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Showing 2926 to 2950 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3192	2108: Altered, white brain matter	341: Impairment, Learning and memory	Apr 12, 2024	Apr 12, 2024	2 AOPs 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2975	1392: Increase, Oxidative Stress	149: Increase, Inflammation	Jul 31, 2023	Oct 19, 2023	2 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 472: DNA adduct formation leading to kidney failure
2977	1513: General Apoptosis	885: Increase, Cancer	Jul 31, 2023	Oct 19, 2023	2 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
2981	2009: Activation, inflammation pathway	1928: increased，Vascular endothelial dysfunction	Aug 19, 2023	Aug 19, 2023	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2987	2164: Activation, Dll4-Notch pathway	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	2 AOPs 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3316	1392: Increase, Oxidative Stress	2244: Altered Stress Response Signaling	Jul 24, 2024	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
3320	2245: Altered cell differentiation signaling	2089: Altered Bone Cell Homeostasis	Jul 24, 2024	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1789	1548: Necrotic Tissue	1549: Liver Injury	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1775	1539: Endocytosis	898: Disruption, Lysosome	Nov 12, 2018	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1769	221: Reduction, Plasma vitellogenin concentrations	78: Reduction, Cumulative fecundity and spawning	Sep 18, 2018	Sep 18, 2018	2 AOPs 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
1938	1615: Impaired inguinoscrotal phase	1616: Malformation, cryptorchidism	Jun 3, 2019	Dec 3, 2024	2 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
1918	1640: Altered, Photoreceptor patterning	1643: Altered, Visual function	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1913	1634: Increase, Oxidative DNA damage	1635: Increase, DNA strand breaks	May 19, 2019	Dec 17, 2024	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts
1724	149: Increase, Inflammation	1457: EMT	Mar 18, 2018	Jan 30, 2019	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans
1718	55: Cell injury/death	1492: Tissue resident cell activation	Feb 1, 2018	Aug 2, 2018	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis
1742	1522: Inhibition, CHS-1	1523: Decrease, Cuticular chitin content	May 24, 2018	Feb 17, 2021	2 AOPs 360: Chitin synthase 1 inhibition leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1709	1502: Histone deacetylase inhibition	1503: Histone acetylation, increase	Jan 21, 2018	Aug 5, 2021	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 275: Histone deacetylase inhibition leads to neural tube defects
1896	185: Increase, Mutations	1182: Increase, Cell Proliferation (Epithelial Cells)	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1897	1194: Increase, DNA Damage	185: Increase, Mutations	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1898	1194: Increase, DNA Damage	1492: Tissue resident cell activation	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1902	1493: Increased pro-inflammatory mediators	1193: N/A, Breast Cancer	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1903	1493: Increased pro-inflammatory mediators	1632: Increase in RONS	May 7, 2019	May 9, 2019	2 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1905	1494: Leukocyte recruitment/activation	1632: Increase in RONS	May 7, 2019	May 9, 2019	2 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1906	1632: Increase in RONS	1492: Tissue resident cell activation	May 7, 2019	May 9, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1907	1182: Increase, Cell Proliferation (Epithelial Cells)	185: Increase, Mutations	May 8, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer

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