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Showing 3101 to 3125 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1503	424: Inhibition, Na+/I- symporter (NIS)	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1506	277: TH synthesis, Decreased	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
403	281: T4 in serum, Decreased	402: Cognitive function, decreased	Nov 29, 2016	Apr 27, 2026	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3790	2428: PAMPs, increased	1392: Increase, Oxidative Stress	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3791	1392: Increase, Oxidative Stress	902: Inflammation, Liver	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3792	902: Inflammation, Liver	1931: Disruption of the intestinal barrier	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3793	902: Inflammation, Liver	1489: Increase, Steatohepatitis	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3794	1417: NFE2/Nrf2 repression	2421: FXR inhibition	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3795	2421: FXR inhibition	2423: Hepatic SHP, decreased	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3796	2423: Hepatic SHP, decreased	1421: Activated, LXR	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	May 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3797	1635: Increase, DNA strand breaks	55: Cell injury/death	May 12, 2026	May 12, 2026	1 AOP 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
3645	2370: A1AR Agonism	2371: Increased cortisol	Oct 1, 2025	May 29, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3647	968: Decreased, release of kisspeptin from AVPV neurons	530: Decreased, GnRH pulsatility/release	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3648	530: Decreased, GnRH pulsatility/release	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3649	1986: Decreased, Gonadotropins	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
2665	1065: Activation, ERα	1985: Increased Kisspeptin levels in AVPV	Jun 6, 2022	Jun 2, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3716	2137: Increase, Gonadotropins concentration in plasma	2402: Increased, E2 production in ovaries	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3718	2294: Plasma E2, increased	2306: Persistent vaginal cornification	Jan 29, 2026	Jun 2, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3746	2294: Plasma E2, increased	2413: Increased, uterine weight	Mar 13, 2026	Jun 2, 2026	1 AOP 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining
3761	2294: Plasma E2, increased	2415: Precocious puberty	Mar 26, 2026	Jun 2, 2026	1 AOP 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release

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