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All KERs

Showing 3001 to 3025 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2824	1532: Decrease, Cardiac contractility	1535: Heart failure	Jan 5, 2023	Jan 5, 2023	3 AOPs 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
2828	1614: Decrease, AR activation	2082: Hypospadias	Jan 11, 2023	Mar 20, 2026	3 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
2811	1392: Increase, Oxidative Stress	1635: Increase, DNA strand breaks	Dec 16, 2022	Jul 29, 2024	3 AOPs 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling
1939	1635: Increase, DNA strand breaks	1636: Increase, Chromosomal aberrations	Jun 3, 2019	Jan 9, 2023	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1034	1007: Reduced, Anterior swim bladder inflation	1005: Reduced, Swimming performance	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1035	1003: Decreased, Triiodothyronine (T3)	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1317	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1142: Increased, valve movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1318	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	621: Increase, cilia movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1333	626: Increased, serotonin (5-HT)	621: Increase, cilia movement	Jan 30, 2017	Jan 30, 2017	3 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1346	988: Decrease, Circulating ETH	1266: Decrease, Circulating CCAP	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1347	1266: Decrease, Circulating CCAP	1267: Decrease, Ecdysis motor program activity	Feb 9, 2017	Feb 9, 2017	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1446	1328: Inactivated, 5-HTR	1329: Reduce expression, BDNF	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1448	1330: Decreased, neuroplasticity	1345: Increased, agitation	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1458	1355: Activated, membrane depolarization	1362: Increased, hippocampal hyperdepolarization	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1702	1495: Interaction with the lung cell membrane	1496: Increased proinflammatory mediators	Jan 5, 2018	Jun 22, 2026	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
1524	1397: Increased, serotonin transporter activity	1398: Increased, intracellular serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1525	1398: Increased, intracellular serotonin	1399: Increased, packaged serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1526	1399: Increased, packaged serotonin	1400: Increased, synaptic release	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1527	1400: Increased, synaptic release	1320: Increased, extracellular serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1528	1397: Increased, serotonin transporter activity	1347: Decreased, extracellular serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1567	317: Altered, Cardiovascular development/function	947: Increase, Early Life Stage Mortality	Jun 9, 2017	Mar 23, 2018	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
1134	1097: Occurrence, renal proximal tubular necrosis	1098: Increased, blood potassium concentration	Nov 29, 2016	Dec 3, 2016	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1140	1098: Increased, blood potassium concentration	1106: Occurrence, cardiac arrhythmia	Nov 29, 2016	Dec 3, 2016	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1141	1106: Occurrence, cardiac arrhythmia	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality

Key Event Relationships (KERs)

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