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Showing 3026 to 3050 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1151	1108: Abnormal, Role change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
1247	1182: Increase, Cell Proliferation (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1252	1192: Increased, Ductal Hyperplasia	1193: N/A, Breast Cancer	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1752	1366: Decrease, Oogenesis	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	3 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3)
1763	1492: Tissue resident cell activation	1493: Increased pro-inflammatory mediators	Aug 2, 2018	Aug 2, 2018	3 AOPs 38: Protein Alkylation leading to Liver Fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1743	1523: Decrease, Cuticular chitin content	1524: Increase, Premature molting	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1777	1493: Increased pro-inflammatory mediators	1494: Leukocyte recruitment/activation	Nov 12, 2018	Nov 12, 2018	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1931	1635: Increase, DNA strand breaks	185: Increase, Mutations	Jun 2, 2019	Jan 9, 2023	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
1904	1632: Increase in RONS	1194: Increase, DNA Damage	May 7, 2019	May 8, 2019	3 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3490	1115: Increase, ROS	1634: Increase, Oxidative DNA damage	Feb 25, 2025	Feb 25, 2025	3 AOPs 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 330: Excessive reactive oxygen species production leading to mortality (4)
3503	1840: Inhibition, cytochrome oxidase	1825: Increase, Cell death	Mar 5, 2025	Mar 18, 2025	3 AOPs 368: Cytochrome oxidase inhibition leading to increased nasal lesions 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
3348	1614: Decrease, AR activation	1786: nipple retention, increased	Sep 26, 2024	Mar 20, 2026	3 AOPs 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3391	2251: Increased E2 availability	1065: Activation, ERα	Nov 15, 2024	Nov 21, 2024	3 AOPs 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
3448	2298: Decrease, intratesticular testosterone	1690: Decrease, circulating testosterone levels	Dec 12, 2024	Mar 20, 2026	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
2237	1158: Increased, Hepatic thyroid hormone uptake/transport	281: T4 in serum, Decreased	Dec 9, 2020	Dec 9, 2020	3 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2309	1172: Increased activation, Nuclear factor kappa B (NF-kB)	1496: Increased proinflammatory mediators	Mar 30, 2021	Mar 30, 2021	3 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 319: Binding to ACE2 leading to lung fibrosis
2333	1862: Decrease, Photosystem II efficiency	1475: Decrease, Photosynthesis	Apr 11, 2021	Feb 23, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
2127	286: Altered, Transcription of genes by the AR	1688: AGD, decreased	May 11, 2020	Feb 4, 2026	3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
2125	413: Reduction, Testosterone synthesis in Leydig cells	1690: Decrease, circulating testosterone levels	May 11, 2020	May 1, 2024	3 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
2292	406: decreased, Fertility	360: Decrease, Population growth rate	Mar 26, 2021	Mar 26, 2021	3 AOPs 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3146	177: Increase, Mitochondrial dysfunction	1262: Apoptosis	Mar 13, 2024	Mar 13, 2024	3 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 595: Emerging OPFRS reproductive outcome pathway
3141	177: Increase, Mitochondrial dysfunction	1115: Increase, ROS	Mar 6, 2024	Apr 11, 2024	3 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 273: Mitochondrial complex inhibition leading to liver injury 472: DNA adduct formation leading to kidney failure
3116	1392: Increase, Oxidative Stress	1445: Increase, LPO	Jan 24, 2024	Jun 23, 2026	3 AOPs 521: Essential element imbalance leads to reproductive failure via oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation
3264	1392: Increase, Oxidative Stress	1097: Occurrence, renal proximal tubular necrosis	Jul 3, 2024	Jul 3, 2024	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
2038	281: T4 in serum, Decreased	1003: Decreased, Triiodothyronine (T3)	Feb 19, 2020	Oct 10, 2022	4 AOPs 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning

Key Event Relationships (KERs)

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