Recently added AOPs

Title Point of Contact MIE AO
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 5-HTT increased predation
ACE2 dysregulation leading to microvascular disfunction Julija Filipovska
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan
Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe
Alkylation of DNA leading to reduced sperm count Carole Yauk
Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen
Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve
Androgen receptor antagonism leading to testicular cancer Chander K. Negi
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim
Chitin synthase 1 inhibition leading to mortality Simon Schmid
Chitinase inhibition leading to mortality Simon Schmid
Chitobiase inhibition leading to mortality Simon Schmid
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders
Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark
DNA damage leading to population decline via programmed cell death Knut Erik Tollefsen
DNA methyltransferase inhibition leading to population decline (3) You Song
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Gillina Bezemer
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering
Excessive reactive oxygen species production leading to mortality (1) You Song
Excessive reactive oxygen species production leading to mortality (2) You Song
Excessive reactive oxygen species production leading to mortality (3) You Song
Excessive reactive oxygen species production leading to mortality (4) You Song
Excessive reactive oxygen species production leading to population decline via lipid peroxidation Knut Erik Tollefsen
Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction You Song
Formation of DNA photoproducts leading to growth inhibition (1) You Song
Formation of DNA photoproducts leading to growth inhibition (2) You Song
Formation of DNA photoproducts leading to growth inhibition (3) You Song
Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone GR increased disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole
Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens
Histone deacetylase inhibition leads to neural tube defects Marvin Martens
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim
IKK complex inhibition leading to liver injury Nanette Vrijenhoek
Immune mediated hepatitis Jung-Hwa Oh
Increased reactive oxygen species production leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen
Increased reactive oxygen species production leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen
Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe
Inhibition of 11β-hydroxylase leading to decresed trajectory in fish Young Jun Kim
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased trajectory in fish Young Jun Kim
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim
Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Young Jun Kim
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz
Inhibition of N-linked glycosylation leads to liver injury Marvin Martens
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim
Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens
Mitochondrial complex inhibition leading to liver injury Wanda van der Stel
Mitochondrial dysfunction to metabolic diseases Chander K. Negi
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song
Photosystem II antagonism leading to growth inhibition via oxidative damage You Song
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song
PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson
Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen
S-adenosylmethionine depletion leading to population decline (1) You Song
S-adenosylmethionine depletion leading to population decline (2) You Song
Sensitization induction of the intestinal tract by food proteins Erwin Roggen
Sulfonylureareceptor binding leading to mortality Simon Schmid
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee
test AOP Kevin Crofton
Thermal stress leading to population decline (1) You Song
Thermal stress leading to population decline (2) You Song
Thermal stress leading to population decline (3) You Song
Thyroperoxidase inhibition leading to increased mortality via altered eye structure Lucia Vergauwen
Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Lucia Vergauwen
Thyroperoxidase inhibition leading to increased mortality via decreased eye size Lucia Vergauwen
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon
α-diketone-induced bronchiolitis obliterans Marvin Martens