Key Event Relationships (KERs)

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Showing 251 to 275 of 3158 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
499 18: Activation, AhR 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Nov 29, 2016 Dec 3, 2016
501 54: Up Regulation, CD36 465: Increased, FA Influx Nov 29, 2016 Dec 3, 2016
503 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
504 465: Increased, FA Influx 291: Accumulation, Triglyceride Nov 29, 2016 Dec 3, 2016 None
505 465: Increased, FA Influx 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
506 18: Activation, AhR 466: Up Regulation, LDLR (low density lipoprotein receptor) Nov 29, 2016 Dec 3, 2016
507 466: Up Regulation, LDLR (low density lipoprotein receptor) 467: Increased, LDL uptake Nov 29, 2016 Dec 3, 2016
508 467: Increased, LDL uptake 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
509 18: Activation, AhR 450: Decrease, VLDL export capacity Nov 29, 2016 Dec 3, 2016
510 167: Activation, LXR 468: Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016
511 468: Inhibition, PPAR alpha 451: Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
512 458: Increased, De Novo FA synthesis 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
514 327: Accumulation, Fatty acid 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
515 327: Accumulation, Fatty acid 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016
516 167: Activation, LXR 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Nov 29, 2016 Dec 3, 2016
517 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
518 245: Activation, PXR/SXR 471: Inhibition, FoxA2 Nov 29, 2016 Dec 3, 2016
519 471: Inhibition, FoxA2 472: Down Regulation, CPT1A Nov 29, 2016 Dec 3, 2016
520 472: Down Regulation, CPT1A 179: Decrease, Fatty acid β-oxidation Nov 29, 2016 Dec 3, 2016
523 471: Inhibition, FoxA2 474: Down Regulation, HMGCS2 Nov 29, 2016 Dec 3, 2016
524 474: Down Regulation, HMGCS2 477: Decreased, Ketogenesis Nov 29, 2016 Dec 3, 2016
526 245: Activation, PXR/SXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
529 245: Activation, PXR/SXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
532 478: Activation, NRF2 479: Activation, NR1H4 Nov 29, 2016 Dec 3, 2016
533 479: Activation, NR1H4 480: Activation, SHP Nov 29, 2016 Dec 3, 2016