • Decrease, 20-hydroxyecdysone
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
  • Activation, Latent Transforming Growth Factor Beta 1
  • Pulmonary fibrosis
Liver X Receptor (LXR) activation leads to liver steatosis John Frisch
  • Activation, LXR
  • Increased, Liver Steatosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim
  • Antagonism,LH receptor
  • Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
  • Binding of microtubule stabilizing agents (MSA) to microtubules
  • Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
  • Increase, Mitochondrial complex III antagonism
  • Mitochondrial Complex IV inhibition
  • Mitochondrial Complex V inhibition
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Inhibition, NADH-ubiquinone oxidoreductase (complex I)
  • Binding of inhibitor to mitochondrial complex III
  • Binding of inhibitor to mitochondrial complex IV
  • Binding of inhibitor to mitochondrial complex V
  • Necrotic Tissue
  • Liver Injury
Mitochondrial dysfunction to metabolic diseases Chander K. Negi
Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish
  • Decreased Na/K ATPase activity
  • Hypertension
Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR
  • Acetylcholinesterase (AchE) Inhibition
  • Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain
  • Oxidation, Glutathione (To be considered with MIE)
  • Increased Mortality
Oxidative stress Leading to Decreased Lung Function Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich
  • Oxidative Stress
  • Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song
PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li
PM-related Adverse outcome pathway frameworks on various systems Tianyu Li
PM2.5-related AOP frameworks on liver diseases Zhou Du
PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker
  • Activation, PPARα
  • Decreased, Viable Offspring
  • Decrease, Population growth rate
PPARG activation leading to intrahepatic cholestasis Yuan Jin
Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch
  • Activation, Pregnane-X receptor, NR1l2
  • Increased, Liver Steatosis
Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch
  • Increased, Reactive oxygen species
  • Increase, Cancer
Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch
  • Increased, Reactive oxygen species
  • Increase, Cancer
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population ruiyang Ding
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population ruiyang Ding
Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Diana Lupu
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen
  • Increase, Uncoupling of photophosphorylation
  • Decrease, Growth
Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu
  • Agonism, Retinoic acid receptor
  • Impairment, Learning and memory
Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu
  • Agonism, Retinoic acid receptor
  • Increase risk, microcephaly
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality ruiyang Ding
S-adenosylmethionine depletion leading to population decline (1) You Song
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2) You Song
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan
  • Binding to ACE2
  • Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan
  • Binding to ACE2
  • Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos
  • Binding to ACE2
  • Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins Erwin L Roggen
Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas
  • Succinate dehydrogenase, inhibited
  • Insulin resistance, increased
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca
  • Inhibition of Sulfotransferase E1 (SULT1E1)
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee
  • Inhibition, TBX1
  • Anomalies, Congenital cardiac conotruncal
test AOP Kevin Crofton
The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei
  • Increase, Reactive Oxygen Species production
  • Increase, Vascular disrupting effects
The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li
Thermal stress leading to population decline (1) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thermal stress leading to population decline (2) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thermal stress leading to population decline (3) You Song
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy
  • Thyroperoxidase, Inhibition
  • Periventricular heterotopia formation
  • Increase, seizure
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon
  • Toll-like receptor 4 activation
  • Inactivation of PPARγ
  • Pulmonary fibrosis
Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska
  • Unknown, MIE
  • Cognitive Function, Decreased
Various neuronal effects induced by elavl3, sox10, and mbp Donggon Yoo
  • Increase, CNS Neural cell death
  • impaired, Learning and memory
  • Encephalitis
  • Parkinsonian motor deficits
  • Increase, seizure
  • Increased, epilepsy
  • Increase, Mortality
  • Inhibition, Feeding
Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska
  • Binding to ACE2
α-diketone-induced bronchiolitis obliterans Marvin Martens
  • Interaction of α-diketones with arginine residues
  • Bronchiolitis obliterans