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All KERs

Showing 276 to 300 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

534	479: Activation, NR1H4	227: Activation, PPARα	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
535	227: Activation, PPARα	483: Activation, LXR alpha	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
537	482: Decreased, DHB4/HSD17B4	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
538	451: Inhibition, Mitochondrial fatty acid beta-oxidation	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
541	486: inflammation	484: Activation, AKT2	Nov 29, 2016	Dec 3, 2016	1 AOP 62: AKT2 activation leading to hepatic steatosis
544	488: Decrease, Ovulation	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Dec 3, 2016	None
547	493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	376: Increased, Induced Mutations in Critical Genes	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
548	373: Formation, Pro-mutagenic DNA Adducts	493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
549	376: Increased, Induced Mutations in Critical Genes	491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
550	491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
551	373: Formation, Pro-mutagenic DNA Adducts	491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
552	424: Inhibition, Na+/I- symporter (NIS)	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	2 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
558	561: Reduced, Food storage	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	None
559	572: Decrease, Number of worker bees	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
562	561: Reduced, Food storage	566: impaired, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
564	341: Impairment, Learning and memory	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
565	564: Abnormal, Roll change within caste	565: Reduced, Brood care	Nov 29, 2016	Dec 3, 2016	3 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
566	565: Reduced, Brood care	566: impaired, Larval development	Nov 29, 2016	Dec 3, 2016	3 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
567	573: Increase, Energetic demands and therefore metabolic stress	574: Increased, Appetite and hunger	Nov 29, 2016	Dec 3, 2016	1 AOP 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
568	574: Increased, Appetite and hunger	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
569	560: Abnormal, Foraging activity and behavior	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
570	403: Suppression, Immune system	576: Increased, Viral susceptibility	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
571	576: Increased, Viral susceptibility	577: impaired, Development	Nov 29, 2016	Dec 3, 2016	1 AOP 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
572	577: impaired, Development	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure

Key Event Relationships (KERs)

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